Autoimmune Diseases最新文献_第5页

Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis 浸润性CD16+与外周CD14+CD16++单核细胞减少和严重狼疮性肾炎有关

IF 4

Autoimmune Diseases Pub Date : 2016-12-13 DOI: 10.1155/2016/9324315

Anabel Barrera García, J. A. Gómez-Puerta, L. Arias, C. Burbano, M. Restrepo, A. Vanegas, C. H. Muñoz, M. Rojas, L. A. González, G. Vásquez

{"title":"Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis","authors":"Anabel Barrera García, J. A. Gómez-Puerta, L. Arias, C. Burbano, M. Restrepo, A. Vanegas, C. H. Muñoz, M. Rojas, L. A. González, G. Vásquez","doi":"10.1155/2016/9324315","DOIUrl":"https://doi.org/10.1155/2016/9324315","url":null,"abstract":"Our aim was to characterize glomerular monocytes (Mo) infiltration and to correlate them with peripheral circulating Mo subsets and severity of lupus nephritis (LN). Methods. We evaluated 48 LN biopsy samples from a referral hospital. Recognition of Mo cells was done using microscopic view and immunohistochemistry stain with CD14 and CD16. Based on the number of cells, we classified LN samples as low degree of diffuse infiltration (<5 cells) and high degree of diffuse infiltration (≥5 cells). Immunophenotyping of peripheral Mo subsets was done using flow cytometry. Results. Mean age was 34.0 ± 11.7 years and the mean SLEDAI was 17.5 ± 6.9. The most common SLE manifestations were proteinuria (91%) and hypocomplementemia (75%). Severe LN was found in 70% of patients (Class III, 27%; Class IV, 43%). Severe LN patients and patients with higher grade of CD16+ infiltration had lower levels of nonclassical (CD14+CD16++) Mo in peripheral blood. Conclusions. Our results might suggest that those patients with more severe forms of LN had a higher grade of CD14+CD16+ infiltration and lower peripheral levels of nonclassical (CD14+CD16++) Mo and might reflect a recruitment process in renal tissues. However, given the small sample, our results must be interpreted carefully.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"130 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85140783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease 存在DQ2.2和DQ2.5会增加患乳糜泻的风险

IF 4

Autoimmune Diseases Pub Date : 2016-11-30 DOI: 10.1155/2016/5409653

Lucas Malta Almeida, L. Gandolfi, R. Pratesi, R. H. Uenishi, F. C. de Almeida, Nicole Selleski, Yanna Karla de Medeiros Nóbrega

{"title":"Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease","authors":"Lucas Malta Almeida, L. Gandolfi, R. Pratesi, R. H. Uenishi, F. C. de Almeida, Nicole Selleski, Yanna Karla de Medeiros Nóbrega","doi":"10.1155/2016/5409653","DOIUrl":"https://doi.org/10.1155/2016/5409653","url":null,"abstract":"Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p < 0.05. Disease risk was expressed as 1 : N for each HLA-DQ category described at this study. Results. DQ2.5 and/or DQ8 were detected in 224 celiac patients (94.5%) and 84 controls (35.4%). Eight celiac patients (3.4%) and 38 controls (16%) disclosed only DQ2.2. Even though DQ2.2 (β2/β2 or β2/x) showed a low CD risk of 1 : 251 and 1 : 550, respectively, the genotype DQ2.5/DQ2.2 (β2/β2) showed high CD risk of 1 : 10 (p < 0.0001). The disease risk gradient ranged from 1 : 3014 to 1 : 7. Conclusion. Our study allowed the determination of a risk gradient for celiac disease development in at-risk population, showing that DQ2.2 variant was relevant when associated with DQ2.5.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"77 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85990839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

The Prevalence of S. aureus Skin and Soft Tissue Infections in Patients with Pemphigus 天疱疮患者金黄色葡萄球菌皮肤和软组织感染的患病率

IF 4

Autoimmune Diseases Pub Date : 2016-10-09 DOI: 10.1155/2016/7529078

Zeinab Fagheei Aghmiyuni, A. Khorshidi, R. Moniri, T. Soori, Seyed Gholam Abbas Musavi

{"title":"The Prevalence of S. aureus Skin and Soft Tissue Infections in Patients with Pemphigus","authors":"Zeinab Fagheei Aghmiyuni, A. Khorshidi, R. Moniri, T. Soori, Seyed Gholam Abbas Musavi","doi":"10.1155/2016/7529078","DOIUrl":"https://doi.org/10.1155/2016/7529078","url":null,"abstract":"Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of S. aureus infection and PVL gene in patients with pemphigus admitted to dermatology clinic. Materials and Methods. This descriptive study was conducted on 196 pemphigus vulgaris patients (119 males, 77 females) admitted to dermatology clinic between 2014 and 2015. In this study, the diagnosis of pemphigus vulgaris was made by histology, immunofluorescence pattern of perilesional skin, and indirect immunofluorescence testing of serum. Data were collected through a questionnaire. Results. 59.1% of pemphigus vulgaris patients had S. aureus infection. 49 out of 116 were methicillin-resistant. PVL gene was detected in 25 out of 116 S. aureus positive patients. Conclusion. This is the first report of S. aureus infection in pemphigus patients in Iran. More than forty percent of isolates were methicillin-resistant S. aureus. PVL gene carried by methicillin-resistant S. aureus was high in this study.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"126 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74919097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis 高须动脉炎患者循环Th17细胞、血清IL-17A和IL-23增加

IF 4

Autoimmune Diseases Pub Date : 2016-03-13 DOI: 10.1155/2016/7841718

D. Misra, S. Chaurasia, R. Misra

{"title":"Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis","authors":"D. Misra, S. Chaurasia, R. Misra","doi":"10.1155/2016/7841718","DOIUrl":"https://doi.org/10.1155/2016/7841718","url":null,"abstract":"Introduction. Th17, γδT, NK, and NKT cells in peripheral blood and serum IL-17 and IL-23 in Takayasu arteritis (TA) were measured and correlated with disease activity. Methods. Th17 (anti-CD3APC, CD4PECy7, and IL-17PE), NKT, NK (anti-CD3APC, CD56FITC), and γδT (anti-CD3FITC and γδTCRAPC) cells were enumerated by flow cytometry in peripheral blood of 30 patients with TA (ACR1990 criteria) and 20 healthy controls, serum IL-17 and IL-23 measured by ELISA. Relation with disease activity (NIH criteria, ITAS2010) was analyzed (using nonparametric tests, median with interquartile range). Results. Mean age of patients was 33.47 ± 11.78 years (25 females); mean symptom duration was 7.1 ± 5.3 years. 13 were not on immunosuppressants; 12 were active (ITAS2010 ≥ 4). The percentage of Th17 cells was significantly expanded in TA (patients 2.1 (1.5–3.2) versus controls 0.75 (0.32–1.2); p < 0.0001) with no differences in other cell populations. Serum IL-17 and IL-23 (pg/mL) in patients (6.2 (4.6–8.5) and 15 (14.9–26.5), resp.) were significantly higher (p < 0.001) than controls (3.9 (3.9–7.3) and undetectable median value, resp.). Subgroup analysis revealed no correlation of Th17 cells, serum IL-17, and IL-23 with disease activity or medications, nor any significant difference before and after medication. Conclusions. There is significant expansion of Th17 cells and elevated serum IL-17 and IL-23 levels in TA patients compared to healthy controls.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"16 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77124564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Mechanism of Xinfeng Capsule on Adjuvant-Induced Arthritis via Analysis of Urinary Metabolomic Profiles 心风胶囊治疗佐剂性关节炎的作用机制:尿代谢组学分析

IF 4

Autoimmune Diseases Pub Date : 2016-02-18 DOI: 10.1155/2016/5690935

Hui Jiang, Jian Liu, Ting Wang, Jiarong Gao, Yue Sun, Chuanbing Huang, Mei Meng, Xiu-juan Qin

引用次数: 6

Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings 系统性红斑狼疮患者的促氧化-抗氧化平衡及其与临床和实验室结果的关系

IF 4

Autoimmune Diseases Pub Date : 2016-01-26 DOI: 10.1155/2016/4343514

S. Jafari, S. Salimi, A. Nakhaee, H. Kalani, S. Tavallaie, F. Farajian-Mashhadi, Z. Zakeri, M. Sandoughi

{"title":"Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings","authors":"S. Jafari, S. Salimi, A. Nakhaee, H. Kalani, S. Tavallaie, F. Farajian-Mashhadi, Z. Zakeri, M. Sandoughi","doi":"10.1155/2016/4343514","DOIUrl":"https://doi.org/10.1155/2016/4343514","url":null,"abstract":"Aim. This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations. Methods. In this case-control study, 60 patients with SLE and 60 healthy individuals were enrolled. The blood samples were collected and their sera were separated. Subsequently, the prooxidant-antioxidant balance value was evaluated using PAB assay for each sample. Results. The mean of PAB values in SLE patients was significantly higher than healthy controls (147.3 ± 42 versus 84.8 ± 32.2 HK, P < 0.0001). Furthermore, in SLE patients, there was a positive significant correlation between the PAB and erythrocyte sedimentation rate (ESR) (r = 0.492, P < 0.001). In addition, the PAB values in patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis were significantly higher than those without these manifestations. Conclusion. The findings of current study showed that the mean of PAB was significantly higher in SLE patients and PAB was correlated with ESR. Moreover increased PAB was found in SLE patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis. These findings suggest that the measurement of PAB may be useful to show oxidative stress condition in SLE patients.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"147 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74263084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab 危险因素和不良事件难以预测接受利妥昔单抗的肉芽肿合并多血管炎患者的感染和低丙种球蛋白血症

IF 4

Autoimmune Diseases Pub Date : 2016-01-18 DOI: 10.1155/2016/8095695

E. Besada

{"title":"Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab","authors":"E. Besada","doi":"10.1155/2016/8095695","DOIUrl":"https://doi.org/10.1155/2016/8095695","url":null,"abstract":"Background. 29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance. 24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia. The aim of the study was to examine how known predictors and adverse events interacted with adverse events using structural statistical methods. Methods. Five predictors (age, cyclophosphamide, total Ig and CD4/CD8 ratio prior RTX, and type of RTX maintenance regimen) and 4 adverse events (severe and chronic infections, hypogammaglobulinemia, and RTX discontinuation) were modeled in principal component and redundancy analyses. Results. The 5 predictors explained 51% of the variance of the GPA cohort. Models including cyclophosphamide exposure and total Ig level predicted best adverse events. However total Ig level has low R squared. The 2 best combinations of adverse events explained 13% of the variance of the predictors and adverse events. Only chronic infections were associated with combination of all adverse events (P = 0.014). Hypogammaglobulinemia did not seem associated with the other adverse events. Conclusions. Traditional risk factors for infections and hypogammaglobulinemia seemed to poorly predict adverse events in our GPA cohort.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"41 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81917069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus. 系统性红斑狼疮患者血清可溶性白介素-7受体与抗c1q抗体的相关性

IF 4

Autoimmune Diseases Pub Date : 2016-01-01 Epub Date: 2016-03-16 DOI: 10.1155/2016/8252605

Shuhong Chi, Jing Xue, Feng Li, Caixia Zhu, Yunxia Yu, Haibo Li, Xuemei Wang, Yurong Zhang, Jijuan Yang, Shaolan Zhou, Lijuan Yang, Chen Ji, Xiaoming Liu

{"title":"Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus.","authors":"Shuhong Chi, Jing Xue, Feng Li, Caixia Zhu, Yunxia Yu, Haibo Li, Xuemei Wang, Yurong Zhang, Jijuan Yang, Shaolan Zhou, Lijuan Yang, Chen Ji, Xiaoming Liu","doi":"10.1155/2016/8252605","DOIUrl":"https://doi.org/10.1155/2016/8252605","url":null,"abstract":"Background. Serum concentrations of soluble interleukin-7 receptor (sIL-7R) and anti-C1q antibody have recently been identified as unique serological markers for lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the correlation of serum sIL-7R and anti-C1q in SLE patients. Methods. Sera from 134 patients with SLE and 84 healthy cohorts were tested for levels of sIL-7R and anti-C1q antibodies in terms of ELISA. Correlations of the sIL-7R and anti-C1q autoantibodies were evaluated. Results. The serum concentrations of sIL-7R and anti-C1q antibodies were significantly higher in SLE patients and LN patients in comparison with healthy individuals/controls and SLE patients with non-LN, respectively. In addition, both sIL-7R and anti-C1q concentrations were found to significantly correlate with the SLE disease activity as evaluated by SLEDAI scores. Interestingly, the serum sIL-7R concentration was strongly correlated with the level of anti-C1q antibodies (r = 0.2871, p = 0.0008) but not statistically correlated with other serological markers, including the anti-dsDNA and complements C3 and C4 concentrations in SLE patients. Conclusion. Both serum sIL-7R and anti-C1q antibodies were strongly associated with disease activity and LN in SLE patients, suggesting that they may be reliable serological markers for identification of SLE patients with active diseases and LN. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2016 ","pages":"8252605"},"PeriodicalIF":4.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8252605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34454051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

[(18)F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune Encephalitis. [(18)F]-自身免疫性脑炎应及早进行氟脱氧葡萄糖正电子发射断层扫描。

IF 4

Autoimmune Diseases Pub Date : 2016-01-01 Epub Date: 2016-07-31 DOI: 10.1155/2016/9450452

C R Newey, A Sarwal, S Hantus

{"title":"[(18)F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune Encephalitis.","authors":"C R Newey, A Sarwal, S Hantus","doi":"10.1155/2016/9450452","DOIUrl":"https://doi.org/10.1155/2016/9450452","url":null,"abstract":"Introduction. Autoimmune encephalitis (AE) is a clinically challenging diagnosis with nonspecific neurological symptoms. Prompt diagnosis is important and often relies on neuroimaging. We present a case series of AE highlighting the importance of an early [(18)F]-fluoro-deoxy-glucose positron emission tomography (FDG-PET) scan. Methods. Retrospective review of seven consecutive cases of autoimmune encephalitis. Results. All patients had both magnetic resonance imaging (MRI) and FDG-PET scans. Initial clinical presentations included altered mental status and/or new onset seizures. Six cases had serum voltage-gated potassium channel (VGKC) antibody and one had serum N-methyl-D-aspartate (NMDA) antibody. MRI of brain showed mesial temporal lobe hyperintensity in five cases of VGKC. The other two patients with VGKC or NMDA AE had restiform body hyperintensity on MRI brain or a normal MRI, respectively. Mesial temporal lobe hypermetabolism was noted in three cases on FDG-PET, despite initial unremarkable MRI. Malignancy workup was negative in all patients. Conclusion. A high index of suspicion for AE should be maintained in patients presenting with cognitive symptoms, seizures, and limbic changes on neuroimaging. In cases with normal initial brain MRI, FDG-PET can be positive. Additionally, extralimbic hyperintensity on MRI may also be observed. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2016 ","pages":"9450452"},"PeriodicalIF":4.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9450452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34335916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus 系统性红斑狼疮患者戊烷素3血浆水平与疾病活动性

IF 4

Autoimmune Diseases Pub Date : 2015-11-03 DOI: 10.1155/2015/354014

R. Assandri, M. Monari, A. Colombo, Alessandra Dossi, A. Montanelli

{"title":"Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus","authors":"R. Assandri, M. Monari, A. Colombo, Alessandra Dossi, A. Montanelli","doi":"10.1155/2015/354014","DOIUrl":"https://doi.org/10.1155/2015/354014","url":null,"abstract":"SLE is an autoimmune disorder that involves polyclonal autoimmunity against multiple autoantigens. PTX3, a marker of the acute-phase inflammatory response, plays an important role in innate immunity and in modulation of the adaptive immune response. Our study tried to resolve some rather controversial aspects of the use of PTX3 as a biomarker of disease activity in SLE patients. We demonstrated that plasma PTX3 concentration of the SLE patients was significantly higher than the healthy control groups and reflected disease activity. ROC curve analysis was used to determine best cut-off point (2.8 ng/mL) with a good sensitivity and specificity. In patients with SLE, PTX3 concentrations were correlated with SLEDAI. Trend to remission (TTR) curve was created by plotting PTX3 levels and SLEDAI and we applied the curve as a model for the analysis of two patients with different follow-up. PTX3 plasma levels declined significantly and this decline occurred parallel to the clinical improvement with a complete remission of disease. In patients who experienced a clinical relapse, an increase in PTX3 levels followed the lupus flare. The proposal of PTX3 cut-off associated with TTR and monitoring of PTX3 plasma levels could be an innovative approach to follow-up of SLE patients.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"67 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2015-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79962340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22