Lancet Microbe最新文献

{"title":"Paying more attention to HIV-1 recombinants among men who have sex with men","authors":"Zhenzhou Wan , Yakhouba Kane , Chiyu Zhang","doi":"10.1016/j.lanmic.2024.101058","DOIUrl":"10.1016/j.lanmic.2024.101058","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101058"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Institute of Allergy and Infectious Diseases’ commitment to advancing innovative bioinformatics resources","authors":"Emily Erbelding","doi":"10.1016/j.lanmic.2024.101068","DOIUrl":"10.1016/j.lanmic.2024.101068","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101068"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Call for prudent use of the term hypervirulence in carbapenem-resistant Klebsiella pneumoniae","authors":"Yongqiang Yang , Alan McNally , Zhiyong Zong","doi":"10.1016/j.lanmic.2025.101090","DOIUrl":"10.1016/j.lanmic.2025.101090","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101090"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli","authors":"Tommi Mäklin PhD ,&nbsp;Aurora Taira MSc ,&nbsp;Sergio Arredondo-Alonso PhD ,&nbsp;Yan Shao PhD ,&nbsp;Prof Michael R Stratton PhD ,&nbsp;Trevor D Lawley PhD ,&nbsp;Prof Lauri A Aaltonen MD ,&nbsp;Prof Jukka Corander PhD","doi":"10.1016/j.lanmic.2024.101015","DOIUrl":"10.1016/j.lanmic.2024.101015","url":null,"abstract":"<div><div>Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal cancer. Colibactin has been known to drive tumorigenesis by inducing double-strand breaks in the DNA of epithelial cells exposed to colibactin-producing bacteria. Some phylogroup B2 <em>Escherichia coli</em> secrete colibactin during interbacterial warfare, concomitantly exposing the host to an increasing risk of DNA damage. This Personal View reviews the current knowledge about the cancer–colibactin interface and summarises metagenomics-based and population-genomics-based surveys to show that the prevalence of dominant colibactin-producing lineages of <em>E coli</em> varies considerably across geographical regions. The prevalence is further strongly associated with the age-standardised incidences of colorectal cancer, bladder cancer, and prostate cancer, suggesting that the degree of colibactin exposure in a population might contribute to the geographical variation of these cancers. Our observations provide a strong impetus for further research and the development of novel interventions to reduce the risks for colibactin-related cancers.</div></div>","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101015"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex-situ trans-Gram transfer of clinically relevant antimicrobial resistance genes from a genomic perspective: natural or contamination-related events?","authors":"João Pedro Rueda Furlan ,&nbsp;Sergio Schenkman ,&nbsp;Fábio Parra Sellera ,&nbsp;Shuangshuang Li ,&nbsp;Yilu Zhuang ,&nbsp;Zhi Ruan","doi":"10.1016/j.lanmic.2024.101067","DOIUrl":"10.1016/j.lanmic.2024.101067","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101067"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogen aetiology and risk factors for death among neonates with bloodstream infections at lower-tier South African hospitals: a cross-sectional study","authors":"Susan Meiring PhD ,&nbsp;Vanessa Quan MBBCh ,&nbsp;Rudzani Mashau MPH ,&nbsp;Olga Perovic FCPath ,&nbsp;Rindidzani Magobo PhD ,&nbsp;Marshagne Smith BTech ,&nbsp;Ruth Mpembe BTech ,&nbsp;Anne von Gottberg PhD ,&nbsp;Linda de Gouveia BTech ,&nbsp;Sibongile Walaza PhD ,&nbsp;Prof Cheryl Cohen PhD ,&nbsp;Constance Kapongo FCPaed ,&nbsp;Cheryl Mackay FCPaed ,&nbsp;Mphekwa Thomas Mailula FCPaed ,&nbsp;Omphile Mekgoe FCPaed ,&nbsp;Lerato Motjale FCPaed ,&nbsp;Rose Phayane FCPaed ,&nbsp;Angela Dramowski PhD ,&nbsp;Prof Nelesh P Govender FRCPath ,&nbsp;Vanessa Pearce","doi":"10.1016/j.lanmic.2024.100989","DOIUrl":"10.1016/j.lanmic.2024.100989","url":null,"abstract":"<div><h3>Background</h3><div>Infections are among the top causes of neonatal mortality, particularly in low-income and middle-income countries. We aimed to describe the clinical characteristics of neonates diagnosed with culture-confirmed bloodstream infections at six lower-tier hospitals in South Africa.</div></div><div><h3>Methods</h3><div>We did a cross-sectional study of culture-confirmed bloodstream infections among neonates (aged 0–27 days) at six lower-tier hospitals in South Africa. Clinical, demographic, and pathogen data from sick, hospitalised neonates were analysed and bloodstream infections were categorised as early-onset sepsis (EOS; 0–2 days of life) or late-onset sepsis (LOS; 3–27 days of life). Incidence of bloodstream infection and crude in-hospital mortality in neonates with bloodstream infection were calculated and factors associated with death were analysed using multivariable logistic regression models.</div></div><div><h3>Findings</h3><div>From Oct 1, 2019 to Sept 30, 2020, we identified 907 neonatal bloodstream infection episodes. Incidence was 6·4 cases per 1000 patient-days. Most neonates were preterm (median gestation 33 weeks [IQR 29–37]), with 30·5% (n=277) of bloodstream infections classified as EOS and 69·5% (n=630) as LOS. Gram-negative pathogens dominated (63·2% [n=573]), including <em>Klebsiella pneumoniae</em> (25·7% [n=233]) and <em>Acinetobacter baumannii</em> (19·2% [n=174]). Crude in-hospital mortality in neonates with bloodstream infection was 25·5% (n=231), accounting for 21·4% (231 of 1078 cases) of all in-hospital neonatal deaths. Increased all-cause mortality was associated with Gram-negative bloodstream infection (<em>vs</em> Gram-positive pathogens, adjusted odds ratio 3·70 [95% CI 1·46–9·39]; p=0·0059), inborn LOS (<em>vs</em> EOS, 2·42 [1·11–5·29];  p=0·027), preterm birth (5·00 [2·16–11·59]; p=0·0002), and neonatal intensive care unit admission (3·26 [1·51–7·03]; p=0·0026).</div></div><div><h3>Interpretation</h3><div>Hospitalised, preterm neonates who developed Gram-negative bloodstream infections had high in-hospital mortality. Many small vulnerable newborns require prolonged stays in lower-tier hospitals and acquire life-threatening bloodstream infection; appropriate resources are needed at this level of care to prevent infections and save lives.</div></div><div><h3>Funding</h3><div>Bill &amp; Melinda Gates Foundation.</div></div>","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 100989"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection of Plasmodium falciparum kelch13 mutations in Uganda in comparison with southeast Asia: a modelling study","authors":"Cecile P G Meier-Scherling BSc ,&nbsp;Oliver J Watson PhD ,&nbsp;Victor Asua MSc ,&nbsp;Isaac Ghinai MBBS ,&nbsp;Thomas Katairo MSc ,&nbsp;Shreeya Garg BSc ,&nbsp;Melissa D Conrad PhD ,&nbsp;Prof Philip J Rosenthal MD ,&nbsp;Lucy C Okell PhD ,&nbsp;Jeffrey A Bailey MD PhD","doi":"10.1016/j.lanmic.2024.101027","DOIUrl":"10.1016/j.lanmic.2024.101027","url":null,"abstract":"<div><h3>Background</h3><div>Artemisinin partial resistance, mediated by mutations in the <em>Plasmodium falciparum kelch13</em> gene (<em>k13</em>), rapidly spread in southeast Asia, undermining the antimalarial effectiveness of artemisinin-based combination therapies. <em>k13</em> mutations have also arisen in Africa, but their rates of increase are not well characterised. We aimed to quantify the selection of <em>k13</em> mutations in Africa and compare the selection with that in southeast Asia.</div></div><div><h3>Methods</h3><div>In this modelling study, we investigated <em>k13</em> mutation allele frequency at 16 sites in Uganda (2016–22) and five sites in southeast Asia (in Cambodia, Thailand, and Viet Nam; 2003–14). The Ugandan data were obtained from annual clinical surveillance studies and the southeast Asian data were obtained from the MalariaGEN Pf7 dataset. We investigated five validated and candidate <em>k13</em> mutations: Pro441Leu, Cys469Phe, Cys469Tyr, Arg561His, and Ala675Val. We calculated annual selection coefficients using Bayesian mixed-effect linear models. We then tested whether the <em>k13</em> mutation allele frequency in southeast Asia could have been forecast accurately using up to the first 5 years of available data and forecast future <em>k13</em> mutation allele frequency in Uganda.</div></div><div><h3>Findings</h3><div>We used data from 7564 samples from Uganda and 6568 samples from southeast Asia. The annual selection coefficient of evaluable <em>k13</em> mutations (Pro441Leu, Cys469Phe/Tyr, Arg561His, and Ala675Val) across all sites was estimated at 0·381 (95% credible interval 0·298 to 0·472) per year, a 38% increase in relative allele frequency. Selection coefficients across Uganda were 0·494 (−0·462 to 1·410) for Pro441Leu, 0·324 (−0·629 to 1·150) for Cys469Phe, 0·383 (0·207 to 0·591) for Cys469Tyr, and 0·237 (0·087 to 0·403) for Ala675Val. In southeast Asia, the selection coefficients were 0·627 (−0·088 to 1·312) for Cys580Tyr, 0·224 (−0·903 to 1·397) for Arg539Thr, and 0·330 (−0·075 to 0·683) for all validated <em>k13</em> mutations. Compared with out-of-sample data, the forecasts for southeast Asia underestimated mutation allele frequency and were of variable accuracy. Overall, forecast allele frequencies for Uganda, assuming constant selection, neared fixation (&gt;0·95 allele frequency) within a decade (between 2031 and 2033) for combined <em>k13</em> mutations.</div></div><div><h3>Interpretation</h3><div><em>k13</em> mutation selection in Uganda was similar to that observed in southeast Asia, suggesting that frequencies of <em>k13</em> mutations will continue to increase quickly in Uganda. These commensurate levels of selection indicate a high potential for rapid transmission across other parts of Africa, underscoring the urgent need for treatments and policies to mitigate the spread and impact of <em>k13</em> mutations.</div></div><div><h3>Funding</h3><div>US National Institutes of Health.</div></div>","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101027"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New dengue vaccine for UK travellers: recommended only for those with a previous infection","authors":"Angela McBride ,&nbsp;Nicky Longley ,&nbsp;Jane Osborne ,&nbsp;Tommy Rampling ,&nbsp;Catherine F Houlihan","doi":"10.1016/j.lanmic.2024.101054","DOIUrl":"10.1016/j.lanmic.2024.101054","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101054"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combating regional outbreaks: One Health strategy integrating reverse microbial aetiology to avert global pandemics","authors":"Xulong Lang ,&nbsp;Jianhai Yin ,&nbsp;Yang Sun","doi":"10.1016/j.lanmic.2025.101091","DOIUrl":"10.1016/j.lanmic.2025.101091","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101091"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHO's antibiotic waste management guidelines: advancements and shortcomings","authors":"Jerin James","doi":"10.1016/j.lanmic.2024.101066","DOIUrl":"10.1016/j.lanmic.2024.101066","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 5","pages":"Article 101066"},"PeriodicalIF":20.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}