International Journal of Tryptophan Research最新文献_第10页

Effects of tranilast on the urinary excretion of kynurenic and quinolinic Acid under conditions of L tryptophan loading. 曲尼司特对L色氨酸负荷条件下尿尿尿酸和喹啉酸排泄的影响。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-09-22 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S12797

Rowland R Noakes

{"title":"Effects of tranilast on the urinary excretion of kynurenic and quinolinic Acid under conditions of L tryptophan loading.","authors":"Rowland R Noakes","doi":"10.4137/IJTR.S12797","DOIUrl":"https://doi.org/10.4137/IJTR.S12797","url":null,"abstract":"The pathogenesis of morphea and other cutaneous sclerosing disorders remain poorly understood. Although they are considered to be autoimmune disorders, abnormal tryptophan metabolism may be involved. Current therapy is directed to supressing the autoimmune response. Demonstration of a therapeutic response to manipulation of the kynurenine pathway would both support a role for abnormal tryptophan metabolism and offer additional targets for therapy. Tranilast is a 3-hydroxyanthranilic acid derivative known to target the kynurenine pathway. The aim of this study was to see if tranilast lowered the urinary excretion of the kynurenine metabolites kynurenic and quinolinic acid under condition of L tryptophan loading in a volunteer. Mean baseline value for kynurenic acid and quinolinic acid were 1.1 and 2.1 mmol/mol creatinine, respectively. This rose to 5.6 and 3.8 mmol/mol creatinine respectively under conditions of L tryptophan loading 2 grams daily. Adding 1 g of tranilast daily lowered the values to 2.0 and 2.9 mmol/mol creatinine, respectively. These data suggest that tranilast acts as a competitive inhibitor of either indoleamine 2, 3-dioxygenase (IDO), tryptophan 2, 3-di-oxygenase (TDO) or both. As it involved only 1 subject, the results may not be representative of the larger population and must be considered preliminary. ","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"6 ","pages":"67-71"},"PeriodicalIF":4.4,"publicationDate":"2013-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/IJTR.S12797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31780433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The kynurenine pathway in stem cell biology. 干细胞生物学中的犬尿氨酸途径。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-09-15 DOI: 10.4137/IJTR.S12626

Simon P Jones, Gilles J Guillemin, Bruce J Brew

引用次数: 0

Kynurenic Acid in the digestive system-new facts, new challenges. 消化系统中的犬尿酸--新事实、新挑战。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-09-04 DOI: 10.4137/IJTR.S12536

Michal P Turski, Monika Turska, Piotr Paluszkiewicz, Jolanta Parada-Turska, Gregory F Oxenkrug

引用次数: 0

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1. 肿瘤选择性细胞毒剂β-拉帕醌是一种强效的 IDO1 抑制剂。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-08-19 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S12094

Hollie E Flick, Judith M Lalonde, William P Malachowski, Alexander J Muller

{"title":"The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1.","authors":"Hollie E Flick, Judith M Lalonde, William P Malachowski, Alexander J Muller","doi":"10.4137/IJTR.S12094","DOIUrl":"10.4137/IJTR.S12094","url":null,"abstract":"β-lapachone is a naturally occurring 1,2-naphthoquinone-based compound that has been advanced into clinical trials based on its tumor-selective cytotoxic properties. Previously, we focused on the related 1,4-naphthoquinone pharmacophore as a basic core structure for developing a series of potent indoleamine 2,3-dioxygenase 1 (IDO1) enzyme inhibitors. In this study, we identified IDO1 inhibitory activity as a previously unrecognized attribute of the clinical candidate β-lapachone. Enzyme kinetics-based analysis of β-lapachone indicated an uncompetitive mode of inhibition, while computational modeling predicted binding within the IDO1 active site consistent with other naphthoquinone derivatives. Inhibition of IDO1 has previously been shown to breach the pathogenic tolerization that constrains the immune system from being able to mount an effective anti-tumor response. Thus, the finding that β-lapachone has IDO1 inhibitory activity adds a new dimension to its potential utility as an anti-cancer agent distinct from its cytotoxic properties, and suggests that a synergistic benefit can be achieved from its combined cytotoxic and immunologic effects. ","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"6 ","pages":"35-45"},"PeriodicalIF":4.4,"publicationDate":"2013-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31723111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-tryptophan metabolism in pregnant mice fed a high L-tryptophan diet and the effect on maternal, placental, and fetal growth. 高左旋色氨酸饮食对妊娠小鼠左旋色氨酸代谢及对母体、胎盘和胎儿生长的影响。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-08-14 eCollection Date: 2013-01-01 DOI: 10.4137/IJTR.S12715

Ai Tsuji, Chifumi Nakata, Mitsue Sano, Tsutomu Fukuwatari, Katsumi Shibata

引用次数: 20

Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages. 猕猴巨噬细胞犬尿氨酸途径和喹啉酸生成的表征。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-05-15 Print Date: 2013-01-01 DOI: 10.4137/IJTR.S11789

Chai K Lim, Margaret M C Yap, Stephen J Kent, Gabriel Gras, Boubekeur Samah, Jane C Batten, Robert De Rose, Benjamin Heng, Bruce J Brew, Gilles J Guillemin

引用次数: 23

Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1. 大鼠有机阴离子转运体rOAT1和rOAT3对犬尿酸的转运:人和大鼠在OAT1中的物种差异

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-01-01 Epub Date: 2013-02-17 DOI: 10.4137/IJTR.S11206

Yuichi Uwai, Hiroaki Hara, Kikuo Iwamoto

{"title":"Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1.","authors":"Yuichi Uwai, Hiroaki Hara, Kikuo Iwamoto","doi":"10.4137/IJTR.S11206","DOIUrl":"https://doi.org/10.4137/IJTR.S11206","url":null,"abstract":"A tryptophan catabolite, kynurenic acid, is involved in schizophrenia and uremia; there is little information on the mechanism of its disposition. Recently, our laboratory showed that kynurenic acid is a good substrate of human organic anion transporters hOAT1 and hOAT3. In this study, we performed uptake experiment using Xenopus laevis oocytes to characterize the transport of kynurenic acid by rat homologs of the transporters, rOAT1, and rOAT3. These transporters stimulated the uptake of kynurenic acid into oocytes, and transport by rOAT3 was marked. The Km values of the transport were estimated to be 8.46 μM for rOAT1 and 4.81 μM for rOAT3, and these values are comparable to their human homologs. The transport activity of kynurenic acid by rOAT1 was about one quarter of that of p-aminohippurate, although they were at the similar levels in hOAT1. A comparative experiment with hOAT1 was added in this study, showing that uptake amounts of kynurenic acid by hOAT1-expressing oocytes were 4 times greater than rOAT1-expressing oocytes. rOAT3 transported kynurenic acid as efficiently as estrone sulfate; this phenomenon was also observed in hOAT3. In conclusion, transport of kynurenic acid by rOAT1 and rOAT3 was shown. The characteristics of rOAT3 were similar to hOAT3, but low transport activity of kynurenic acid by rOAT1 was exhibited compared with hOAT1.","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"6 ","pages":"1-6"},"PeriodicalIF":4.4,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/IJTR.S11206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31379168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity 高脂喂养对小鼠肝脏TDO2和IDO2的诱导:与人类肥胖的差异

IF 4.4

International Journal of Tryptophan Research Pub Date : 2013-01-01 DOI: 10.4137/IJTR.S11717

O. Poulain-Godefroy, Elodie Eury, A. Leloire, B. Hennart, G. Guillemin, D. Allorge, P. Froguel

{"title":"Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity","authors":"O. Poulain-Godefroy, Elodie Eury, A. Leloire, B. Hennart, G. Guillemin, D. Allorge, P. Froguel","doi":"10.4137/IJTR.S11717","DOIUrl":"https://doi.org/10.4137/IJTR.S11717","url":null,"abstract":"Low-grade and chronic inflammation is elicited in white adipose tissue in human obesity. The presence of inflammatory molecules leads to an increased tryptophan catabolism through the induction of indoleamine-2,3-dioxygenase-1 (IDO1). In order to characterize the mechanisms underlying this dysregulation, we have studied 2 mouse models of obesity. Unexpectedly, we did not detect any IDO1 expression in obese or lean mice adipose tissue. In a previous study, we did not find any significant difference in the liver for IDO2 and tryptophan-2,3-dioxygenase (TDO2) gene expression between normal weight and obese patients. IDO2 and TDO2 expression was increased in the liver of high-fat fed mice, but not in ob/ob mice, and was strongly correlated with hydroxysteroid-(11-beta) dehydrogenase-1 (HSD11B1) expression, an enzyme that generates active cortisol within tissues. In conclusion, despite a dysregulation of tryptophan metabolism, obese mice display discrepancies with human obesity metabolism, rendering them inappropriate for further investigations in this animal model.","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"23 1","pages":"29 - 37"},"PeriodicalIF":4.4,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89471659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

A jerte valley cherry-based product as a supply of tryptophan. 一种以樱桃为基础的产品，提供色氨酸。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2012-01-01 Epub Date: 2012-04-16 DOI: 10.4137/IJTR.S9394

María Garrido, Javier Espino, Antonio F Toribio-Delgado, Javier Cubero, Juan I Maynar-Mariño, Carmen Barriga, Sergio D Paredes, Ana B Rodríguez

{"title":"A jerte valley cherry-based product as a supply of tryptophan.","authors":"María Garrido, Javier Espino, Antonio F Toribio-Delgado, Javier Cubero, Juan I Maynar-Mariño, Carmen Barriga, Sergio D Paredes, Ana B Rodríguez","doi":"10.4137/IJTR.S9394","DOIUrl":"https://doi.org/10.4137/IJTR.S9394","url":null,"abstract":"L-Tryptophan (tryptophan) is an essential amino acid in humans. It has important roles as a precursor of different bioactive compounds. Based on previous studies in which tryptophan has been shown to be present in fresh cherries, the aim of the present work was to analyze the tryptophan content of a Jerte Valley cherry-based product. A previously optimized method of analysis of tryptophan was used, ie, high-performance liquid chromatography with fluorescence detection (HPLC/FL). As expected, HPLC/FL technique permitted to detect and quantify the tryptophan content in a different matrix rather than fresh cherries. In fact, the Jerte Valley cherry-based product contained 69.54 ± 10.64 ppm of tryptophan, thereby showing that this product is a good source of tryptophan. In summary, it has been proven that the Jerte Valley cherry-based product is rich in tryptophan and may be indicated as a supply of this essential amino acid as well as having potential health benefits for conditions where tryptophan is necessary.","PeriodicalId":46603,"journal":{"name":"International Journal of Tryptophan Research","volume":"5 ","pages":"9-14"},"PeriodicalIF":4.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/IJTR.S9394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30589273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM). 与色氨酸相关的临床疾病的简要历史概述:与慢性疲劳综合征(CFS)和纤维肌痛(FM)的相关性。

IF 4.4

International Journal of Tryptophan Research Pub Date : 2012-01-01 Epub Date: 2012-09-17 DOI: 10.4137/IJTR.S10085

Adele Blankfield

引用次数: 15