{"title":"Extensive Mandibular Bone Regeneration Following Iodoform and Lyophilized Bone Grafting in a Patient Initially Indicated for Hemimandibulectomy.","authors":"Renato Zacura, Moema A Hausen, Marli Gerenutti","doi":"10.1155/crid/5757136","DOIUrl":"https://doi.org/10.1155/crid/5757136","url":null,"abstract":"<p><p>Mandibular cysts arise from various etiologies and generally exhibit benign characteristics, with favorable treatment outcomes. Nevertheless, extensive cystic lesions may involve cortical bone, leading to substantial bone loss, reduced mechanical integrity of the mandible, and an increased risk of pathological fractures. In severe cases, hemimandibulectomy may become a clinical option, potentially resulting in functional and aesthetic impairment and requiring complex mandibular reconstruction. Therefore, conservative regenerative strategies aimed at preserving mandibular continuity may provide substantial benefits for patient recovery and quality of life. In this case report, we present a successful approach in which a mandible severely affected by benign cyst-induced bone loss was preserved and extensively regenerated over a 6-year follow-up period. Following preoperative endodontic management with iodoform, the cyst was completely enucleated, and the resulting extensive bone defect was filled with lyophilized bovine bone combined with iodoform and covered with collagen membranes and a titanium mesh. Long-term radiographic follow-up demonstrated progressive increases in radiopacity and integration of the treated area, whereas computed tomography at 5.5 years revealed restoration of cortical bone continuity and extensive mandibular remodeling. At 6 years, the treated region exhibited radiopacity similar to that of the contralateral preserved mandibular region. These findings suggest that, in carefully selected extensive benign mandibular lesions, a conservative regenerative approach may preserve mandibular continuity and potentially avoid extensive mandibular resection.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"5757136"},"PeriodicalIF":0.9,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149301040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cementoblastoma With Bony and Soft Tissue Recurrences Following a Primary Molar Lesion: A Case Report.","authors":"Eman Allam, Craig C Thiede, Yi-Ling Lin","doi":"10.1155/crid/8903042","DOIUrl":"https://doi.org/10.1155/crid/8903042","url":null,"abstract":"<p><p>Cementoblastoma is a rare benign odontogenic neoplasm defined by its fusion to the root of a tooth and characterized by radiating cementoid deposition with peripheral active cementoblasts. Although recurrence is uncommon following complete excision, when it occurs, it typically arises at the original site. We report an unusual recurrent cementoblastoma associated with a primary mandibular molar in a pediatric patient. Review of records from the initial presentation documented a radiopaque mandibular lesion fused to the roots of the lower right primary first molar with cortical expansion, which was treated by extraction of the involved tooth and removal of the associated lesion. Eighteen months later, the patient presented with recurrence as multiple discrete, noncoalescent masses involving the alveolar crest, lingual cortical bone, and buccal gingival soft tissue. All recurrent lesions, including the soft tissue lesion, showed histologic features consistent with developing cementoblastoma. Each lesion demonstrated a radial growth pattern forming a well-circumscribed spherical mass. This case documents recurrence after apparently conservative initial removal of a cementoblastoma arising in the primary dentition, and supports the concept that neither persistent root attachment nor an osseous environment is required for lesion development or for maintaining the characteristic radial growth pattern. The findings highlight the importance of complete excision at initial presentation to reduce the risk of recurrence.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"8903042"},"PeriodicalIF":0.9,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13711489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Ledergerber, Matthew Lama, Antonio Gabriel Lanata-Flores
{"title":"Ten-Year Split-Mouth Follow-Up of Tunnel Technique Using Connective Tissue Graft Versus Acellular Dermal Matrix for Multiple Gingival Recession Coverage: A Case Report.","authors":"Roberto Ledergerber, Matthew Lama, Antonio Gabriel Lanata-Flores","doi":"10.1155/crid/1995303","DOIUrl":"https://doi.org/10.1155/crid/1995303","url":null,"abstract":"<p><strong>Introduction: </strong>Long-term split-mouth comparisons between autogenous connective tissue grafts and acellular dermal matrices using the tunnel technique remain limited in the literature. Gingival recession may lead to root exposure, hypersensitivity, and esthetic concerns. Connective tissue grafts are widely considered the gold standard for root coverage; however, palatal harvesting is associated with postoperative morbidity when multiple sites are treated. Acellular dermal matrix has been proposed as a donor-site-free alternative.</p><p><strong>Case presentation: </strong>A 55-year-old female patient presented with multiple RT1 gingival recessions and dentin hypersensitivity. A split-mouth design was performed. On the right maxilla, a tunnel technique combined with an autogenous connective tissue graft was used, whereas on the left maxilla, the same technique was combined with acellular dermal matrix. Clinical measurements and photographic documentation were obtained up to 10 years.</p><p><strong>Results: </strong>During the first 2 years, mean root coverage was 100% on the CTG-treated side and 95% on the ADM-treated side. At Year 6, mean root coverage remained 100% on the CTG-treated side and decreased to 67% on the ADM-treated side. Complete root coverage was maintained in 75% and 40% of sites, respectively. Relapse occurred primarily in acellular dermal matrix-treated teeth after Year 6, whereas the soft-tissue phenotype remained clinically stable on both sides. The patient reported high satisfaction and complete resolution of hypersensitivity.</p><p><strong>Conclusion: </strong>In this single case, the CTG-treated side showed greater observed stability at 10 years, whereas ADM provided satisfactory clinical outcomes with lower donor-site morbidity. These observations are descriptive and should not be interpreted as evidence of comparative effectiveness or generalized beyond this patient.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"1995303"},"PeriodicalIF":0.9,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149275377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nonsurgical Management of Extensive Internal Root Resorption: A 48-Month Follow-Up Case Report.","authors":"Hamdi Alperen Yalcin, Aybike Sayar","doi":"10.1155/crid/4482522","DOIUrl":"https://doi.org/10.1155/crid/4482522","url":null,"abstract":"<p><p>A 21-year-old male presented with a nonvital right maxillary central incisor with percussion sensitivity and mild mobility. Cone-beam computed tomography (CBCT) confirmed extensive internal root resorption (IRR) involving nearly the entire root, with a buccal cortical bone defect but no perforation of the root. Nonsurgical treatment was completed in three sessions using chemomechanical preparation with ProTaper Gold and 2.5% sodium hypochlorite irrigation at each session, with an interim calcium hydroxide dressing between sessions. The calcium hydroxide was removed using 17% EDTA with EDDY sonic activation, followed by a final saline rinse. Obturation was performed using a hybrid technique: MTA Angelus in the resorptive defect and an epoxy resin sealer with warm vertical gutta-percha condensation coronally. Clinical and radiographic follow-ups at 6, 12, and 48 months demonstrated resolution of clinical symptoms, periapical healing, and no further progression of resorption on periapical radiographs. A follow-up CBCT at 48 months showed healing of the buccal cortical bone defect. In this case, nonsurgical orthograde treatment, combining CBCT-guided diagnosis, chemomechanical debridement, and hybrid bioceramic-resin obturation, was associated with clinical and radiographic healing, suggesting that a nonsurgical orthograde approach may be a feasible tooth-preserving option for selected cases of extensive nonperforating IRR.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"4482522"},"PeriodicalIF":0.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13689543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149275379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luahra Peserico, Luís Eduardo Cechin, Camilla Dos Santos Tibúrcio-Machado, Carlos Alexandre Souza Bier, Cláudia Medianeira Londero Pagliarin, Renata Dornelles Morgental
{"title":"New Approach Using Ultrasonic Irrigant Activation and Propolis in Regenerative Endodontics: A Case Report.","authors":"Luahra Peserico, Luís Eduardo Cechin, Camilla Dos Santos Tibúrcio-Machado, Carlos Alexandre Souza Bier, Cláudia Medianeira Londero Pagliarin, Renata Dornelles Morgental","doi":"10.1155/crid/2616239","DOIUrl":"https://doi.org/10.1155/crid/2616239","url":null,"abstract":"<p><p>This study is aimed at describing a clinical case of a regenerative endodontic procedure (REP) in an immature permanent maxillary central incisor with pulp necrosis and apical periodontitis, using a modified protocol that included ultrasonic activation of 1.5% sodium hypochlorite (NaOCl) and 17% EDTA as irrigating solutions, along with an intracanal medicament (ICM) composed of propolis extract and calcium hydroxide (CH) powder, with a 7-year follow-up. An 8-year-old patient underwent an REP on Tooth 11 following trauma to the anterior teeth. Two weeks after procedure, a buccal sinus tract was observed. Cone-beam computed tomography (CBCT) revealed a wide root canal, thin dentinal walls, a periapical osteolytic lesion, and an atypical apical formation resembling an \"apical cap\", with no evidence of root development on the buccal aspect. With the aim of improving root canal disinfection, ultrasonic activation of the irrigating solutions was performed in cycles, first using 1.5% NaOCl, followed by 17% EDTA, and a final cycle with 1.5% NaOCl. A final rinse with saline was conducted before placement of the ICM, which consisted of propolis extract and CH powder. After 4 weeks, the patient remained asymptomatic, allowing a second REP to be performed. Seven years later, radiographic and tomographic examinations revealed continued root development, increased dentinal wall thickness, and new bone formation. This case report suggests that a second REP incorporating a modified disinfection strategy with ultrasonic activation of irrigating solutions and an ICM based on propolis and CH may be a feasible approach in selected immature permanent teeth with persistent infection following an initial regenerative procedure.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"2616239"},"PeriodicalIF":0.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13691525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149275443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Extensive Calcifying Epithelial Odontogenic Tumor: Multidisciplinary Diagnostic Approach.","authors":"Manika Shrestha, Prabhat Chandra Thakur, Dipshikha Bajracharya","doi":"10.1155/crid/6290361","DOIUrl":"https://doi.org/10.1155/crid/6290361","url":null,"abstract":"<p><p>A calcifying epithelial odontogenic tumor (CEOT), also known as a Pindborg tumor, is a rare benign odontogenic neoplasm with variable biological behavior and potential for locally aggressive growth. Its clinical, radiological, and histopathological features may mimic malignancy, creating diagnostic challenges. We report the subsequent clinical course and definitive management of an extensive CEOT in a 34-year-old woman whose lesion had previously been reported as CEOT. Approximately 8 years later, she presented with persistent nonhealing ulcer of the right buccal mucosa and progressive swelling of the right posterior mandible. An incisional biopsy performed at another institution was diagnosed as oral squamous cell carcinoma (OSCC). The patient was subsequently referred to specialized cancer hospital for further evaluation. Repeat histopathological examination revealed anastomosing islands and well-defined nests of polyhedral tumor cells with eosinophilic cytoplasm and centrally located round nuclei. Basophilic calcifications and homogenous eosinophilic material were also observed, supporting the diagnosis of CEOT. Considering the aggressive clinical presentation and extensive involvement, segmental resection of the mandible followed by reconstruction was performed. The case emphasizes the importance of careful clinicoradiographic and histopathological correlation in establishing an accurate diagnosis and guiding appropriate management of CEOT.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"6290361"},"PeriodicalIF":0.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13689540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149275497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimizing Esthetics in Maxillary Anterior Periradicular Surgery: A Case Report on Vestibular Incision.","authors":"Manish Rathi, Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Ujjwal Joshi","doi":"10.1155/crid/9688218","DOIUrl":"https://doi.org/10.1155/crid/9688218","url":null,"abstract":"<p><strong>Background: </strong>Persistent periapical infections may necessitate surgical intervention when nonsurgical endodontic treatment fails. Conventional surgical approaches in the maxillary anterior region often lead to visible scarring and prolonged healing, compromising esthetic outcomes. The vestibular incision subperiosteal tunnel access (VISTA) technique offers a minimally invasive alternative that preserves soft tissue integrity and reduces scarring.</p><p><strong>Case report: </strong>A 32-year-old male presented with symptomatic apical periodontitis of the maxillary left central incisor; universal Tooth #9 following failed nonsurgical retreatment. Periapical surgery was performed using the VISTA approach via a vestibular incision beneath the maxillary labial frenum to access the lesion with minimal tissue trauma. After debridement and apicoectomy, the defect was filled with a demineralized xenograft and covered with L-PRF membrane. The flap was sutured for optimal healing. Postoperative follow-up at 12 months demonstrated complete radiographic resolution of the periapical lesion, excellent soft tissue healing without visible scarring, and patient-reported minimal discomfort and anxiety.</p><p><strong>Conclusion: </strong>This case illustrates a potential application of the VISTA approach in anterior periradicular surgery, a well-established method in periodontal plastic surgery. The integration of VISTA with regenerative materials, such as xenografts and platelet-rich fibrin (PRF), may enhance bone healing and esthetic outcomes, thereby generating hypotheses for future research.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"9688218"},"PeriodicalIF":0.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149246803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Digital Surgical Management of Traumatic Occlusal Disorder: A Case Report.","authors":"Yuwei Liang, Qian Jiang, Junhui Ma, Yewei Xin, Feng Qiu","doi":"10.1155/crid/9103011","DOIUrl":"https://doi.org/10.1155/crid/9103011","url":null,"abstract":"<p><strong>Background: </strong>Traumatic occlusal disorders secondary to complex mandibular fractures, particularly those involving the condylar region, present a dual challenge: achieving anatomical reduction while restoring physiological function. Conventional surgical approaches are constrained by limited access, soft tissue swelling, and the inherent difficulty of occlusal reconstruction.</p><p><strong>Case presentation: </strong>A 33-year-old male presented with an anterior open bite 3 days after maxillofacial trauma. Clinical examination revealed limited mouth opening with preserved facial symmetry. Computed tomography confirmed a sagittal fracture of the right mandibular premolar region and a displaced left condylar neck fracture. A comprehensive digital surgical workflow was deployed, integrating virtual surgical planning, 3D-printed occlusal splint fabrication, and intraoperative guided fracture fixation. Postoperative outcomes demonstrated stable occlusal contact, anatomical condylar reduction, and satisfactory functional recovery.</p><p><strong>Conclusion: </strong>The integration of digital surgical techniques enables precise, function-oriented reconstruction in complex mandibular fractures. This approach aligns with the concept of \"physiological reduction\" and provides a reproducible strategy for managing traumatic occlusal disorders.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"9103011"},"PeriodicalIF":0.9,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149246761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
May Ahmed Alsenani, Rana Saud Alshagroud, Emad Hadlaq, Bader Mutrik Aldawsari, Hassan Ibrahim Khormi, Abdulrahman A Altariqi, Norah Ameen Aloushan, Abdulaziz Khalid Aloshaywi, Mohammed Abdulaziz Alangari
{"title":"A Lip Mass Revealing Syphilis: A Case Report With a Review of the Literature.","authors":"May Ahmed Alsenani, Rana Saud Alshagroud, Emad Hadlaq, Bader Mutrik Aldawsari, Hassan Ibrahim Khormi, Abdulrahman A Altariqi, Norah Ameen Aloushan, Abdulaziz Khalid Aloshaywi, Mohammed Abdulaziz Alangari","doi":"10.1155/crid/2125721","DOIUrl":"10.1155/crid/2125721","url":null,"abstract":"<p><strong>Background: </strong>Syphilis is a chronic systemic infection caused by <i>Treponema pallidum</i> and is well known for its wide spectrum of clinical presentations. Oral manifestations are uncommon and often mimic benign or reactive lesions, making diagnosis challenging, particularly in the absence of overt systemic symptoms.</p><p><strong>Case presentation: </strong>We report a case of a 26-year-old male who presented with a nonpainful swelling of the lower lip that had persisted for 2 months, with a differential diagnosis including both reactive and neoplastic processes, and underwent a biopsy for definitive diagnosis. Histopathological examination demonstrated ulcerated oral mucosa with psoriasiform epithelial hyperplasia, neutrophilic transmigration, and a dense chronic inflammatory infiltrate rich in plasma cells. Immunohistochemical staining highlighted <i>Treponema pallidum</i> organisms within the lesional tissue, and serologic testing was positive, confirming the diagnosis of syphilis. At follow-up, the patient developed additional oral ulcers and a maculopapular rash involving the palms, soles, and genitalia, consistent with systemic disease, and was referred for medical management.</p><p><strong>Conclusion: </strong>This case underscores the importance of considering syphilis in the differential diagnosis of atypical oral lesions. Early recognition by dental practitioners, supported by histopathological evaluation, immunohistochemistry, and serologic testing, is essential for timely diagnosis, appropriate referral, and prevention of disease progression and transmission.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"2125721"},"PeriodicalIF":0.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gian Marco Podda, Lucia Borghetti, Federica Rocchetti, Niccolò Di Giosaffatte, Irene Bottillo, Paola Grammatico, Cira Rosaria Tiziana Di Gioia, Umberto Romeo
{"title":"Oral Manifestations of Cowden Syndrome in a Young Patient: A Case Report With Clinical, Histological, and Genetic Findings.","authors":"Gian Marco Podda, Lucia Borghetti, Federica Rocchetti, Niccolò Di Giosaffatte, Irene Bottillo, Paola Grammatico, Cira Rosaria Tiziana Di Gioia, Umberto Romeo","doi":"10.1155/crid/7101797","DOIUrl":"10.1155/crid/7101797","url":null,"abstract":"<p><strong>Aims: </strong>This study is aimed at describing the oral manifestations and diagnostic pathway of Cowden syndrome in a young patient, highlighting the role of dental professionals in early detection of PTEN-related disorders.</p><p><strong>Case presentation: </strong>A 25-year-old woman presented with long-standing, progressive multifocal oral papillomatous lesions since childhood. Clinical examination revealed macrocephaly and extensive papillomatosis involving the lips, tongue, palate, and buccal mucosa. Histopathological analysis demonstrated verrucous epithelial proliferation with parakeratosis, acanthosis, elongated rete ridges, and low-grade dysplasia. Based on the clinical and histological findings, genetic testing was performed and identified a pathogenic PTEN variant (c.388C>T; p.Arg130Ter), confirming the diagnosis of Cowden syndrome. The patient was subsequently enrolled in a multidisciplinary surveillance program.</p><p><strong>Conclusion: </strong>Persistent multifocal oral papillomatosis associated with systemic findings should raise suspicion for Cowden syndrome. Early recognition by dental professionals is essential for prompt diagnosis and timely initiation of risk-adapted surveillance strategies.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2026 ","pages":"7101797"},"PeriodicalIF":0.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}