KEIO JOURNAL OF MEDICINE最新文献_第4页

Fundamental principle of adult spinal deformity. 成人脊柱畸形的基本原理。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2024-01-01 DOI: 10.2302/kjm.ABSTRACT_73-2-1

Munish Gupta

引用次数: 0

Current Management of Chronic Constipation in Japan. 日本对慢性便秘的管理现状。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-12-25 Epub Date: 2023-08-22 DOI: 10.2302/kjm.2022-0036-IR

Tatsuhiro Masaoka

引用次数: 0

Aseptic Meningitis after BNT-162b2 COVID-19 Vaccination: Case Report and Literature Review. BNT-162b2新冠肺炎疫苗接种后无菌性脑膜炎：病例报告和文献回顾。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-12-25 Epub Date: 2023-09-23 DOI: 10.2302/kjm.2022-0034-CR

Yuji Kato, Takashi Osada, Nobuo Araki, Shinichi Takahashi

引用次数: 0

Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease. 足细胞靶向DNA甲基化治疗慢性肾脏疾病。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-09-25 Epub Date: 2023-06-03 DOI: 10.2302/kjm.2022-0017-IR

Kaori Hayashi

{"title":"Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease.","authors":"Kaori Hayashi","doi":"10.2302/kjm.2022-0017-IR","DOIUrl":"10.2302/kjm.2022-0017-IR","url":null,"abstract":"The number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly related to their function. Epigenetic changes responsible for the regulation of gene expression related to podocyte morphology have been shown to be important in the pathogenesis of CKD. Although epigenetic mechanisms include DNA methylation, histone modifications, and RNA-based regulation, we have focused on DNA methylation changes because they are more stable than other epigenetic modifications. This review summarizes recent literature about the role of altered DNA methylation in the kidney, especially in glomerular podocytes, focusing on transcription factors and DNA damage responses that are closely associated with the formation of DNA methylation changes.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"67-76"},"PeriodicalIF":2.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9946209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Mutations within Individual Oncogenes: Examples and Clinical Implications. 单个癌基因内的多重突变：实例和临床意义。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-09-25 Epub Date: 2023-03-21 DOI: 10.2302/kjm.2022-0026-OA

Keisuke Kataoka, Yuki Saito

引用次数: 0

Senso-immunology: The Emerging Connection between Pain and Immunity. Senso免疫学：疼痛和免疫之间的新联系。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-09-25 Epub Date: 2023-07-15 DOI: 10.2302/kjm.2022-0037-IR

Kenta Maruyama

{"title":"Senso-immunology: The Emerging Connection between Pain and Immunity.","authors":"Kenta Maruyama","doi":"10.2302/kjm.2022-0037-IR","DOIUrl":"10.2302/kjm.2022-0037-IR","url":null,"abstract":"The sensory and immune systems have been studied independently for a long time, whereas the interaction between the two has received little attention. We have carried out research to understand the interaction between the sensory and immune systems and have found that inflammation and bone destruction caused by fungal infection are suppressed by nociceptors. Furthermore, we have elucidated the molecular mechanism whereby fungal receptors are expressed on nociceptors and skin epithelium, how they cooperate to generate fungal pain, and how colitis and bone metabolism are regulated by mechanosensors expressed on the gut epithelium. Recently, we found that nociceptors prevent septic death by inhibiting microglia via nociceptor-derived hormones. This review summarizes our current state of knowledge on pain biology and outlines the mechanisms whereby pain and immunity interact. Our findings indicate that the sensory and immune systems share a variety of molecules and interact with each other to regulate our pathological and homeostatic conditions. This prompted us to advocate the interdisciplinary science named \"senso-immunology,\" and this emerging field is expected to generate new ideas in both physiology and immunology, leading to the development of novel drugs to treat pain and inflammation.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"77-87"},"PeriodicalIF":2.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10185805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Complete Response of Recurrent Gastric Cancer after Third-line CPT-11 Chemotherapy. 胃癌复发三线CPT-11化疗后的临床完全缓解

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-06-25 DOI: 10.2302/kjm.2022-0004-CR

Masato Hayashi, Takeshi Fujita, Hisayuki Matsushita

{"title":"Clinical Complete Response of Recurrent Gastric Cancer after Third-line CPT-11 Chemotherapy.","authors":"Masato Hayashi, Takeshi Fujita, Hisayuki Matsushita","doi":"10.2302/kjm.2022-0004-CR","DOIUrl":"https://doi.org/10.2302/kjm.2022-0004-CR","url":null,"abstract":"A 75-year-old man underwent distal gastrectomy for advanced gastric cancer in September 2018. During the adjuvant chemotherapy, computed tomography (CT) revealed recurrence sites in the liver and para-aortic lymph nodes. Therefore, chemotherapy was initiated. After first-line (capecitabine with oxaliplatin) and second-line (paclitaxel with ramucirumab) treatments, nivolumab was used as third-line chemotherapy. This treatment showed a strong effect against the tumor. However, following an immune-related adverse effect (irAE) because of nivolumab, the therapy was halted. The irAE was diagnosed with central adrenal insufficiency that was controllable by oral intake of steroids. CPT-11 was started and showed a similarly strong effect to that observed for nivolumab. Eventually, the recurrent tumor lesions became too small to be detected by CT. We discontinued CPT-11 at the request of the patient. Even after discontinuation, no recurrent sites have been observed, allowing us to declare a case of clinical complete response (cCR). In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":"72 2","pages":"60-64"},"PeriodicalIF":2.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9690290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse Using a Recurrent Neural Network. 基于瞳孔动态的头部固定小鼠睡眠阶段分类。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-06-25 DOI: 10.2302/kjm.2022-0020-OA

Goh Kobayashi, Kenji F Tanaka, Norio Takata

{"title":"Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse Using a Recurrent Neural Network.","authors":"Goh Kobayashi, Kenji F Tanaka, Norio Takata","doi":"10.2302/kjm.2022-0020-OA","DOIUrl":"https://doi.org/10.2302/kjm.2022-0020-OA","url":null,"abstract":"The standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional magnetic resonance imaging. To overcome these shortcomings, we propose a pupil dynamics-based vigilance state classification method for a head-fixed mouse using a long short-term memory (LSTM) model, a variant of a recurrent neural network, for multi-class labeling of NREM, REM, and WAKE states. For supervisory hypnography, EEG and EMG recording were performed on head-fixed mice. This setup was combined with left eye pupillometry using a USB camera and a markerless tracking toolbox, DeepLabCut. Our open-source LSTM model with feature inputs of pupil diameter, pupil location, pupil velocity, and eyelid opening for 10 s at a 10 Hz sampling rate achieved vigilance state estimation with a higher classification performance (macro F1 score, 0.77; accuracy, 86%) than a feed-forward neural network. Findings from a diverse range of pupillary dynamics implied possible subdivision of the vigilance states defined by EEG and EMG. Pupil dynamics-based hypnography can expand the scope of alternatives for sleep stage scoring of head-fixed mice.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":"72 2","pages":"44-59"},"PeriodicalIF":2.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9690291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network Approaches to Uncover Pathogenesis and Therapeutic Targets of Inflammatory Bowel Diseases. 揭示炎症性肠病发病机制和治疗靶点的网络方法。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-06-25 DOI: 10.2302/kjm.2022-0015-IR

Yohei Mikami, Takanori Kanai

引用次数: 0

Reoperative Aortic Valve Replacement for Structural Valve Deterioration through a Lower Hemisternotomy after a Previous Bentall Procedure in a Patient with Tracheostomy. 气管切开术患者行本特尔手术后经下半叶切开术治疗结构性瓣膜恶化的再手术主动脉瓣置换术。

IF 2

KEIO JOURNAL OF MEDICINE Pub Date : 2023-03-25 DOI: 10.2302/kjm.2022-0009-CR

Kaori Katsumata, Yujiro Kawai, Tsutomu Ito, Hideyuki Shimizu

{"title":"Reoperative Aortic Valve Replacement for Structural Valve Deterioration through a Lower Hemisternotomy after a Previous Bentall Procedure in a Patient with Tracheostomy.","authors":"Kaori Katsumata, Yujiro Kawai, Tsutomu Ito, Hideyuki Shimizu","doi":"10.2302/kjm.2022-0009-CR","DOIUrl":"https://doi.org/10.2302/kjm.2022-0009-CR","url":null,"abstract":"Patients with tracheostomy who undergo a full sternotomy have an increased risk of mediastinitis and sternal infection. This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and was administered antibiotic medication (piperacillin/tazobactam) for pneumonia. Echocardiography revealed severe aortic regurgitation caused by SVD. There was a risk that a full sternotomy in a patient with tracheostomy could cause mediastinitis; therefore, we performed a re-AVR through a lower hemisternotomy (second T incision). The re-AVR surgery proceeded without complications, and the bioprosthetic valve was removed while preserving the vascular graft from the previous Bentall procedure. The postoperative course was uneventful, and the patient was discharged from hospital 31 days after the tracheostomy was closed. The success of this procedure demonstrates the viability of re-AVR through a lower hemisternotomy in patients with SVD who are at risk of additional surgical complications.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":"72 1","pages":"21-25"},"PeriodicalIF":2.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9535066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0