KEIO JOURNAL OF MEDICINE最新文献_第2页

Palliative Radiotherapy for Colorectal Villous Adenoma with Severe Diarrhea and Electrolyte Imbalance. 结直肠绒毛腺瘤伴严重腹泻及电解质失衡的姑息性放疗。

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-10-25 DOI: 10.2302/kjm.2025-0010-CR

Hirofumi Toyama, Yoshihiro Nakazato, Yuka Katsurada, Yutaka Shiraishi, Masashi Tamura, Takashi Hanada, Toshio Ohashi, Yutaka Ando, Naoyuki Shigematsu, Atsuya Takeda

引用次数: 0

Chemotherapy for Breast Cancer with Pre-existing Cryptogenic Organizing Pneumonia: Epirubicin/cyclophosphamide Followed by Weekly Paclitaxel. 存在隐源性组织性肺炎的乳腺癌的化疗：表柔比星/环磷酰胺，随后每周紫杉醇。

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-10-21 DOI: 10.2302/kjm.2025-0008-CR

Ouki Kuniyoshi, Yuta Yokoyama, Yuma Nonomiya, Takashi Nakakuma, Tomonori Nakamura

{"title":"Chemotherapy for Breast Cancer with Pre-existing Cryptogenic Organizing Pneumonia: Epirubicin/cyclophosphamide Followed by Weekly Paclitaxel.","authors":"Ouki Kuniyoshi, Yuta Yokoyama, Yuma Nonomiya, Takashi Nakakuma, Tomonori Nakamura","doi":"10.2302/kjm.2025-0008-CR","DOIUrl":"https://doi.org/10.2302/kjm.2025-0008-CR","url":null,"abstract":"The incidence of breast cancer in patients with pre-existing interstitial lung disease has been rarely reported. Consequently, evidence supporting the safety of chemotherapy in this population remains limited. This report describes the case of a 55-year-old woman with a history of cryptogenic organizing pneumonia who received adjuvant chemotherapy for the management of breast cancer. The chemotherapy regimen comprised the administration of epirubicin/cyclophosphamide followed by the weekly administration of paclitaxel. This regimen was selected based on the findings of previous studies that assessed the utility of chemotherapy regimens for the treatment of lung cancer in patients with interstitial lung disease. Chemotherapy was completed without worsening of the cryptogenic organizing pneumonia or the appearance of new abnormal lung fields. Therefore, the administration of epirubicin/cyclophosphamide followed by the weekly administration of paclitaxel may be safe in patients with pre-existing interstitial lung disease. This regimen may be a suitable choice for the perioperative management of this population.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental Health Care among Cancer Patients with BRCA Gene Mutations: The Potential of Mindfulness-based Intervention. BRCA基因突变癌症患者的心理健康护理：正念干预的潜力。

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-09-25 Epub Date: 2025-02-22 DOI: 10.2302/kjm.2024-0019-RE

Mari Takeuchi, Sunre Park

引用次数: 0

Exploring Breast Cancer Risk Management in HBOC Patients: Image Surveillance Versus Risk-reducing Surgery. 探索HBOC患者的乳腺癌风险管理：图像监测与降低风险的手术。

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-09-25 Epub Date: 2025-04-02 DOI: 10.2302/kjm.2024-0021-RE

Tomoko Seki, Yusuke Kobayashi, Kenta Masuda, Kohei Nakamura, Mamiko Yamada, Yumiko Goto, Kumiko Misu, Ikumi Ono, Aiko Nagayama, Tetsu Hayashida, Yuko Kitagawa

{"title":"Exploring Breast Cancer Risk Management in HBOC Patients: Image Surveillance Versus Risk-reducing Surgery.","authors":"Tomoko Seki, Yusuke Kobayashi, Kenta Masuda, Kohei Nakamura, Mamiko Yamada, Yumiko Goto, Kumiko Misu, Ikumi Ono, Aiko Nagayama, Tetsu Hayashida, Yuko Kitagawa","doi":"10.2302/kjm.2024-0021-RE","DOIUrl":"10.2302/kjm.2024-0021-RE","url":null,"abstract":"In Japan, the rising incidence of hereditary breast and ovarian cancer syndrome (HBOC) follows partial insurance coverage introduced in 2020. Compared with the general population (~11% lifetime risk), individuals with HBOC face a significantly higher lifetime risk of breast cancer (48%-76%), often presenting at younger ages. BRCA1 mutations are linked to triple-negative breast cancer, whereas BRCA2 mutations typically result in luminal-type disease. Key risk management strategies include surveillance and prophylactic surgery. Annual magnetic resonance imaging and mammography are recommended at younger ages than in the general population, despite concerns regarding contrast agents, radiation exposure, and examination-related burdens. Although risk-reducing mastectomy lowers breast cancer risk by over 90%, it remains underutilized because of cosmetic and psychological considerations. Nipple-sparing or skin-sparing mastectomy combined with immediate or delayed reconstruction offers a balance between risk reduction and postoperative outcomes, although safety and procedure details still warrant careful evaluation. Managing the high breast cancer risk associated with HBOC requires ongoing efforts to refine current strategies while minimizing patient burden.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"130-137"},"PeriodicalIF":1.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Cancer in Hereditary Breast and Ovarian Cancer Syndrome: Is Early Detection Possible? 胰腺癌在遗传性乳腺癌和卵巢癌综合征：早期发现是可能的吗？

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-09-25 Epub Date: 2025-04-19 DOI: 10.2302/kjm.2024-0018-OA

Kodai Abe, Minoru Kitago, Yusuke Kobayashi, Kenta Masuda, Tomoko Seki, Mamiko Yamada, Yumiko Goto, Ikumi Ono, Kumiko Misu, Kohei Nakamura, Yuko Kitagawa

{"title":"Pancreatic Cancer in Hereditary Breast and Ovarian Cancer Syndrome: Is Early Detection Possible?","authors":"Kodai Abe, Minoru Kitago, Yusuke Kobayashi, Kenta Masuda, Tomoko Seki, Mamiko Yamada, Yumiko Goto, Ikumi Ono, Kumiko Misu, Kohei Nakamura, Yuko Kitagawa","doi":"10.2302/kjm.2024-0018-OA","DOIUrl":"10.2302/kjm.2024-0018-OA","url":null,"abstract":"A program of recruiting families with hereditary pancreatic cancer and hereditary breast and ovarian cancer (HBOC) syndrome as high-risk individuals for pancreatic cancer surveillance using magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound (EUS) has proven effective, resulting in the improvement of early detection rates and life expectancy. Given this, recent guidelines recommend pancreatic surveillance for patients with familial pancreatic cancer and pathological variants of ten genes, including BRCA1/2. In April 2021, our hospital established the HBOC Center, which is operated by nine departments, including obstetrics and gynecology, breast surgery, pancreatology, urology, medical genetics, dermatology, psychiatry and neurology, and oncology. Currently, MRCP or EUS is performed once or twice a year in 63 cases with pathogenic variants in 54 families. Although 4 cases (6.3%) revealed pancreatic microcysts or branched intraductal papillary mucinous neoplasms, no sign of pancreatic cancer was detected. Since January 2021, the germline BRCA1/2 test for companion diagnosis of pancreatic cancer has been covered by insurance, improving the accessibility of genetic testing among patients with pancreatic cancer. However, the BRCA1/2 positivity rate remains low at 1.3%, and its indication for use is very limited. The implementation of genetic testing, including BRCA1/2 analysis, is necessary for the prevention and early detection of pancreatic cancer in high-risk families.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"146-150"},"PeriodicalIF":1.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer Management. 庆应义塾HBOC中心：遗传性乳腺癌和卵巢癌管理的典范。

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-09-25 Epub Date: 2025-06-20 DOI: 10.2302/kjm.2025-0004-OA

Yusuke Kobayashi, Kenta Masuda, Tomoko Seki, Takeo Kosaka, Minoru Kitago, Ikumi Ono, Kumiko Misu, Arisa Ueki, Tomoko Yoshihama, Aiko Nagayama, Yota Yasumizu, Yumiko Goto, Kohei Nakamura, Mamiko Yamada, Megumi Yokota, Sayaka Uchida, Mari Takeuchi, Takeru Funakoshi, Wataru Yamagami

{"title":"The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer Management.","authors":"Yusuke Kobayashi, Kenta Masuda, Tomoko Seki, Takeo Kosaka, Minoru Kitago, Ikumi Ono, Kumiko Misu, Arisa Ueki, Tomoko Yoshihama, Aiko Nagayama, Yota Yasumizu, Yumiko Goto, Kohei Nakamura, Mamiko Yamada, Megumi Yokota, Sayaka Uchida, Mari Takeuchi, Takeru Funakoshi, Wataru Yamagami","doi":"10.2302/kjm.2025-0004-OA","DOIUrl":"10.2302/kjm.2025-0004-OA","url":null,"abstract":"The management of hereditary breast and ovarian cancer (HBOC) in Japan has changed drastically with the expansion of indications for poly ADP-ribose polymerase inhibitors, the increase in diagnostic opportunities with the spread of companion diagnoses, and partial insurance coverage of HBOC management. These circumstances require a response that is coordinated across the entire hospital rather than from individual departments. In April 2021, we established the HBOC Center, which is operated by nine departments: Obstetrics and Gynecology, Reproduction, Surgery (breast group, hepato-pancreato-biliary group), Urology, Dermatology, Neuropsychiatry, the Center for Medical Genetics, and the Cancer Center. In addition to discussions of individual cases, our monthly conferences have enabled us to establish indication criteria and appropriate items for surveillance, visualize the examination flow in the hospital, construct a patient database, and provide open lectures to educate the public. The future HBOC management system should not only fulfill the existing requirements for risk-reducing surgery and facility standards but also offer comprehensive and diversified attention based on the needs of patients and their family members.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"124-129"},"PeriodicalIF":1.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Situation and Future Directions of Risk-reducing Salpingo-oophorectomy. 输卵管卵巢切除术的现状及未来发展方向。

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-09-25 Epub Date: 2025-03-22 DOI: 10.2302/kjm.2024-0024-RE

Kenta Masuda, Yusuke Kobayashi, Tomoko Seki, Tomoko Yoshihama, Kohei Nakamura, Yumiko Goto, Mamiko Yamada, Aiko Nagayama, Sayaka Uchida, Ikumi Ono, Kumiko Misu, Megumi Yokota, Wataru Yamagami

{"title":"Current Situation and Future Directions of Risk-reducing Salpingo-oophorectomy.","authors":"Kenta Masuda, Yusuke Kobayashi, Tomoko Seki, Tomoko Yoshihama, Kohei Nakamura, Yumiko Goto, Mamiko Yamada, Aiko Nagayama, Sayaka Uchida, Ikumi Ono, Kumiko Misu, Megumi Yokota, Wataru Yamagami","doi":"10.2302/kjm.2024-0024-RE","DOIUrl":"10.2302/kjm.2024-0024-RE","url":null,"abstract":"High-grade serous carcinoma (HGSC), the most aggressive subtype of epithelial ovarian cancer, is strongly associated with hereditary breast and ovarian cancer (HBOC) syndrome and is primarily linked to germline BRCA1/2 pathogenic variants (PVs). The cumulative risks of ovarian cancer by the age of 70 years are 40% and 18% for carriers of BRCA1 and BRCA2 PVs, respectively. Risk-reducing salpingo-oophorectomy (RRSO) is a recommended preventive strategy that reduces the risk of ovarian cancer by more than 80% and may improve overall survival. However, surgical menopause after RRSO poses several challenges, including infertility and hormonal deficiency. Although the use of hormone replacement therapy may alleviate symptoms, it requires careful consideration of breast cancer risk. Emerging strategies, such as prophylactic salpingectomy with delayed oophorectomy, are being investigated to balance cancer prevention and patient quality of life. Further research is required to refine personalized prevention and management approaches for HBOC-associated ovarian cancer.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"138-145"},"PeriodicalIF":1.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential New Tumors Associated with Hereditary Breast and Ovarian Cancer (HBOC). 与遗传性乳腺癌和卵巢癌（HBOC）相关的潜在新肿瘤

IF 1.5

KEIO JOURNAL OF MEDICINE Pub Date : 2025-09-25 Epub Date: 2025-03-12 DOI: 10.2302/kjm.2024-0023-RE

Kohei Nakamura, Kenta Masuda, Tomoko Seki, Minoru Kitago, Takeo Kosaka, Yumiko Goto, Mamiko Yamada, Kumiko Misu, Ikumi Ono, Yusuke Kobayashi, Wataru Yamagami

{"title":"Potential New Tumors Associated with Hereditary Breast and Ovarian Cancer (HBOC).","authors":"Kohei Nakamura, Kenta Masuda, Tomoko Seki, Minoru Kitago, Takeo Kosaka, Yumiko Goto, Mamiko Yamada, Kumiko Misu, Ikumi Ono, Yusuke Kobayashi, Wataru Yamagami","doi":"10.2302/kjm.2024-0023-RE","DOIUrl":"10.2302/kjm.2024-0023-RE","url":null,"abstract":"Hereditary breast and ovarian cancer syndrome (HBOC) is traditionally associated with mutations in the BRCA1 and BRCA2 genes, predominantly impacting breast, ovarian, pancreatic, and prostate cancers. However, recent research suggests that these mutations may also predispose carriers to a broader spectrum of malignancies, including biliary tract, cervical, colorectal, endometrial, esophageal, and gastric cancers. This review presents findings from extensive datasets, including a significant study from a nationwide Japanese biobank that examined cancer risks in 63,828 patients and 37,086 controls. Our review highlights notable associations, such as an increased risk of uterine and cervical cancers in BRCA1 mutation carriers and increased risk of esophageal and gastric cancers in BRCA2 mutation carriers. These emerging associations underscore the necessity of revisiting and potentially expanding current clinical guidelines to incorporate these additional risks. These findings advocate a comprehensive approach to genetic counseling and underscore the importance of tailored cancer surveillance strategies in populations carrying BRCA mutations. This expanded understanding could significantly influence preventive, diagnostic, and therapeutic strategies, promoting personalized approaches to manage and potentially prevent these malignancies in genetically susceptible populations.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"158-161"},"PeriodicalIF":1.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Regeneration-associated Cell Transplantation Enhances Tissue Recovery in Mice with Acute Ischemic Stroke. 静脉注射再生相关细胞移植可增强急性缺血性中风小鼠的组织恢复。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2024-11-02 DOI: 10.2302/kjm.2024-0005-OA

Taira Nakayama, Takato Abe, Haruchika Masuda, Takayuki Asahara, Shunya Takizawa, Eiichiro Nagata

{"title":"Intravenous Regeneration-associated Cell Transplantation Enhances Tissue Recovery in Mice with Acute Ischemic Stroke.","authors":"Taira Nakayama, Takato Abe, Haruchika Masuda, Takayuki Asahara, Shunya Takizawa, Eiichiro Nagata","doi":"10.2302/kjm.2024-0005-OA","DOIUrl":"10.2302/kjm.2024-0005-OA","url":null,"abstract":"Previously, we reported that transplantation of regeneration-associated cells (RACs) via the ipsilateral external carotid artery reduced stroke volume in mice with permanent occlusion of the middle cerebral artery (MCA). However, intracarotid arterial transplantation is invasive and requires skill, and severe complications may occur, such as thromboembolism, infection, and decreased cerebral blood flow. This study aimed to investigate the efficacy of intravenous injection of RACs in reducing stroke volume and increasing anti-inflammatory and angiogenic factors in mice with focal cerebral ischemia. Mice with occluded MCAs received intravenous injections of phosphate-buffered saline (PBS) (control), low-dose RACs, or high-dose RACs. The proximal part of the left MCA was occluded to induce permanent focal ischemia. After 3 days, we administered PBS or low-dose (1 × 104 /50 µL) or high-dose RACs (1 × 105 /50 µL) through the tail vein and assessed the infarct volume on day 7. High-dose RACs significantly decreased infarct volume compared to PBS, whereas low-dose RACs showed no effect. The number of interleukin-10 (IL-10)-positive and vascular endothelial growth factor (VEGF)-positive cells in the peri-infarct area on day 7 was significantly higher in mice treated with low-dose and high-dose RACs than in the PBS control group. Intravenous injection of RACs can reduce ischemic stroke volume; however, a higher dose of RACs is required than the dose used in intraarterial transplantation. By assessing IL-10 and VEGF expression, the study sheds light on the underlying mechanisms of RAC therapy, revealing its potential anti-inflammatory and angiogenic properties in the treatment of cerebral ischemia.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"79-85"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Cancer: A Comprehensive Review. 糖尿病酮症酸中毒作为胰腺癌的首发症状：综述。

IF 1.1

KEIO JOURNAL OF MEDICINE Pub Date : 2025-06-25 Epub Date: 2025-05-01 DOI: 10.2302/kjm.2024-0015-OA

Khaled Saad, Mustafa Mahmoud, Mahmoud M Younes, Alaa Reda, Ramez M Odat, Hassaan Mady, Mayar S Abdelal, Saleh Helmy, Mohamed M Ghonaim, Abdelrahman A Ebaid, Sara Y Alsaidi, Rady Elmonier, Amira Elhoufey, Hamad Ghaleb Dailah, Doaa Ali Gamal, Hoda Atef Abdelsattar Ibrahim, Anas Elgenidy

{"title":"Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Cancer: A Comprehensive Review.","authors":"Khaled Saad, Mustafa Mahmoud, Mahmoud M Younes, Alaa Reda, Ramez M Odat, Hassaan Mady, Mayar S Abdelal, Saleh Helmy, Mohamed M Ghonaim, Abdelrahman A Ebaid, Sara Y Alsaidi, Rady Elmonier, Amira Elhoufey, Hamad Ghaleb Dailah, Doaa Ali Gamal, Hoda Atef Abdelsattar Ibrahim, Anas Elgenidy","doi":"10.2302/kjm.2024-0015-OA","DOIUrl":"10.2302/kjm.2024-0015-OA","url":null,"abstract":"Recent studies have indicated that diabetic ketoacidosis (DKA) can be the primary presenting symptom of pancreatic cancer. This comprehensive review assesses the existing research on the incidence of DKA as an initial symptom of pancreatic cancer, including its clinical characteristics, diagnostic challenges, and implications for treatment and prognosis. A comprehensive search was conducted across four electronic databases (PubMed, Scopus, Web of Science, and Cochrane), complemented by a manual search. The search criteria focused on original case reports of pancreatic cancer patients who presented with DKA. Among the 360 studies reviewed, 9 met the eligibility criteria. Among the cases, pancreatic adenocarcinoma was the most common type, followed by somatostatinoma and cystadenocarcinoma. Diagnostic modalities included computed tomography, ultrasound, biopsy, and endoscopic ultrasound. Elevated tumor markers such as CA19-9 were reported in several cases. Most patients presented with gastrointestinal and neurological symptoms, with high levels of glucose and ketone bodies. This review highlights that DKA can serve as a rare but significant initial presentation of pancreatic cancer. Identifying this association is critical for facilitating early diagnosis, which may improve the otherwise poor prognosis of pancreatic cancer. Our findings suggest that clinicians should maintain a high index of suspicion for pancreatic malignancy in patients presenting with unexplained DKA, particularly those without traditional risk factors or precipitating events. Early imaging and multidisciplinary evaluation are essential in such cases.","PeriodicalId":46245,"journal":{"name":"KEIO JOURNAL OF MEDICINE","volume":" ","pages":"69-78"},"PeriodicalIF":1.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0