Egyptian Rheumatologist最新文献

{"title":"Sleep disorders in rheumatoid arthritis patients","authors":"Mouna Brahem ,&nbsp;Azer Chebil ,&nbsp;Hayfa Abid ,&nbsp;Olfa Jomaa ,&nbsp;Rihab Sarraj ,&nbsp;Besma Jebali ,&nbsp;Sirine Abdellatif ,&nbsp;Amani ben Salem ,&nbsp;Haifa Hachfi ,&nbsp;Khalifa Mighri ,&nbsp;Mohamed Younes","doi":"10.1016/j.ejr.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.03.001","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To determine the frequency of sleep disturbances in patients with rheumatoid arthritis (RA) and to identify associated factors.</p></div><div><h3>Patients and methods</h3><p>This study included 100 RA patients. The disease activity score (DAS28), tender joint count (TJC), swollen joint count (SJC), Visual Analog Scale (VAS)-pain and Health Assessment Questionnaire (HAQ) were assessed. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess sleep quality.</p></div><div><h3>Results</h3><p>The patients were 89 females and 11 males, mean age 53.2 ± 11.2 years (21–76 years) and disease duration was 11.1 ± 8.9 years (1–40 years).The meanTJC was 8.5 ± 7.9 (0–24), SJC 4 ± 4.8 (0–24) and VAS 51 ± 21 mm (10–90 mm). Their mean DAS28 was 3.9 ± 1.1 (1–6.15) and HAQ 1.3 ± 0.7 (0–2.9). The ESS was 7.9 ± 5.6 (0–24). 28 % of patients had signs of daytime sleepiness (ESS ≥ 11 points) with a significant association with female sex (p = 0.03), TJC (p = 0.03), SJC (p = 0.02), DAS28 (p = 0.05), VAS (p = 0.04) and HAQ (p &lt; 0.01). The mean Pittsburgh score was 6.9 ± 5.1 (0–19). 51 % of patients had disturbed sleep (PSQI &gt; 5.5 points). The most disturbed components were respectively sleep latency (1.5 ± 1.1), subjective sleep quality (1.25 ± 0.8) and sleep disorders (1.19 ± 0.8). Disturbed sleep assessed by PSQI had a significant association with TJC (p &lt; 0.01), SJC (p &lt; 0.01), C-reactive protein, nocturnal awakening (p &lt; 0.01), DAS28 (p &lt; 0.01), VAS-pain (p &lt; 0.01), HAQ (p &lt; 0.01), and corticosteroid intake (p = 0.01).</p></div><div><h3>Conclusion</h3><p>Half of the patients had sleep disorders with a significant association with disease activity parameters which underline the importance of ensuring remission or low level of activity to improve the quality of sleep of patients.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 3","pages":"Pages 107-111"},"PeriodicalIF":0.9,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid arthritis presentation in elderly patients: How different from the usual presentation?","authors":"Rahma A. Elziaty ,&nbsp;Aya M. Sayed ,&nbsp;Ahmed A. Khalifa","doi":"10.1016/j.ejr.2024.02.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.02.004","url":null,"abstract":"<div><h3>Aim of the work</h3><p>This work aimed to compare the outcomes between elderly- and younger-onset rheumatoid arthritis (EORA and YORA, respectively).</p></div><div><h3>Patients and methods</h3><p>This study included 140 RA patients recruited from the rheumatology outpatient clinic of Ain Shams University Hospitals. The study included 70 EORA (&gt;60 years) patients and a similar number of YORA (&lt;60 years) cases. Both groups were compared based on demographic data, clinical manifestations, disease activity markers, and drug history.</p></div><div><h3>Results</h3><p>Large joint arthritis and myalgia were higher in the EORA group (p &lt; 0.0001) while small joint arthritis was higher in the YORA (p &lt; 0.0001). The frequency of interstitial lung disease (ILD), rheumatoid nodules, and deformities was higher in the YORA group (p = 0.03, p = 0.03, and p = 0.02 respectively). Anti-citrullinated protein antibody (ACPA) positivity and erythrocyte sedimentation rate (ESR) were higher in YORA (p = 0.01). The disease activity scores (DAS28, SDAI, and CDAI) were higher in the YORA than in the EORA (p &lt; 0.0001). YORA were significantly receiving sulfasalazine (34.3 %) and hydroxychloroquine (84.3 %) at a higher frequency than EORA (67.1 % and 8.6 %, p &lt; 0.0001 and p = 0.02 respectively) while EORA were more receiving leflunomide (57.1 % vs 40 %; p = 0.04). Biologic therapy was received only by YORA patients.</p></div><div><h3>Conclusion</h3><p>EORA presents with distinct features from YORA, including a more insidious onset with myalgia and large joint affection making the diagnosis more challenging. EORA has a lower severe course with less deformities and disease activity with a tendency to be controlled by a single DMARD rather than combinations or biologics.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 102-105"},"PeriodicalIF":0.9,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140069425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen receptor ß is high in the minor salivary glands of female patients with primary Sjögren's syndrome","authors":"Ahmet Kor ,&nbsp;Aydan Kılıçarslan","doi":"10.1016/j.ejr.2024.02.005","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.02.005","url":null,"abstract":"<div><h3>Aim of the work</h3><p>This study aimed to investigate the expression levels of estrogen receptor (ER) beta (ß) and alpha (α) in the minor salivary gland tissues of patients with primary Sjögren's syndrome (pSS), which has a female predominance and reaches its highest incidence at menopause.</p></div><div><h3>Patients and methods</h3><p>Sixty-six female pSS patients and 23 matched control were studied. The ER ß and α expressions from salivary gland tissues were immunohistochemically evaluated. The European League Against Rheumatism (EULAR) Sjögren's syndrome disease activity index was assessed.</p></div><div><h3>Results</h3><p>The 66 female pSS patients had a mean age of 50.1 ± 13.4 years. The ESSDAI was 7 (9–13). The ER ß expressions of the salivary gland were significantly higher in pSS patients than in control both ductal (B: 0.68, OR 1.97, 95 %CI 1.34–2.88, p = 0.001) and acinar (B: 2.18, OR 8.87, 95 %CI 2.34–33.6, p = 0.001). Lymphocytes in the salivary gland infiltrate of pSS cases expressed high levels of ER ß (8, 6–8). Expression of ERα was not detected in the minor salivary gland ductal and acini epithelium and lymphocytes of pSS and control. No significant relationship was found between ER ß expression levels and complement, rheumatoid factor, immunoglobulin G, anti-nuclear antibody, the ESSDAI and the presence of menopause in pSS patients.</p></div><div><h3>Conclusion</h3><p>pSS patients have higher salivary gland ER ß expression (ductal and acinar epithelial) than controls, and lymphocytes infiltrating the salivary gland in pSS express high levels of ER ß. This study showed that salivary gland ER expression levels in pSS are different from controls, regardless of disease activity.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 97-101"},"PeriodicalIF":0.9,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140014336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal vasculitis in two patients with rheumatoid arthritis: A case-based review","authors":"Saoussen Miladi,&nbsp;Ons Boudriga,&nbsp;Alia Fazaa,&nbsp;Hiba Boussaâ,&nbsp;Kawther Ben Abdelghani,&nbsp;Ahmed Laatar","doi":"10.1016/j.ejr.2024.02.006","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.02.006","url":null,"abstract":"<div><h3>Background</h3><p>Rheumatoid arthritis (RA) is a systemic autoimmune disease that can be associated with extra-articular manifestations including vasculitis that occurs exceptionally in the retina.</p></div><div><h3>Aim of the work</h3><p>To present two active RA cases with retinal vasculitis (RV) and compare them to similar cases presented worldwide.</p></div><div><h3>Case presentations</h3><p>The first case was a 44-year-old male patient with seropositive and erosive RA with a sudden bilateral blurred vision and myodesopsias and developed bilateral occlusive venous RV. It occurred concomitantly with an increased disease activity (disease activity score 4.4) that was treated with high doses of prednisolone. Then the patient had a recurrence of RV with another flare-up of his RA disease. Workup of RV included markers of infection, antinuclear antibody (ANA) and anti-neutrophil cytopasmic antibody (ANCA) and all were negative. The patient received pulse intravenous corticosteroids and was transitioned to oral steroids with the addition of methotrexate 20 mg/week with a favorable outcome. The second case was a 33-year-old female with history of bilateral retinal detachment treated surgically, followed for seronegative non-erosive RA. She presented with left RV complicated by a preretinal hemorrhage. Workup of RV included markers of infection and autoimmune markers were negative. A magnetic resonance imaging (MRI) hands showed bony erosions at the metacarpophalangeal joints with bilateral active synovitis. Systemic steroids were initiated with articular and visual improvement.</p></div><div><h3>Conclusion</h3><p>The retina should be examined for evidence of vasculitis in RA and RV should be kept in mind as an<!--> <!-->ocular complication or association.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 93-96"},"PeriodicalIF":0.9,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140014335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance enterography in diagnosing and monitoring of adult-onset IgA vasculitis (Henoch-Schönlein purpura) with gastro-intestinal involvement: Report of two cases","authors":"Edoardo Conticini ,&nbsp;Susanna Guerrini ,&nbsp;Paolo Falsetti ,&nbsp;Maria Antonietta Mazzei ,&nbsp;Luca Cantarini ,&nbsp;Bruno Frediani","doi":"10.1016/j.ejr.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><p>IgA vasculitis (IgAV) is a small vessel vasculitis affecting children and, less commonly, adults; in the latter, gastro-intestinal (GI) involvement occurs in up to 50% of cases. Diagnosis is made with computed tomography, ultrasonography and endoscopy, but no data have been to date published about the use of magnetic resonance enterography (MRE).</p></div><div><h3>Aim of the work</h3><p>This work reports two leading cases of adult-onset IgAV with GI involvement in which MRE was used at baseline and during follow-up.</p></div><div><h3>Case report</h3><p>The first case was for a 55-year old male presenting with microhematuria and elevated markers of inflammation at admission. MRE evidenced jejunum and proximal ileum diffuse and asymmetric thickening and hypervascularization. Leukocytoclastic vasculitis and glomerulonephritis with IgA deposit were evidenced at skin and renal biopsy, respectively. At one-year follow-up, a relapse was suspected: microhematuria and proteinuria were found at routine urinalysis, while MRE findings were similar to the ones at baseline. The second case was for a 49-year old male previously treated with methotrexate for mild seronegative arthritis, reporting hematochezia and worsening of arthralgias. Inflammatory bowel disease (IBD) was suspected and colonoscopy revealed diffuse mucosal hyperemia. Computerized tomography of the terminal ileum appeared thickened and edematous, while skin biopsy showed leukocytoclastic vasculitis with IgA infiltrate. The patient was successfully treated with oral prednisone and, after two months from discharge, MRE was negative.</p></div><div><h3>Conclusion</h3><p>IgAV may occur in adults and presenting with GI involvement may be particularly severe, mimicking IBD. MRE is a promising tool in diagnosing and monitoring IgAV.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 90-92"},"PeriodicalIF":0.9,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatologic manifestations of female patients with idiopathic granulomatous mastitis","authors":"Ahmad Elahi ,&nbsp;Amir Eyvazi ,&nbsp;Ali Faegh ,&nbsp;Golbarg Mehrpoor","doi":"10.1016/j.ejr.2024.02.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.02.002","url":null,"abstract":"<div><h3>Background</h3><p>Idiopathic granulomatous mastitis (IGM) is an infrequent inflammatory breast disease that typically presents with unilateral and sometimes bilateral breast masses, leading to pain, erythema, and nipple discharge. IGM may be accompanied by extramammary symptoms, including episcleritis and arthralgia suggesting and underlying autoimmune process.</p></div><div><h3>Aim of the work</h3><p>To evaluate the frequency of characteristics manifestations including rheumatologic in females with IGM referred to Imam Ali Hospital (Karaj, Iran).</p></div><div><h3>Patients and methods</h3><p>This study was performed on 178 females referred to the breast surgery department of Imam Ali Hospital and diagnosed with IGM based on core needle biopsy and histopathological examination. The various manifestations including rheumatic presented for those patients were recorded.</p></div><div><h3>Results</h3><p>The mean age of the patients was 35.17 ± 5.88 years and body mass index was 26.38 ± 2.45. 91 % of the patients were nulliparous and only 3 used oral contraceptive pills. The breast-feeding duration of parous patients was 28.91 ± 14.97 months. Associated minor thalassemia was present in 2.25 %, bronchial asthma, diabetes, psoriasis and hypothyroidism were present in 2 patients each. 7 (3.92 %) of cases had history of previous breast surgery. Twenty-five (14 %) patients with IGM had associated manifestations including arthralgia (10.11 %), arthritis (2.25 %) and erythema nodosum (2.81 %). Only one patient had peripheral and another optic neuritis. 158 (88.76 %) patients had no notable past medical history. IGM was bilateral in 21 (11.8 %) patients.</p></div><div><h3>Conclusions</h3><p>The coexistence of erythema nodosum and arthritis with IGM is not uncommon. They are mostly unilaterally present in nulliparous Iranian females. Optic and peripheral neuropathies are rarely associated.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 86-89"},"PeriodicalIF":0.9,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139719742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Egyptian rheumatology legend: The prosperous journey of late prof. Tahsin El-Hadidi","authors":"Tamer A. Gheita","doi":"10.1016/j.ejr.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.006","url":null,"abstract":"","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 82-85"},"PeriodicalIF":0.9,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extra-articular calcification of the lateral collateral ligament (LCL) presenting with recurrent acute knee periarthritis: A case-based review","authors":"Yasser Ragab ,&nbsp;Khalid Alhusseiny ,&nbsp;Amr A. Saad ,&nbsp;Yasser Emad ,&nbsp;Farida Y. Emad ,&nbsp;Johannes J. Rasker","doi":"10.1016/j.ejr.2024.01.005","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.005","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To present a case with extra-articular calcification of the lateral collateral ligament<span> (LCL) presenting with recurrent acute knee periarthritis.</span></p></div><div><h3>Case presentation</h3><p><span>A 53-year-old Saudi male patient presented with acute onset of right-sided knee pain, localized swelling and tenderness along the lateral aspect after sport related activity. He reported a similar attack at the same knee joint a few years earlier. Plain X-ray and magnetic resonance imaging (MRI) after the initial attack showed calcification along the LCL. On examination, the patient had mild knee effusion, painful knee extension, and localized swelling along the LCL. A recent MRI and complementary computerized tomography (CT) showed a fragmented calcific shadow along the LCL. The latter was associated with soft tissue hyperintensity, which indicated extensive local inflammatory reaction. After ruling out internal derangement and infection, it was concluded that the patient had an acute episode of </span><em>peri</em>-arthritis caused by calcification along the LCL of the affected knee joint. Intramuscular (IM) betemetazone sodium dipropionate/phosphate was used to treat the <em>peri</em><span>-arthritis and as such deposits may cause a potent neutrophilic chemotactic response and intense inflammation, colchicine<span> was added for its anti-inflammatory properties and other known mechanisms that are effective in treating crystal-induced arthritis. On the second day following treatment, a significant improvement was seen. A case-based review was presented.</span></span></p></div><div><h3>Conclusion</h3><p>Despite the rare incidence of symptomatic LCL calcification, fragmentation of the calcific deposits may lead to acute intense inflammatory exacerbation and <em>peri</em>-arthritis. Successful and optimum management may involve IM steroid with oral colchicine.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 78-81"},"PeriodicalIF":0.9,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of corona virus disease-2019 (COVID-19) vaccination on patients with systemic rheumatic diseases attending a tertiary care university-based hospital","authors":"Rasha E. Gheith ,&nbsp;Eman Elsebaie ,&nbsp;Abeer Kandeel ,&nbsp;Shaimaa Badran","doi":"10.1016/j.ejr.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.004","url":null,"abstract":"<div><h3>Background</h3><p>Safety and efficacy of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine among systemic rheumatic diseases (SRDs) remain a serious concern.</p></div><div><h3>Aim of the work</h3><p>To explore different corona virus<span> disease-2019 (COVID-19) vaccine adverse reactions, post-vaccination COVID-19 infection, disease flare and acceptability of vaccine among patients with SRDs.</span></p></div><div><h3>Patients and methods</h3><p>This study was conducted on 750 patients with SRDs attending the Rheumatology Department, Cairo University Hospitals (December 2022 – February 2023). All patients were subjected to full clinical history, COVID-19 infection, vaccine history, adverse events, disease flare and assessment of their acceptability to the vaccine.</p></div><div><h3>Results</h3><p>The mean age of the patients was 41.6 ± 11.7 years with a female:male 8.4:1 and 52.5 % were educated. 414 (55.2 %) received COVID-19 vaccine. Only 26 (6.3 %) suffered from post-vaccination COVID- 19 infection (one mild attack). The causes for not receiving the vaccine were either due to unacceptability (78.9 %) or doctors’ advice (21.1 %). 64.8 % received inactivated virus vaccines (64.8 %) and 87.9 % received two doses. The commonest local and systemic side effects were pain (73.9 %) and headache (30.2 %). Only four (0.96 %) patients reported disease flare. There was a significant difference between the diagnosis, type of vaccines and some of the adverse effects of the vaccines such as pain (p = 0.019) and fever (p = 0.021), redness (p = 0.007) and swelling (p = 0.013).</p></div><div><h3>Conclusion</h3><p>The efficacy and safety of SARS-CoV-2 vaccine among Egyptian patients with SRDs is confirmed. There were significant differences in certain vaccine side effects especially pain, fever, redness and swelling. Most patients well tolerated the COVID-19 vaccine providing reassurance.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 73-77"},"PeriodicalIF":0.9,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical characteristics of Malaysian patients with Takayasu Arteritis: A retrospective study of 3 decades","authors":"Ping S. Ong ,&nbsp;Chiew G. Khor ,&nbsp;Sow L. Kan ,&nbsp;Ee L. Lai ,&nbsp;Malehah M. Noh ,&nbsp;Shereen S. Ch'ng ,&nbsp;Liza B. Isa ,&nbsp;Chong H. Lim ,&nbsp;Swee G. Ong ,&nbsp;Cheng L. Teh ,&nbsp;Ahmad Z. Bin Othman ,&nbsp;Suhaida A. Maulana ,&nbsp;Shahrul S. Shaharir ,&nbsp;Guo R. Ling ,&nbsp;Ruhaila Abdul Rahim ,&nbsp;Nurulraziquin M. Jamid ,&nbsp;Siti M. Ab Rahim ,&nbsp;Swee M. Liau ,&nbsp;Asmahan M. Ismail ,&nbsp;Hwee C. Chong ,&nbsp;Fariz Yahya","doi":"10.1016/j.ejr.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.003","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To understand the clinical features, angiographic involvement patterns and outcomes of Takayasu Arteritis (TA) in Malaysian patients.</p></div><div><h3>Patients and methods</h3><p>This was a retrospective study of 85 TA patients from 20 tertiary rheumatology<span> centers in Malaysia from 1990 until 2020. Demographic information, clinical features, angiographic patterns, treatment and comorbidities were analyzed.</span></p></div><div><h3>Results</h3><p><span><span>The female-to-male ratio was 13.1:1. The age at disease onset was 27.47 ± 10.4 years. The duration of delay in diagnosis was 6 ± 27.5 months. 48.2 % were Malay, 12.9 % Chinese, 23.5 % Indian and 14.3 % other ethnicities. Hypertension emerged as the most common comorbidity (52.9 %), followed by dyslipidemia (29.4 %). The most prevalent angiographic pattern was Type V (55.3 %), with </span>left subclavian artery (65.9 %) and left carotid (55.3 %) being the most commonly involved vessels. </span>Glucocorticoids<span><span> constituted the mainstay of treatment; however, approximately half of the patients required treatment with methotrexate<span> and azathioprine<span>. There were six deaths, primarily attributed to coronary artery disease and infections. Surgical interventions, including </span></span></span>angioplasty<span> and bypass surgery, were performed on 11 patients. Out of 44 pregnancies, 79.5 % were successful.</span></span></p></div><div><h3>Conclusion</h3><p><span>This study revealed a pattern of TA disease in Malaysia that aligns with findings from other cohort studies. The most prevalent angiographic type observed was type V, with the subclavian and </span>carotid arteries being the most commonly involved vessels among TA patients in Malaysia. This research contributes to a better understanding of the clinical presentations observed over the past three decades, offering valuable insights for the improved management of TA patients in Malaysia.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":"46 2","pages":"Pages 67-72"},"PeriodicalIF":0.9,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}