Lancet Microbe最新文献

{"title":"US Government cuts funding for long COVID research","authors":"Priya Venkatesan","doi":"10.1016/j.lanmic.2025.101166","DOIUrl":"10.1016/j.lanmic.2025.101166","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101166"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking bacterial communication: the future of next-generation antibiotics","authors":"Shobana Rajaramon , Helma David , Anusree Sajeevan , Swathi Sujith , Adline Princy Solomon","doi":"10.1016/j.lanmic.2025.101172","DOIUrl":"10.1016/j.lanmic.2025.101172","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101172"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of bacterial secondary resistome on antimicrobial susceptibility","authors":"Viviane A Ferreira , Mauro M S Saraiva , Valdinete P Benevides , Angelo Berchieri Junior","doi":"10.1016/j.lanmic.2025.101171","DOIUrl":"10.1016/j.lanmic.2025.101171","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101171"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Microbe 2025; 6: 101034","authors":"","doi":"10.1016/j.lanmic.2025.101175","DOIUrl":"10.1016/j.lanmic.2025.101175","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101175"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the use of bacteriophages to tackle AMR","authors":"Timothy Jesudason","doi":"10.1016/j.lanmic.2025.101204","DOIUrl":"10.1016/j.lanmic.2025.101204","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101204"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study","authors":"Adela Alcolea-Medina PhD , Luke B Snell MRCP , Gul Humayun MSc , Noor Al-Yaakoubi BSc , Daniel Ward PhD , Christopher Alder MSc , Vishwa Patel BSc , Fredrik Vivian MRCP , Christopher I S Meadows FFICM , Duncan Wyncoll FFICM , Richard Paul FFICM , Nick Barratt FFICM , Rahul Batra MD , Prof Jonathan Edgeworth FRCPath , Gaia Nebbia FRCPath , James Whitehorn FRCPath","doi":"10.1016/j.lanmic.2025.101174","DOIUrl":"10.1016/j.lanmic.2025.101174","url":null,"abstract":"<div><h3>Background</h3><div>Most clinical metagenomic studies do not provide rapid results, detect pathogens from all microbial kingdoms, or measure clinical impacts. We aimed to evaluate the feasibility, performance, and clinical impacts of a rapid pan-microbial respiratory metagenomic service for patients admitted to intensive care units (ICUs).</div></div><div><h3>Methods</h3><div>This was a single-centre observational study of a rapid metagenomics service that tests respiratory samples from ICU patients at Guy’s and St Thomas’ hospitals, London, UK, between Dec 5, 2023, and April 12, 2024. Testing used a previously published pan-microbial metagenomics workflow, which simultaneously detects bacteria, fungi, and DNA and RNA viruses; provides same-day preliminary results after 2 h; and provides final results after 24 h. Patients were included if they were aged 18 years or older, admitted to the ICU, had confirmed respiratory failure requiring supplemental oxygen or advanced airway support, and had at least one of the following: (1) clinical suspicion of lower respiratory tract infection based on clinical, biochemical, or radiological findings, (2) sepsis of unknown origin, and (3) concern from an intensive care physician regarding inflammatory pathology. Patients with a suspected or confirmed containment level three organism were excluded. The outcome was performance characteristics of the metagenomic test compared with routine diagnostic testing, detection of additional pathogens by metagenomics, change in antimicrobial prescribing within 24 h of testing, and initiation of immunomodulation.</div></div><div><h3>Findings</h3><div>We processed 114 samples (1–5 per day) from 74 patients (39 [53%] female and 35 [47%] male). 107 (94%) of 114 samples passed quality control, of which 101 (94%) provided same-day preliminary results. Bacteria were detected in 45 (43%) of 104 tested specimens, fungal organisms in 17 (16%) of 104 tested specimens, and viruses in 28 (34%) of 83 tested specimens. Sensitivity in lower respiratory tract samples after 24 h was 97% (95% CI 87–100) for bacteria, 89% (65–99) for fungi, and 89% (71–98) for viruses, with only one false positive for bacteria. Metagenomics identified 42 pathogens not detected by other tests in 32 (30%) of 107 samples. Antimicrobial therapy was changed after metagenomic results from 30 (28%) of 107 samples: 22 (21%) were de-escalated and eight (7%) were escalated. Metagenomics contributed to the initiation of immunomodulation in 15 (20%) of 74 patients for a range of inflammatory conditions. Pathogens with clinical significance to local infection control or national public health were found in ten (14%) of 74 patients, including three invasive Group A streptococci, two parvovirus B19<em>,</em> and one each of HIV-1, measles virus, <em>Mycobacterium tuberculosis, Neisseria meningitidis,</em> and <em>Mycoplasma pneumoniae</em>.</div></div><div><h3>Interpretation</h3><div>Respiratory metagenomics for ICU","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101174"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pandemic preparedness: the need for historical epistemology in research alliances","authors":"Francesco Maria Galassi , Roberto Burioni , Elena Varotto","doi":"10.1016/j.lanmic.2025.101164","DOIUrl":"10.1016/j.lanmic.2025.101164","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101164"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heteroresistance and clinical outcomes: knowledge gaps","authors":"Gabriele Maria Leanza , Rita Murri , Maurizio Sanguinetti , Carlo Torti","doi":"10.1016/j.lanmic.2025.101141","DOIUrl":"10.1016/j.lanmic.2025.101141","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101141"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global health equity and diagnosis of sepsis in low-income and middle-income countries","authors":"Kenneth Iregbu , Rong Zhang , Yuqing Zhou , Timothy R Walsh","doi":"10.1016/j.lanmic.2025.101158","DOIUrl":"10.1016/j.lanmic.2025.101158","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101158"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying genomic surveillance gaps in Africa for the global public health response to West Nile virus: a systematic review","authors":"Monika Moir PhD ,&nbsp;Nikita Sitharam MSc ,&nbsp;Laura Marije Hofstra MD PhD ,&nbsp;Graeme Dor MSc ,&nbsp;Gaspary Mwanyika PhD ,&nbsp;Yajna Ramphal MSc ,&nbsp;Martina L Reichmuth PhD ,&nbsp;James Emmanuel San PhD ,&nbsp;Robert Gifford PhD ,&nbsp;Eduan Wilkinson PhD ,&nbsp;Derek Tshiabuila MSc ,&nbsp;Prof Wolfgang Preiser MD ,&nbsp;Abla Ahouefa Konou PhD ,&nbsp;Molalegne Bitew PhD ,&nbsp;Anyebe Bernard Onoja PhD ,&nbsp;Giacomo Maria Paganotti PhD ,&nbsp;Adugna Abera MSc ,&nbsp;James Ayei Maror MSc ,&nbsp;John Kayiwa MSc ,&nbsp;Sara Abuelmaali PhD ,&nbsp;Houriiyah Tegally PhD","doi":"10.1016/j.lanmic.2025.101176","DOIUrl":"10.1016/j.lanmic.2025.101176","url":null,"abstract":"<div><div>West Nile virus (WNV) is a priority pathogen that poses a high risk for public health emergencies of global concern. Although WNV is endemic to Africa, only few (n=63) whole genomic sequences are available from the continent. In this Review, we examined the status of the molecular testing and genomic sequencing of WNV across Africa and mapped its global spatiotemporal spread. WNV has been detected in 39 African countries, the Canary Islands, and Réunion Island. Although publications, including those with molecular data, originated from 24 of these countries, genomic sequences were available from only 16 countries. Our analysis identified regions with detected viral circulation but without molecular surveillance. The current literature has substantial knowledge gaps in terms of the disease burden, molecular epidemiology, and distribution of WNV in Africa. Addressing these gaps requires an integrated One Health surveillance approach, which is challenging to establish. We propose three key surveillance needs that could improve the current understanding of the WNV disease burden in Africa, to strengthen the global public health response to this vector-borne disease.</div></div>","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"6 10","pages":"Article 101176"},"PeriodicalIF":20.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}