Rambam Maimonides Medical Journal最新文献

Mifepristone: Reflections on its Early Clinical Development for Medical Abortion. 米非司酮用于药物流产早期临床发展的思考。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-04-26 DOI: 10.5041/RMMJ.10576

Irving M Spitz

引用次数: 0

Relationship Between Visual Perception and Participation Performance in Children with Autism Spectrum Disorder Aged 4-6 Years: A Cross-Sectional Study. 4-6岁自闭症谱系障碍儿童视觉知觉与参与表现关系的横断面研究

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-04-26 DOI: 10.5041/RMMJ.10572

Redkar Simran Sandeep, Ganapathy Sankar Umaiorubagam

{"title":"Relationship Between Visual Perception and Participation Performance in Children with Autism Spectrum Disorder Aged 4-6 Years: A Cross-Sectional Study.","authors":"Redkar Simran Sandeep, Ganapathy Sankar Umaiorubagam","doi":"10.5041/RMMJ.10572","DOIUrl":"10.5041/RMMJ.10572","url":null,"abstract":"Objectives: This study explored the relationship between visual perceptual skills and participation performance in 4-6-year-old children diagnosed with autism spectrum disorder (ASD).Methods: A cross-sectional design was employed for children diagnosed with ASD. Visual perceptual abilities were assessed using the Motor-Free Visual Perception Test-Fourth Edition (MVPT-4), and participation levels were measured using the Children Participation Questionnaire (CPQ). Statistical analysis was done using SPSS version 26, employing one-sample t-tests and Pearson correlation analysis.Results: A total of 48 participants were included in the study: mean age, 4.98±0.82 years; 66.7% were male; 79.2% attended regular schools. One-sample t-tests indicated significant deficits across all CPQ dimensions (P<0.001). Visual perception was negatively correlated with autism severity (r=-0.429, P=0.002) and positively correlated with participation diversity (r=0.404, P=0.004). In the activities of daily living (ADL) and instrumental ADL (IADL) occupations, visual perception was significantly associated with all CPQ elements. Conversely, play and leisure occupations showed mostly negative correlations with the CPQ occupations, while social participation and education showed mixed results. Visual perception was positively correlated with most elements but negatively associated with enjoyment (r=-0.428; P=0.002).Conclusions: Preschool children with ASD demonstrate significant participation restrictions. Visual perception emerged as a critical determinant of participation, particularly in ADL and educational contexts. Early interventions targeting visual perception skills may enhance independence and functional engagement, though interventions should also address the enjoyment and emotional experience occupations to ensure holistic participation outcomes.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deprescribing: Reducing Harm, Enhancing Care. 处方化：减少伤害，加强护理。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-04-26 DOI: 10.5041/RMMJ.10575

Carla Matos, Cindy Pinheiro

{"title":"Deprescribing: Reducing Harm, Enhancing Care.","authors":"Carla Matos, Cindy Pinheiro","doi":"10.5041/RMMJ.10575","DOIUrl":"10.5041/RMMJ.10575","url":null,"abstract":"Introduction: Polypharmacy carries the potential for increased risk and severity of adverse reactions. Deprescribing may reduce adverse events and possibly hospitalizations, although evidence on hard outcomes such as mortality is mixed. As the medication experts responsible for the close monitoring of their patient, doctors, nurses, and pharmacists play a crucial role in the process of medication deprescribing. They are involved in the therapeutic process and contribute to the appropriate use of medications and the proper discontinuation of those that no longer benefit the patient or are harmful. This role is particularly important for vulnerable groups, such as older people, who often take chronic medication.Objective: This study aims to review the literature on polypharmacy and the importance of suspending unnecessary or harmful medications in older people, emphasizing the role of healthcare professionals in the process.Methods: A narrative review of recent publications (articles from 2023 to 2025) in Web of Science, PubMed, and Scopus databases, addressing polypharmacy and deprescribing in older adults was conducted.Conclusions: A multidisciplinary team including doctors, nurses, and pharmacists plays a pivotal role in this process by reviewing patients' therapeutic regimens, identifying inappropriate medications, and monitoring the withdrawal process. Their intervention can support more appropriate medication use, may improve patients' quality of life, and has the potential to reduce healthcare costs.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why Is PaO₂ Not Enough? Arterial Oxygen Content as a Prognostic Indicator in COPD Patients. 为什么只有PaO2还不够？动脉血氧含量作为COPD患者的预后指标。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-04-26 DOI: 10.5041/RMMJ.10573

Stephany Ivonne Briones Alvarado, Walther Iván Girón Matute

{"title":"Why Is PaO2 Not Enough? Arterial Oxygen Content as a Prognostic Indicator in COPD Patients.","authors":"Stephany Ivonne Briones Alvarado, Walther Iván Girón Matute","doi":"10.5041/RMMJ.10573","DOIUrl":"10.5041/RMMJ.10573","url":null,"abstract":"Background: Chronic hypoxemia in patients with COPD is associated with increased morbidity and mortality. Although arterial partial pressure of oxygen (PaO2) is widely used, it does not adequately reflect systemic oxygen transport. Arterial oxygen content (CaO2) may provide a more comprehensive assessment.Objective: This study aimed to evaluate whether or not CaO2 is a better predictor of mortality than PaO2 in patients with COPD.Methods: This retrospective observational cohort study included 147 COPD patients aged ≥45 years. Patients were categorized according to CaO2 levels (low, normal, high). Mortality at 1, 3, and 5 years was analyzed. Statistical methods included ROC curves, Kaplan-Meier survival analysis, and Cox regression models.Results: A total of 66 deaths (45.2%) occurred in the study cohort. Mortality was highest in the low CaO2 group. The CaO2 demonstrated better predictive performance than PaO2 (AUC 0.73 versus 0.53, respectively). Low CaO2 was associated with a 2.5-fold increased risk of mortality. Despite improvements in PaO2 after long-term oxygen therapy, CaO2 did not significantly change.Conclusions: The CaO2 is a more informative marker of oxygen transport and mortality risk than PaO2 in COPD patients. It should be considered a complementary parameter in clinical assessment.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jewish Contributions to Plastic and Reconstructive Surgery. 犹太人对整形和重建外科的贡献。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-04-26 DOI: 10.5041/RMMJ.10577

Daniel M Portnoy, Coral Levkovitz, Zachary M Stauber, Nicholas A Mirsky, Seth R Thaller

{"title":"Jewish Contributions to Plastic and Reconstructive Surgery.","authors":"Daniel M Portnoy, Coral Levkovitz, Zachary M Stauber, Nicholas A Mirsky, Seth R Thaller","doi":"10.5041/RMMJ.10577","DOIUrl":"10.5041/RMMJ.10577","url":null,"abstract":"While individual Jewish plastic surgeons have been recognized in the literature for their groundbreaking achievements, a comprehensive review of their collective contributions to plastic surgery is lacking. The goal of this review is to document and highlight the major advancements made by Jewish physicians whose work significantly impacted plastic and reconstructive surgery from its inception as a discipline to the present day. A comprehensive literature search was conducted to identify key developments in the history of plastic surgery, which were then narrowed to those made by Jewish practitioners. The Jewish identity of these practitioners, along with the significance of their work, was verified through historical records, newspaper archives, and peer-reviewed publications. Contributions were then organized chronologically to construct a cohesive historical narrative. Beginning in the 1800s and accelerating through the 20th century, Jewish plastic surgeons have been instrumental in shaping the field. Their innovations include advancements in the treatment of facial deformities, the development of the lumpectomy with adjunctive radiation therapy as a less invasive alternative to radical mastectomy, and the founding of key institutions such as the American Society of Plastic Surgeons and the International College of Surgeons. Additional breakthroughs include the use of albumin in burn management, foundational work in angiogenesis physiology, and numerous innovations in cosmetic surgery. The history of plastic and reconstructive surgery is a rich tapestry of discovery and evolution. Fully understanding its development is not possible without acknowledging the enduring and transformative contributions of Jewish surgeons and researchers.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Red Blood Cell Features in Israeli Circassians: The Possible Effect of Residential Altitude. 以色列切尔克斯人红细胞特征的比较：居住海拔的可能影响。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-04-26 DOI: 10.5041/RMMJ.10574

Leonid Livshits, Carina Levin, Galina Petukhova, Snait Ayalon, Sireen Sharif, Ariel Koren

{"title":"Comparison of Red Blood Cell Features in Israeli Circassians: The Possible Effect of Residential Altitude.","authors":"Leonid Livshits, Carina Levin, Galina Petukhova, Snait Ayalon, Sireen Sharif, Ariel Koren","doi":"10.5041/RMMJ.10574","DOIUrl":"10.5041/RMMJ.10574","url":null,"abstract":"Background: The Circassian community in Israel represents a unique, endogamous population residing in two villages in the northern region of Israel: Kfar Kama (209 meters above sea level [m.a.s.l.]) and Rihaniya (674 m.a.s.l.).Objectives: This study sought to investigate whether the small difference in altitude between these two locations (465 m) affects red blood cell (RBC) and hemoglobin (Hb) parameters in the residents.Methods: We examined the data from 2,517 blood samples collected from adult Israeli Circassians over 2.5 years (January 2020-June 2022). To ensure independent observations, analysis was limited to each participant's most recent complete blood count (CBC). Subjects were stratified by sex, age, anemia status, and residential location.Results: Our analysis revealed that a difference of about 465 meters in residential altitude significantly elevated Hb, RBC count, and hematocrit (HCT) levels in non-anemic male and female cohorts. This elevation was accompanied by a small but significant decrease in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). Furthermore, we found that the effect of altitude on most RBC characteristics differed in anemic individuals of both sexes, although their RBC count still increased.Conclusions: Even minor differences in residential altitude can significantly influence Hb and RBC parameters. This observation appears only in non-anemic individuals, probably reflecting physiological altitude Hb adaptation mechanisms. While further research is needed to fully elucidate the underlying mechanisms, our findings provide new data on the physiological impact of altitude on human health, particularly at low altitudes.","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-04-26 DOI: 10.5041/RMMJ.10578

Payam S Pahlavan

引用次数: 0

Methodological Considerations in Assessing Mental Health Burden Among Caregivers of Special Needs Children. 评估特殊需要儿童照顾者心理健康负担的方法学考虑。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-01-28 DOI: 10.5041/RMMJ.10570

Harikrishnan Balakrishna

引用次数: 0

Immune Checkpoint Inhibitor-induced Hepatitis, an Emerging Issue in Precision Cancer Therapy Era: A Narrative Literature Review. 免疫检查点抑制剂诱导肝炎，精准癌症治疗时代的新问题：叙述性文献综述。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-01-28 DOI: 10.5041/RMMJ.10571

Randy Adiwinata, Caroline Tanadi, Fegita Beatrix Pajala, Kevin Tandarto, Maureen Miracle Stella, Jeffry Beta Tenggara, Ralph Girson Gunarsa, Paulus Simadibrata, Lianda Siregar, Saut Horas Hatoguan Nababan, Budiman Sujatmika Sulaiman, Irsan Hasan, Cosmas Rinaldi Adithya Lesmana, Aru Wisaksono Sudoyo

引用次数: 0

Bringing Rehabilitation Home: A Policy and Practice Perspective on COPD Management. 将康复带回家：COPD管理的政策与实践视角。

IF 1.3

Rambam Maimonides Medical Journal Pub Date : 2026-01-28 DOI: 10.5041/RMMJ.10567

Abins Thozhuthinkal Kasim, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam

引用次数: 0