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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-04-02 DOI: 10.1109/TRPMS.2025.3552178

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-04-02 DOI: 10.1109/TRPMS.2025.3552176

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-04-02 DOI: 10.1109/TRPMS.2025.3552150

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-04-02 DOI: 10.1109/TRPMS.2025.3552148

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-03-04 DOI: 10.1109/TRPMS.2025.3542198

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-03-04 DOI: 10.1109/TRPMS.2025.3542196

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-02-04 DOI: 10.1109/TRPMS.2025.3530624

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-02-04 DOI: 10.1109/TRPMS.2025.3530622

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A Statistical Reconstruction Algorithm for Positronium Lifetime Imaging Using Time-of-Flight Positron Emission Tomography

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-01-17 DOI: 10.1109/TRPMS.2025.3531225

Hsin-Hsiung Huang;Zheyuan Zhu;Slun Booppasiri;Zhuo Chen;Shuo Pang;Chien-Min Kao

{"title":"A Statistical Reconstruction Algorithm for Positronium Lifetime Imaging Using Time-of-Flight Positron Emission Tomography","authors":"Hsin-Hsiung Huang;Zheyuan Zhu;Slun Booppasiri;Zhuo Chen;Shuo Pang;Chien-Min Kao","doi":"10.1109/TRPMS.2025.3531225","DOIUrl":"https://doi.org/10.1109/TRPMS.2025.3531225","url":null,"abstract":"Positron emission tomography (PET) is an important modality for diagnosing diseases, such as cancer and Alzheimer’s disease, capable of revealing the uptake of radiolabeled molecules that target specific pathological markers of the diseases. Recently, positronium lifetime imaging (PLI) that adds to traditional PET the ability to explore properties of the tissue microenvironment beyond tracer uptake has been demonstrated with time-of-flight (TOF) PET and the use of nonpure positron emitters. However, achieving accurate reconstruction of lifetime images from data acquired by systems having a finite TOF resolution still presents a challenge. This article focuses on the 2-D PLI, introducing a maximum-likelihood estimation (MLE) method that employs an exponentially modified Gaussian (EMG) probability distribution that describes the positronium lifetime data produced by TOF PET. We evaluate the performance of our EMG-based MLE method against approaches using exponential likelihood functions and penalized surrogate methods. Results from computer-simulated data reveal that the proposed EMG-MLE method can yield quantitatively accurate lifetime images. We also demonstrate that the proposed MLE formulation can be extended to handle PLI data containing multiple positron populations.","PeriodicalId":46807,"journal":{"name":"IEEE Transactions on Radiation and Plasma Medical Sciences","volume":"9 4","pages":"478-486"},"PeriodicalIF":4.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10844904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pseudo-MRI-Guided PET Image Reconstruction Method Based on a Diffusion Probabilistic Model

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IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2025-01-16 DOI: 10.1109/TRPMS.2025.3528728

Weijie Gan;Huidong Xie;Carl von Gall;Günther Platsch;Michael T. Jurkiewicz;Andrea Andrade;Udunna C. Anazodo;Ulugbek S. Kamilov;Hongyu An;Jorge Cabello

{"title":"Pseudo-MRI-Guided PET Image Reconstruction Method Based on a Diffusion Probabilistic Model","authors":"Weijie Gan;Huidong Xie;Carl von Gall;Günther Platsch;Michael T. Jurkiewicz;Andrea Andrade;Udunna C. Anazodo;Ulugbek S. Kamilov;Hongyu An;Jorge Cabello","doi":"10.1109/TRPMS.2025.3528728","DOIUrl":"https://doi.org/10.1109/TRPMS.2025.3528728","url":null,"abstract":"Anatomically guided positron emission tomography (PET) reconstruction using magnetic resonance imaging (MRI) information has been shown to have the potential to improve PET image quality. However, these improvements are limited to PET scans with paired MRI information. In this work, we employed a diffusion probabilistic model (DPM) to infer T1-weighted-MRI (deep-MRI) images from FDG-PET brain images. We then use the DPM-generated T1w-MRI to guide the PET reconstruction. The model was trained with brain FDG scans, and tested in datasets containing multiple levels of counts. Deep-MRI images appeared somewhat degraded and in some cases showed inaccuracies compared to the acquired MRI images. Regarding PET image quality, volume of interest analysis in different brain regions showed that both PET reconstructed images using the acquired and the deep-MRI images improved image quality compared to ordered subset expected maximum (OSEM). Same conclusions were found analysing the decimated datasets. A subjective evaluation performed by two physicians confirmed that OSEM scored consistently worse than the MRI-guided PET images and no significant differences were observed between the MRI-guided PET images. This proof of concept shows that it is possible to infer DPM-based MRI imagery to guide the PET reconstruction, enabling the possibility of changing reconstruction parameters, such as the strength of the prior on anatomically guided PET reconstruction in the absence of MRI.","PeriodicalId":46807,"journal":{"name":"IEEE Transactions on Radiation and Plasma Medical Sciences","volume":"9 4","pages":"412-420"},"PeriodicalIF":4.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10843797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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