Rambam Maimonides Medical Journal最新文献_第4页

The Role of CCL24 in Systemic Sclerosis. CCL24 在系统性硬化症中的作用

IF 1.4

Rambam Maimonides Medical Journal Pub Date : 2023-07-31 DOI: 10.5041/RMMJ.10504

Hilit Levy, Udi Gluschnaider, Alexandra Balbir-Gurman

{"title":"The Role of CCL24 in Systemic Sclerosis.","authors":"Hilit Levy, Udi Gluschnaider, Alexandra Balbir-Gurman","doi":"10.5041/RMMJ.10504","DOIUrl":"10.5041/RMMJ.10504","url":null,"abstract":"Systemic sclerosis (SSc) is a chronic immune-mediated disease characterized by microangiopathy, immune dysregulation, and progressive fibrosis of the skin and internal organs. Though not fully understood, the pathogenesis of SSc is dominated by microvascular injury, endothelial dysregulation, and immune response that are thought to be associated with fibroblast activation and related fibrogenesis. Among the main clinical subsets, diffuse SSc (dSSc) is a progressive form with rapid and disseminated skin thickening accompanied by internal organ fibrosis and dysfunction. Despite recent advances and multiple randomized clinical trials in early dSSc patients, an effective disease-modifying treatment for progressive skin fibrosis is still missing, and there is a crucial need to identify new targets for therapeutic intervention. Eotaxin-2 (CCL24) is a chemokine secreted by immune cells and epithelial cells, which promotes trafficking of immune cells and activation of pro-fibrotic cells through CCR3 receptor binding. Higher levels of CCL24 and CCR3 were found in the skin and sera of patients with SSc compared with healthy controls; elevated levels of CCL24 and CCR3 were associated with fibrosis and predictive of greater lung function deterioration. Growing evidence supports the potency of a CCL24-blocking antibody as an anti-inflammatory and anti-fibrotic modulating agent in multiple preclinical models that involve liver, skin, and lung inflammation and fibrosis. This review highlights the role of CCL24 in orchestrating immune, vascular, and fibrotic pathways, and the potential of CCL24 inhibition as a novel treatment for SSc.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"14 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remembering Dr Mark/Meir Dvorjetski: Physician, Survivor, Teacher, Historian, and Pioneer of Shoah Medicine Research. 纪念马克/梅尔·德沃杰斯基博士:医生、幸存者、教师、历史学家和大屠杀医学研究的先驱。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-07-31 DOI: 10.5041/RMMJ.10505

Deborah E-S Hemstreet, George M Weisz

引用次数: 0

Authorship Disputes in Scholarly Biomedical Publications and Trust in the Research Institution. 生物医学学术出版物的作者争议与科研机构的信任。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-07-31 DOI: 10.5041/RMMJ.10503

Itamar Ashkenazi, Oded Olsha

{"title":"Authorship Disputes in Scholarly Biomedical Publications and Trust in the Research Institution.","authors":"Itamar Ashkenazi, Oded Olsha","doi":"10.5041/RMMJ.10503","DOIUrl":"https://doi.org/10.5041/RMMJ.10503","url":null,"abstract":"Introduction: When authorship disputes arise in academic publishing, research institutions may be asked to investigate the circumstances. We evaluated the association between the prevalence of misattributed authorship and trust in the institution involved.Methods: We measured trust using a newly validated Opinion on the Institution's Research and Publication Values (OIRPV) scale (range 1-4). Mayer and Davies' Organizational Trust for Management Instrument served as control. Association between publication misconduct, gender, institution type, policies, and OIRPV-derived Trust Scores were evaluated.Results: A total of 197 responses were analyzed. Increased reporting of authorship misconduct, such as gift authorship, author displacement within the authors' order on the byline, and ghost authorship, were associated with low Trust Scores (P<0.001). Respondents from institutions whose administration had made known (declared or published) their policy on authorship in academic publications awarded the highest Trust Scores (median 3.06, interquartile range 2.25 to 3.56). Only 17.8% favored their administration as the best authority to investigate authorship dispute honestly. Of those who did not list the administration as their preferred option for resolving disputes, 58.6% (95/162) provided a Trust Score <2.5, which conveys mistrust in the institution.Conclusions: Increased reporting of publication misconducts such as gift authorship, author displacement within the order of the authors' byline, and ghost authorship was associated with lower Trust Scores in the research institutions. Institutions that made their policies known were awarded the highest Trust Scores. Our results question whether the research institutions' administrations are the appropriate authority for clarifying author disputes in all cases.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"14 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Risk of Rectal Temperature Measurement in Neutropenia. 中性粒细胞减少症患者直肠测温的风险。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-07-31 DOI: 10.5041/RMMJ.10501

Judith Olchowski, Noa Zimhony-Nissim, Lior Nesher, Leonid Barski, Elli Rosenberg, Iftach Sagy

{"title":"The Risk of Rectal Temperature Measurement in Neutropenia.","authors":"Judith Olchowski, Noa Zimhony-Nissim, Lior Nesher, Leonid Barski, Elli Rosenberg, Iftach Sagy","doi":"10.5041/RMMJ.10501","DOIUrl":"https://doi.org/10.5041/RMMJ.10501","url":null,"abstract":"Background: Avoiding rectal thermometry is recommended in patients with neutropenic fever. Permeability of the anal mucosa may result in a higher risk of bacteremia in these patients. Still, this recommendation is based on only a few studies.Methods: This retrospective study included all individuals admitted to our emergency department during 2014-2017 with afebrile (body temperature <38.3°C) neutropenia (neutrophil count <500 cells/microL) who were over the age of 18. Patients were stratified by the presence or absence of a rectal temperature measurement. The primary outcome was bacteremia during the first five days of index hospitalization; the secondary outcome was in-hospital mortality.Results: The study included 40 patients with rectal temperature measurements and 407 patients whose temperatures were only measured orally. Among patients with oral temperature measurements, 10.6% had bacteremia, compared to 5.1% among patients who had rectal temperature measurements. Rectal temperature measurement was not associated with bacteremia, neither in non-matched (odds ratio [OR] 0.36, 95% confidence interval [CI] 0.07-1.77) nor in matched cohort analyses (OR 0.37, 95% CI 0.04-3.29). In-hospital mortality was also similar between the groups.Conclusions: Patients with neutropenia who had their temperature taken using a rectal thermometer did not experience a higher frequency of events of documented bacteremia or increased in-hospital mortality.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"14 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10334921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Can Jewish and Non-Jewish People Collaborate to Improve Healthcare in the US? Considering Community, Autonomy, and Solidarity. 犹太人和非犹太人如何合作改善美国的医疗保健?考虑社区、自治和团结。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-07-31 DOI: 10.5041/RMMJ.10502

Zackary Berger

{"title":"How Can Jewish and Non-Jewish People Collaborate to Improve Healthcare in the US? Considering Community, Autonomy, and Solidarity.","authors":"Zackary Berger","doi":"10.5041/RMMJ.10502","DOIUrl":"https://doi.org/10.5041/RMMJ.10502","url":null,"abstract":"The coronavirus 2019 (COVID) pandemic has highlighted the ways in which municipal, state, and Federal agencies in the USA have failed to address the inequities of present-day health systems. As alternative organizing centers outside these agencies, local communities are potentially situated to redress the inequities of present-day health systems in a collaborative manner that demonstrates solidarity by supplementing a purely scientific model of medicine and healthcare. In the mid-twentieth century, the Black Panthers, a revolutionary African American nationalist organization that focused on socialism and self-defense, introduced highly influential free clinics, which sought to bring expertise to the Black community on their own terms. This required bringing the benefits of biomedicine to those who customarily had not seen them. By extension, their approach raises questions regarding community- and expertise-centered approaches for the Jewish community: how is it engaged in healthcare for itself (in its diverse subcategories) and for others? Moreover, understanding how the Jewish community has been ill-served by present-day health-care systems might spur Jewish institutions to reimagine how healthcare should work.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"14 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Cell Arteritis: State of the Art in Diagnosis, Monitoring, and Treatment. 巨细胞动脉炎：诊断、监测和治疗的最新技术。

IF 1.4

Rambam Maimonides Medical Journal Pub Date : 2023-04-30 DOI: 10.5041/RMMJ.10496

Abid Awisat, Shiri Keret, Amal Silawy, Lisa Kaly, Itzhak Rosner, Michael Rozenbaum, Nina Boulman, Aniela Shouval, Doron Rimar, Gleb Slobodin

引用次数: 0

Implementation of Calcium and Vitamin D Supplementation in Glucocorticosteroid-Induced Osteoporosis Prevention Guidelines-Insights from Rheumatologists. 在糖皮质激素引起的骨质疏松预防指南中钙和维生素D补充的实施-风湿病学家的见解。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-04-30 DOI: 10.5041/RMMJ.10497

Alexandra Balbir-Gurman, Tal Gazitt, Joy Feld, Devy Zisman

引用次数: 0

Basic Lessons From India on Vaccination [Letter to the Editor]. 印度在疫苗接种方面的基本经验[给编辑的信]。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-04-30 DOI: 10.5041/RMMJ.10499

Thorakkal Shamim

引用次数: 0

Response to Letter From Dr. Thorakkal Shamim. 对Thorakkal Shamim博士来信的回应。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-04-30 DOI: 10.5041/RMMJ.10500

Peter J Hotez

引用次数: 0

Biological Therapies in Inflammatory Myopathies. 炎症性肌病的生物治疗。

IF 1.5

Rambam Maimonides Medical Journal Pub Date : 2023-04-30 DOI: 10.5041/RMMJ.10495

Abd El Haleem Natour, Shaye Kivity

引用次数: 2