Autoimmune Diseases最新文献_第6页

Social Support and Self-Reported Stress Levels in a Predominantly African American Sample of Women with Systemic Lupus Erythematosus. 以非洲裔美国人为主的系统性红斑狼疮女性样本中的社会支持和自述压力水平。

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Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-09 DOI: 10.1155/2015/401620

Edith Marie Williams, Jiajia Zhang, Judith Anderson, Larisa Bruner, Laurene Tumiel-Berhalter

引用次数: 0

Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis. 多发性硬化症患者抗人和植物水通道蛋白抗体的检测。

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Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-26 DOI: 10.1155/2015/905208

Aristo Vojdani, Partha Sarathi Mukherjee, Joshua Berookhim, Datis Kharrazian

{"title":"Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis.","authors":"Aristo Vojdani, Partha Sarathi Mukherjee, Joshua Berookhim, Datis Kharrazian","doi":"10.1155/2015/905208","DOIUrl":"https://doi.org/10.1155/2015/905208","url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune disease that affects the body's central nervous system. Around 90% of MS sufferers are diagnosed with relapsing-remitting MS (RRMS). We used ELISA to measure IgG, IgA, and IgM antibodies against linear epitopes of human and plant aquaporins (AQP4) as well as neural antigens in RRMS patients and controls to determine whether patients suffering from RRMS have simultaneous elevations in antibodies against these peptides and antigens. In comparison to controls, significant elevations in isotype-specific antibodies against human and plant AQP4 and neural antigens such as MBP, MOG, and S100B were detected in RRMS patients, indicating a high correlation in antibody reaction between plant aquaporins and brain antigens. This correlation between the reactivities of RRMS patients with various tested antigens was the most significant for the IgM isotype. We conclude that a subclass of patients with RRMS reacts to both plant and human AQP4 peptides. This immune reaction against different plant aquaporins may help in the development of dietary modifications for patients with MS and other neuroimmune disorders. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"905208"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/905208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34106360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. 肝脏而非中枢神经系统表达的人c反应蛋白抑制实验性自身免疫性脑脊髓炎的转基因小鼠

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Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-03 DOI: 10.1155/2015/640171

Tyler T Wright, Rachel V Jimenez, Todd E Morgan, Namrata Bali, Xiaogang Hou, Mark A McCrory, Caleb E Finch, Alexander J Szalai

引用次数: 7

Gender and Ethnicity Based Differences in Clinical and Laboratory Features of Myasthenia Gravis. 重症肌无力临床和实验室特征的性别和种族差异。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-06-14 DOI: 10.1155/2015/197893

Fawzi Abukhalil, Bijal Mehta, Erin Saito, Sejal Mehta, Aaron McMurtray

{"title":"Gender and Ethnicity Based Differences in Clinical and Laboratory Features of Myasthenia Gravis.","authors":"Fawzi Abukhalil, Bijal Mehta, Erin Saito, Sejal Mehta, Aaron McMurtray","doi":"10.1155/2015/197893","DOIUrl":"https://doi.org/10.1155/2015/197893","url":null,"abstract":"Background. Previous reports describe ethnicity based differences in clinical and laboratory features between Caucasians and African Americans with myasthenia gravis. However, it is not known whether these findings apply to other ethnicities. Methods. Retrospective analysis of all patients treated for myasthenia gravis during a three-year period at a community based medical center. Results. A total of 44 patients were included, including 19 of Hispanic, 16 of African American, 6 of Caucasian, and 3 of Asian ethnicities. Female gender was more common among those with Hispanic, Asian, and African American ethnicities compared to Caucasian ethnicity (p = 0.029). Anti-acetylcholine receptor antibody subtypes demonstrated no significant ethnicity based differences in either generalized or ocular myasthenia gravis. A trend was noted towards greater frequency of blocking antibodies among Hispanics (52.6%) compared to African American (37.5%) and Caucasian (33.3%) patients (p = 0.059). Generalized but not ocular myasthenia patients showed greater frequency of anti-muscle specific kinase antibodies in Asians and Hispanics compared to African Americans and Caucasians (p = 0.041). Conclusions. The results of this study support the existence of ethnicity based differences in clinical and laboratory features of myasthenia gravis. Further study of genetic factors influencing clinical features of myasthenia gravis is indicated. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"197893"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/197893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33905925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice. C57BL/6和BALB/C小鼠胸腺免疫调节基因的转录修饰

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-17 DOI: 10.1155/2015/503087

Breno Luiz Melo-Lima, Danillo Lucas Alves Espósito, Benedito Antônio Lopes da Fonseca, Luiz Tadeu Moraes Figueiredo, Philippe Moreau, Eduardo Antonio Donadi

{"title":"The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice.","authors":"Breno Luiz Melo-Lima, Danillo Lucas Alves Espósito, Benedito Antônio Lopes da Fonseca, Luiz Tadeu Moraes Figueiredo, Philippe Moreau, Eduardo Antonio Donadi","doi":"10.1155/2015/503087","DOIUrl":"https://doi.org/10.1155/2015/503087","url":null,"abstract":"Thymus is involved in induction of self-tolerance in T lymphocytes, particularly due to Aire activity. In peripheral tissues, Treg cells and immunomodulatory molecules, like the major histocompatibility complex (MHC) class Ib molecules, are essential for maintenance of autotolerance during immune responses. Viral infections can trigger autoimmunity and modify thymic function, and YFV17D immunization has been associated with the onset of autoimmunity, being contraindicated in patients with thymic disorders. Aiming to study the influence of YFV17D immunization on the transcriptional profiles of immunomodulatory genes in thymus, we evaluated the gene expression of AIRE, FOXP3, H2-Q7 (Qa-2/HLA-G), H2-T23 (Qa-1/HLA-E), H2-Q10, and H2-K1 following immunization with 10,000 LD50 of YFV17D in C57BL/6 and BALB/c mice. The YFV17D virus replicated in thymus and induced the expression of H2-Q7 (Qa-2/HLA-G) and H2-T23 (Qa-1/HLA-E) transcripts and repressed the expression of AIRE and FOXP3. Transcriptional expression varied according to tissue and mouse strain analyzed. Expression of H2-T23 (Qa-1/HLA-E) and FOXP3 was induced in thymus and liver of C57BL/6 mice, which exhibited defective control of viral load, suggesting a higher susceptibility to YFV17D infection. Since the immunization with YFV17D modulated thymus gene expression in genetically predisposed individuals, the vaccine may be related to the onset of autoimmunity disorders. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"503087"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/503087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34250148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Predisposition to Cervical Atypia in Systemic Lupus Erythematosus: A Clinical and Cytopathological Study. 系统性红斑狼疮患者宫颈异型的易感性:临床和细胞病理学研究。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-09 DOI: 10.1155/2015/751853

Hend Hilal Al-Sherbeni, Ahmed Mohamed Fahmy, Nadine Sherif

{"title":"Predisposition to Cervical Atypia in Systemic Lupus Erythematosus: A Clinical and Cytopathological Study.","authors":"Hend Hilal Al-Sherbeni, Ahmed Mohamed Fahmy, Nadine Sherif","doi":"10.1155/2015/751853","DOIUrl":"https://doi.org/10.1155/2015/751853","url":null,"abstract":"Introduction. Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course, and prognosis. The female genital tract may be a potential target organ in SLE since cervical inflammation may be associated with disease activity. An increase in cervical dysplasia, a precursor of cervical cancer, has been reported in females with SLE. Aim of the Work. This work aimed to study the prevalence of abnormal cervicovaginal smears in patients with systemic lupus erythematosus (SLE) and to correlate abnormal smear findings with exposure to infection with human papilloma virus (HPV) in SLE patients. Patients and Methods. Thirty-two patients with SLE, fulfilling the 1997 revised criteria for the classification of SLE, were included in this study. They were subjected to full history taking, clinical examination, laboratory investigations, and cervicovaginal smearing. Twenty healthy subjects not known to suffer from any rheumatological disease were used as controls, and they were subjected to cervicovaginal smearing. Results. Four out of 32 SLE patients showed abnormal Pap smears (12.5%) compared to none showing any cervical changes in the control group (0%). Among these 4 patients, 3 were having ASCU and one was having LSIL (HPV). Conclusion. Cervicovaginal smearing is an easy, economic, safe, repeatable, and noninvasive technique for screening and early detection of cervical neoplastic lesions in SLE. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"751853"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/751853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34063904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Pathophysiological Relationship between Infections and Systemic Vasculitis. 感染与全身血管炎的病理生理关系。

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Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-07 DOI: 10.1155/2015/286783

Carolina Muñoz-Grajales, Juan C Pineda

引用次数: 23

Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies. 与白癜风治疗相关的免疫学参数:基于临床研究的文献综述。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-17 DOI: 10.1155/2015/196537

Ana Cláudia Guimarães Abreu, Gabriela Guy Duarte, Juliana Yasmin Pains Miranda, Daniel Gontijo Ramos, Camila Gontijo Ramos, Mariana Gontijo Ramos

{"title":"Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies.","authors":"Ana Cláudia Guimarães Abreu, Gabriela Guy Duarte, Juliana Yasmin Pains Miranda, Daniel Gontijo Ramos, Camila Gontijo Ramos, Mariana Gontijo Ramos","doi":"10.1155/2015/196537","DOIUrl":"https://doi.org/10.1155/2015/196537","url":null,"abstract":"Vitiligo, a depigmentary disorder, caused by the loss of melanocytes, affects approximately 1% of the world population, irrespective of skin type, with a serious psychological impact on the patient quality of life. So far, the origin of vitiligo has not been traced and the pathogenesis is complex, involving the interplay of a multitude of variables. Although there is no treatment that ensures the complete cure of the disorder, there are some pharmacological, phototherapy, and surgical therapies available. A series of variables can affect treatment outcome, such as individual characteristics, emotional issues, type of vitiligo, stability of the lesions, and immunological status. The present literature review identified the main immunological parameters associated with treatments for vitiligo. Cytotoxic CD8+ T lymphocytes are the main cell type involved in treatment success, as fewer cells in skin lesions are associated with better results. Other parameters such as cytokines and regulatory T cells may also be involved. Further clinical scientific studies are needed to elucidate the complex mechanisms underlying vitiligo and its treatments, in order to expand the range of therapeutic approaches for each individual case. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"196537"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/196537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34248163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis. IFN-γ: IL-10细胞因子比值与非节段性白癜风发病机制的关系

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-09-09 DOI: 10.1155/2015/423490

Yaswanth Ala, Mohammed Khalid Pasha, Raja Narasimha Rao, Prasanna Latha Komaravalli, Parveen Jahan

{"title":"Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis.","authors":"Yaswanth Ala, Mohammed Khalid Pasha, Raja Narasimha Rao, Prasanna Latha Komaravalli, Parveen Jahan","doi":"10.1155/2015/423490","DOIUrl":"https://doi.org/10.1155/2015/423490","url":null,"abstract":"Background and Objectives. Cytokines regulate immune response and inflammation and play a crucial role in depigmentation process of vitiligo. The present study aimed to estimate the serum levels of pro- and anti-inflammatory cytokines, IFN-γ and IL-10, and their ratios in nonsegmental vitiligo patients and healthy individuals from India. Methods. Blood samples were collected from 280 subjects and serum IFN-γ and IL-10 levels were measured using standard ELISA. Results. Nonsegmental vitiligo patients showed increased levels of IFN-γ (12.4 ± 3.2 versus 9.9 ± 4.4 pg/mL) and decreased levels of IL-10 (9.3 ± 1.7 versus 11.5 ± 5 pg/mL) compared to controls. Ratio of IFN-γ : IL-10 differed significantly from patients to controls (p < 0.05). IFN-γ concentrations and IFN-γ : IL-10 ratio varied significantly with respect to clinical variants, disease stability, and social habits (smoking and alcohol consumption) and showed a positive correlation with disease duration. Family history of vitiligo was significantly associated with IFN-γ : IL-10 ratio but not with their individual levels. Conclusion. The ratio of IFN-γ : IL-10 serum levels may be considered as one of the promising immunological markers in nonsegmental vitiligo. This is the first study considering multiple aspects in relation to ratio of cytokine levels. Similar studies with large samples are warranted to confirm our observations. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"423490"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/423490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34066571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families. 在大量狼疮家族中继发性和原发性Sjögren综合征的关联。

IF 4

Autoimmune Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-12 DOI: 10.1155/2015/298506

Rachna Aggarwal, Juan-Manuel Anaya, Kristi A Koelsch, Biji T Kurien, R Hal Scofield

{"title":"Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families.","authors":"Rachna Aggarwal, Juan-Manuel Anaya, Kristi A Koelsch, Biji T Kurien, R Hal Scofield","doi":"10.1155/2015/298506","DOIUrl":"https://doi.org/10.1155/2015/298506","url":null,"abstract":"Objective. Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10(-5) compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p = 1 × 10(-8)). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease. ","PeriodicalId":46314,"journal":{"name":"Autoimmune Diseases","volume":"2015 ","pages":"298506"},"PeriodicalIF":4.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/298506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33966621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16