Therapeutic Advances in Infectious Disease最新文献

{"title":"Emerging trends in fungal endocarditis: clinical complexity, diagnostic challenges, and therapeutic implications - a case series and literature review.","authors":"Santhanam Naguthevar, Akshatha Ravindra, Deepak Kumar, Durga Shankar Meena, Gopal Krishana Bohra, Vidhi Jain, M K Garg, Surender Deora, Rahul Choudhary","doi":"10.1177/20499361241293655","DOIUrl":"https://doi.org/10.1177/20499361241293655","url":null,"abstract":"<p><strong>Background: </strong>Fungal infective endocarditis (IE) is a rare, yet increasingly recognised condition associated with substantial mortality rates. <i>Candida</i> and <i>Histoplasma</i> are among the notable causative agents, presenting diverse clinical manifestations and complexities in diagnosis and management.</p><p><strong>Objectives: </strong>This study was undertaken to examine the clinical profiles, diagnostic challenges, treatment modalities, and outcomes of four compelling cases involving <i>Candida</i> and <i>Histoplasma</i> endocarditis.</p><p><strong>Methods & design: </strong>This was a descriptive case series study conducted from July 2021 to July 2023. All patients with definite/possible endocarditis diagnosed based on modified Duke's criteria were reviewed in this study. Data on demographics, risk factors, clinical signs and symptoms, echocardiography findings, microbiological aetiology, complications, treatment, and outcomes were collected.</p><p><strong>Results: </strong>Among 212 suspected IE cases reviewed, 54 met the modified Duke's criteria for possible or definite IE, with four instances identified as fungal endocarditis. <i>Candida</i> species accounted for three cases, while an uncommon instance of <i>Histoplasma</i> Endocarditis (HE) was also observed. Clinical presentations varied, with fever and dyspnoea being prominent symptoms. Risk factors included chronic kidney disease, prior surgeries, prosthetic valves, and immunocompromised states. Diagnosis posed challenges due to the resemblance to bacterial IE, low blood culture yields, and delayed suspicion. Various diagnostic approaches, including blood cultures, serological markers, and imaging, were employed. Therapeutic strategies involved antifungal agents and surgical intervention, where feasible. However, despite prompt treatment initiation, many patients faced rapid clinical deterioration, emphasising the severity and aggressive nature of fungal endocarditis. Mortality rates remained notably high across the cohort.</p><p><strong>Conclusion: </strong>This study highlights the criticality of early suspicion, prompt diagnosis, and a multidisciplinary approach to managing fungal endocarditis. While recognising the limitations in current diagnostic tools and therapeutic options, the study underscores the urgent need for enhanced diagnostic modalities and novel treatment strategies to improve outcomes in these challenging cases.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241293655"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying CNS infections in transplantation and immunomodulatory therapy.","authors":"Luisa F Alviz, Benjamin A Jones, Shruti P Agnihotri, Kiran T Thakur","doi":"10.1177/20499361241298456","DOIUrl":"https://doi.org/10.1177/20499361241298456","url":null,"abstract":"<p><p>Opportunistic central nervous system (CNS) infections are a significant cause of morbidity and mortality in immunocompromized patients, including those undergoing transplantation and receiving immunomodulatory therapy. Particularly in these individuals, the clinical presentation of these infections may have atypical patterns, emphasizing the need to consider various diagnostic possibilities, including noninfectious conditions. Quick and accurate identification, along with prompt treatment, is crucial for improving patient outcomes. Therefore, understanding which pathogens are likely to cause infection based on factors such as timing post-transplantation, specific organ transplant, and the mechanism of action of immunomodulatory medications is essential. This review will provide a detailed description of the types of infections that may arise in the context of transplantation and immunomodulatory therapy.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241298456"},"PeriodicalIF":3.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of generalized cat scratch disease in a patient with ulcerative colitis on immunosuppressive therapy.","authors":"Bruna Rošić Despalatović, Andre Bratanić, Dora Božić, Katarina Vilović, Nenad Kunac, Žarko Ardalić","doi":"10.1177/20499361241271832","DOIUrl":"https://doi.org/10.1177/20499361241271832","url":null,"abstract":"<p><p>Cat scratch disease (CSD) is a zoonotic disease transmitted to humans, usually via scratches or bites. <i>Bartonella henselae</i> is the primary causative agent. It causes a mild, self-limiting disease. In immunocompromised patients, the course of the infection can be more serious because of the suppressed antibacterial response, causing a life-threatening disease. A 54-year-old male patient presented with ulcerative colitis. Five days after receiving the first dose of infliximab 400 mg intravenously and 0.5 mg/kg methylprednisolone, he presented with enlarged axillary lymph nodes and colliquation of the intraabdominal lymph node with intrahepatic colliquating areas caused by <i>B. henselae</i> after cat bites. Long-term treatment with multiple antibiotics and prednisolone resulted in clinical improvement and regression of the liver and intra-abdominal lymph nodes. After further treatment for ulcerative colitis, we assessed the possibility of reintroducing immunosuppressive therapy. Adalimumab was introduced after consulting an infectious disease specialist. At the follow-up visit, the patient was in remission of ulcerative colitis and without signs of reactivation of bartonellosis. Diseases such as CSD with a benign clinical appearance and prognosis can develop a severe and life-threatening course in immunocompromised patients. This requires a complex understanding of the immune processes in such patients, and the reintroduction of immunosuppressive therapy after successful treatment of CSD probably does not increase the risk of reactivation.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241271832"},"PeriodicalIF":3.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical malaria among pregnant women living in refugee settlements in Northern Uganda.","authors":"Winnie Kibone, Felix Bongomin, Sarah Lebu, Stephen Ochaya, Ritah Nantale, Jerom Okot, Byron Awekonimungu, Rachel Beardsley, Chimdi Muoghalu, Musa Manga","doi":"10.1177/20499361241296002","DOIUrl":"https://doi.org/10.1177/20499361241296002","url":null,"abstract":"<p><strong>Background: </strong>Malaria during pregnancy contributes to significant perinatal morbidity and mortality, accounting for almost 25% of global maternal mortality. However, the epidemiology and risk factors for subclinical malaria among pregnant women living in refugee settlements is poorly understood.</p><p><strong>Objective: </strong>To determine the prevalence and predictors of subclinical malaria among pregnant women in refugee settlements in Northern Uganda.</p><p><strong>Design: </strong>We conducted a multi-center, cross-sectional study.</p><p><strong>Methods: </strong>The study was conducted between April and June 2023 and involved pregnant women aged 18-45 years attending routine antenatal care (ANC) at three health facilities serving refugee communities in Adjumani district, Uganda. We collected sociodemographic, environmental, maternal, and obstetric factors using a structured questionnaire. Both CareStart Malaria HRP-2/pLDH (Pf/Pan) combo rapid diagnostic test (RDT) and blood smear microscopy with 3% Giemsa staining were simultaneously performed on samples from each patient. Logistic regression analysis identified factors independently associated with subclinical malaria, reported as adjusted odds ratios (aORs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>We enrolled 304 pregnant women, with a mean age of 25 years. In total, 68.8% (<i>n</i> = 209) had lived in the settlement for over 12 months, 25.7% (<i>n</i> = 78) were primigravida, and 1.0% (<i>n</i> = 3) were living with HIV. Malaria prevalence was 5.3% (<i>n</i> = 16) by RDT and 3.2% (<i>n</i> = 10; seven <i>Plasmodium falciparum</i> and three <i>P. malariae</i>) by microscopy. Only 4 (25.0%) of the RDT-positive cases were also positive by microscopy (Cohen's kappa: 0.278-Fair agreement). All participants were asymptomatic. Factors associated with higher odds of subclinical malaria included primiparity (aOR: 2.79, 95% CI: 1.25-6.25, <i>p</i> = 0.013), ⩾4 ANC visits (aOR: 2.41, 95% CI: 1.34-4.34, <i>p</i> = 0.003), and residence in the settlement for less than 12 months (aOR: 2.54, 95% CI: 2.0-3.22, <i>p</i> < 0.001). Living in the settlement for over 3 years, being primigravida, and being married were associated with 68%, 50%, and 68% lower odds of subclinical malaria, respectively (aOR: 0.32, 95% CI: 0.13-0.79, <i>p</i> = 0.014; aOR: 0.50, 95% CI: 1.22-5.52, <i>p</i> = 0.016; aOR: 0.32, 95% CI: 0.13-0.78, <i>p</i> = 0.012).</p><p><strong>Conclusion: </strong>Our study reveals the high prevalence of subclinical malaria among pregnant women in refugee settlements, particularly among primiparous women and recent arrivals. The poor agreement between RDT and microscopy suggests the need for dual screening in asymptomatic pregnant women.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241296002"},"PeriodicalIF":3.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-hypertension treatment outcomes among adults on antiretroviral therapy in two states in Northern and Southern Nigeria: a cross-sectional design approach.","authors":"Oluseye Ayodele Ajayi, Deborah Babatunde, Oluwaseun Kikelomo Ajayi, Temitope Olumuyiwa Ojo, Prosper Okonkwo","doi":"10.1177/20499361241293704","DOIUrl":"10.1177/20499361241293704","url":null,"abstract":"<p><strong>Background: </strong>The combined effect of the aging human immunodeficiency virus (HIV) population, HIV's natural progression, and HIV drugs have great implications for comorbidity burden and hypertension control among people living with HIV (PLHIV).</p><p><strong>Objectives: </strong>This study assessed hypertension burden, treatment outcomes, and treatment outcome predictors among PLHIV in Nigeria.</p><p><strong>Design: </strong>Cross-sectional design.</p><p><strong>Methods: </strong>A cross-sectional study of 2613 adult PLHIV who initiated antiretroviral therapy (ART) between 2004 and 2020 in two HIV clinics in Northern and Southern Nigeria. Study outcomes were: (1) controlled blood pressure defined as two consecutive blood pressure (BP) measurements of <140/90 mmHg (Joint National Committee guideline (JNC) 7) on the interview day in previously diagnosed hypertensive participants; and (2) HIV viral suppression defined as recent viral load count of <1000 copies/ml in a hypertensive participant. Data were analyzed using Statistical Package of Social Sciences IBM version 23. Univariate and multivariate logistic regression was done to ascertain factors associated with the study outcomes at <i>p</i> < 0.05.</p><p><strong>Result: </strong>The mean age of respondents at the point of the study was 45.3 ± 9.8 years. Most of the participants were female, 1940 (74.2%), on a dolutegravir-based therapy, 2433 (93.2%). About 452 (17.3%) of the participants had clinically diagnosed hypertension. Of those diagnosed hypertensives, 443 (98.0%) were on antihypertensive drugs. About 407 (90.0%) and 229 (51.7%) of the hypertensive PLHIV had HIV viral suppression and controlled hypertension respectively. Factors associated with controlled hypertension were age at ART initiation (adjusted odds ratio (AOR): 0.96, 95% CI: 0.94-0.98), use of thiazide only antihypertensive (AOR: 1.91, 95% CI: 1.73-3.24, Ref: calcium channel blocker only) and thiazide-calcium channel blocker combination (AOR: 2.19, 95% CI: 1.05-4.58). No hypertension comorbidity-related factors were found to be associated with HIV viral suppression.</p><p><strong>Conclusion: </strong>There is suboptimal hypertension control among hypertensive PLHIV especially those on non-thiazide-based antihypertensive drugs. Close monitoring should be given to hypertension management in PLHIV.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241293704"},"PeriodicalIF":3.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an antibiotic stewardship program on adherence to antibiotic prescription in children admitted with urinary tract infection.","authors":"Giulia Brigadoi, Cecilia Liberati, Emelyne Gres, Elisa Barbieri, Elena Boreggio, Sara Rossin, Francesca Tirelli, Francesca Tesser, Lorenzo Chiusaroli, Giulia Camilla Demarin, Linda Maestri, Carlo Giaquinto, Liviana Da Dalt, Silvia Bressan, Daniele Donà","doi":"10.1177/20499361241282824","DOIUrl":"10.1177/20499361241282824","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTIs) are the most common bacterial infections in children. The high variability in pathogen susceptibility rates leads to the lack of clear guidelines for empiric and targeted therapies. In this view, local microbiological surveillance and locally adapted stewardship interventions need to be implemented.</p><p><strong>Objective: </strong>The study aims to describe the results of a pediatric antimicrobial stewardship program on antibiotic prescriptions for UTIs over 8 years in a pediatric general ward of a tertiary center.</p><p><strong>Design: </strong>This quasi-experimental study was conducted between 2015 and 2022, with two different implementations, one in 2018 and one in 2021.</p><p><strong>Methods: </strong>Demographic, clinical, microbiological, and therapeutic data were retrieved from the electronic clinical records of included patients. The primary outcomes were adherence to local guidelines for empiric therapies and the adequacy of targeted therapy. Secondary outcomes were evaluating antibiotic prescription patterns stratified by antibiotics during hospital stay and at discharge, and assessing the microbiological characteristics of UTI episodes.</p><p><strong>Results: </strong>During the study period, 7038 patients were admitted to the pediatric acute care unit (PACU), and 264 (3.7%) were included in this study. Adherence to local guidelines was highest immediately after the interventions, and it slightly decreased thereafter. Use of cephalosporins remained high throughout the 8 years but the changing microbiological scenario observed led to changing recommendations within the study period. An increase in <i>E. coli</i> strains resistant to co-amoxiclav was observed in the last years. Oral second-line agent consumption remained high but was adequate considering the prevalence of resistant bacteria.</p><p><strong>Conclusion: </strong>The variability of antimicrobial consumption reflects the changing resistance patterns for UTIs pathogens, underlying the importance of locally adapted, persevering antimicrobial stewardship interventions.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241282824"},"PeriodicalIF":3.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practice of screening and antimicrobial prophylaxis to prevent Gram-negative bacterial infection in high-risk haematology patients: results from a pan-European survey.","authors":"Jannik Stemler, Eleni Gavriilaki, Oksana Hlukhareva, Nina Khanna, Dionysios Neofytos, Murat Akova, Livio Pagano, José-Miguel Cisneros, Oliver A Cornely, Jon Salmanton-García","doi":"10.1177/20499361241271863","DOIUrl":"10.1177/20499361241271863","url":null,"abstract":"<p><strong>Background: </strong>Bacterial infections frequently occur in haematological patients, especially during prolonged neutropenia after intensive chemotherapy, often leading to bloodstream infections and pneumonia.</p><p><strong>Objective: </strong>Routine antimicrobial prophylaxis (AMP) for high-risk haematology patients is still debated while prevalence of multi-drug resistant (MDR) Gram-negative bacteria (GNB) is rising globally. We aimed to assess the current practice of AMP in this population.</p><p><strong>Design: </strong>Cross-sectional observational survey study.</p><p><strong>Methods: </strong>Haematologists and infectious diseases physicians Europewide were invited to an online survey including questions on routine screening for GNB, incidence of MDR-GNB colonization, antimicrobial prophylaxis practices, rates of bloodstream infections (BSI), ICU admission and mortality differentiated by infections due to GNB versus MDR-GNB.</p><p><strong>Results: </strong>120 haematology centres from 28 countries participated. Screening for MDR-GNB is performed in 86.7% of centres, mostly via rectal swabs (58.3%). In 39.2% of routine AMP is used, mostly with fluoroquinolones. Estimates of GNB-BSI yielded higher rates in patients not receiving anti-GNB prophylaxis than in those who do for <i>E. coli</i> (10% vs 7%) <i>Klebsiella</i> spp. (10% vs 5%), and <i>Pseudomonas</i> spp. (5% vs 4%). Rates for MDR-GNB infection were estimated lower in centres that administer AMP for MDR <i>E. coli</i> (5% vs 3%) <i>Klebsiella</i> spp. (5% vs 3%), and <i>Pseudomonas</i> spp. (2% vs 1%). In an exploratory analysis, Southern and Eastern European countries expected higher rates of MDR-GNB infections with lower ICU admission and mortality rates which may be subject to estimation bias.</p><p><strong>Conclusion: </strong>Screening for MDR-GNB is frequently performed. AMP against GNB infections is still often implemented. Estimated BSI rates are rather low, while the rate of MDR-GNB infections rises. Tailored prophylaxis including antimicrobial stewardship becomes more important.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241271863"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urgent call for vaccine supply to Africa amid ongoing Mpox clade I outbreak: addressing a public health emergency of international concern.","authors":"Jack Feehan, Ranjit Sah, Rachana Mehta, Kahumba Byanga, Krishnan Anand, Martin Krsak, Jaffar A Al-Tawfiq, Andrés F Henao-Martínez, Vasso Apostolopoulos","doi":"10.1177/20499361241290965","DOIUrl":"10.1177/20499361241290965","url":null,"abstract":"","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241290965"},"PeriodicalIF":3.8,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and opportunities in the face of Mpox in Latin America.","authors":"Diego Alejandro Cubides-Diaz, Carlos Arturo Alvarez-Moreno","doi":"10.1177/20499361241292627","DOIUrl":"10.1177/20499361241292627","url":null,"abstract":"","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241292627"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The top 10 papers on the treatment of invasive fungal infections, 2018-2023.","authors":"Kayla R Stover, Harleigh M Aldridge, Katherine L Pollan, Douglas Slain, Christopher M Bland, P Brandon Bookstaver, Katie E Barber","doi":"10.1177/20499361241290349","DOIUrl":"https://doi.org/10.1177/20499361241290349","url":null,"abstract":"<p><strong>Background: </strong>Invasive fungal infections are responsible for a large number of infections in hospitalized patients annually and are responsible for high morbidity and mortality. Familiarity with novel agents or strategies in this area can be challenging.</p><p><strong>Objectives: </strong>To identify the top 10 manuscripts on the treatment of invasive fungal infections from 2018 to 2023.</p><p><strong>Design: </strong>Modified Delphi consensus-building technique.</p><p><strong>Methods: </strong>A three-stage consensus-building approach was used comprised of (1) identifying relevant articles; (2) voting by a panel of experts to establish consensus on the importance of these articles; and (3) finalizing the list of top articles by a small group. Members of the Southeastern Research Group Endeavor network served as content experts. Publications from 2018 to 2023 were evaluated if articles met the following inclusion criteria: (1) published between 2018 and 2023, (2) contained content related to fungal infections, and (3) included an actionable intervention.</p><p><strong>Results: </strong>A total of 6518 potential publications were assessed. After applying inclusion and exclusion criteria, 82 articles were reviewed. The top 10 publications related to invasive fungal infections, selected by a panel of experts, are summarized in this manuscript and include publications related to the treatment of invasive aspergillosis, candidiasis, and cryptococcosis.</p><p><strong>Conclusion: </strong>This article highlights the selected publications and may serve as a key resource for teaching and training. Clinicians may also employ these reported interventions to identify new opportunities to optimize antifungal therapeutic strategies within one's institution.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"11 ","pages":"20499361241290349"},"PeriodicalIF":3.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}