KEIO JOURNAL OF MEDICINE最新文献

Analysis of the Stability of 0.04% Mitomycin C Ophthalmic Solution under Various Storage Conditions. 0.04%丝裂霉素C眼用液不同贮存条件下的稳定性分析。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-28 DOI: 10.2302/kjm.2025-0003-OA

Yuma Nonomiya, Koki Yamaguchi, Yuta Yokoyama, Isana Nakajima, Ryusei Hara, Daigo Shoji, Tomomi Takiguchi, Kazumi Takehana, Aya Jibiki, Sayo Suzuki, Tomonori Nakamura, Hideki Tsuji, Masakazu Yamaguchi

{"title":"Analysis of the Stability of 0.04% Mitomycin C Ophthalmic Solution under Various Storage Conditions.","authors":"Yuma Nonomiya, Koki Yamaguchi, Yuta Yokoyama, Isana Nakajima, Ryusei Hara, Daigo Shoji, Tomomi Takiguchi, Kazumi Takehana, Aya Jibiki, Sayo Suzuki, Tomonori Nakamura, Hideki Tsuji, Masakazu Yamaguchi","doi":"10.2302/kjm.2025-0003-OA","DOIUrl":"https://doi.org/10.2302/kjm.2025-0003-OA","url":null,"abstract":"A 0.04% mitomycin C (MMC) ophthalmic solution is not commercially available and is prepared in hospitals as required. The physical properties and stability of the MMC ophthalmic solution have not been clarified because of a lack of data. This study aimed to assess the stability of the MMC ophthalmic solution under various storage conditions. The MMC ophthalmic solution was prepared by dissolving 2 mg of MMC in 5 mL of saline solution. Each batch of ophthalmic solution was stored under three conditions [cold/shaded light, room temperature/shaded light, and room temperature/scattered light (approximately 4000 lx)], and MMC concentration was determined using high-performance liquid chromatography on days 0, 1, 3, 5, 7, 14, and 21. The expiry date was calculated based on the results of the degradation analysis. pH measurements and bacterial culture tests were conducted for each storage condition. The MMC concentrations on day 21 under cold/shaded light, room temperature/shaded light, and room temperature/scattered light were 340, 287, and 227 µg/mL, respectively. MMC concentrations decreased over time, and the decrease was highest when the samples were stored at room temperature and exposed to light, and lowest under cold conditions and protected from light. The pH of MMC solutions was 5.8 after preparation, which increased to 6.9 with time under all storage conditions. Culture tests did not detect any bacteria under any storage conditions. The MMC ophthalmic solution was most stable under cold/shaded conditions, and our study clarifies its expiry date for clinical use.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Regeneration-associated Cell Transplantation Enhances Tissue Recovery in Mice with Acute Ischemic Stroke. 静脉注射再生相关细胞移植可增强急性缺血性中风小鼠的组织恢复。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2024-11-02 DOI: 10.2302/kjm.2024-0005-OA

Taira Nakayama, Takato Abe, Haruchika Masuda, Takayuki Asahara, Shunya Takizawa, Eiichiro Nagata

{"title":"Intravenous Regeneration-associated Cell Transplantation Enhances Tissue Recovery in Mice with Acute Ischemic Stroke.","authors":"Taira Nakayama, Takato Abe, Haruchika Masuda, Takayuki Asahara, Shunya Takizawa, Eiichiro Nagata","doi":"10.2302/kjm.2024-0005-OA","DOIUrl":"10.2302/kjm.2024-0005-OA","url":null,"abstract":"Previously, we reported that transplantation of regeneration-associated cells (RACs) via the ipsilateral external carotid artery reduced stroke volume in mice with permanent occlusion of the middle cerebral artery (MCA). However, intracarotid arterial transplantation is invasive and requires skill, and severe complications may occur, such as thromboembolism, infection, and decreased cerebral blood flow. This study aimed to investigate the efficacy of intravenous injection of RACs in reducing stroke volume and increasing anti-inflammatory and angiogenic factors in mice with focal cerebral ischemia. Mice with occluded MCAs received intravenous injections of phosphate-buffered saline (PBS) (control), low-dose RACs, or high-dose RACs. The proximal part of the left MCA was occluded to induce permanent focal ischemia. After 3 days, we administered PBS or low-dose (1 × 104 /50 µL) or high-dose RACs (1 × 105 /50 µL) through the tail vein and assessed the infarct volume on day 7. High-dose RACs significantly decreased infarct volume compared to PBS, whereas low-dose RACs showed no effect. The number of interleukin-10 (IL-10)-positive and vascular endothelial growth factor (VEGF)-positive cells in the peri-infarct area on day 7 was significantly higher in mice treated with low-dose and high-dose RACs than in the PBS control group. Intravenous injection of RACs can reduce ischemic stroke volume; however, a higher dose of RACs is required than the dose used in intraarterial transplantation. By assessing IL-10 and VEGF expression, the study sheds light on the underlying mechanisms of RAC therapy, revealing its potential anti-inflammatory and angiogenic properties in the treatment of cerebral ischemia.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"79-85"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Issues Related to Enteral Nutrients Using a Database of Near-miss Events from Community Pharmacies. 使用社区药房的未遂事件数据库识别肠内营养素相关问题。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2025-03-13 DOI: 10.2302/kjm.2024-0014-OA

Shingo Kondo, Mari Maese, Hiroki Iwata, Noriko Kobayashi, Katsunori Yamaura

{"title":"Identification of Issues Related to Enteral Nutrients Using a Database of Near-miss Events from Community Pharmacies.","authors":"Shingo Kondo, Mari Maese, Hiroki Iwata, Noriko Kobayashi, Katsunori Yamaura","doi":"10.2302/kjm.2024-0014-OA","DOIUrl":"10.2302/kjm.2024-0014-OA","url":null,"abstract":"Undernutrition is a common risk after surgery or during periods when oral dietary intake is challenging. Enteral nutrients, frequently utilized in nutritional management, are drugs associated with multiple contraindications involving pathology and allergy, and they require careful attention in dispensing. However, the occurrence of nutrition-related incidents in community pharmacies remains unknown. This study aimed to identify issues regarding the safety of pharmacotherapy in patients requiring enteral nutrition using the database of Project to Collect and Analyze Pharmaceutical Near-Miss Event Information. We highlighted the critical information that pharmacists should focus on to prevent accidents and elucidated the details and prescription drugs of cases that matched the search for \"Nutrition (all included)\" in Japanese. There were 475 cases reported between January 2009 and September 2023. Of these, 347 cases (73%) were classified as \"inquiry about prescription and provision of information to prescribing physician\" (Category II) and 115 cases (24%) were classified as \"drug dispensing\" (Category I). In both cases, the top five drugs were enteral nutrients. Among the life-threatening Category II cases, 9 cases were for pathological contraindications including severe liver or renal dysfunction, 6 cases were for adverse reactions including diarrhea, and 5 cases were for allergies or patient constitutions. Notably, the incidence of adverse reactions was higher than in data for the latest annual reports. Therefore, pharmacists should be mindful while dealing with prescriptions involving possible contraindications in patients requiring enteral nutrition. Pharmacists should contribute to the provision of safe pharmacotherapy by remaining vigilant against dispensing errors.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"86-95"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Cancer: A Comprehensive Review. 糖尿病酮症酸中毒作为胰腺癌的首发症状：综述。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2025-05-01 DOI: 10.2302/kjm.2024-0015-OA

Khaled Saad, Mustafa Mahmoud, Mahmoud M Younes, Alaa Reda, Ramez M Odat, Hassaan Mady, Mayar S Abdelal, Saleh Helmy, Mohamed M Ghonaim, Abdelrahman A Ebaid, Sara Y Alsaidi, Rady Elmonier, Amira Elhoufey, Hamad Ghaleb Dailah, Doaa Ali Gamal, Hoda Atef Abdelsattar Ibrahim, Anas Elgenidy

{"title":"Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Cancer: A Comprehensive Review.","authors":"Khaled Saad, Mustafa Mahmoud, Mahmoud M Younes, Alaa Reda, Ramez M Odat, Hassaan Mady, Mayar S Abdelal, Saleh Helmy, Mohamed M Ghonaim, Abdelrahman A Ebaid, Sara Y Alsaidi, Rady Elmonier, Amira Elhoufey, Hamad Ghaleb Dailah, Doaa Ali Gamal, Hoda Atef Abdelsattar Ibrahim, Anas Elgenidy","doi":"10.2302/kjm.2024-0015-OA","DOIUrl":"10.2302/kjm.2024-0015-OA","url":null,"abstract":"Recent studies have indicated that diabetic ketoacidosis (DKA) can be the primary presenting symptom of pancreatic cancer. This comprehensive review assesses the existing research on the incidence of DKA as an initial symptom of pancreatic cancer, including its clinical characteristics, diagnostic challenges, and implications for treatment and prognosis. A comprehensive search was conducted across four electronic databases (PubMed, Scopus, Web of Science, and Cochrane), complemented by a manual search. The search criteria focused on original case reports of pancreatic cancer patients who presented with DKA. Among the 360 studies reviewed, 9 met the eligibility criteria. Among the cases, pancreatic adenocarcinoma was the most common type, followed by somatostatinoma and cystadenocarcinoma. Diagnostic modalities included computed tomography, ultrasound, biopsy, and endoscopic ultrasound. Elevated tumor markers such as CA19-9 were reported in several cases. Most patients presented with gastrointestinal and neurological symptoms, with high levels of glucose and ketone bodies. This review highlights that DKA can serve as a rare but significant initial presentation of pancreatic cancer. Identifying this association is critical for facilitating early diagnosis, which may improve the otherwise poor prognosis of pancreatic cancer. Our findings suggest that clinicians should maintain a high index of suspicion for pancreatic malignancy in patients presenting with unexplained DKA, particularly those without traditional risk factors or precipitating events. Early imaging and multidisciplinary evaluation are essential in such cases.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"69-78"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral Frosted Branch Angiitis Following COVID-19 Disease: Case Report and Literature Review. 新冠肺炎后单侧霜状支血管炎病例报告及文献复习

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2025-02-05 DOI: 10.2302/kjm.2024-0010-CR

Asma Alzuabi, Abdulrahman AlBloushi

{"title":"Unilateral Frosted Branch Angiitis Following COVID-19 Disease: Case Report and Literature Review.","authors":"Asma Alzuabi, Abdulrahman AlBloushi","doi":"10.2302/kjm.2024-0010-CR","DOIUrl":"10.2302/kjm.2024-0010-CR","url":null,"abstract":"Frosted branch angiitis (FBA) is a rare and aggressive form of retinal vasculitis that can cause vision loss. This condition is typically idiopathic and can be associated with various infections or malignancies. Recently, FBA has been linked to COVID-19 in some reports. This report describes a rare association between COVID-19 and FBA and presents characteristic findings from multimodal imaging. We describe the case of a 30-year-old man, otherwise healthy, who experienced acute vision loss in his left eye 1 week after testing positive for COVID-19. His initial visual acuity was 20/20 in the right eye and counting fingers at 2 feet in the left eye. A fundus examination disclosed extensive vascular sheathing affecting the arteries and veins, accompanied by widespread intraretinal, preretinal, and subretinal hemorrhages indicative of FBA. Fundus fluorescein angiography revealed notably delayed filling in both arterial and venous systems. Optical coherence tomography of the left eye displayed inner retinal layer hyperreflectivity, suggesting ischemia coupled with substantial subretinal fluid. The systemic evaluation of the patient was unremarkable. The treatment included systemic corticosteroids, azathioprine, intravitreal bevacizumab, and panretinal photocoagulation. After 6 months of treatment, the left eye examination showed resolution of vascular sheathing, retinal hemorrhages, and subretinal fluid, although the final visual acuity in the left eye remained unchanged. In conclusion, FBA may manifest in otherwise healthy and immunocompetent individuals following SARS-CoV-2 infection.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"101-105"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Kidney Injury as the First Manifestation of Sarcoidosis. 急性肾损伤是结节病的首要表现。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2025-01-29 DOI: 10.2302/kjm.2023-0020-CR

Leonid Dvoretsky, Nina Sidoruk, Sergey Krivushkin, Andrey Stepanchenko, Svetlana Rachina, Ekaterina Stolyarevich, Heshan Radeesha de Silva

{"title":"Acute Kidney Injury as the First Manifestation of Sarcoidosis.","authors":"Leonid Dvoretsky, Nina Sidoruk, Sergey Krivushkin, Andrey Stepanchenko, Svetlana Rachina, Ekaterina Stolyarevich, Heshan Radeesha de Silva","doi":"10.2302/kjm.2023-0020-CR","DOIUrl":"10.2302/kjm.2023-0020-CR","url":null,"abstract":"We describe a case of sarcoidosis in a previously healthy 39-year-old man with the development of an acute kidney injury, requiring renal replacement therapy, as the first manifestation of the disease. The course of the disease was complicated by a сatheter-associated bloodstream infection. According to the histological examination of kidney biopsy samples, granulomatous interstitial nephritis was diagnosed. Extensive examination of the patient revealed persistent hypercalcemia, elevated transaminase levels, intrathoracic lymphadenopathy, and infiltrates in the lungs. Other diseases, such as anti-neutrophil cytoplasmic antibody-associated vasculitis, tuberculosis, autoimmune liver diseases, and systemic lupus erythematosus, were ruled out. The patient was treated with pulse therapy of methylprednisolone, which then switched to oral glucocorticoids (prednisolone 60 mg/day followed by a gradual decrease in the dose). The 9-month follow-up revealed a regression of lung lesions and improvement of the impaired renal function. The prednisolone dose was reduced to 7.5 mg/day, and renal replacement therapy was discontinued.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"96-100"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intractable Pruritus as Initial Presentation of Cytomegalovirus -Tuberculosis Coinfections. 顽固性瘙痒是巨细胞病毒-结核合并感染的初始表现。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2025-02-07 DOI: 10.2302/kjm.2024-0012-CR

Shivnarayan Sahu, Priyavadhana Balasubramanian, Prasan Kumar Panda, Prativa Sethi

{"title":"Intractable Pruritus as Initial Presentation of Cytomegalovirus -Tuberculosis Coinfections.","authors":"Shivnarayan Sahu, Priyavadhana Balasubramanian, Prasan Kumar Panda, Prativa Sethi","doi":"10.2302/kjm.2024-0012-CR","DOIUrl":"10.2302/kjm.2024-0012-CR","url":null,"abstract":"Coinfection of cytomegalovirus (CMV) and Mycobacterium tuberculosis presenting with acquired perforating dermatosis is a rare occurrence and remains poorly described in the literature. A man in his 40s, a farmer and chronic smoker, who was partially treated for tuberculosis, presented with a history of fever, weight loss, cough, generalized lymphadenopathy, severe pruritus, and skin lesions. Imaging findings suggested tuberculosis, which was confirmed by sputum examination. Histopathological examinations confirmed CMV lymphadenitis associated with acquired perforating dermatosis. Treatment included antitubercular therapy and a multidrug regimen for severe pruritus, leading to symptomatic improvement. Despite initial progress, the patient was lost to follow-up and later succumbed at home, emphasizing the importance of timely intervention for coinfected tuberculosis and cytomegalovirus diseases. This case highlights the rarity of cytomegalovirus and tuberculosis coinfection, the diagnostic complexities, the challenges associated with the treatment of intractable pruritus, and the necessity of ensuring proper follow-up.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"106-112"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poorly Differentiated Carcinoma with only Clear Glandular Differentiation Arising from the Bladder Trigone: A Case of Adenocarcinoma or Urothelial Carcinoma? 膀胱三角区低分化癌伴腺分化：是腺癌还是尿路上皮癌？

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2025-03-26 DOI: 10.2302/kjm.2024-0017-CR

Kaoru Furihata, Atsushi Kurabayashi, Waka Iwashita, Noriko Wada, Makoto Toi, Jo Yoshimichi, Hideo Fukuhara, Keiji Inoue, Mutsuo Furihata

{"title":"Poorly Differentiated Carcinoma with only Clear Glandular Differentiation Arising from the Bladder Trigone: A Case of Adenocarcinoma or Urothelial Carcinoma?","authors":"Kaoru Furihata, Atsushi Kurabayashi, Waka Iwashita, Noriko Wada, Makoto Toi, Jo Yoshimichi, Hideo Fukuhara, Keiji Inoue, Mutsuo Furihata","doi":"10.2302/kjm.2024-0017-CR","DOIUrl":"10.2302/kjm.2024-0017-CR","url":null,"abstract":"Invasive urothelial carcinoma (UC) has diverse morphological presentations. Here, we describe the case of a Japanese woman aged in her early 60s with UC with unclear differentiation. The patient presented with distinct glandular differentiation and concurrent cystitis glandularis (CG) and intestinal metaplasia (IM) without a conventional UC component. Up to 2% of patients with bladder cancer develop adenocarcinoma. However, differentiating UC with glandular differentiation (UCg) from adenocarcinoma can be challenging. Although CG and IM are associated with adenocarcinoma, their presence does not necessarily imply that the comorbid cancer is adenocarcinoma. In this case, cytokeratin 7 (CK7) and CK5/6 positivity was assessed to establish the diagnosis of poorly differentiated UCg. A poorly differentiated pure UCg without conventional UC components has not yet been reported, which makes diagnosis extremely difficult. Moreover, because of the highly differentiated glandular structures within poorly differentiated UCs, the mechanism of tumorigenesis remains unclear. Further studies involving a larger case series should be conducted to elucidate the association between CG and IM and investigate the genetic background of these tumors, all of which would improve the accuracy of differentiation between poorly differentiated UC and adenocarcinoma.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"113-118"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer Management. 庆应义塾HBOC中心：遗传性乳腺癌和卵巢癌管理的典范。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-20 DOI: 10.2302/kjm.2025-0004-OA

Yusuke Kobayashi, Kenta Masuda, Tomoko Seki, Takeo Kosaka, Minoru Kitago, Ikumi Ono, Kumiko Misu, Arisa Ueki, Tomoko Yoshihama, Aiko Nagayama, Yota Yasumizu, Yumiko Goto, Kohei Nakamura, Mamiko Yamada, Megumi Yokota, Sayaka Uchida, Mari Takeuchi, Takeru Funakoshi, Wataru Yamagami

{"title":"The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer Management.","authors":"Yusuke Kobayashi, Kenta Masuda, Tomoko Seki, Takeo Kosaka, Minoru Kitago, Ikumi Ono, Kumiko Misu, Arisa Ueki, Tomoko Yoshihama, Aiko Nagayama, Yota Yasumizu, Yumiko Goto, Kohei Nakamura, Mamiko Yamada, Megumi Yokota, Sayaka Uchida, Mari Takeuchi, Takeru Funakoshi, Wataru Yamagami","doi":"10.2302/kjm.2025-0004-OA","DOIUrl":"10.2302/kjm.2025-0004-OA","url":null,"abstract":"The management of hereditary breast and ovarian cancer (HBOC) in Japan has changed drastically with the expansion of indications for poly ADP-ribose polymerase inhibitors, the increase in diagnostic opportunities with the spread of companion diagnoses, and partial insurance coverage of HBOC management. These circumstances require a response that is coordinated across the entire hospital rather than from individual departments. In April 2021, we established the HBOC Center, which is operated by nine departments: Obstetrics and Gynecology, Reproduction, Surgery (breast group, hepato-pancreato-biliary group), Urology, Dermatology, Neuropsychiatry, the Center for Medical Genetics, and the Cancer Center. In addition to discussions of individual cases, our monthly conferences have enabled us to establish indication criteria and appropriate items for surveillance, visualize the examination flow in the hospital, construct a patient database, and provide open lectures to educate the public. The future HBOC management system should not only fulfill the existing requirements for risk-reducing surgery and facility standards but also offer comprehensive and diversified attention based on the needs of patients and their family members.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pemphigus: An Autoimmune Disease Model for Understanding the Role of Autoreactive T Cells. 天疱疮：了解自身反应性T细胞作用的自身免疫性疾病模型。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-05-28 DOI: 10.2302/kjm.2025-0002-IR

Hayato Takahashi

{"title":"Pemphigus: An Autoimmune Disease Model for Understanding the Role of Autoreactive T Cells.","authors":"Hayato Takahashi","doi":"10.2302/kjm.2025-0002-IR","DOIUrl":"https://doi.org/10.2302/kjm.2025-0002-IR","url":null,"abstract":"Finding cures is the ultimate goal of research on autoimmune diseases. Pemphigus is an autoantibody-mediated autoimmune skin disease in which specific autoantibodies target desmogleins 1 and 3 as autoantigens. The condition leads to painful blisters and erosions in the skin and oral mucosa, impacting patients' ability to eat and other daily activities, significantly affecting quality of life. The molecular mechanisms by which these pathogenic autoantibodies induce blisters have been extensively studied and understanding has advanced considerably. However, many critical questions remain, such as the exact cause of the disease, the mechanisms that normally prevent autoimmunity, and the pathogenic cells involved, other than autoantibodies. This article focuses on the role of autoreactive T cells in pemphigus and uses the pemphigus model to answer some of these questions. Research into pemphigus has enhanced our understanding of both the pathogenic and regulatory mechanisms involved, not only in pemphigus but also in other skin diseases caused by cellular autoimmunity. The growing body of scientific evidence on pemphigus has made it a model disease, paving the way for the development of novel therapeutic approaches, including antigen-specific immunotherapy for autoimmune diseases and chronic inflammatory disorders.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0