Daniel M Portnoy, Coral Levkovitz, Zachary M Stauber, Nicholas A Mirsky, Seth R Thaller
{"title":"Jewish Contributions to Plastic and Reconstructive Surgery.","authors":"Daniel M Portnoy, Coral Levkovitz, Zachary M Stauber, Nicholas A Mirsky, Seth R Thaller","doi":"10.5041/RMMJ.10577","DOIUrl":"10.5041/RMMJ.10577","url":null,"abstract":"<p><p>While individual Jewish plastic surgeons have been recognized in the literature for their groundbreaking achievements, a comprehensive review of their collective contributions to plastic surgery is lacking. The goal of this review is to document and highlight the major advancements made by Jewish physicians whose work significantly impacted plastic and reconstructive surgery from its inception as a discipline to the present day. A comprehensive literature search was conducted to identify key developments in the history of plastic surgery, which were then narrowed to those made by Jewish practitioners. The Jewish identity of these practitioners, along with the significance of their work, was verified through historical records, newspaper archives, and peer-reviewed publications. Contributions were then organized chronologically to construct a cohesive historical narrative. Beginning in the 1800s and accelerating through the 20th century, Jewish plastic surgeons have been instrumental in shaping the field. Their innovations include advancements in the treatment of facial deformities, the development of the lumpectomy with adjunctive radiation therapy as a less invasive alternative to radical mastectomy, and the founding of key institutions such as the American Society of Plastic Surgeons and the International College of Surgeons. Additional breakthroughs include the use of albumin in burn management, foundational work in angiogenesis physiology, and numerous innovations in cosmetic surgery. The history of plastic and reconstructive surgery is a rich tapestry of discovery and evolution. Fully understanding its development is not possible without acknowledging the enduring and transformative contributions of Jewish surgeons and researchers.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IgG4-related Mastitis: An Underrecognized Diagnosis in Breast Core Biopsies.","authors":"Payam S Pahlavan","doi":"10.5041/RMMJ.10578","DOIUrl":"10.5041/RMMJ.10578","url":null,"abstract":"","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Red Blood Cell Features in Israeli Circassians: The Possible Effect of Residential Altitude.","authors":"Leonid Livshits, Carina Levin, Galina Petukhova, Snait Ayalon, Sireen Sharif, Ariel Koren","doi":"10.5041/RMMJ.10574","DOIUrl":"10.5041/RMMJ.10574","url":null,"abstract":"<p><strong>Background: </strong>The Circassian community in Israel represents a unique, endogamous population residing in two villages in the northern region of Israel: Kfar Kama (209 meters above sea level [m.a.s.l.]) and Rihaniya (674 m.a.s.l.).</p><p><strong>Objectives: </strong>This study sought to investigate whether the small difference in altitude between these two locations (465 m) affects red blood cell (RBC) and hemoglobin (Hb) parameters in the residents.</p><p><strong>Methods: </strong>We examined the data from 2,517 blood samples collected from adult Israeli Circassians over 2.5 years (January 2020-June 2022). To ensure independent observations, analysis was limited to each participant's most recent complete blood count (CBC). Subjects were stratified by sex, age, anemia status, and residential location.</p><p><strong>Results: </strong>Our analysis revealed that a difference of about 465 meters in residential altitude significantly elevated Hb, RBC count, and hematocrit (HCT) levels in non-anemic male and female cohorts. This elevation was accompanied by a small but significant decrease in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). Furthermore, we found that the effect of altitude on most RBC characteristics differed in anemic individuals of both sexes, although their RBC count still increased.</p><p><strong>Conclusions: </strong>Even minor differences in residential altitude can significantly influence Hb and RBC parameters. This observation appears only in non-anemic individuals, probably reflecting physiological altitude Hb adaptation mechanisms. While further research is needed to fully elucidate the underlying mechanisms, our findings provide new data on the physiological impact of altitude on human health, particularly at low altitudes.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Methodological Considerations in Assessing Mental Health Burden Among Caregivers of Special Needs Children.","authors":"Harikrishnan Balakrishna","doi":"10.5041/RMMJ.10570","DOIUrl":"10.5041/RMMJ.10570","url":null,"abstract":"","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Randy Adiwinata, Caroline Tanadi, Fegita Beatrix Pajala, Kevin Tandarto, Maureen Miracle Stella, Jeffry Beta Tenggara, Ralph Girson Gunarsa, Paulus Simadibrata, Lianda Siregar, Saut Horas Hatoguan Nababan, Budiman Sujatmika Sulaiman, Irsan Hasan, Cosmas Rinaldi Adithya Lesmana, Aru Wisaksono Sudoyo
{"title":"Immune Checkpoint Inhibitor-induced Hepatitis, an Emerging Issue in Precision Cancer Therapy Era: A Narrative Literature Review.","authors":"Randy Adiwinata, Caroline Tanadi, Fegita Beatrix Pajala, Kevin Tandarto, Maureen Miracle Stella, Jeffry Beta Tenggara, Ralph Girson Gunarsa, Paulus Simadibrata, Lianda Siregar, Saut Horas Hatoguan Nababan, Budiman Sujatmika Sulaiman, Irsan Hasan, Cosmas Rinaldi Adithya Lesmana, Aru Wisaksono Sudoyo","doi":"10.5041/RMMJ.10571","DOIUrl":"https://doi.org/10.5041/RMMJ.10571","url":null,"abstract":"<p><p>Immunotherapy using immune checkpoint inhibitor (ICI) has been increasingly used in the oncology treatment field. Although ICIs could help suppress cancer and improve survival rates, it could also lead to certain adverse events, including immune-mediated liver injury caused by ICIs (ILICI). The manifestation of ILICI ranged greatly from asymptomatic disease to liver failure and even death. In this review article, we will discuss the pathogenesis, manifestation, and clinical approach of ILICI.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abins Thozhuthinkal Kasim, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam
{"title":"Bringing Rehabilitation Home: A Policy and Practice Perspective on COPD Management.","authors":"Abins Thozhuthinkal Kasim, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam","doi":"10.5041/RMMJ.10567","DOIUrl":"10.5041/RMMJ.10567","url":null,"abstract":"","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Halakhic Heartbeat at the Edge of Life: Navigating Maternal Brain Death and Fetal Life.","authors":"John D Loike, Rabbi Tzvi Flaum, Alan Kadish","doi":"10.5041/RMMJ.10563","DOIUrl":"https://doi.org/10.5041/RMMJ.10563","url":null,"abstract":"<p><p>This paper presents a halakhic-ethical analysis of a 2025 case involving A.S., a brain-dead pregnant woman who was maintained on somatic support to enable fetal maturation and delivery. The case raises profound questions at the intersection of Jewish law and contemporary medical practice, particularly regarding the halakhic definition of death-brain versus cardiac cessation-and the moral status of the fetus. The paper explores divergent rabbinic opinions on whether sustaining a brain-dead body for fetal viability is halakhically permissible or obligatory. Key halakhic parameters examined include the principle of pikuach nefesh (saving life), the fetus as a potential nefesh, and the permissibility of delaying burial to perform a Cesarean section. We argue that Halakhah offers nuanced and compassionate responses to unprecedented bioethical dilemmas. Moreover, the paper affirms that Jewish law is ethically responsive, evolving through dialogue with changing human circumstances while remaining rooted in balancing reverence for life with the dignity of death. It underscores the importance of interdisciplinary collaboration between halakhic authorities and medical professionals to navigate ethically complex and medically novel scenarios with both compassion and rigor. This case illustrates that the moral courage of Halakhah's heartbeat compels rabbinical scholars to navigate its boundaries with empathy, wisdom, and fidelity to tradition.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to the Editor: Prospective Validation of PaDd-A Roadmap.","authors":"Ramon Cohen, Daniel Elbirt","doi":"10.5041/RMMJ.10569","DOIUrl":"10.5041/RMMJ.10569","url":null,"abstract":"","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incretin Analogues for Weight Reduction in Non-Diabetic Obese: A Review of Liraglutide, Semaglutide, and Tirzepatide Beyond Glycemic Control.","authors":"Krishna Nikhila Bonga, Milan Padhan","doi":"10.5041/RMMJ.10565","DOIUrl":"https://doi.org/10.5041/RMMJ.10565","url":null,"abstract":"<p><p>Obesity is a complex, multifactorial disease that contributes to a broad range of cardiometabolic, reproductive, and psychological disorders. Representing a major global health challenge, obesity can be addressed by lifestyle modifications such as reduced calorie intake, physical activity, adequate sleep, and stress management to help achieve sustainable weight loss and improve metabolic health in the long term. Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the two naturally produced incretin hormones in the gastrointestinal tract. Incretin analogues were initially approved for type 2 diabetes mellitus but were later found to exhibit weight-reducing properties. Liraglutide, semaglutide, and tirzepatide are the three incretin analogues approved for obesity in non-diabetic patients. This narrative review presents detailed comparisons of the three approved incretin analogues for obesity, their cost-effectiveness, and trends in the clinical setting.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A PaDd-informed, Assay-calibrated Diagnostic Pathway for Suspected Pulmonary Embolism in Older Adults: From Signal to Strategy.","authors":"Mulavagili Vijayasimha, Sivaji Ganesh Adusumalli","doi":"10.5041/RMMJ.10568","DOIUrl":"10.5041/RMMJ.10568","url":null,"abstract":"","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}