Egyptian Rheumatologist最新文献

{"title":"Magnetic resonance enterography in diagnosing and monitoring of adult-onset IgA vasculitis (Henoch-Schönlein purpura) with gastro-intestinal involvement: Report of two cases","authors":"Edoardo Conticini ,&nbsp;Susanna Guerrini ,&nbsp;Paolo Falsetti ,&nbsp;Maria Antonietta Mazzei ,&nbsp;Luca Cantarini ,&nbsp;Bruno Frediani","doi":"10.1016/j.ejr.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><p>IgA vasculitis (IgAV) is a small vessel vasculitis affecting children and, less commonly, adults; in the latter, gastro-intestinal (GI) involvement occurs in up to 50% of cases. Diagnosis is made with computed tomography, ultrasonography and endoscopy, but no data have been to date published about the use of magnetic resonance enterography (MRE).</p></div><div><h3>Aim of the work</h3><p>This work reports two leading cases of adult-onset IgAV with GI involvement in which MRE was used at baseline and during follow-up.</p></div><div><h3>Case report</h3><p>The first case was for a 55-year old male presenting with microhematuria and elevated markers of inflammation at admission. MRE evidenced jejunum and proximal ileum diffuse and asymmetric thickening and hypervascularization. Leukocytoclastic vasculitis and glomerulonephritis with IgA deposit were evidenced at skin and renal biopsy, respectively. At one-year follow-up, a relapse was suspected: microhematuria and proteinuria were found at routine urinalysis, while MRE findings were similar to the ones at baseline. The second case was for a 49-year old male previously treated with methotrexate for mild seronegative arthritis, reporting hematochezia and worsening of arthralgias. Inflammatory bowel disease (IBD) was suspected and colonoscopy revealed diffuse mucosal hyperemia. Computerized tomography of the terminal ileum appeared thickened and edematous, while skin biopsy showed leukocytoclastic vasculitis with IgA infiltrate. The patient was successfully treated with oral prednisone and, after two months from discharge, MRE was negative.</p></div><div><h3>Conclusion</h3><p>IgAV may occur in adults and presenting with GI involvement may be particularly severe, mimicking IBD. MRE is a promising tool in diagnosing and monitoring IgAV.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatologic manifestations of female patients with idiopathic granulomatous mastitis","authors":"Ahmad Elahi ,&nbsp;Amir Eyvazi ,&nbsp;Ali Faegh ,&nbsp;Golbarg Mehrpoor","doi":"10.1016/j.ejr.2024.02.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.02.002","url":null,"abstract":"<div><h3>Background</h3><p>Idiopathic granulomatous mastitis (IGM) is an infrequent inflammatory breast disease that typically presents with unilateral and sometimes bilateral breast masses, leading to pain, erythema, and nipple discharge. IGM may be accompanied by extramammary symptoms, including episcleritis and arthralgia suggesting and underlying autoimmune process.</p></div><div><h3>Aim of the work</h3><p>To evaluate the frequency of characteristics manifestations including rheumatologic in females with IGM referred to Imam Ali Hospital (Karaj, Iran).</p></div><div><h3>Patients and methods</h3><p>This study was performed on 178 females referred to the breast surgery department of Imam Ali Hospital and diagnosed with IGM based on core needle biopsy and histopathological examination. The various manifestations including rheumatic presented for those patients were recorded.</p></div><div><h3>Results</h3><p>The mean age of the patients was 35.17 ± 5.88 years and body mass index was 26.38 ± 2.45. 91 % of the patients were nulliparous and only 3 used oral contraceptive pills. The breast-feeding duration of parous patients was 28.91 ± 14.97 months. Associated minor thalassemia was present in 2.25 %, bronchial asthma, diabetes, psoriasis and hypothyroidism were present in 2 patients each. 7 (3.92 %) of cases had history of previous breast surgery. Twenty-five (14 %) patients with IGM had associated manifestations including arthralgia (10.11 %), arthritis (2.25 %) and erythema nodosum (2.81 %). Only one patient had peripheral and another optic neuritis. 158 (88.76 %) patients had no notable past medical history. IGM was bilateral in 21 (11.8 %) patients.</p></div><div><h3>Conclusions</h3><p>The coexistence of erythema nodosum and arthritis with IGM is not uncommon. They are mostly unilaterally present in nulliparous Iranian females. Optic and peripheral neuropathies are rarely associated.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139719742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Egyptian rheumatology legend: The prosperous journey of late prof. Tahsin El-Hadidi","authors":"Tamer A. Gheita","doi":"10.1016/j.ejr.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.006","url":null,"abstract":"","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extra-articular calcification of the lateral collateral ligament (LCL) presenting with recurrent acute knee periarthritis: A case-based review","authors":"Yasser Ragab ,&nbsp;Khalid Alhusseiny ,&nbsp;Amr A. Saad ,&nbsp;Yasser Emad ,&nbsp;Farida Y. Emad ,&nbsp;Johannes J. Rasker","doi":"10.1016/j.ejr.2024.01.005","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.005","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To present a case with extra-articular calcification of the lateral collateral ligament<span> (LCL) presenting with recurrent acute knee periarthritis.</span></p></div><div><h3>Case presentation</h3><p><span>A 53-year-old Saudi male patient presented with acute onset of right-sided knee pain, localized swelling and tenderness along the lateral aspect after sport related activity. He reported a similar attack at the same knee joint a few years earlier. Plain X-ray and magnetic resonance imaging (MRI) after the initial attack showed calcification along the LCL. On examination, the patient had mild knee effusion, painful knee extension, and localized swelling along the LCL. A recent MRI and complementary computerized tomography (CT) showed a fragmented calcific shadow along the LCL. The latter was associated with soft tissue hyperintensity, which indicated extensive local inflammatory reaction. After ruling out internal derangement and infection, it was concluded that the patient had an acute episode of </span><em>peri</em>-arthritis caused by calcification along the LCL of the affected knee joint. Intramuscular (IM) betemetazone sodium dipropionate/phosphate was used to treat the <em>peri</em><span>-arthritis and as such deposits may cause a potent neutrophilic chemotactic response and intense inflammation, colchicine<span> was added for its anti-inflammatory properties and other known mechanisms that are effective in treating crystal-induced arthritis. On the second day following treatment, a significant improvement was seen. A case-based review was presented.</span></span></p></div><div><h3>Conclusion</h3><p>Despite the rare incidence of symptomatic LCL calcification, fragmentation of the calcific deposits may lead to acute intense inflammatory exacerbation and <em>peri</em>-arthritis. Successful and optimum management may involve IM steroid with oral colchicine.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of corona virus disease-2019 (COVID-19) vaccination on patients with systemic rheumatic diseases attending a tertiary care university-based hospital","authors":"Rasha E. Gheith ,&nbsp;Eman Elsebaie ,&nbsp;Abeer Kandeel ,&nbsp;Shaimaa Badran","doi":"10.1016/j.ejr.2024.01.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.004","url":null,"abstract":"<div><h3>Background</h3><p>Safety and efficacy of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine among systemic rheumatic diseases (SRDs) remain a serious concern.</p></div><div><h3>Aim of the work</h3><p>To explore different corona virus<span> disease-2019 (COVID-19) vaccine adverse reactions, post-vaccination COVID-19 infection, disease flare and acceptability of vaccine among patients with SRDs.</span></p></div><div><h3>Patients and methods</h3><p>This study was conducted on 750 patients with SRDs attending the Rheumatology Department, Cairo University Hospitals (December 2022 – February 2023). All patients were subjected to full clinical history, COVID-19 infection, vaccine history, adverse events, disease flare and assessment of their acceptability to the vaccine.</p></div><div><h3>Results</h3><p>The mean age of the patients was 41.6 ± 11.7 years with a female:male 8.4:1 and 52.5 % were educated. 414 (55.2 %) received COVID-19 vaccine. Only 26 (6.3 %) suffered from post-vaccination COVID- 19 infection (one mild attack). The causes for not receiving the vaccine were either due to unacceptability (78.9 %) or doctors’ advice (21.1 %). 64.8 % received inactivated virus vaccines (64.8 %) and 87.9 % received two doses. The commonest local and systemic side effects were pain (73.9 %) and headache (30.2 %). Only four (0.96 %) patients reported disease flare. There was a significant difference between the diagnosis, type of vaccines and some of the adverse effects of the vaccines such as pain (p = 0.019) and fever (p = 0.021), redness (p = 0.007) and swelling (p = 0.013).</p></div><div><h3>Conclusion</h3><p>The efficacy and safety of SARS-CoV-2 vaccine among Egyptian patients with SRDs is confirmed. There were significant differences in certain vaccine side effects especially pain, fever, redness and swelling. Most patients well tolerated the COVID-19 vaccine providing reassurance.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical characteristics of Malaysian patients with Takayasu Arteritis: A retrospective study of 3 decades","authors":"Ping S. Ong ,&nbsp;Chiew G. Khor ,&nbsp;Sow L. Kan ,&nbsp;Ee L. Lai ,&nbsp;Malehah M. Noh ,&nbsp;Shereen S. Ch'ng ,&nbsp;Liza B. Isa ,&nbsp;Chong H. Lim ,&nbsp;Swee G. Ong ,&nbsp;Cheng L. Teh ,&nbsp;Ahmad Z. Bin Othman ,&nbsp;Suhaida A. Maulana ,&nbsp;Shahrul S. Shaharir ,&nbsp;Guo R. Ling ,&nbsp;Ruhaila Abdul Rahim ,&nbsp;Nurulraziquin M. Jamid ,&nbsp;Siti M. Ab Rahim ,&nbsp;Swee M. Liau ,&nbsp;Asmahan M. Ismail ,&nbsp;Hwee C. Chong ,&nbsp;Fariz Yahya","doi":"10.1016/j.ejr.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.003","url":null,"abstract":"<div><h3>Aim of the work</h3><p>To understand the clinical features, angiographic involvement patterns and outcomes of Takayasu Arteritis (TA) in Malaysian patients.</p></div><div><h3>Patients and methods</h3><p>This was a retrospective study of 85 TA patients from 20 tertiary rheumatology<span> centers in Malaysia from 1990 until 2020. Demographic information, clinical features, angiographic patterns, treatment and comorbidities were analyzed.</span></p></div><div><h3>Results</h3><p><span><span>The female-to-male ratio was 13.1:1. The age at disease onset was 27.47 ± 10.4 years. The duration of delay in diagnosis was 6 ± 27.5 months. 48.2 % were Malay, 12.9 % Chinese, 23.5 % Indian and 14.3 % other ethnicities. Hypertension emerged as the most common comorbidity (52.9 %), followed by dyslipidemia (29.4 %). The most prevalent angiographic pattern was Type V (55.3 %), with </span>left subclavian artery (65.9 %) and left carotid (55.3 %) being the most commonly involved vessels. </span>Glucocorticoids<span><span> constituted the mainstay of treatment; however, approximately half of the patients required treatment with methotrexate<span> and azathioprine<span>. There were six deaths, primarily attributed to coronary artery disease and infections. Surgical interventions, including </span></span></span>angioplasty<span> and bypass surgery, were performed on 11 patients. Out of 44 pregnancies, 79.5 % were successful.</span></span></p></div><div><h3>Conclusion</h3><p><span>This study revealed a pattern of TA disease in Malaysia that aligns with findings from other cohort studies. The most prevalent angiographic type observed was type V, with the subclavian and </span>carotid arteries being the most commonly involved vessels among TA patients in Malaysia. This research contributes to a better understanding of the clinical presentations observed over the past three decades, offering valuable insights for the improved management of TA patients in Malaysia.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin is associated with atherosclerosis in females with lupus nephritis","authors":"Emad M. El Shebiny ,&nbsp;Sabry A. Shoeib ,&nbsp;Dina A. Shahin ,&nbsp;Ashraf Dawood ,&nbsp;Mohammed R. Mazen ,&nbsp;Enas S. Zahran","doi":"10.1016/j.ejr.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.001","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Lupus nephritis<span> (LN) is a common presentation for systemic lupus erythematosus (SLE) in </span></span>rheumatology<span> practice. SLE is associated with increased risk of atherosclerosis<span>. Irisin plays a potential role in preventing</span></span></span> <!-->atherosclerosis.</p></div><div><h3>Aim of the work</h3><p>This study aimed to measure serum irisin level and carotid intima media thickness (CIMT) and to unravel the possible risk factors for atherosclerosis in females with LN.</p></div><div><h3>Patients and methods</h3><p><span>This study was carried out on 55 females with LN and 55 matched controls. Laboratory investigations included urinary protein/creatinine ratio, anti-double stranded deoxyribonucleic acid (anti-ds-DNA) titre and lipid profile and carotid intima media thickness (CIMT) estimated by duplex ultrasound. The </span>SLE disease activity index (SLEDAI) was assessed. Serum irisin level was measured by enzyme linked immunosorbent assay.</p></div><div><h3>Results</h3><p><span>CIMT was 0.8 ± 0.12 mm in cases, and serum irisin mean was 10.3 ± 3.1 ng/ml. Serum irisin significantly correlated with high density lipoprotein (HDL) (r = 0.3,p &lt; 0.0001) and inversely with platelet count (r = -0.29, p = 0.03), anti-ds-DNA titre (r = -0.25,p = 0.05), LDL (r = -0.46,p &lt; 0.0001) and SLEDAI (r = -0.37,p = 0.005). The CIMT significantly correlated with white blood cell count (r = 0.23,p = 0.05), platelets count (r = 0.28,p = 0.03), protein/creatinine ratio (r = 0.33,p = 0.01), anti-ds-DNA titre (r = 0.35,p = 0.007), LDL (r = 0.51,p &lt; 0.0001) and SLEDAI (r = 0.51,p &lt; 0.0001) and inversely with HDL (r = -0.52, p &lt; 0.0001) and serum irisin (r = -0.47, p &lt; 0.0001). Univariate </span>logistic regression showed that only serum irisin level was an independent risk factor for atherosclerosis (OR = 4.5, CI = 1.5–11.1, P value 0.004).</p></div><div><h3>Conclusion</h3><p>Serum irisin is considered an independent risk factor for atherosclerosis in females with LN.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of face affected questionnaire in patients with systemic sclerosis: Translation, cross-cultural adaptation and psychometric properties in the Turkish version","authors":"Fulden Sari ,&nbsp;Zilan B Apaydin ,&nbsp;Hakan A Apaydin ,&nbsp;Mehmet Kayaalp ,&nbsp;Abdulsamet Erden ,&nbsp;Serdar C Güven ,&nbsp;Berkan Armağan ,&nbsp;Ahmet Omma ,&nbsp;Orhan Küçükşahin ,&nbsp;Şükran Erten","doi":"10.1016/j.ejr.2024.01.002","DOIUrl":"https://doi.org/10.1016/j.ejr.2024.01.002","url":null,"abstract":"<div><p><em>Aim of the work:</em><span><span> Facial skin<span> involvement is one of the most important features in systemic sclerosis (SSc) patients with physical, emotional and social effects. A newly developed burden of face affected (BoFA) questionnaire is available to quantify the disability associated with facial involvement in SSc patients. This study aimed to translate the BoFA questionnaire into Turkish (BoFA-T) and investigate its </span></span>psychometric properties. </span><em>Patients and Methods:</em><span><span> Forty-nine SSc patients were included in the study. The translation and cross-cultural adaptation of the BoFA-T were conducted. The BoFA-T, the scleroderma mouth handicap in SSc scale (MHISS), the Rosenberg self-esteem scale (RSS), and the </span>perceived stress scale (PSS) were applied to construct validity. The patients were re-evaluated 7 days later to assess the test–retest reliability of the BoFA-T. </span><em>Results:</em>The mean age of the 49 patients was 48.5 ± 9.97 years, age at diagnosis 40.1 ± 11.5 years,48 females and 1 male. 24 had diffuse cutaneous and 25 limited cutaneous SSc. The mean BoFA-T was 16.81 ± 22.37, MHISS was 16.93 ± 12.19, RSS was 2.04 ± 1.92 and PSS was 24.89 ± 12.31. BoFA-T has excellent internal consistency (Cronbach’s α = 0.97) and test–retest reliability (ICC = 0.94, 95 %CI = 0.88–0.97). The correlation of BoFA-T with MHISS (r = 0.56, p &lt; 0.001), RSS (r = 0.51, p &lt; 0.001), and PSS (r = 0.57, p &lt; 0.001) was moderate. The BoFA-T questionnaire consists of three-factor subgroups (''self-esteem'', ''future anxiety'', and ''sexuality''), and no floor or ceiling effects were observed in relation to BoFA-T. <em>Conclusion:</em> The BoFA-T demonstrates appropriate psychometric properties and may be effectively utilized to assess facial involvement and disability in Turkish SSc patients.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139111800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of angiotensin converting enzyme 2 in patients with systemic sclerosis","authors":"Noha A. Azab ,&nbsp;Samah A. Mohamed ,&nbsp;Mariam Onsy F. Hanna ,&nbsp;Wafaa H. Hussein","doi":"10.1016/j.ejr.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.12.003","url":null,"abstract":"<div><h3>Background</h3><p><span>Systemic sclerosis (SSc) is an autoimmune disorder with fibrosis of the skin and internal organs. Angiotensin-converting enzyme 2 (ACE2) breaks down </span>angiotensin II to the antifibrotic and anti-inflammatory angiotensin (1–7).</p></div><div><h3>Aim of the work</h3><p>To assess the serum levels of ACE2 in SSc patients and to determine the association between its levels with the clinical features and disease severity.</p></div><div><h3>Patients and methods</h3><p>Serum from 44 patients with SSc and 35 age and sex matched controls were assayed for ACE2 concentrations by enzyme linked immunosorbent assay. The modified Rodnan skin score (mRSS) was evaluated.</p></div><div><h3>Results</h3><p><span>Patients were 41 females and 3 males (F:M 13.7:1) with a mean age of 40.4 ± 11.3 years, and median disease duration of 5 years. Thirty-four patients had limited cutaneous SSc (lcSSc) and 10 had diffuse cutaneous SSc (dcSSc). Interstitial lung disease<span> was present in 30 (68.2 %) patients. The median mRss was 11 (4–35). The antiscleroderma-70 and anticentromere antibodies were positive in 36.4 % and 29 %, respectively. The ACE2 level was significantly lower in SSc (1.02 ng/ml; 0.13–4.25 ng/ml) compared to control (1.57 ng/ml; 0.24–23.69 ng/ml) (p = 0.026) and in females compared to males (0.8; 0.13–4.15 ng/ml vs 3.33; 1.32–4.25 ng/ml) (p = 0.04) while the levels were comparable between lcSSc and dcSSc (p = 0.88). The level was lower in those with </span></span>telangiectasia<span> (n = 24), (p = 0.048) and in those receiving cyclophosphamide (n = 11), (p = 0.038) compared to those without. There was a non-significant correlation between ACE2 level and mRss (p = 0.16).</span></p></div><div><h3>Conclusions</h3><p>Serum ACE2 levels are decreased in patients with SSc and related to telangiectasias and the use of cyclophosphamide.</p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139107901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of mortality among people with rheumatoid arthritis and depression","authors":"Srikanta Banerjee ,&nbsp;Jagdish Khubchandani ,&nbsp;Latrice Noonan ,&nbsp;Kavita Batra ,&nbsp;Ayana Pai ,&nbsp;Michael Schwab","doi":"10.1016/j.ejr.2023.12.004","DOIUrl":"https://doi.org/10.1016/j.ejr.2023.12.004","url":null,"abstract":"<div><p><em>Aim of the work:</em><span> To investigate the mortality risk in a random sample of community-dwelling adult Americans with rheumatoid arthritis (RA), depression, or both. </span><em>Patients and methods:</em> National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2010 on American adults aged 30 years and older were analyzed after linking individual participant data with mortality files from the National Death Index (NDI) up to December 31, 2019. Sociodemographic and health-related variables were accounted for in the multivariable analysis. The average duration of follow-up to mortality for participants was 9.6 years. <em>Results:</em><span> A total of 22,155 adult Americans were included in the final sample where 1,670 had RA. Females, older, widowed or divorced, and those with lower education or income levels were statistically significantly more likely to have RA. Individuals with RA were also more likely to smoke, have higher BMI, or history of hypertension, cancer, or cardiovascular diseases (CVD). In adjusted analysis, no significant difference was found for mortality between those with and without RA (HR = 1.24, 95 % CI = 0.60–2.59). However, the risk of mortality was statistically significantly higher in participants with both RA and depression (HR = 2.44, 95 %CI = 1.14–5.21). Smoking, age, and income were consistent moderators for the relationship between RA or depression and mortality. </span><em>Conclusions:</em><span> Depression increases the likelihood of premature mortality<span><span> among those with RA. Psychotherapeutic and pharmacotherapy interventions should be implemented using collaborative and interdisciplinary care teams for those with RA and depression. Aggressive management of comorbidities and providing </span>smoking cessation interventions are also warranted for people with both RA and depression.</span></span></p></div>","PeriodicalId":46152,"journal":{"name":"Egyptian Rheumatologist","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}