Autoimmune Diseases最新文献_第4页

Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study. 全血粘度增加与系统性硬化症中数字溃疡的存在有关:一项横断面试点研究的结果。

IF 4

Autoimmune Diseases Pub Date : 2017-01-01 Epub Date: 2017-11-29 DOI: 10.1155/2017/3529214

Peter Korsten, Timothy B Niewold, Michael Zeisberg, Tammy O Utset, Daniel Cho, Lawrence S Zachary, Nadera J Sweiss, Suncica Volkov

{"title":"Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study.","authors":"Peter Korsten, Timothy B Niewold, Michael Zeisberg, Tammy O Utset, Daniel Cho, Lawrence S Zachary, Nadera J Sweiss, Suncica Volkov","doi":"10.1155/2017/3529214","DOIUrl":"https://doi.org/10.1155/2017/3529214","url":null,"abstract":"Objective: To investigate the role of whole blood viscosity in digital ulcer (DU) development in patients with diffuse and limited Systemic sclerosis.Methods: A convenience sample of patients with Systemic sclerosis (SSc) was selected from the adult Rheumatology clinic at the University of Chicago. The study group consisted of patients with SSc (with ulcers present, a history of ulcers, and no ulcers); the control group consisted of matched healthy Rheumatology clinic staff. WBV was measured using a scanning capillary viscometer at different shear rates (1-1000 1/s).Results: Whole blood viscosity as measured by a scanning capillary viscometer was increased in patients with SSc compared to healthy controls (p < 0.0001). Additionally, patients with present DU had significantly higher whole blood viscosity when compared to patients with a history of DU and patients with no history of DU (p < 0.0001). These findings were most pronounced at lower shear rates between 1 and 10 1/s.Conclusion: Whole blood viscosity might be a contributing factor in DU development in patients with SSc. Further studies with larger patient cohorts are required to fully evaluate how increased WBV contributes to the development of DU and whether the currently available treatment options improve the microcirculation by influencing WBV.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2017 ","pages":"3529214"},"PeriodicalIF":4.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3529214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35723634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus. 青少年系统性红斑狼疮累及肝脏和胃肠道的频率和类型。

IF 4

Autoimmune Diseases Pub Date : 2017-01-01 Epub Date: 2017-11-29 DOI: 10.1155/2017/8097273

Leila Tahernia, Hosein Alimadadi, Fatemeh Tahghighi, Zahra Amini, Vahid Ziaee

{"title":"Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus.","authors":"Leila Tahernia, Hosein Alimadadi, Fatemeh Tahghighi, Zahra Amini, Vahid Ziaee","doi":"10.1155/2017/8097273","DOIUrl":"https://doi.org/10.1155/2017/8097273","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a frequent rheumatology disorder among children. Since hepatic involvement is a common systemic manifestation in lupus, the frequency and type of hepatic involvement were determined in pediatric cases of SLE admitted to Children's Medical Hospital from 2005 to 2014.Methods and patients: In this observational case-series study, 138 pediatric cases of SLE were admitted in Children's Medical Center (a pediatric rheumatology referral center in Tehran, Iran) enrolled from 2005 to 2014 and the outcomes, frequency, and type of hepatic involvement were assessed among them.Results: Hepatic involvement was reported in 48.55% of total SLE patients. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and both enzymes higher than normal upper limits were detected in 8.7%, 5%, and 34.7% of lupus patients, respectively. Increased level of liver enzymes was categorized as less than 100, between 100 and 1000, and more than 1000 levels in 23.1%, 23.1%, and 2.1% of cases. The only gastrointestinal involvement in lupus patients contributing to hepatic involvement was gastrointestinal bleeding. Rising in liver enzymes was detected mostly in lupus patients without gastrointestinal bleeding (52.2% without versus 25.8% with gastrointestinal bleeding, P = 0.007).Conclusion: Approximately half of the pediatric patients suffering from SLE have hepatic involvement. No significant correlation was observed between various organs involvement and abnormal level of liver enzymes.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2017 ","pages":"8097273"},"PeriodicalIF":4.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8097273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35723635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment 不完全性红斑狼疮的临床和免疫学特征及羟氯喹治疗的改善

IF 4

Autoimmune Diseases Pub Date : 2016-12-28 DOI: 10.1155/2016/8791629

N. Olsen, C. McAloose, J. Carter, B. K. Han, Indu Raman, Quanzhen Li, D. Liao

{"title":"Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment","authors":"N. Olsen, C. McAloose, J. Carter, B. K. Han, Indu Raman, Quanzhen Li, D. Liao","doi":"10.1155/2016/8791629","DOIUrl":"https://doi.org/10.1155/2016/8791629","url":null,"abstract":"Objective. The study goals were to evaluate performance of SLE classification criteria, to define patients with incomplete lupus erythematosus (ILE), and to probe for features in these patients that might be useful as indicators of disease status and hydroxychloroquine response. Methods. Patients with ILE (N = 70) and SLE (N = 32) defined by the 1997 American College of Rheumatology criteria were reclassified using the 2012 Systemic Lupus International Collaborating Clinics criteria. Disease activity, patient reported outcomes, and levels of Type I interferon- (IFN-) inducible genes, autoantibodies, and cytokines were measured. Subgroups treated with hydroxychloroquine (HCQ) were compared to patients not on this drug. Results. The classification sets were correlated (R2 = 0.87). ILE patients were older (P = 0.0043) with lower disease activity scores (P < 0.001) and greater dissatisfaction with health status (P = 0.034) than SLE patients. ILE was associated with lower levels of macrophage-derived cytokines and levels of expressed Type I IFN-inducible genes. Treatment of ILE with HCQ was associated with better self-reported health status scores and lower expression levels of Type I IFN-inducible genes than ILE patients not on HCQ. Conclusion. The 2012 SLICC SLE classification criteria will be useful to define ILE in trials. Patients with ILE have better health status and immune profiles when treated with HCQ.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"62 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74655337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis GAKG-RGEKG:普雷沃氏菌与人胶原蛋白之间免疫交叉反应的表位:慢性牙周炎分子模拟的证据

IF 4

Autoimmune Diseases Pub Date : 2016-12-25 DOI: 10.1155/2016/5472320

G. Obando-Pereda

{"title":"GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis","authors":"G. Obando-Pereda","doi":"10.1155/2016/5472320","DOIUrl":"https://doi.org/10.1155/2016/5472320","url":null,"abstract":"Periodontal disease afflicts 20% of world population. This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process. All chronic diseases constantly cause activation of the immune system, and therefore the presentation of microbial peptides which are presented to lymphocytes by professional antigen presenting cells can present microbial peptides very similar to important structures of human economy causing autoimmune diseases, process known as molecular mimicry. Thus, the aim of this study was to verify the presence of molecular mimicry phenomenon between periodontopathogens and human proteins. Blasting microbes of Socransky periodontal complexes against human collagen were performed and then the proteins with similarities were modelled and were screened in the MHI binding virtual methods. The epitopes selected were produced and plasma of chronic periodontal volunteers was obtained and a dot immunobinding assay was performed. Hypothetical protein of Prevotella sp. and human collagen epitopes with high similarities were positive for dot immunobinding assay. With this result it can be suggested that the mimicry phenomena can occur on periodontal disease.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"30 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86253619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis 浸润性CD16+与外周CD14+CD16++单核细胞减少和严重狼疮性肾炎有关

IF 4

Autoimmune Diseases Pub Date : 2016-12-13 DOI: 10.1155/2016/9324315

Anabel Barrera García, J. A. Gómez-Puerta, L. Arias, C. Burbano, M. Restrepo, A. Vanegas, C. H. Muñoz, M. Rojas, L. A. González, G. Vásquez

{"title":"Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis","authors":"Anabel Barrera García, J. A. Gómez-Puerta, L. Arias, C. Burbano, M. Restrepo, A. Vanegas, C. H. Muñoz, M. Rojas, L. A. González, G. Vásquez","doi":"10.1155/2016/9324315","DOIUrl":"https://doi.org/10.1155/2016/9324315","url":null,"abstract":"Our aim was to characterize glomerular monocytes (Mo) infiltration and to correlate them with peripheral circulating Mo subsets and severity of lupus nephritis (LN). Methods. We evaluated 48 LN biopsy samples from a referral hospital. Recognition of Mo cells was done using microscopic view and immunohistochemistry stain with CD14 and CD16. Based on the number of cells, we classified LN samples as low degree of diffuse infiltration (<5 cells) and high degree of diffuse infiltration (≥5 cells). Immunophenotyping of peripheral Mo subsets was done using flow cytometry. Results. Mean age was 34.0 ± 11.7 years and the mean SLEDAI was 17.5 ± 6.9. The most common SLE manifestations were proteinuria (91%) and hypocomplementemia (75%). Severe LN was found in 70% of patients (Class III, 27%; Class IV, 43%). Severe LN patients and patients with higher grade of CD16+ infiltration had lower levels of nonclassical (CD14+CD16++) Mo in peripheral blood. Conclusions. Our results might suggest that those patients with more severe forms of LN had a higher grade of CD14+CD16+ infiltration and lower peripheral levels of nonclassical (CD14+CD16++) Mo and might reflect a recruitment process in renal tissues. However, given the small sample, our results must be interpreted carefully.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"130 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85140783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease 存在DQ2.2和DQ2.5会增加患乳糜泻的风险

IF 4

Autoimmune Diseases Pub Date : 2016-11-30 DOI: 10.1155/2016/5409653

Lucas Malta Almeida, L. Gandolfi, R. Pratesi, R. H. Uenishi, F. C. de Almeida, Nicole Selleski, Yanna Karla de Medeiros Nóbrega

{"title":"Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease","authors":"Lucas Malta Almeida, L. Gandolfi, R. Pratesi, R. H. Uenishi, F. C. de Almeida, Nicole Selleski, Yanna Karla de Medeiros Nóbrega","doi":"10.1155/2016/5409653","DOIUrl":"https://doi.org/10.1155/2016/5409653","url":null,"abstract":"Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p < 0.05. Disease risk was expressed as 1 : N for each HLA-DQ category described at this study. Results. DQ2.5 and/or DQ8 were detected in 224 celiac patients (94.5%) and 84 controls (35.4%). Eight celiac patients (3.4%) and 38 controls (16%) disclosed only DQ2.2. Even though DQ2.2 (β2/β2 or β2/x) showed a low CD risk of 1 : 251 and 1 : 550, respectively, the genotype DQ2.5/DQ2.2 (β2/β2) showed high CD risk of 1 : 10 (p < 0.0001). The disease risk gradient ranged from 1 : 3014 to 1 : 7. Conclusion. Our study allowed the determination of a risk gradient for celiac disease development in at-risk population, showing that DQ2.2 variant was relevant when associated with DQ2.5.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"77 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85990839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

The Prevalence of S. aureus Skin and Soft Tissue Infections in Patients with Pemphigus 天疱疮患者金黄色葡萄球菌皮肤和软组织感染的患病率

IF 4

Autoimmune Diseases Pub Date : 2016-10-09 DOI: 10.1155/2016/7529078

Zeinab Fagheei Aghmiyuni, A. Khorshidi, R. Moniri, T. Soori, Seyed Gholam Abbas Musavi

{"title":"The Prevalence of S. aureus Skin and Soft Tissue Infections in Patients with Pemphigus","authors":"Zeinab Fagheei Aghmiyuni, A. Khorshidi, R. Moniri, T. Soori, Seyed Gholam Abbas Musavi","doi":"10.1155/2016/7529078","DOIUrl":"https://doi.org/10.1155/2016/7529078","url":null,"abstract":"Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of S. aureus infection and PVL gene in patients with pemphigus admitted to dermatology clinic. Materials and Methods. This descriptive study was conducted on 196 pemphigus vulgaris patients (119 males, 77 females) admitted to dermatology clinic between 2014 and 2015. In this study, the diagnosis of pemphigus vulgaris was made by histology, immunofluorescence pattern of perilesional skin, and indirect immunofluorescence testing of serum. Data were collected through a questionnaire. Results. 59.1% of pemphigus vulgaris patients had S. aureus infection. 49 out of 116 were methicillin-resistant. PVL gene was detected in 25 out of 116 S. aureus positive patients. Conclusion. This is the first report of S. aureus infection in pemphigus patients in Iran. More than forty percent of isolates were methicillin-resistant S. aureus. PVL gene carried by methicillin-resistant S. aureus was high in this study.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"126 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74919097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis 高须动脉炎患者循环Th17细胞、血清IL-17A和IL-23增加

IF 4

Autoimmune Diseases Pub Date : 2016-03-13 DOI: 10.1155/2016/7841718

D. Misra, S. Chaurasia, R. Misra

{"title":"Increased Circulating Th17 Cells, Serum IL-17A, and IL-23 in Takayasu Arteritis","authors":"D. Misra, S. Chaurasia, R. Misra","doi":"10.1155/2016/7841718","DOIUrl":"https://doi.org/10.1155/2016/7841718","url":null,"abstract":"Introduction. Th17, γδT, NK, and NKT cells in peripheral blood and serum IL-17 and IL-23 in Takayasu arteritis (TA) were measured and correlated with disease activity. Methods. Th17 (anti-CD3APC, CD4PECy7, and IL-17PE), NKT, NK (anti-CD3APC, CD56FITC), and γδT (anti-CD3FITC and γδTCRAPC) cells were enumerated by flow cytometry in peripheral blood of 30 patients with TA (ACR1990 criteria) and 20 healthy controls, serum IL-17 and IL-23 measured by ELISA. Relation with disease activity (NIH criteria, ITAS2010) was analyzed (using nonparametric tests, median with interquartile range). Results. Mean age of patients was 33.47 ± 11.78 years (25 females); mean symptom duration was 7.1 ± 5.3 years. 13 were not on immunosuppressants; 12 were active (ITAS2010 ≥ 4). The percentage of Th17 cells was significantly expanded in TA (patients 2.1 (1.5–3.2) versus controls 0.75 (0.32–1.2); p < 0.0001) with no differences in other cell populations. Serum IL-17 and IL-23 (pg/mL) in patients (6.2 (4.6–8.5) and 15 (14.9–26.5), resp.) were significantly higher (p < 0.001) than controls (3.9 (3.9–7.3) and undetectable median value, resp.). Subgroup analysis revealed no correlation of Th17 cells, serum IL-17, and IL-23 with disease activity or medications, nor any significant difference before and after medication. Conclusions. There is significant expansion of Th17 cells and elevated serum IL-17 and IL-23 levels in TA patients compared to healthy controls.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"16 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77124564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Mechanism of Xinfeng Capsule on Adjuvant-Induced Arthritis via Analysis of Urinary Metabolomic Profiles 心风胶囊治疗佐剂性关节炎的作用机制:尿代谢组学分析

IF 4

Autoimmune Diseases Pub Date : 2016-02-18 DOI: 10.1155/2016/5690935

Hui Jiang, Jian Liu, Ting Wang, Jiarong Gao, Yue Sun, Chuanbing Huang, Mei Meng, Xiu-juan Qin

引用次数: 6

Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings 系统性红斑狼疮患者的促氧化-抗氧化平衡及其与临床和实验室结果的关系

IF 4

Autoimmune Diseases Pub Date : 2016-01-26 DOI: 10.1155/2016/4343514

S. Jafari, S. Salimi, A. Nakhaee, H. Kalani, S. Tavallaie, F. Farajian-Mashhadi, Z. Zakeri, M. Sandoughi

{"title":"Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings","authors":"S. Jafari, S. Salimi, A. Nakhaee, H. Kalani, S. Tavallaie, F. Farajian-Mashhadi, Z. Zakeri, M. Sandoughi","doi":"10.1155/2016/4343514","DOIUrl":"https://doi.org/10.1155/2016/4343514","url":null,"abstract":"Aim. This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations. Methods. In this case-control study, 60 patients with SLE and 60 healthy individuals were enrolled. The blood samples were collected and their sera were separated. Subsequently, the prooxidant-antioxidant balance value was evaluated using PAB assay for each sample. Results. The mean of PAB values in SLE patients was significantly higher than healthy controls (147.3 ± 42 versus 84.8 ± 32.2 HK, P < 0.0001). Furthermore, in SLE patients, there was a positive significant correlation between the PAB and erythrocyte sedimentation rate (ESR) (r = 0.492, P < 0.001). In addition, the PAB values in patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis were significantly higher than those without these manifestations. Conclusion. The findings of current study showed that the mean of PAB was significantly higher in SLE patients and PAB was correlated with ESR. Moreover increased PAB was found in SLE patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis. These findings suggest that the measurement of PAB may be useful to show oxidative stress condition in SLE patients.","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"147 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2016-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74263084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4