Autoimmune Diseases最新文献_第5页

Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab 危险因素和不良事件难以预测接受利妥昔单抗的肉芽肿合并多血管炎患者的感染和低丙种球蛋白血症

IF 4

Autoimmune Diseases Pub Date : 2016-01-18 DOI: 10.1155/2016/8095695

E. Besada

{"title":"Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab","authors":"E. Besada","doi":"10.1155/2016/8095695","DOIUrl":"https://doi.org/10.1155/2016/8095695","url":null,"abstract":"Background. 29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance. 24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia. The aim of the study was to examine how known predictors and adverse events interacted with adverse events using structural statistical methods. Methods. Five predictors (age, cyclophosphamide, total Ig and CD4/CD8 ratio prior RTX, and type of RTX maintenance regimen) and 4 adverse events (severe and chronic infections, hypogammaglobulinemia, and RTX discontinuation) were modeled in principal component and redundancy analyses. Results. The 5 predictors explained 51% of the variance of the GPA cohort. Models including cyclophosphamide exposure and total Ig level predicted best adverse events. However total Ig level has low R squared. The 2 best combinations of adverse events explained 13% of the variance of the predictors and adverse events. Only chronic infections were associated with combination of all adverse events (P = 0.014). Hypogammaglobulinemia did not seem associated with the other adverse events. Conclusions. Traditional risk factors for infections and hypogammaglobulinemia seemed to poorly predict adverse events in our GPA cohort.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"41 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81917069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus. 系统性红斑狼疮患者血清可溶性白介素-7受体与抗c1q抗体的相关性

IF 4

Autoimmune Diseases Pub Date : 2016-01-01 Epub Date: 2016-03-16 DOI: 10.1155/2016/8252605

Shuhong Chi, Jing Xue, Feng Li, Caixia Zhu, Yunxia Yu, Haibo Li, Xuemei Wang, Yurong Zhang, Jijuan Yang, Shaolan Zhou, Lijuan Yang, Chen Ji, Xiaoming Liu

{"title":"Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus.","authors":"Shuhong Chi, Jing Xue, Feng Li, Caixia Zhu, Yunxia Yu, Haibo Li, Xuemei Wang, Yurong Zhang, Jijuan Yang, Shaolan Zhou, Lijuan Yang, Chen Ji, Xiaoming Liu","doi":"10.1155/2016/8252605","DOIUrl":"https://doi.org/10.1155/2016/8252605","url":null,"abstract":"Background. Serum concentrations of soluble interleukin-7 receptor (sIL-7R) and anti-C1q antibody have recently been identified as unique serological markers for lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the correlation of serum sIL-7R and anti-C1q in SLE patients. Methods. Sera from 134 patients with SLE and 84 healthy cohorts were tested for levels of sIL-7R and anti-C1q antibodies in terms of ELISA. Correlations of the sIL-7R and anti-C1q autoantibodies were evaluated. Results. The serum concentrations of sIL-7R and anti-C1q antibodies were significantly higher in SLE patients and LN patients in comparison with healthy individuals/controls and SLE patients with non-LN, respectively. In addition, both sIL-7R and anti-C1q concentrations were found to significantly correlate with the SLE disease activity as evaluated by SLEDAI scores. Interestingly, the serum sIL-7R concentration was strongly correlated with the level of anti-C1q antibodies (r = 0.2871, p = 0.0008) but not statistically correlated with other serological markers, including the anti-dsDNA and complements C3 and C4 concentrations in SLE patients. Conclusion. Both serum sIL-7R and anti-C1q antibodies were strongly associated with disease activity and LN in SLE patients, suggesting that they may be reliable serological markers for identification of SLE patients with active diseases and LN. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2016 ","pages":"8252605"},"PeriodicalIF":4.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8252605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34454051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

[(18)F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune Encephalitis. [(18)F]-自身免疫性脑炎应及早进行氟脱氧葡萄糖正电子发射断层扫描。

IF 4

Autoimmune Diseases Pub Date : 2016-01-01 Epub Date: 2016-07-31 DOI: 10.1155/2016/9450452

C R Newey, A Sarwal, S Hantus

{"title":"[(18)F]-Fluoro-Deoxy-Glucose Positron Emission Tomography Scan Should Be Obtained Early in Cases of Autoimmune Encephalitis.","authors":"C R Newey, A Sarwal, S Hantus","doi":"10.1155/2016/9450452","DOIUrl":"https://doi.org/10.1155/2016/9450452","url":null,"abstract":"Introduction. Autoimmune encephalitis (AE) is a clinically challenging diagnosis with nonspecific neurological symptoms. Prompt diagnosis is important and often relies on neuroimaging. We present a case series of AE highlighting the importance of an early [(18)F]-fluoro-deoxy-glucose positron emission tomography (FDG-PET) scan. Methods. Retrospective review of seven consecutive cases of autoimmune encephalitis. Results. All patients had both magnetic resonance imaging (MRI) and FDG-PET scans. Initial clinical presentations included altered mental status and/or new onset seizures. Six cases had serum voltage-gated potassium channel (VGKC) antibody and one had serum N-methyl-D-aspartate (NMDA) antibody. MRI of brain showed mesial temporal lobe hyperintensity in five cases of VGKC. The other two patients with VGKC or NMDA AE had restiform body hyperintensity on MRI brain or a normal MRI, respectively. Mesial temporal lobe hypermetabolism was noted in three cases on FDG-PET, despite initial unremarkable MRI. Malignancy workup was negative in all patients. Conclusion. A high index of suspicion for AE should be maintained in patients presenting with cognitive symptoms, seizures, and limbic changes on neuroimaging. In cases with normal initial brain MRI, FDG-PET can be positive. Additionally, extralimbic hyperintensity on MRI may also be observed. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2016 ","pages":"9450452"},"PeriodicalIF":4.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9450452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34335916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus 系统性红斑狼疮患者戊烷素3血浆水平与疾病活动性

IF 4

Autoimmune Diseases Pub Date : 2015-11-03 DOI: 10.1155/2015/354014

R. Assandri, M. Monari, A. Colombo, Alessandra Dossi, A. Montanelli

{"title":"Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus","authors":"R. Assandri, M. Monari, A. Colombo, Alessandra Dossi, A. Montanelli","doi":"10.1155/2015/354014","DOIUrl":"https://doi.org/10.1155/2015/354014","url":null,"abstract":"SLE is an autoimmune disorder that involves polyclonal autoimmunity against multiple autoantigens. PTX3, a marker of the acute-phase inflammatory response, plays an important role in innate immunity and in modulation of the adaptive immune response. Our study tried to resolve some rather controversial aspects of the use of PTX3 as a biomarker of disease activity in SLE patients. We demonstrated that plasma PTX3 concentration of the SLE patients was significantly higher than the healthy control groups and reflected disease activity. ROC curve analysis was used to determine best cut-off point (2.8 ng/mL) with a good sensitivity and specificity. In patients with SLE, PTX3 concentrations were correlated with SLEDAI. Trend to remission (TTR) curve was created by plotting PTX3 levels and SLEDAI and we applied the curve as a model for the analysis of two patients with different follow-up. PTX3 plasma levels declined significantly and this decline occurred parallel to the clinical improvement with a complete remission of disease. In patients who experienced a clinical relapse, an increase in PTX3 levels followed the lupus flare. The proposal of PTX3 cut-off associated with TTR and monitoring of PTX3 plasma levels could be an innovative approach to follow-up of SLE patients.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"67 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2015-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79962340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Social Support and Self-Reported Stress Levels in a Predominantly African American Sample of Women with Systemic Lupus Erythematosus. 以非洲裔美国人为主的系统性红斑狼疮女性样本中的社会支持和自述压力水平。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-09 DOI: 10.1155/2015/401620

Edith Marie Williams, Jiajia Zhang, Judith Anderson, Larisa Bruner, Laurene Tumiel-Berhalter

引用次数: 0

Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis. 多发性硬化症患者抗人和植物水通道蛋白抗体的检测。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-26 DOI: 10.1155/2015/905208

Aristo Vojdani, Partha Sarathi Mukherjee, Joshua Berookhim, Datis Kharrazian

{"title":"Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis.","authors":"Aristo Vojdani, Partha Sarathi Mukherjee, Joshua Berookhim, Datis Kharrazian","doi":"10.1155/2015/905208","DOIUrl":"https://doi.org/10.1155/2015/905208","url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune disease that affects the body's central nervous system. Around 90% of MS sufferers are diagnosed with relapsing-remitting MS (RRMS). We used ELISA to measure IgG, IgA, and IgM antibodies against linear epitopes of human and plant aquaporins (AQP4) as well as neural antigens in RRMS patients and controls to determine whether patients suffering from RRMS have simultaneous elevations in antibodies against these peptides and antigens. In comparison to controls, significant elevations in isotype-specific antibodies against human and plant AQP4 and neural antigens such as MBP, MOG, and S100B were detected in RRMS patients, indicating a high correlation in antibody reaction between plant aquaporins and brain antigens. This correlation between the reactivities of RRMS patients with various tested antigens was the most significant for the IgM isotype. We conclude that a subclass of patients with RRMS reacts to both plant and human AQP4 peptides. This immune reaction against different plant aquaporins may help in the development of dietary modifications for patients with MS and other neuroimmune disorders. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"905208"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/905208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34106360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. 肝脏而非中枢神经系统表达的人c反应蛋白抑制实验性自身免疫性脑脊髓炎的转基因小鼠

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-03 DOI: 10.1155/2015/640171

Tyler T Wright, Rachel V Jimenez, Todd E Morgan, Namrata Bali, Xiaogang Hou, Mark A McCrory, Caleb E Finch, Alexander J Szalai

引用次数: 7

Gender and Ethnicity Based Differences in Clinical and Laboratory Features of Myasthenia Gravis. 重症肌无力临床和实验室特征的性别和种族差异。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-06-14 DOI: 10.1155/2015/197893

Fawzi Abukhalil, Bijal Mehta, Erin Saito, Sejal Mehta, Aaron McMurtray

{"title":"Gender and Ethnicity Based Differences in Clinical and Laboratory Features of Myasthenia Gravis.","authors":"Fawzi Abukhalil, Bijal Mehta, Erin Saito, Sejal Mehta, Aaron McMurtray","doi":"10.1155/2015/197893","DOIUrl":"https://doi.org/10.1155/2015/197893","url":null,"abstract":"Background. Previous reports describe ethnicity based differences in clinical and laboratory features between Caucasians and African Americans with myasthenia gravis. However, it is not known whether these findings apply to other ethnicities. Methods. Retrospective analysis of all patients treated for myasthenia gravis during a three-year period at a community based medical center. Results. A total of 44 patients were included, including 19 of Hispanic, 16 of African American, 6 of Caucasian, and 3 of Asian ethnicities. Female gender was more common among those with Hispanic, Asian, and African American ethnicities compared to Caucasian ethnicity (p = 0.029). Anti-acetylcholine receptor antibody subtypes demonstrated no significant ethnicity based differences in either generalized or ocular myasthenia gravis. A trend was noted towards greater frequency of blocking antibodies among Hispanics (52.6%) compared to African American (37.5%) and Caucasian (33.3%) patients (p = 0.059). Generalized but not ocular myasthenia patients showed greater frequency of anti-muscle specific kinase antibodies in Asians and Hispanics compared to African Americans and Caucasians (p = 0.041). Conclusions. The results of this study support the existence of ethnicity based differences in clinical and laboratory features of myasthenia gravis. Further study of genetic factors influencing clinical features of myasthenia gravis is indicated. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"197893"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/197893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33905925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice. C57BL/6和BALB/C小鼠胸腺免疫调节基因的转录修饰

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-17 DOI: 10.1155/2015/503087

Breno Luiz Melo-Lima, Danillo Lucas Alves Espósito, Benedito Antônio Lopes da Fonseca, Luiz Tadeu Moraes Figueiredo, Philippe Moreau, Eduardo Antonio Donadi

{"title":"The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice.","authors":"Breno Luiz Melo-Lima, Danillo Lucas Alves Espósito, Benedito Antônio Lopes da Fonseca, Luiz Tadeu Moraes Figueiredo, Philippe Moreau, Eduardo Antonio Donadi","doi":"10.1155/2015/503087","DOIUrl":"https://doi.org/10.1155/2015/503087","url":null,"abstract":"Thymus is involved in induction of self-tolerance in T lymphocytes, particularly due to Aire activity. In peripheral tissues, Treg cells and immunomodulatory molecules, like the major histocompatibility complex (MHC) class Ib molecules, are essential for maintenance of autotolerance during immune responses. Viral infections can trigger autoimmunity and modify thymic function, and YFV17D immunization has been associated with the onset of autoimmunity, being contraindicated in patients with thymic disorders. Aiming to study the influence of YFV17D immunization on the transcriptional profiles of immunomodulatory genes in thymus, we evaluated the gene expression of AIRE, FOXP3, H2-Q7 (Qa-2/HLA-G), H2-T23 (Qa-1/HLA-E), H2-Q10, and H2-K1 following immunization with 10,000 LD50 of YFV17D in C57BL/6 and BALB/c mice. The YFV17D virus replicated in thymus and induced the expression of H2-Q7 (Qa-2/HLA-G) and H2-T23 (Qa-1/HLA-E) transcripts and repressed the expression of AIRE and FOXP3. Transcriptional expression varied according to tissue and mouse strain analyzed. Expression of H2-T23 (Qa-1/HLA-E) and FOXP3 was induced in thymus and liver of C57BL/6 mice, which exhibited defective control of viral load, suggesting a higher susceptibility to YFV17D infection. Since the immunization with YFV17D modulated thymus gene expression in genetically predisposed individuals, the vaccine may be related to the onset of autoimmunity disorders. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"503087"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/503087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34250148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Predisposition to Cervical Atypia in Systemic Lupus Erythematosus: A Clinical and Cytopathological Study. 系统性红斑狼疮患者宫颈异型的易感性:临床和细胞病理学研究。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-09 DOI: 10.1155/2015/751853

Hend Hilal Al-Sherbeni, Ahmed Mohamed Fahmy, Nadine Sherif

{"title":"Predisposition to Cervical Atypia in Systemic Lupus Erythematosus: A Clinical and Cytopathological Study.","authors":"Hend Hilal Al-Sherbeni, Ahmed Mohamed Fahmy, Nadine Sherif","doi":"10.1155/2015/751853","DOIUrl":"https://doi.org/10.1155/2015/751853","url":null,"abstract":"Introduction. Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course, and prognosis. The female genital tract may be a potential target organ in SLE since cervical inflammation may be associated with disease activity. An increase in cervical dysplasia, a precursor of cervical cancer, has been reported in females with SLE. Aim of the Work. This work aimed to study the prevalence of abnormal cervicovaginal smears in patients with systemic lupus erythematosus (SLE) and to correlate abnormal smear findings with exposure to infection with human papilloma virus (HPV) in SLE patients. Patients and Methods. Thirty-two patients with SLE, fulfilling the 1997 revised criteria for the classification of SLE, were included in this study. They were subjected to full history taking, clinical examination, laboratory investigations, and cervicovaginal smearing. Twenty healthy subjects not known to suffer from any rheumatological disease were used as controls, and they were subjected to cervicovaginal smearing. Results. Four out of 32 SLE patients showed abnormal Pap smears (12.5%) compared to none showing any cervical changes in the control group (0%). Among these 4 patients, 3 were having ASCU and one was having LSIL (HPV). Conclusion. Cervicovaginal smearing is an easy, economic, safe, repeatable, and noninvasive technique for screening and early detection of cervical neoplastic lesions in SLE. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"751853"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/751853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34063904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9