CoDAS最新文献

{"title":"Individual anatomical variability and interrelations: impacts on swallowing functionality and clinical perspectives.","authors":"Guilherme Maia Zica, Maria Inês Rebelo Gonçalves","doi":"10.1590/2317-1782/e20240360pt","DOIUrl":"10.1590/2317-1782/e20240360pt","url":null,"abstract":"<p><p>Have you ever wondered during clinical practice why the manifestations of swallowing dysfunctions are so heterogeneous? For example, an individual may go through the aging process and different illnesses with functional swallowing or, in another scenario, may present different forms of dysphagia manifestation. What would be the possible factors associated with the development or not of dysphagia besides those already known? By reading a book on human anatomy, it is possible to understand the complexity of anatomical structures and their different forms and correlations. For years, there have been countless descriptions in the literature regarding the anatomical and physiological variability between individuals and how this may or may not promote changes in functionality. There are countless anatomical and physiological variations known in human beings. However, the individual and personalized approach to individual anatomical correlations of swallowing and their impact on dysfunctions, therapeutic programs and prognosis is still rarely found in the literature. In this paper, we will describe a brief history of research into individual anatomical variations in the area of health and dysphagia and the complex human evolutionary context, in an attempt to reflect on the question: would it be possible for some individuals to have an anatomy and/or physiology that is naturally more prone to swallowing dysfunctions? Mastering anatomy and physiology is fundamental for intervention in dysphagia, however, we believe that other aspects should be considered in the future for assertive and personalized assessment, planning and intervention.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 4","pages":"e20240360"},"PeriodicalIF":0.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early symptoms of autism spectrum disorders and association with Brazilian children's development and behavior.","authors":"Rafaela Silva Moreira, Marina Aguiar Pires Guimarães, Lívia de Castro Magalhães, Janaina Matos Moreira, Claudia Regina Lindgren Alves","doi":"10.1590/2317-1782/e20240306en","DOIUrl":"10.1590/2317-1782/e20240306en","url":null,"abstract":"<p><strong>Purpose: </strong>to examine the association between the early autism spectrum disorder (ASD) signs and developmental and behavioral performance of Brazilian children aged 18 to 34 months.</p><p><strong>Methods: </strong>A cross-sectional study with 221 children recruited at public healthcare and early education services. Early symptoms of ASD were screened using the Parental Observations of Social Interaction (POSI). Children's development and behavior were examined using the Ages and Stages Questionnaires (ASQ-3) and Survey of Well-being of Young Children (SWYC-BR). The results of children at risk for ASD were compared to the no-risk ones using Chi-square and t-test.</p><p><strong>Results: </strong>The overall frequency of children at risk for ASD (POSI-positive screening) was 33% and did not differ across children's age range and gender. Children at risk for ASD showed worse socio-emotional behaviors (p=0.004) and lower scores for overall development (p=0.0001), communication (p=0.0007), fine motor (p=0.04), and personal-social domains (p=0.01). Differences between groups varied according to children's age and across developmental/behavioral domains and were more evident in older children. Children aged 30 to 34 months presented significant differences in overall development (p=0.001), behavior (p=0.004), and the personal-social domains (p=0.03).</p><p><strong>Conclusions: </strong>The frequency of children at risk for ASD was higher than described in the literature. Also, the development and behavior of children at risk for ASD were significantly different from their peers and compatible with the presentation of ASD in young children. Our findings reinforce the need for systematic and holistic surveillance of child development during well-being visits to improve ASD early detection.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 4","pages":"e20240306"},"PeriodicalIF":0.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of an oral motor and swallowing rehabilitation program in patients with congenital myopathies.","authors":"Ana Luísa Capitelli Dornellas, Fernanda Chiarion Sassi, Ana Paula Ritto, Gisele Chagas de Medeiros, Claudia Regina Furquim de Andrade","doi":"10.1590/2317-1782/e20240294en","DOIUrl":"10.1590/2317-1782/e20240294en","url":null,"abstract":"<p><strong>Purpose: </strong>To identify factors related to swallowing and oral motor skills in patients with congenital myopathies and evaluate the outcomes of an oral motor and swallowing intervention for this population.</p><p><strong>Methods: </strong>Participants of this study were twenty-six individuals with diagnosed myopathies or muscular dystrophy, referred to the Division of Speech-Language Pathology. Data collection occurred at three time points: pre-treatment, post-treatment, and three-month follow-up. Oral motor and swallowing assessments were performed using validated protocols. Participants completed a speech therapy program for oropharyngeal dysphagia, consisting of four weekly 30-minute sessions, with daily practice encouraged. Each session was supervised by a speech-language pathologist until independent practice was possible.</p><p><strong>Results: </strong>The study found that patients with congenital myopathies had significant impairments in posture, mobility, oral functions, and feeding, especially in mastication and swallowing of solid foods. The therapy program resulted in substantial improvements at all evaluation points. Significant differences were observed between pre- and post-treatment, and between pre-treatment and the three-month follow-up, as measured by the ASHA NOMS scale. Oral motor skill assessments showed improved scores on all measures of the AMIOFE-E protocol, except mastication.</p><p><strong>Conclusion: </strong>The rehabilitation program effectively improved oral motor and swallowing functions in patients with congenital myopathies, reducing the risk of pulmonary aspiration and related complications. The therapy program demonstrated to be highly effective for this patient group.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 4","pages":"e20240294"},"PeriodicalIF":0.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERRATUM: Characterization of swallowing in older adults with dementia.","authors":"","doi":"10.1590/2317-1782/e20230183pt","DOIUrl":"10.1590/2317-1782/e20230183pt","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/2317-1782/e20230358pt] [This corrects the article doi: 10.1590/2317-1782/e20230358en].</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 3","pages":"e20230183"},"PeriodicalIF":0.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term effects of acoustically controlled auditory training in children with impaired school performance.","authors":"Júlia Roja Tavoni, Maria Francisca Colella Dos Santos","doi":"10.1590/2317-1782/e20240135pt","DOIUrl":"10.1590/2317-1782/e20240135pt","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effectiveness of acoustically controlled auditory training (ACAT) and the maintenance of auditory skills acquired by children with impaired school performance.</p><p><strong>Methods: </strong>Sample consisting of 20 schoolchildren: Control Group (CG - N=10) and Intervention Group (IG - N=10), aged from 8 to 13 years old, results below expectations in a school performance screening, adequate results in a cognitive screening and diagnosed with central auditory processing disorder (CAPD) after a battery of behavioral tests. The CG did not receive any type of intervention, only evaluation and reevaluation after three months. The IG was assessed immediately after eight ACAT sessions and three months post-intervention. Auditory processing assessment and reassessment data were subjected to statistical analysis (p<0.05).</p><p><strong>Results: </strong>The sample was considered homogeneous regarding gender, age, education level and academic performance. Regarding CAP assessment data, both groups were homogeneous (excepting the Synthetic Sentence Identification - SSI test). Children from IG improved their performance on the Dichotic Digit, Consonant Vowel, SSI and Frequency Pattern (FPT) tests immediately after the intervention. After three months of ACAT, these values remained the same or increased, except for FPT. In the qualitative analysis, between normal and altered, the IG maintained adequate results after three months of ACAT. In the CG, six children maintained altered results and four reached normality in the reassessment after three months.</p><p><strong>Conclusion: </strong>ACAT proved to be effective for rehabilitating the auditory skills of children with impaired school performance even three months after the end of the intervention.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 3","pages":"e20240135"},"PeriodicalIF":0.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of central facial paralysis: an agreement analysis.","authors":"Nathallie Angel Conceição da Silva Andrade, Raquel Karoline Gonçalves Amaral, Laélia Cristina Caseiro Vicente, Aline Mansueto Mourão","doi":"10.1590/2317-1782/e20240158pt","DOIUrl":"10.1590/2317-1782/e20240158pt","url":null,"abstract":"<p><strong>Purpose: </strong>To identify whether there is interrater and intrarater agreement in the classification of the degree of central facial paralysis using two scales and verify which one is more appropriate to classify the severity of facial expressions according to experts' opinion.</p><p><strong>Method: </strong>Observational, prospective, cross-sectional study of agreement analysis of the House & Brackmann (HB) scale and the Sunnybrook Facial Grading System (SFGS). Five speech-language-hearing pathologists with clinical experience analyzed post-stroke facial expression of 30 adults for interrater agreement. They were evaluated in two stages, with a 10-day interval; the second stage involved 20% ​​of the initial sample for intrarater agreement. The study used weighted kappa coefficient for the HB scale and the intraclass correlation coefficient for the SFGS classification.</p><p><strong>Results: </strong>The HB scale indicated considerable interrater and excellent intrarater agreements. The SFGS had good interrater and intrarater agreements. All speech-language-hearing pathologists considered the SFGS the most appropriate scale for classifying central facial paralysis.</p><p><strong>Conclusion: </strong>The SFGS performed better in interrater agreement analysis. The HB scale had considerable merits in the intrarater assessment. Both scales are adaptable and useful to assess and classify central facial paralysis. However, the speech-language-hearing pathologists indicated the SFGS as the most appropriate.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 3","pages":"e20240158"},"PeriodicalIF":0.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orofacial myofunctional signs and symptoms in adults with sleep breathing disorder: is there a correlation?","authors":"Gabriele Ramos de Luccas, Raphaela Godoi Abu Halawa, Carlos Henrique Ferreira Martins, Giédre Berretin-Felix","doi":"10.1590/2317-1782/e20240033pt","DOIUrl":"https://doi.org/10.1590/2317-1782/e20240033pt","url":null,"abstract":"<p><strong>Purpose: </strong>to verify whether orofacial myofunctional symptoms are related to findings from orofacial myofunctional clinical assessment in adults sleeping breathing disorders (SBD).</p><p><strong>Methods: </strong>observational study; 15 adults, with a mean age of 43 years and diagnosed with primary snoring or OSA by polysomnography; evaluated using the Orofacial Myofunctional Assessment Protocol MBGR, including the Clinical History Protocol to assess symptoms, and the Clinical Examination Protocol to identify signs, considering tests of mobility of lips, tongue, soft palate and jaw; tone of lips, tongue, cheeks and chin; respiratory mode; chewing; and swallowing solids and liquids. For the correlation between signs and symptoms, Spearman's Correlation Coefficient, considering p<0.05 statistically significant, was used.</p><p><strong>Results: </strong>The main orofacial myofunctional complaints were related to chewing (use of only one side during chewing and the need to drink liquids during meals), and swallowing (choking and residue after swallowing). In the orofacial myofunctional assessment, there was a greater frequency of alterations in tongue tone; lip mobility; unilateral chewing pattern with increased speed and chewing inefficiency; swallowing with excessive contraction of the perioral muscles, associated head movement and presence of residue in the oral cavity. The correlation between the scores of orofacial myofunctional signs and symptoms showed significance only between the aspects related to the chewing function (p=0.034), being moderate and inversely proportional (r=-0.548).</p><p><strong>Conclusion: </strong>a moderate negative correlation was found between masticatory signs and symptoms in adults with SBD, and no correlation was observed for breathing and swallowing functions.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 3","pages":"e20240033"},"PeriodicalIF":0.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tongue pressure in sarcopenic and dynapenic elderly.","authors":"Ívina Thaiana de Almeida Menezes, Igor de Matos Pinheiro, Júlia Canto E Souza, Débora Matias Dos Santos, Jaiele Freitas do Nascimento, Manuela Oliveira de Cerqueira Magalhães, Ana Caline Nóbrega","doi":"10.1590/2317-1782/e20240124pt","DOIUrl":"https://doi.org/10.1590/2317-1782/e20240124pt","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to describe tongue pressure in sarcopenic and dynapenic older adults.</p><p><strong>Methods: </strong>An exploratory observational cross-sectional study was performed. Data were gathered from 29 institutionalized older adults (over 60 years old) and several methods were used in order to assess sarcopenia - handgrip strength (dynamometer), muscle mass (bioelectrical impedance analysis and calf circumference); physical performance (Short Physical Performance Balance); and tongue pressure (PLL Pró-Fono). For descriptive analysis, means and medians were described for quantitative variables and absolute and relative frequencies were described for qualitative variables. In the inferential analysis, Pearson's and Spearman's coefficients were used for correlation measurements and Chi-square and Fisher's were used for association, 5% significance level.</p><p><strong>Results: </strong>Most patients were female (79.31%), with a median age of 81 years (IQR 12). Regarding diagnosis, 79.31% were sarcopenic, 17.24% were dynapenic and 3.45% did not present sarcopenia. Fifty-eight point six percent of patients presented low tongue pressure, being 88.2% aged 70-79 years old. Among sarcopenic older adults, 65.2% showed a decline in tongue pressure, while 40% showed similar results in the dynapenic group. There was a statistically significant positive correlation between handgrip and tongue pressure in the 70-79 years age group (p=0.03). With regards to women, there was an association between tongue pressure and sarcopenia (p=0.039) and a positive correlation between tongue pressure and handgrip (p=0.003).</p><p><strong>Conclusion: </strong>A decline in tongue strength was observed in the two studied groups, with worse outcomes in sarcopenic older adults.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 3","pages":"e20240124"},"PeriodicalIF":0.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate effects of photobiomodulation with low-level laser in women with no laryngeal or voice changes: preliminary results.","authors":"Viviane Souza Bicalho Bacelete, Elisa Meiti Ribeiro Lin Plec, Flávio Barbosa Nunes, Andréa Rodrigues Motta, Ana Cristina Côrtes Gama","doi":"10.1590/2317-1782/e20240222en","DOIUrl":"10.1590/2317-1782/e20240222en","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the safety and immediate effect of photobiomodulation of low-level laser in vocally healthy women.</p><p><strong>Methods: </strong>Experimental research in 36 vocally healthy women aged 18 to 45 years, with skin phototype I to III and body mass index below 25. Participants were randomized to form four groups: Group 1: placebo laser photobiomodulation followed by voiced tongue trill technique (VTTT); Group 2: 3 J infrared laser per point (total 21 J) followed by VTTT; Group: 3: 6 J infrared laser per point (total 42 J) followed by VTTT; and Group 4: 9 J infrared laser per point (total 63 J) followed by VTTT. The following outcomes were assessed: auditory-perceptual evaluation, acoustic analysis (jitter, shimmer, amplitude perturbation quotient [APQ], noise-to-harmonic ratio, period perturbation quotient, cepstral peak prominence, and cepstral peak prominence smoothed), and self-perceived phonatory effort. All participants' records were taken before and immediately after the experiments.</p><p><strong>Results: </strong>There was no significant difference in voice quality, acoustic parameters, or self-perceived phonatory discomfort between intervention moments in the placebo, VTTT + 3 J, and VTTT + 6 J groups in the intragroup comparison. G4 (VTTT + 9 J) decreased shimmer and APQ aperiodicity measures (respective p-values: 0.033; 0.044).</p><p><strong>Conclusion: </strong>Results indicate aperiodicity measures improved with VTTT preceded by 9 J low-level laser application per point, commending this irradiation dosimetry as a possible energy for voice therapy in light-skinned and normal-BMI women. There was no evidence of worsened measures or in-creased discomfort with this resource, indicating it is safe for clinical practice.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 3","pages":"e20240222"},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FonoTCS: validation of a tool for assessing clinical reasoning in Speech-Language pathology.","authors":"Ana Cristina Côrtes Gama, Roberto da Costa Quinino, Adriane Mesquita Medeiros, Patrícia Cotta Mancini, Aline Mansueto Mourão, Lara Gama Santos, Thais Helena Machado, Nayara Ribeiro Gomes","doi":"10.1590/2317-1782/e20240206pt","DOIUrl":"10.1590/2317-1782/e20240206pt","url":null,"abstract":"<p><strong>Purpose: </strong>To validate the internal structure of the Speech-Language Pathology Script Concordance Test (FonoTCS), which will be developed in a virtual, open-access format, to be used in the assessment of clinical reasoning among young professionals and students of speech-language pathology with a generalist background, speakers of Brazilian Portuguese.</p><p><strong>Methods: </strong>This is a study to validate the internal structure of the instrument. Twenty-five specialist speech-language pathologists, with more than 10 years of generalist clinical experience, and 35 students summoned for Enade participated. Both groups evaluated the 30 clinical cases with 120 items from FonoTCS. For the final selection of specialists who made up the sample, judges whose evaluations showed Z2 results >2 and Z<-2 distant from the modal response were removed. For the selection of items present in the final format of the test, those that remained had a Pearson correlation between the transformed scores of students for a given item and the sum of the transformed scores for all items, with a value greater than 0.05. The Cronbach's Alpha test was applied to measure the internal consistency of FonoTCS, and the score of each item was defined based on the aggregated score method.</p><p><strong>Results: </strong>The responses of 13 specialists were considered for the definition of the final test score. The final instrument had 88 items distributed across 28 clinical cases. The internal consistency was 0.903 with a 95% confidence interval expressed by 0.86|---|0.95. These values indicate a high internal consistency among the items of FonoTCS.</p><p><strong>Conclusion: </strong>FonoTCS is valid and reliable for use in evaluating the clinical reasoning of young professionals and speech-language pathology students with generalist training, who are Brazilian Portuguese speakers.</p>","PeriodicalId":46547,"journal":{"name":"CoDAS","volume":"37 3","pages":"e20240206"},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}