Autoimmune Diseases最新文献_第4页

Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases. 血浆置换治疗复杂系统性红斑狼疮及其他自身免疫性疾病。

IF 4

Autoimmune Diseases Pub Date : 2019-03-11 eCollection Date: 2019-01-01 DOI: 10.1155/2019/5350960

David Aguirre-Valencia, Juan Naranjo-Escobar, Iván Posso-Osorio, María Carmenza Macía-Mejía, Ivana Nieto-Aristizábal, Tatiana Barrera, María Alejandra Obando, Gabriel J Tobón

{"title":"Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases.","authors":"David Aguirre-Valencia, Juan Naranjo-Escobar, Iván Posso-Osorio, María Carmenza Macía-Mejía, Ivana Nieto-Aristizábal, Tatiana Barrera, María Alejandra Obando, Gabriel J Tobón","doi":"10.1155/2019/5350960","DOIUrl":"https://doi.org/10.1155/2019/5350960","url":null,"abstract":"Introduction: Autoimmune diseases include a diverse and complex group of pathologies with a broad clinical spectrum due to the production of autoantibodies, which generates multisystemic compromise. Therapeutic plasma exchange (TPE) is a good additive treatment for immunosuppression due to its action over the autoantibodies.Objectives: To describe the main clinical characteristics and outcomes of patients with systemic lupus erythematosus and other systemic autoimmune diseases managed with TPE.Methodology: This descriptive retrospective study enrolled patients with systemic autoimmune diseases who received TPE.Results: In total, 66 patients with a median age of 33.5 years (24-53 years) were included; the majority were females [n=51 (77.27%)]. Forty (60.61%) patients were diagnosed with systemic lupus erythematosus. In these cases, the main indication for TPE was diffuse alveolar hemorrhage (DAH; n=20, 30.3%) and neurolupus (n=9, 13.6%). No TPE-related deaths occurred, and the main complication was hemorrhage, without significant differences among the four types of TPE solutions used. The overall outcome was improvement in 41 (62.12%) patients.Conclusion: TPE is safe and effective in patients with severe manifestations of autoimmune diseases.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2019 ","pages":"5350960"},"PeriodicalIF":4.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/5350960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37315380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Identification of Levels of Serum Amyloid A and Apolipoprotein A1 in Serum Proteomic Analysis of Neuropsychiatric Systemic Lupus Erythematosus Patients. 神经精神系统性红斑狼疮患者血清蛋白质组学分析中血清淀粉样蛋白A和载脂蛋白A1水平的鉴定。

IF 4

Autoimmune Diseases Pub Date : 2018-11-21 DOI: 10.1155/2018/6728541

Nancy P Duarte-Delgado, Tania P Lujan, Álvaro Arbeláez-Cortés, Jenny García-Valencia, Adriana Zapata, Mauricio Rojas, Mauricio Restrepo-Escobar, Gloria Vásquez, Blanca L Ortiz-Reyes

{"title":"Identification of Levels of Serum Amyloid A and Apolipoprotein A1 in Serum Proteomic Analysis of Neuropsychiatric Systemic Lupus Erythematosus Patients.","authors":"Nancy P Duarte-Delgado, Tania P Lujan, Álvaro Arbeláez-Cortés, Jenny García-Valencia, Adriana Zapata, Mauricio Rojas, Mauricio Restrepo-Escobar, Gloria Vásquez, Blanca L Ortiz-Reyes","doi":"10.1155/2018/6728541","DOIUrl":"10.1155/2018/6728541","url":null,"abstract":"Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) has multiple pathogenic mechanisms that cause diverse manifestations and whose diagnosis is challenging because of the absence of appropriate diagnostic tests. In the present study the application of proteomics using two-dimensional electrophoresis (2D) and mass spectrometry (MS) allowed the comparison of the protein profile of the serum low and high abundance protein fractions of NPSLE patients (NPSLE group) and SLE without neuropsychiatric syndromes (SLE group), Neuropsychiatric syndromes not associated with SLE (NPnoSLE groups), and healthy controls (CTRL group). The gels obtained were digitalized and analyzed with the PDQuest software. The statistical analysis of the spots was performed using the nonparametric Kruskal Wallis and Dunn's multiple comparison tests. Two spots showed significant differences and were identified by MS. Spot 4009 was significantly lower in NPSLE with regard to NPnoSLE (p= 0,004) and was identified as apolipoprotein A1 (APOA1) (score 809-1132). Spot 8001 was significantly higher in NPSLE regarding CTRL and NPnoSLE (p= 0,01 y 0,03, respectively) and was identified as serum amyloid A (SAA) (score 725-2488). The proinflammatory high density lipoproteins (HDL) have been described in SLE. In this HDL the decrease of APOA1 is followed by an increase in SAA. This altered level of both proteins may be related to the inflammatory state that is characteristic of an autoimmune disease like SLE, but this is not specific for NPSLE.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2018 ","pages":"6728541"},"PeriodicalIF":4.0,"publicationDate":"2018-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6728541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36812691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Nail Involvement in Patients with Psoriatic Arthritis in Northern Iran. 伊朗北部银屑病关节炎患者的指甲受累。

IF 4

Autoimmune Diseases Pub Date : 2018-10-15 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4608490

O Zargari, E Kazemnezhad Leyli, S Z Azimi

{"title":"Nail Involvement in Patients with Psoriatic Arthritis in Northern Iran.","authors":"O Zargari, E Kazemnezhad Leyli, S Z Azimi","doi":"10.1155/2018/4608490","DOIUrl":"https://doi.org/10.1155/2018/4608490","url":null,"abstract":"Background: Psoriatic arthritis (PsA) results in an increased burden of psoriasis and impairs both quality of life and an individual's functional capacity. The relationship between nail involvement and PsA in psoriasis is not fully characterized.Aim: To evaluate the frequency and characteristics of nail involvement in psoriatic patients and to assess the relationship with joint involvement.Methods: A total of 197 patients with moderate-to-severe psoriasis were consecutively invited to participate in this cross-sectional study. The patients are divided into two groups: those with and those without psoriatic arthritis.Results: 69.5% of psoriatic (137 out of 197) patients had nail involvement. The most common nail abnormality was onycholysis, followed by pitting and oil droplet changes. Nail involvement was more common in patients with psoriatic arthritis (82.1% versus 57.8%, p=0.001).Conclusion: Nail involvement is commonly associated with PsA. Onycholysis, splinter hemorrhage, and oil drop were significantly more common in the PsA group as opposed to patients with just skin findings. In general, psoriatic patients with arthritis had more severe disease.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2018 ","pages":"4608490"},"PeriodicalIF":4.0,"publicationDate":"2018-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/4608490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36661546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital. 巴西一家公立医院抗可提取核抗原抗体、抗核抗体和自身免疫性疾病的关系

IF 4

Autoimmune Diseases Pub Date : 2018-09-30 eCollection Date: 2018-01-01 DOI: 10.1155/2018/9856910

Fernanda Weyand Banhuk, Bruna Corrêa Pahim, Alex Sandro Jorge, Rafael Andrade Menolli

{"title":"Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital.","authors":"Fernanda Weyand Banhuk, Bruna Corrêa Pahim, Alex Sandro Jorge, Rafael Andrade Menolli","doi":"10.1155/2018/9856910","DOIUrl":"https://doi.org/10.1155/2018/9856910","url":null,"abstract":"One characteristic of autoimmune diseases (ADs) is the production of autoantibodies for extractable nuclear autoantigens, which may aid in the discrimination of the different types of autoimmune diseases and is related to different antinuclear antibody (ANA) patterns. The present study verified the profile of patient samples tested for extractable nuclear antigens (ENA) antibodies in a public hospital and correlated the ENA results with ANA patterns and patient diagnoses. The study reviewed data in the medical records of patients who underwent anti-ENA tests at a public hospital in the West of the State of Paraná from February 2011 to January 2017. Patients were classified according to age, ethnicity, gender, anti-ENA test results, ANA results, and the presence or absence of AD. Thirty-six (20.9%) samples of the 172 anti-ENA tests were positive, seven (4.1%) samples were undetermined, and 129 (75%) exhibited negative results. The ANA reagent was found in 84.3% of the anti-ENA-positive samples. The anti-SSA/Ro autoantibody exhibited the highest frequency in the group, 41.7% (15/36). The most common pattern was nuclear fine speckled, which was found in 24.3% of the samples. The association results indicated a significant relationship between ANA titer and diagnosis in the anti-ENA- and ANA-positive patients. The anti-ENA-negative patients were diagnosed with an AD in 35% (45/129) of the cases, and 75% (27/36) of the anti-ENA-positive patients were diagnosed with an AD. Systemic lupus erythematosus and scleroderma were the most common pathologies in the antigen-positive patients. The anti-ENA test is a good marker to aid in the complex clinical diagnosis of patients with autoimmune diseases.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2018 ","pages":"9856910"},"PeriodicalIF":4.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/9856910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36621134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions. 肥大细胞在口腔扁平苔藓和类地衣反应中的作用。

IF 4

Autoimmune Diseases Pub Date : 2018-01-17 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7936564

Suganya Ramalingam, Narasimhan Malathi, Harikrishnan Thamizhchelvan, Narasimhan Sangeetha, Sharada T Rajan

{"title":"Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions.","authors":"Suganya Ramalingam, Narasimhan Malathi, Harikrishnan Thamizhchelvan, Narasimhan Sangeetha, Sharada T Rajan","doi":"10.1155/2018/7936564","DOIUrl":"https://doi.org/10.1155/2018/7936564","url":null,"abstract":"Introduction: Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Oral lichenoid reactions (OLR) are a group of lesions with diverse aetiologies but have clinical and histological features similar to OLP, thereby posing a great challenge in differentiating both lesions. Mast cells are multifunctional immune cells that play a major role in the pathogenesis of lichen planus by release of certain chemical mediators. Increased mast cell densities with significant percentage of degranulation have been observed as a consistent finding in pathogenesis of oral lichen planus.Aim: The current study was aimed at quantifying the mast cells in histopathological sections of OLP and OLR thereby aiding a means of distinguishing these lesions.Materials and methods: The study group involved 21 cases of oral lichen planus, 21 cases of oral lichenoid reactions, and 10 control specimens of normal buccal mucosa. All the cases were stained with Toluidine Blue and routine haematoxylin and eosin and the mast cells were quantified.Statistical analysis used: The results were analyzed using the Kruskal-Wallis test and an intergroup analysis was performed using Mann-Whitney U test.Conclusion: The number of mast cells showed an increased value in oral lichen planus when compared to oral lichenoid reaction and thus an estimation of mast cells count could aid in distinguishing OLP from OLR histopathologically.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2018 ","pages":"7936564"},"PeriodicalIF":4.0,"publicationDate":"2018-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7936564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35957231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis. 抗髓过氧化物酶抗体与未来的增殖性狼疮肾炎有关。

IF 4

Autoimmune Diseases Pub Date : 2017-01-01 Epub Date: 2017-12-24 DOI: 10.1155/2017/1872846

S W Olson, J J Lee, M Poirier, D J Little, L K Prince, T P Baker, J D Edison, K C Abbott

{"title":"Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis.","authors":"S W Olson, J J Lee, M Poirier, D J Little, L K Prince, T P Baker, J D Edison, K C Abbott","doi":"10.1155/2017/1872846","DOIUrl":"https://doi.org/10.1155/2017/1872846","url":null,"abstract":"Background: The subclinical pathophysiology of proliferative lupus nephritis (PLN) has not been fully elucidated. Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) is associated with PLN, but prediagnostic levels have not been reported.Methods: We performed a retrospective case-control Department of Defense Serum Repository (DoDSR) study comparing MPO-ANCA levels in longitudinal prediagnostic serum samples for 23 biopsy confirmed proliferative lupus nephritis (PLN) patients to DoDSR identified age, sex, race, and age of serum matched healthy and SLE without LN disease controls. We also compared the temporal relationship of MPO-ANCA to anti-double stranded DNA antibodies (dsDNAab).Results: A greater proportion of PLN patients had prediagnostic MPO-ANCA levels above ≥3 U/mL and ≥6 U/mL compared to SLE without LN (91% versus 43%, p < 0.001; 57% versus 5%, p < 0.001, resp.). In subgroup analysis, the MPO-ANCA threshold of ≥3 U/mL was significant at <1 year (88% versus 39%, p = 0.007) and 1-4 years (87% versus 38%, p = 0.009) prior to diagnosis. Statistically significant subclinical MPO-ANCA levels (≥3 U/mL) occurred prior to statistically significant dsDNAab ≥ 3 IU/ml (89% versus 11%, p = 0.003).Conclusions: Subclinical MPO-ANCA levels could distinguish future PLN from SLE without LN. MPO-ANCA manifests prior to clinical disease and subclinical dsDNAab to suggest that it may contribute directly to PLN pathogenicity.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2017 ","pages":"1872846"},"PeriodicalIF":4.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1872846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35825153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study. 全血粘度增加与系统性硬化症中数字溃疡的存在有关:一项横断面试点研究的结果。

IF 4

Autoimmune Diseases Pub Date : 2017-01-01 Epub Date: 2017-11-29 DOI: 10.1155/2017/3529214

Peter Korsten, Timothy B Niewold, Michael Zeisberg, Tammy O Utset, Daniel Cho, Lawrence S Zachary, Nadera J Sweiss, Suncica Volkov

{"title":"Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study.","authors":"Peter Korsten, Timothy B Niewold, Michael Zeisberg, Tammy O Utset, Daniel Cho, Lawrence S Zachary, Nadera J Sweiss, Suncica Volkov","doi":"10.1155/2017/3529214","DOIUrl":"https://doi.org/10.1155/2017/3529214","url":null,"abstract":"Objective: To investigate the role of whole blood viscosity in digital ulcer (DU) development in patients with diffuse and limited Systemic sclerosis.Methods: A convenience sample of patients with Systemic sclerosis (SSc) was selected from the adult Rheumatology clinic at the University of Chicago. The study group consisted of patients with SSc (with ulcers present, a history of ulcers, and no ulcers); the control group consisted of matched healthy Rheumatology clinic staff. WBV was measured using a scanning capillary viscometer at different shear rates (1-1000 1/s).Results: Whole blood viscosity as measured by a scanning capillary viscometer was increased in patients with SSc compared to healthy controls (p < 0.0001). Additionally, patients with present DU had significantly higher whole blood viscosity when compared to patients with a history of DU and patients with no history of DU (p < 0.0001). These findings were most pronounced at lower shear rates between 1 and 10 1/s.Conclusion: Whole blood viscosity might be a contributing factor in DU development in patients with SSc. Further studies with larger patient cohorts are required to fully evaluate how increased WBV contributes to the development of DU and whether the currently available treatment options improve the microcirculation by influencing WBV.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2017 ","pages":"3529214"},"PeriodicalIF":4.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3529214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35723634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus. 青少年系统性红斑狼疮累及肝脏和胃肠道的频率和类型。

IF 4

Autoimmune Diseases Pub Date : 2017-01-01 Epub Date: 2017-11-29 DOI: 10.1155/2017/8097273

Leila Tahernia, Hosein Alimadadi, Fatemeh Tahghighi, Zahra Amini, Vahid Ziaee

{"title":"Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus.","authors":"Leila Tahernia, Hosein Alimadadi, Fatemeh Tahghighi, Zahra Amini, Vahid Ziaee","doi":"10.1155/2017/8097273","DOIUrl":"https://doi.org/10.1155/2017/8097273","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a frequent rheumatology disorder among children. Since hepatic involvement is a common systemic manifestation in lupus, the frequency and type of hepatic involvement were determined in pediatric cases of SLE admitted to Children's Medical Hospital from 2005 to 2014.Methods and patients: In this observational case-series study, 138 pediatric cases of SLE were admitted in Children's Medical Center (a pediatric rheumatology referral center in Tehran, Iran) enrolled from 2005 to 2014 and the outcomes, frequency, and type of hepatic involvement were assessed among them.Results: Hepatic involvement was reported in 48.55% of total SLE patients. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and both enzymes higher than normal upper limits were detected in 8.7%, 5%, and 34.7% of lupus patients, respectively. Increased level of liver enzymes was categorized as less than 100, between 100 and 1000, and more than 1000 levels in 23.1%, 23.1%, and 2.1% of cases. The only gastrointestinal involvement in lupus patients contributing to hepatic involvement was gastrointestinal bleeding. Rising in liver enzymes was detected mostly in lupus patients without gastrointestinal bleeding (52.2% without versus 25.8% with gastrointestinal bleeding, P = 0.007).Conclusion: Approximately half of the pediatric patients suffering from SLE have hepatic involvement. No significant correlation was observed between various organs involvement and abnormal level of liver enzymes.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2017 ","pages":"8097273"},"PeriodicalIF":4.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8097273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35723635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment 不完全性红斑狼疮的临床和免疫学特征及羟氯喹治疗的改善

IF 4

Autoimmune Diseases Pub Date : 2016-12-28 DOI: 10.1155/2016/8791629

N. Olsen, C. McAloose, J. Carter, B. K. Han, Indu Raman, Quanzhen Li, D. Liao

{"title":"Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment","authors":"N. Olsen, C. McAloose, J. Carter, B. K. Han, Indu Raman, Quanzhen Li, D. Liao","doi":"10.1155/2016/8791629","DOIUrl":"https://doi.org/10.1155/2016/8791629","url":null,"abstract":"Objective. The study goals were to evaluate performance of SLE classification criteria, to define patients with incomplete lupus erythematosus (ILE), and to probe for features in these patients that might be useful as indicators of disease status and hydroxychloroquine response. Methods. Patients with ILE (N = 70) and SLE (N = 32) defined by the 1997 American College of Rheumatology criteria were reclassified using the 2012 Systemic Lupus International Collaborating Clinics criteria. Disease activity, patient reported outcomes, and levels of Type I interferon- (IFN-) inducible genes, autoantibodies, and cytokines were measured. Subgroups treated with hydroxychloroquine (HCQ) were compared to patients not on this drug. Results. The classification sets were correlated (R2 = 0.87). ILE patients were older (P = 0.0043) with lower disease activity scores (P < 0.001) and greater dissatisfaction with health status (P = 0.034) than SLE patients. ILE was associated with lower levels of macrophage-derived cytokines and levels of expressed Type I IFN-inducible genes. Treatment of ILE with HCQ was associated with better self-reported health status scores and lower expression levels of Type I IFN-inducible genes than ILE patients not on HCQ. Conclusion. The 2012 SLICC SLE classification criteria will be useful to define ILE in trials. Patients with ILE have better health status and immune profiles when treated with HCQ.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"62 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74655337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis GAKG-RGEKG:普雷沃氏菌与人胶原蛋白之间免疫交叉反应的表位:慢性牙周炎分子模拟的证据

IF 4

Autoimmune Diseases Pub Date : 2016-12-25 DOI: 10.1155/2016/5472320

G. Obando-Pereda

{"title":"GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis","authors":"G. Obando-Pereda","doi":"10.1155/2016/5472320","DOIUrl":"https://doi.org/10.1155/2016/5472320","url":null,"abstract":"Periodontal disease afflicts 20% of world population. This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process. All chronic diseases constantly cause activation of the immune system, and therefore the presentation of microbial peptides which are presented to lymphocytes by professional antigen presenting cells can present microbial peptides very similar to important structures of human economy causing autoimmune diseases, process known as molecular mimicry. Thus, the aim of this study was to verify the presence of molecular mimicry phenomenon between periodontopathogens and human proteins. Blasting microbes of Socransky periodontal complexes against human collagen were performed and then the proteins with similarities were modelled and were screened in the MHI binding virtual methods. The epitopes selected were produced and plasma of chronic periodontal volunteers was obtained and a dot immunobinding assay was performed. Hypothetical protein of Prevotella sp. and human collagen epitopes with high similarities were positive for dot immunobinding assay. With this result it can be suggested that the mimicry phenomena can occur on periodontal disease.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"30 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86253619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6