Autoimmune Diseases最新文献_第6页

Pathophysiological Relationship between Infections and Systemic Vasculitis. 感染与全身血管炎的病理生理关系。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-07 DOI: 10.1155/2015/286783

Carolina Muñoz-Grajales, Juan C Pineda

引用次数: 23

Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies. 与白癜风治疗相关的免疫学参数:基于临床研究的文献综述。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-17 DOI: 10.1155/2015/196537

Ana Cláudia Guimarães Abreu, Gabriela Guy Duarte, Juliana Yasmin Pains Miranda, Daniel Gontijo Ramos, Camila Gontijo Ramos, Mariana Gontijo Ramos

{"title":"Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies.","authors":"Ana Cláudia Guimarães Abreu, Gabriela Guy Duarte, Juliana Yasmin Pains Miranda, Daniel Gontijo Ramos, Camila Gontijo Ramos, Mariana Gontijo Ramos","doi":"10.1155/2015/196537","DOIUrl":"https://doi.org/10.1155/2015/196537","url":null,"abstract":"Vitiligo, a depigmentary disorder, caused by the loss of melanocytes, affects approximately 1% of the world population, irrespective of skin type, with a serious psychological impact on the patient quality of life. So far, the origin of vitiligo has not been traced and the pathogenesis is complex, involving the interplay of a multitude of variables. Although there is no treatment that ensures the complete cure of the disorder, there are some pharmacological, phototherapy, and surgical therapies available. A series of variables can affect treatment outcome, such as individual characteristics, emotional issues, type of vitiligo, stability of the lesions, and immunological status. The present literature review identified the main immunological parameters associated with treatments for vitiligo. Cytotoxic CD8+ T lymphocytes are the main cell type involved in treatment success, as fewer cells in skin lesions are associated with better results. Other parameters such as cytokines and regulatory T cells may also be involved. Further clinical scientific studies are needed to elucidate the complex mechanisms underlying vitiligo and its treatments, in order to expand the range of therapeutic approaches for each individual case. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"196537"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/196537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34248163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis. IFN-γ: IL-10细胞因子比值与非节段性白癜风发病机制的关系

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-09 DOI: 10.1155/2015/423490

Yaswanth Ala, Mohammed Khalid Pasha, Raja Narasimha Rao, Prasanna Latha Komaravalli, Parveen Jahan

{"title":"Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis.","authors":"Yaswanth Ala, Mohammed Khalid Pasha, Raja Narasimha Rao, Prasanna Latha Komaravalli, Parveen Jahan","doi":"10.1155/2015/423490","DOIUrl":"https://doi.org/10.1155/2015/423490","url":null,"abstract":"Background and Objectives. Cytokines regulate immune response and inflammation and play a crucial role in depigmentation process of vitiligo. The present study aimed to estimate the serum levels of pro- and anti-inflammatory cytokines, IFN-γ and IL-10, and their ratios in nonsegmental vitiligo patients and healthy individuals from India. Methods. Blood samples were collected from 280 subjects and serum IFN-γ and IL-10 levels were measured using standard ELISA. Results. Nonsegmental vitiligo patients showed increased levels of IFN-γ (12.4 ± 3.2 versus 9.9 ± 4.4 pg/mL) and decreased levels of IL-10 (9.3 ± 1.7 versus 11.5 ± 5 pg/mL) compared to controls. Ratio of IFN-γ : IL-10 differed significantly from patients to controls (p < 0.05). IFN-γ concentrations and IFN-γ : IL-10 ratio varied significantly with respect to clinical variants, disease stability, and social habits (smoking and alcohol consumption) and showed a positive correlation with disease duration. Family history of vitiligo was significantly associated with IFN-γ : IL-10 ratio but not with their individual levels. Conclusion. The ratio of IFN-γ : IL-10 serum levels may be considered as one of the promising immunological markers in nonsegmental vitiligo. This is the first study considering multiple aspects in relation to ratio of cytokine levels. Similar studies with large samples are warranted to confirm our observations. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"423490"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/423490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34066571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families. 在大量狼疮家族中继发性和原发性Sjögren综合征的关联。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-12 DOI: 10.1155/2015/298506

Rachna Aggarwal, Juan-Manuel Anaya, Kristi A Koelsch, Biji T Kurien, R Hal Scofield

{"title":"Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families.","authors":"Rachna Aggarwal, Juan-Manuel Anaya, Kristi A Koelsch, Biji T Kurien, R Hal Scofield","doi":"10.1155/2015/298506","DOIUrl":"https://doi.org/10.1155/2015/298506","url":null,"abstract":"Objective. Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10(-5) compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p = 1 × 10(-8)). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"298506"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/298506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33966621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study. 尿单核细胞趋化蛋白-1与狼疮肾炎疾病活动性:一项前瞻性纵向研究的初步报告。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-12 DOI: 10.1155/2015/962046

Sabah Alharazy, Norella C T Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Ba'in, Abdul Halim Abdul Gafor

{"title":"Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study.","authors":"Sabah Alharazy, Norella C T Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Ba'in, Abdul Halim Abdul Gafor","doi":"10.1155/2015/962046","DOIUrl":"https://doi.org/10.1155/2015/962046","url":null,"abstract":"Objective. This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN-active or inactive-had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and 4 months. Urinary parameters, renal function test, serological markers, and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uMCP-1. Results. A hundred patients completed the study. At each visit, uMCP-1 levels (pg/mg creatinine) were significantly higher in the active group especially with relapses and were significantly associated with proteinuria and renal SLEDAI-2K. Receiver operating characteristic (ROC) curves showed that uMCP-1 was a potential biomarker for LN. Whereas multiple logistic regression analysis showed that only proteinuria and serum albumin and not uMCP-1 were independent predictors of LN activity. Conclusion. uMCP-1 was increased in active LN. Although uMCP-1 was not an independent predictor for LN activity, it could serve as an adjunctive marker when the clinical diagnosis of LN especially early relapse remains uncertain. Larger and longer studies are indicated. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"962046"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/962046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33966622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Slipping through the Cracks: Linking Low Immune Function and Intestinal Bacterial Imbalance to the Etiology of Rheumatoid Arthritis. 从裂缝中溜走:将免疫功能低下和肠道细菌失衡与类风湿关节炎的病因联系起来。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-03-12 DOI: 10.1155/2015/636207

Kuniaki Terato, Christopher T Do, Hiroshi Shionoya

{"title":"Slipping through the Cracks: Linking Low Immune Function and Intestinal Bacterial Imbalance to the Etiology of Rheumatoid Arthritis.","authors":"Kuniaki Terato, Christopher T Do, Hiroshi Shionoya","doi":"10.1155/2015/636207","DOIUrl":"https://doi.org/10.1155/2015/636207","url":null,"abstract":"Autoimmune diseases (ADs) are considered to be caused by the host immune system which attacks and destroys its own tissue by mistake. A widely accepted hypothesis to explain the pathogenic mechanism of ADs is \"molecular mimicry,\" which states that antibodies against an infectious agent cross-react with a self-antigen sharing an identical or similar antigenic epitope. However, this hypothesis was most likely established based on misleading antibody assay data largely influenced by intense false positive reactions involved in immunoassay systems. Thus reinvestigation of this hypothesis using an appropriate blocking agent capable of eliminating all types of nonspecific reactions and proper assay design is strongly encouraged. In this review, we discuss the possibility that low immune function may be the fundamental, common defect in ADs, which increases the susceptibility to potential disease causative pathogens located in the gastrointestinal tract (GI), such as bacteria and their components or dietary components. In addition to these exogenous agents, aberrations in the host's physical condition may disrupt the host defense system, which is tightly orchestrated by \"immune function,\" \"mucosal barrier function,\" and \"intestinal bacterial balance.\" These disturbances may initiate a downward spiral, which can lead to chronic health problems that will evolve to an autoimmune disorder. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"636207"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/636207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33206381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Understanding and Managing Pregnancy in Patients with Lupus. 了解和管理狼疮患者妊娠。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-12 DOI: 10.1155/2015/943490

Guilherme Ramires de Jesus, Claudia Mendoza-Pinto, Nilson Ramires de Jesus, Flávia Cunha Dos Santos, Evandro Mendes Klumb, Mario García Carrasco, Roger Abramino Levy

{"title":"Understanding and Managing Pregnancy in Patients with Lupus.","authors":"Guilherme Ramires de Jesus, Claudia Mendoza-Pinto, Nilson Ramires de Jesus, Flávia Cunha Dos Santos, Evandro Mendes Klumb, Mario García Carrasco, Roger Abramino Levy","doi":"10.1155/2015/943490","DOIUrl":"https://doi.org/10.1155/2015/943490","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a chronic, multisystemic autoimmune disease that occurs predominantly in women of fertile age. The association of SLE and pregnancy, mainly with active disease and especially with nephritis, has poorer pregnancy outcomes, with increased frequency of preeclampsia, fetal loss, prematurity, growth restriction, and newborns small for gestational age. Therefore, SLE pregnancies are considered high risk condition, should be monitored frequently during pregnancy and delivery should occur in a controlled setting. Pregnancy induces dramatic immune and neuroendocrine changes in the maternal body in order to protect the fetus from immunologic attack and these modifications can be affected by SLE. The risk of flares depends on the level of maternal disease activity in the 6-12 months before conception and is higher in women with repeated flares before conception, in those who discontinue useful medications and in women with active glomerulonephritis at conception. It is a challenge to differentiate lupus nephritis from preeclampsia and, in this context, the angiogenic and antiangiogenic cytokines are promising. Prenatal care of pregnant patients with SLE requires close collaboration between rheumatologist and obstetrician. Planning pregnancy is essential to increase the probability of successful pregnancies. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"943490"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/943490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33899939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 69

Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats. 牛膝富含皂苷部分的治疗作用。佐剂对Sprague-Dawley大鼠关节炎的影响。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-26 DOI: 10.1155/2015/943645

Pankaj S Kothavade, Vipin D Bulani, Dnyaneshwar M Nagmoti, Padmini S Deshpande, Nitin B Gawali, Archana R Juvekar

{"title":"Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats.","authors":"Pankaj S Kothavade, Vipin D Bulani, Dnyaneshwar M Nagmoti, Padmini S Deshpande, Nitin B Gawali, Archana R Juvekar","doi":"10.1155/2015/943645","DOIUrl":"https://doi.org/10.1155/2015/943645","url":null,"abstract":"Objective. Achyranthes aspera Linn. (AA) is used in folklore for the treatment of various inflammatory ailments and arthritis like conditions. Anti-inflammatory activity of saponin rich (SR) fraction of AA has been previously reported. The objective of this study was to assess the antiarthritic effect of SR fraction of Achyranthes aspera in adjuvant-induced arthritic rats. Methods. Arthritis was assessed by arthritis score, paw volume, changes in tibiotarsal joint thickness, hyperalgesic parameters, and spleen and thymus index. Haematological, serum, biochemical, and inflammatory cytokine and in vivo antioxidant parameters were measured on the last day of the study. Results. SR fraction significantly suppressed paw swelling and arthritic score and improved the pain threshold in motility and stair climbing tests. There was a reversal in the levels of altered parameters, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and antioxidant parameters like superoxide dismutase, catalase, glutathione, malondialdehyde, and nitric oxide. SR fraction significantly decreased plasma levels of tumor necrosis factor-alpha and interleukin-6. Moreover, histopathology revealed a significant reduction in synovial hyperplasia, inflammatory cell infiltration, and bone destruction in the joints. Conclusion. These observations explain the therapeutic benefit of SR fraction of AA in suppressing the progression of adjuvant-induced arthritis in rats. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"943645"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/943645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33922459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity. 双酚A (BPA)在自身免疫中的潜在作用。

IF 4

Autoimmune Diseases Pub Date : 2014-01-01 Epub Date: 2014-04-07 DOI: 10.1155/2014/743616

Datis Kharrazian

{"title":"The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity.","authors":"Datis Kharrazian","doi":"10.1155/2014/743616","DOIUrl":"https://doi.org/10.1155/2014/743616","url":null,"abstract":"Bisphenol A (BPA) is a monomer found in commonly used consumer plastic goods. Although much attention in recent years has been placed on BPA's impact as an endocrine disruptor, it also appears to activate many immune pathways involved in both autoimmune disease development and autoimmune reactivity provocation. The current scientific literature is void of research papers linking BPA directly to human or animal onset of autoimmunity. This paper explores the impact of BPA on immune reactivity and the potential roles these mechanisms may have on the development or provocation of autoimmune diseases. Potential mechanisms by which BPA may be a contributing risk factor to autoimmune disease development and progression include its impact on hyperprolactinemia, estrogenic immune signaling, cytochrome P450 enzyme disruption, immune signal transduction pathway alteration, cytokine polarization, aryl hydrocarbon activation of Th-17 receptors, molecular mimicry, macrophage activation, lipopolysaccharide activation, and immunoglobulin pathophysiology. In this paper a review of these known autoimmune triggering mechanisms will be correlated with BPA exposure, thereby suggesting that BPA has a role in the pathogenesis of autoimmunity. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2014 ","pages":"743616"},"PeriodicalIF":4.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/743616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32322663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

The prevalence of antinuclear antibodies in patients with sarcoidosis. 结节病患者抗核抗体的流行。

IF 4

Autoimmune Diseases Pub Date : 2014-01-01 Epub Date: 2014-12-17 DOI: 10.1155/2014/351852

Senol Kobak, Hatice Yilmaz, Fidan Sever, Arzu Duran, Nazime Sen, Ahmet Karaarslan

{"title":"The prevalence of antinuclear antibodies in patients with sarcoidosis.","authors":"Senol Kobak, Hatice Yilmaz, Fidan Sever, Arzu Duran, Nazime Sen, Ahmet Karaarslan","doi":"10.1155/2014/351852","DOIUrl":"https://doi.org/10.1155/2014/351852","url":null,"abstract":"Introduction. Sarcoidosis, which is a chronic inflammatory granulomatous disease, can mimic different rheumatologic diseases including connective tissue diseases. Antinuclear antibodies are the markers used for connective tissue diseases. Aim. To determine antinuclear antibody frequency and any possible correlation with clinical and laboratory data in sarcoidosis patients. Material and Method. Forty-two sarcoidosis patients, 45 rheumatoid arthritis patients, and 45 healthy volunteers who were followed up in rheumatology outpatient clinic were included in this study. Demographic, clinical, serological, and radiological data of all patients were recorded. Antinuclear antibodies were determined with indirect immunofluorescent method and 1/100 titration was accepted as positive. The cases that were ANA positive were evaluated with immunoblot method. Results. Average age of the 42 patients (10 males) with sarcoidosis was 45.2 (20-70 years), and average disease duration was 3.5 years. ANA positivity was detected in 12 (28.5%) patients with sarcoidosis (1/100 in 10 patients, 1/320 in two patients), in 19 of RA patients (42.2%), and in two of healthy volunteers in low titer (P < 0.001). In the subgroup analysis made by immunblot test, one patient had anticentromere antibody, one had anti-Ro antibody, one had anti-Scl-70 antibody, one had anti-dsDNA antibody, and eight patients were negative. The two patients who had anticentromere and anti-Scl-70 antibodies had also Sjögren's syndrome and scleroderma diagnosis, respectively. Discussion. The prevalence of ANA in patients with sarcoidosis was found to be significantly higher than healthy control group and lower than RA patients. This result shows that ANA may have an important role in the pathogenesis of sarcoidosis and also could be important in revealing the overlap syndromes of sarcoidosis-connective tissue diseases. Further studies with larger series are necessary in this subject. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2014 ","pages":"351852"},"PeriodicalIF":4.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/351852","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32968095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47