International Journal of Tryptophan Research最新文献_第10页

Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies. 阿尔茨海默病或伴路易体痴呆患者脑脊液中的犬尿酸水平。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2014-04-28 eCollection Date: 2014-01-01 DOI: 10.4137/IJTR.S13958

Malin Wennström, Henrietta M Nielsen, Funda Orhan, Elisabet Londos, Lennart Minthon, Sophie Erhardt

{"title":"Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies.","authors":"Malin Wennström, Henrietta M Nielsen, Funda Orhan, Elisabet Londos, Lennart Minthon, Sophie Erhardt","doi":"10.4137/IJTR.S13958","DOIUrl":"https://doi.org/10.4137/IJTR.S13958","url":null,"abstract":"Kynurenic acid (KYNA) is implicated in cognitive functions. Altered concentrations of the compound are found in serum and cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Further studies to determine whether KYNA serves as a biomarker for cognitive decline and dementia progression are required. In this study, we measured CSF KYNA levels in AD patients (n = 19), patients with dementia with Lewy bodies (DLB) (n = 18), and healthy age-matched controls (Ctrls)) (n = 20) to further explore possible correlations between KYNA levels, cognitive decline, and well-established AD and inflammatory markers. Neither DLB patients nor AD patients showed significantly altered CSF KYNA levels compared to Ctrls. However, female AD patients displayed significantly higher KYNA levels compared to male AD patients, a gender difference not seen in the Ctrl or DLB group. Levels of KYNA significantly correlated with the AD-biomarker P-tau and the inflammation marker soluble intercellular adhesion molecule-1 (sICAM-1) in the AD patient group. No associations between KYNA and cognitive functions were found. Our study shows that, although KYNA was not associated with cognitive decline in AD or DLB patients, it may be implicated in AD-related hyperphosphorylation of tau and inflammation. Further studies on larger patient cohorts are required to understand the potential role of KYNA in AD and DLB. ","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"7 ","pages":"1-7"},"PeriodicalIF":4.4,"publicationDate":"2014-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/IJTR.S13958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32364750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Immunohistochemical studies of the kynurenine pathway in morphea. 吗啡犬尿氨酸通路的免疫组化研究。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-12-23 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S13371

Rowland Noakes, Nick Mellick

引用次数: 4

Sustained elevation of kynurenic Acid in the cerebrospinal fluid of patients with herpes simplex virus type 1 encephalitis. 单纯疱疹病毒1型脑炎患者脑脊液中肌尿酸持续升高

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-11-25 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S13256

Ann Atlas, Elisabeth Franzen-Röhl, Johan Söderlund, Erik G Jönsson, Martin Samuelsson, Lilly Schwieler, Birgit Sköldenberg, Göran Engberg

{"title":"Sustained elevation of kynurenic Acid in the cerebrospinal fluid of patients with herpes simplex virus type 1 encephalitis.","authors":"Ann Atlas, Elisabeth Franzen-Röhl, Johan Söderlund, Erik G Jönsson, Martin Samuelsson, Lilly Schwieler, Birgit Sköldenberg, Göran Engberg","doi":"10.4137/IJTR.S13256","DOIUrl":"https://doi.org/10.4137/IJTR.S13256","url":null,"abstract":"Herpes simplex virus (HSV) type 1 encephalitis (HSE) is a viral infectious disease with commonly occurring neurodegeneration and neurological/cognitive long-term sequelae. Kynurenic acid (KYNA) is a neuroactive tryptophan metabolite, which is elevated in the cerebrospinal fluid (CSF) during viral infection as a result of immune activation. The aim of the study was to investigate the role of endogenous brain KYNA for the long-term outcome of the disease. CSF KYNA concentration was analyzed in 25 HSE patients along the course of the disease and compared with that of 25 age-matched healthy volunteers. Within 3 weeks of admission CSF KYNA of HSE patients was markedly elevated (median 33.6 nM) compared to healthy volunteers (median 1.45 nM). Following a decline observed after 1-2 months, levels of CSF KYNA were elevated more than 1 year after admission (median 3.4 nM range: 1-9 years). A negative correlation was found between initial CSF KYNA concentrations and severity of the long-term sequelae. This study show a marked elevation in CSF KYNA from patients with HSE, most pronounced during the acute phase of the disease and slowly declining along the recovery. We propose that brain KYNA might potentially protect against neurodegeneration while causing a long-lasting loss in cognitive function associated with the disease. ","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"6 ","pages":"89-96"},"PeriodicalIF":4.4,"publicationDate":"2013-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/IJTR.S13256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31943749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Big brains, meat, tuberculosis, and the nicotinamide switches: co-evolutionary relationships with modern repercussions? 大脑、肉类、结核病和烟酰胺开关:与现代影响的共同进化关系?

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-10-15 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S12838

Adrian C Williams, Robin I M Dunbar

{"title":"Big brains, meat, tuberculosis, and the nicotinamide switches: co-evolutionary relationships with modern repercussions?","authors":"Adrian C Williams, Robin I M Dunbar","doi":"10.4137/IJTR.S12838","DOIUrl":"https://doi.org/10.4137/IJTR.S12838","url":null,"abstract":"Meat-eating was a game changer for human evolution. We suggest that the limiting factors for expanding brains earlier were scarcities of nicotinamide and tryptophan. In humans and some other omnivores, lack of meat causes these deficiencies. Nicotinamide adenine dinucleotide (NADH) is necessary to synthesize adenosine triphosphate (ATP) via either glycolysis or via the mitochondrial respiratory chain. NAD consumption is also necessary for developmental and repair circuits. Inadequate supplies result in \"de-evolutionary\" brain atrophy, as seen with pellagra. If trophic nicotinamide/tryptophan was a \"prime mover\" in building bigger brains, back-up mechanisms should have evolved. One strategy may be to recruit extra gut symbionts that produce NADH precursors or export nicotinamide (though this may cause diarrhea). We propose a novel supplier TB that co-evolved early, which did not originally and does not now inevitably cause disease. TB has highly paradoxical immunology for a pathogen, and secretes and is inhibited by nicotinamide and its analogue, isoniazid. Sharp declines in TB and diarrhea correlated with increased meat intake in the past, suggesting that dietary vitamin B3 and tryptophan deficiencies (also associated with poor cognition and decreased lifespans) are still common where meat is unaffordable. ","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"6 ","pages":"73-88"},"PeriodicalIF":4.4,"publicationDate":"2013-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/IJTR.S12838","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31880134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Effects of tranilast on the urinary excretion of kynurenic and quinolinic Acid under conditions of L tryptophan loading. 曲尼司特对L色氨酸负荷条件下尿尿尿酸和喹啉酸排泄的影响。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-09-22 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S12797

Rowland R Noakes

{"title":"Effects of tranilast on the urinary excretion of kynurenic and quinolinic Acid under conditions of L tryptophan loading.","authors":"Rowland R Noakes","doi":"10.4137/IJTR.S12797","DOIUrl":"https://doi.org/10.4137/IJTR.S12797","url":null,"abstract":"The pathogenesis of morphea and other cutaneous sclerosing disorders remain poorly understood. Although they are considered to be autoimmune disorders, abnormal tryptophan metabolism may be involved. Current therapy is directed to supressing the autoimmune response. Demonstration of a therapeutic response to manipulation of the kynurenine pathway would both support a role for abnormal tryptophan metabolism and offer additional targets for therapy. Tranilast is a 3-hydroxyanthranilic acid derivative known to target the kynurenine pathway. The aim of this study was to see if tranilast lowered the urinary excretion of the kynurenine metabolites kynurenic and quinolinic acid under condition of L tryptophan loading in a volunteer. Mean baseline value for kynurenic acid and quinolinic acid were 1.1 and 2.1 mmol/mol creatinine, respectively. This rose to 5.6 and 3.8 mmol/mol creatinine respectively under conditions of L tryptophan loading 2 grams daily. Adding 1 g of tranilast daily lowered the values to 2.0 and 2.9 mmol/mol creatinine, respectively. These data suggest that tranilast acts as a competitive inhibitor of either indoleamine 2, 3-dioxygenase (IDO), tryptophan 2, 3-di-oxygenase (TDO) or both. As it involved only 1 subject, the results may not be representative of the larger population and must be considered preliminary. ","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"6 ","pages":"67-71"},"PeriodicalIF":4.4,"publicationDate":"2013-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/IJTR.S12797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31780433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The kynurenine pathway in stem cell biology. 干细胞生物学中的犬尿氨酸途径。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-09-15 DOI: 10.4137/IJTR.S12626

Simon P Jones, Gilles J Guillemin, Bruce J Brew

引用次数: 0

Kynurenic Acid in the digestive system-new facts, new challenges. 消化系统中的犬尿酸--新事实、新挑战。

IF 2.7

International Journal of Tryptophan Research Pub Date : 2013-09-04 DOI: 10.4137/IJTR.S12536

Michal P Turski, Monika Turska, Piotr Paluszkiewicz, Jolanta Parada-Turska, Gregory F Oxenkrug

引用次数: 0

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1. 肿瘤选择性细胞毒剂β-拉帕醌是一种强效的 IDO1 抑制剂。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-08-19 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S12094

Hollie E Flick, Judith M Lalonde, William P Malachowski, Alexander J Muller

{"title":"The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1.","authors":"Hollie E Flick, Judith M Lalonde, William P Malachowski, Alexander J Muller","doi":"10.4137/IJTR.S12094","DOIUrl":"10.4137/IJTR.S12094","url":null,"abstract":"β-lapachone is a naturally occurring 1,2-naphthoquinone-based compound that has been advanced into clinical trials based on its tumor-selective cytotoxic properties. Previously, we focused on the related 1,4-naphthoquinone pharmacophore as a basic core structure for developing a series of potent indoleamine 2,3-dioxygenase 1 (IDO1) enzyme inhibitors. In this study, we identified IDO1 inhibitory activity as a previously unrecognized attribute of the clinical candidate β-lapachone. Enzyme kinetics-based analysis of β-lapachone indicated an uncompetitive mode of inhibition, while computational modeling predicted binding within the IDO1 active site consistent with other naphthoquinone derivatives. Inhibition of IDO1 has previously been shown to breach the pathogenic tolerization that constrains the immune system from being able to mount an effective anti-tumor response. Thus, the finding that β-lapachone has IDO1 inhibitory activity adds a new dimension to its potential utility as an anti-cancer agent distinct from its cytotoxic properties, and suggests that a synergistic benefit can be achieved from its combined cytotoxic and immunologic effects. ","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"6 ","pages":"35-45"},"PeriodicalIF":4.4,"publicationDate":"2013-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31723111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-tryptophan metabolism in pregnant mice fed a high L-tryptophan diet and the effect on maternal, placental, and fetal growth. 高左旋色氨酸饮食对妊娠小鼠左旋色氨酸代谢及对母体、胎盘和胎儿生长的影响。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-08-14 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S12715

Ai Tsuji, Chifumi Nakata, Mitsue Sano, Tsutomu Fukuwatari, Katsumi Shibata

引用次数: 20

Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages. 猕猴巨噬细胞犬尿氨酸途径和喹啉酸生成的表征。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-05-15 Print Date: 2013-01-01 DOI: 10.4137/IJTR.S11789

Chai K Lim, Margaret M C Yap, Stephen J Kent, Gabriel Gras, Boubekeur Samah, Jane C Batten, Robert De Rose, Benjamin Heng, Bruce J Brew, Gilles J Guillemin

引用次数: 23