Advanced Fiber Materials最新文献

{"title":"Piezophototronic Effect-Enhanced Highly Sensitive Flexible Photodetectors Based on Electrohydrodynamic Direct-writing Nanofiber Self-stacking","authors":"Xianruo Du,&nbsp;Zhenghui Peng,&nbsp;Yanyang Liang,&nbsp;Chenqi Zheng,&nbsp;Yisheng Zhong,&nbsp;Ruixin Chen,&nbsp;Yinuo Wang,&nbsp;Ziheng Li,&nbsp;Chunyu Xu,&nbsp;Zungui Shao,&nbsp;Yifang Liu,&nbsp;Huatan Chen,&nbsp;Gaofeng Zheng","doi":"10.1007/s42765-025-00554-5","DOIUrl":"10.1007/s42765-025-00554-5","url":null,"abstract":"<div><p>Flexible photodetectors are ideal for short-range communication in lightweight microintegrated systems. However, low-bonding interface and high-power cost of photosensitive components greatly limit their application in flexible communication systems. To address this, herein, piezophototronic effect-enhanced sensing components are proposed for flexible photodetectors. This approach leverages the piezophototronic effect to modulate nanoscale charge transport and the precision of electrohydrodynamic direct-writing to achieve controlled nanofiber assembly, thereby enhancing interfacial bonding and overall device performance. By employing electrohydrodynamic direct-writing, a copper-ammonia complex ((Cu(NH₃))(CN)) nanofiber is self-stacked on a zinc oxide (ZnO) nanofiber to construct a zinc oxide and copper ammine complex (ZnO@(Cu(NH₃))(CN)) photodetector with low static power consumption and high responsiveness through the combined effects of piezoelectricity and fiber self-stacking. The dark current is reduced to 1.12 × 10⁻⁷ A, and the static power consumption of the photodetector is also decreased. The responsiveness is up to 13.3 A/W, with response and recovery times of 11 and 9 ms under ultraviolet (UV) light illumination, respectively, fulfilling the requirements for highly sensitive photodetection owing to the high interface bonding. The detector's threshold voltage is tunable, ranging from 6 V for 5 stacking layers to 20 V for 25 stacking layers, thereby allowing the device's performance to be precisely tailored to specific application requirements. Leveraging the exceptional optoelectronic performance of the ZnO@(Cu(NH₃))(CN) photodetector, this study expands the application scenarios of flexible photodetectors and demonstrates their potential in the fields of 6G technology and battlefield communication.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1232 - 1243"},"PeriodicalIF":21.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring Hierarchical Interfaces Enhances Dielectric and Electrocaloric Performance in Relaxor Ferroelectric Polymers","authors":"Haotian Chen,&nbsp;Donglin Han,&nbsp;Xi Zhao,&nbsp;Ruilin Mai,&nbsp;Cenling Huang,&nbsp;Ruhong Luo,&nbsp;Shanyu Zheng,&nbsp;Qiang Li,&nbsp;Yifan Zhao,&nbsp;Zhenhua Ma,&nbsp;Yezhan Lin,&nbsp;Feiyu Zhang,&nbsp;Tian Yao,&nbsp;Xin Chen,&nbsp;Tiannan Yang,&nbsp;Junye Shi,&nbsp;Jiangping Chen,&nbsp;Feihong Du,&nbsp;Xiaoshi Qian","doi":"10.1007/s42765-025-00564-3","DOIUrl":"10.1007/s42765-025-00564-3","url":null,"abstract":"<div><p>Electrocaloric (EC) polymers have garnered significant attention in recent years due to their zero direct greenhouse gas emissions during cooling processes. However, only a few polymers exhibit sufficient refrigeration capacity at low fields, which limits the application of the EC cooling technology. In this work, we show that electrospinning, a mature polymer processing technology, can introduce a complex fibrous matrix that leads to nano-, meso-, and micro-scale structures, and hence a series of hierarchical polar interfaces. The following thermal treatment was applied to enhance breakdown fields and reduce dielectric losses. A series of polyvinylidene fluoride (PVDF)-based fluoropolymers containing cellulose acetate (CA) were prepared. By introducing 10 wt% of CA, the electrospinning process significantly improves the polar entropy of the fluoropolymer system and significantly improves the polymer’s breakdown strength, polarization, and electrocaloric performances, compared to their solution cast counterparts. The polar entropy variations among various polymeric composites were elucidated using data acquired from multiple structural characterization tools. By linking the optimized hierarchical interface structures and the overall EC performances, this study provides new routes for designing high-performance EC nanocomposites that can be facilely tailored by the matured processes of fibrous, polymeric composites.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1290 - 1301"},"PeriodicalIF":21.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electric-Assisted Coaxial Wet Spinning of Radially Oriented Boron Nitride Nanosheet-Based Composite Fiber with Highly Enhanced Piezoelectricity","authors":"Siyi Cheng,&nbsp;Han Zhang,&nbsp;Xiaoming Chen,&nbsp;Yijie Wang,&nbsp;Fangyi Cheng,&nbsp;Pengyuan Sun,&nbsp;Youyou Li,&nbsp;Zhengjie Yang,&nbsp;Jie Zhang,&nbsp;Jianxu Sun,&nbsp;Jinyou Shao,&nbsp;Bingheng Lu","doi":"10.1007/s42765-025-00567-0","DOIUrl":"10.1007/s42765-025-00567-0","url":null,"abstract":"<div><p>Piezoelectric filler-based composite fiber sensors have emerged as promising candidates for wearable textiles due to their self-powered capability and excellent sensing performance. However, current spinning fabrication methods face significant challenges in achieving uniform distribution and optimal orientation of piezoelectric fillers within polymer matrices, which limits their sensing performance. To address these issues, an innovative electric-assisted coaxial wet spinning method is developed to fabricate piezoelectric composite fiber (denoted as P-B fiber), which was composed of boron nitride nanosheets (BNNSs) as piezoelectric fillers and polyvinylidene fluoride (PVDF) as a piezoelectric polymer matrix. The radial electric field applied during spinning promotes the radial orientation of BNNSs, leading to enhanced stress transfer efficiency and, as a result, improved piezoelectricity. Moreover, the radial electric field enables the simultaneous in-situ polarization of BNNSs and PVDF during spinning process, further improving the piezoelectric performance. As a result, the P-B fiber exhibits an exceptional piezoelectric sensitivity of (186.4 ± 1.1) mV/N, approximately sixfold higher than that of fibers produced without electric field assistance. Accordingly, the P-B fiber demonstrates remarkable capability in detecting tiny mechanical loads, such as pulse waves and respiration, making it particularly suitable for wearable physiological monitoring textiles, providing a promising strategy for developing high-performance piezoelectric fiber sensors.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1302 - 1316"},"PeriodicalIF":21.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA-Like Double-Helix Wrinkled Flexible Fibrous Sensor with Excellent Mechanical Sensibility for Human Motion Monitoring","authors":"Hong Wu,&nbsp;Chun Li,&nbsp;Pengxin Zhao,&nbsp;Lingfeng Zhu,&nbsp;Yitong Li,&nbsp;Erfan Rezvani Ghomi,&nbsp;Hanlin Cao,&nbsp;Mingyang Zhang,&nbsp;Xiaoxuan Weng,&nbsp;Qingling Zhang,&nbsp;Xiaoxiao Wei,&nbsp;Zhenfang Zhang,&nbsp;Seeram Ramakrishna,&nbsp;Chengkun Liu","doi":"10.1007/s42765-025-00560-7","DOIUrl":"10.1007/s42765-025-00560-7","url":null,"abstract":"<div><p>Flexible mechanical sensors offer extensive application prospects in the field of smart wearables. However, developing highly sensitive, flexible mechanical sensors that can simultaneously detect strain and pressure remains a significant challenge. Herein, we present a flexible mechanical sensor based on AgNPs/MWCNTsCOOH/PDA/PU/PVB nanofiber-covered yarn (AMPPPNY) featuring a DNA-like double-helix wrinkled structure. The sensor is fabricated by electrospraying polyvinyl butyral (PVB) onto a pre-stretched double-helix elastic yarn, followed by electrospinning a polyurethane (PU) nanofiber membrane and inducing the self-polymerization of dopamine (DA) to create an adhesive layer. Then, one-dimensional carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) and zero-dimensional silver nanoparticles (AgNPs) are dispersed onto the structure, synergistically forming a stable conductive network for efficient signal transmission. The integration of conductive fillers with different dimensionalities and DNA-like double-helix wrinkled structure endows the sensor with high strain sensitivity (gauge factor of 11,977) in the strain range of 0–310% and high pressure sensitivity (0.475 kPa⁻¹) in the pressure range of 0–2 kPa. Moreover, the fabricated sensor exhibits rapid response and recovery times (130 ms/135 ms) and outstanding cyclic stability (over 10,000 cycles of both strain and pressure). Next, the fibrous sensor is weaved into a large-area fabric, and the developed smart textiles demonstrate impressive performance in detecting both subtle and large human movements. The proposed sensor is a promising candidate for flexible wearable applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1260 - 1273"},"PeriodicalIF":21.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive Printing of Conductive Microfibers for Seamless Functional Enhancement Across Diverse Surfaces and Shapes","authors":"Stanley Gong Sheng Ka,&nbsp;Wenyu Wang,&nbsp;Henry Giddens,&nbsp;Zhuo Chen,&nbsp;Ahsan Noor Khan,&nbsp;Yuan Shui,&nbsp;Andre Sarker Andy,&nbsp;Shuyu Lyu,&nbsp;Tawfique Hasan,&nbsp;Yang Hao,&nbsp;Yan Yan Shery Huang","doi":"10.1007/s42765-025-00561-6","DOIUrl":"10.1007/s42765-025-00561-6","url":null,"abstract":"<div><p>Developing methods to non-destructively deposit conductive materials onto existing objects can enhance their functionalities on-demand. However, designing and creating such structures to accommodate diverse shapes and surface textures of pre-fabricated objects remains challenging. We report an on-demand printing strategy for creating substrate-less, conducting microfiber patterns that can be adaptively deposited onto a wide range of objects, including daily-use stationery, tools, smartwatches, and unconventional materials like porous graphene aerogels. Solution-drawn microfibers are directly deposited onto the object in a semi-wet state upon synthesis, enabling seamless fiber-object integration in a single step. The design and format of the microfiber patterns can be tuned on-demand to adapt to the shapes and surface textures of target objects, ensuring compatibility with user-specific applications. These air-permissive, highly transparent layers minimally obstruct the original appearance and functions of the objects while equipping them with additional sensing, energy conversion, and electronic connectivity capabilities.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1274 - 1289"},"PeriodicalIF":21.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Passive Radiative Cooling Materials: Biomass-Based Photoluminescent Aerogels Opens New Frontiers for Sustainable Energy Efficiency Cooling Solutions","authors":"Zhiyu Huang,&nbsp;Fengxiang Chen,&nbsp;Weilin Xu","doi":"10.1007/s42765-025-00559-0","DOIUrl":"10.1007/s42765-025-00559-0","url":null,"abstract":"<div><p>With the increasing global energy consumption and cooling demands, traditional active cooling technologies face inefficiency and environmental challenges. Recently published in <i>Science</i>, a team led by Prof. Hai-bo Zhao has proposed and developed a biomass-based photoluminescent aerogel made from DNA and gelatin to address these challenges. This material achieves a solar-weighted reflectance of over 100% (0.4–0.8 μm) and provides a cooling effect of 16.0 °C under sunlight. This sustainable material is repairable, recyclable, and biodegradable, offering significant potential for energy-efficient buildings and wearable cooling devices.</p></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"977 - 980"},"PeriodicalIF":21.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145164232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Targeting Trained Immunity Nanofiber Scaffold for Large Bone Defect Repair","authors":"Jingdi Zhan,&nbsp;Zhuolin Chen,&nbsp;Junyan Liu,&nbsp;Qiming Pang,&nbsp;Mingjie Lei,&nbsp;Jiacheng Liu,&nbsp;Yang Song,&nbsp;Wei Huang,&nbsp;Lili Dong","doi":"10.1007/s42765-025-00548-3","DOIUrl":"10.1007/s42765-025-00548-3","url":null,"abstract":"<div><p>Modulating trained immunity while simultaneously initiating regenerative cues presents a significant challenge in large bone defect therapy. This study introduces a cell-free approach utilizing a 3D microenvironment-responsive scaffold to orchestrate immune reprogramming. To mitigate maladaptive trained immunity and activate regenerative signaling, a composite fibrous scaffold is functionalized with immune-engineered exosomes derived from inflammation-primed mesenchymal stem cells (PSS-iEXO) in a reactive oxygen species (ROS)-responsive manner. The PSS-iEXO scaffolds incorporate boronic ester linkages as ROS-sensitive moieties, enabling rapid, dynamic, and “on-demand” exosome release in response to elevated ROS levels characteristic of the early inflammatory phase post-injury, thereby initiating regeneration. In vitro and in vivo analyses reveal that these scaffolds precisely target and modulate maladaptive trained immunity, reprogramming immune responses by shifting macrophage polarization from a hyperactivated type I phenotype to a balanced state while promoting CD4⁺ regulatory T cell activation—both critical for coupling angiogenesis and osteogenesis. Mechanistic insights highlight the role of engineered exosomes in enhancing mitochondrial function and oxidative phosphorylation in macrophages, establishing a cell-free immune-regenerative niche for large bone defect therapy.</p><h3>Graphical Abstract</h3><p>Schematic diagram of the fabrication, function, and mechanism of ROS-responsive 3D electrospun nanofiber scaffolds loaded with immunoengineered exosomes (PSS-iEXO) for promoting large bone repair.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 5","pages":"1423 - 1445"},"PeriodicalIF":21.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrafine Nanofiber-Based Membrane with Rational Hierarchical Networks for Efficient and High-Flux Air and Water Purification","authors":"Xiaoqing Gao,&nbsp;Yuchen Yang,&nbsp;Yukui Gou,&nbsp;Nan Lu,&nbsp;Pinmei Yan,&nbsp;Hong Liu,&nbsp;Mengtong Yi,&nbsp;Weilong Cai,&nbsp;Jianying Huang,&nbsp;Yuekun Lai","doi":"10.1007/s42765-025-00551-8","DOIUrl":"10.1007/s42765-025-00551-8","url":null,"abstract":"<div><p>With the accelerated development of global industrialization, environmental issues, such as airborne and water pollution caused by suspended solid particulate matter (PM) seriously endanger ecosystems and human health. Fibrous filtration and separation membranes provide an effective approach to pollution treatment, yet they still face challenges in efficient and high-flux purification of highly permeable ultrafine particles. Herein, an ultrafine nanofiber-based membrane with rational hierarchical networks is designed for both air and water filtration. Through the proposed jet branching electrospinning strategy, a multiscale fiber membrane consisting of ultrafine nanofibers, medium fibers, and coarse submicron fibers is prepared. It possesses the merits of ultrafine fiber diameter, ultralow pore size, high specific surface area, and unique hybrid structure. Benefiting from these features, the obtained multiscale fibrous filter shows superior PM_0.3 air filtration performance (99.96% PM_0.3 removal, low pressure drop of 89 Pa) and water filtration capacity (ultrafine particle rejection efficiency of 99.50%, water flux of 9028.84 L m⁻² h⁻¹). Moreover, the controllable structure of a multiscale fiber filter also endows itself with stable and durable filtration capacity. This work may provide meaningful references for the development of high-performance filtration and separation materials.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1220 - 1231"},"PeriodicalIF":21.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Suitcordance Intelligent Fibers for Panvascular Disease Monitoring-Intervention","authors":"Lingsen You,&nbsp;Yuchen Luo,&nbsp;Qiang Cheng,&nbsp;Li Shen,&nbsp;Junbo Ge","doi":"10.1007/s42765-025-00542-9","DOIUrl":"10.1007/s42765-025-00542-9","url":null,"abstract":"<div><p>Panvascular diseases, sharing atherosclerosis as a common pathological basis, pose a significant threat to human health. Flexible fibers combined with sensing elements become implantable and interventional smart fibers with monitoring and intervention capabilities. Due to the prolonged course of panvascular diseases, higher requirements are imposed on the monitoring-intervention closed-loop system of flexible fibers—high suitcordance (a combination of short-term suitability and long-term concordance). Suitcordance implies that novel flexible fibers must meet the traditional concept of compatibility and satisfy the new requirement of long-term co-regulation of fiber-vascular fate. This review introduces emerging flexible fiber electronic devices with exceptional performance related to panvascular diseases. These devices adapt well to the complex panvascular environment and provide ideal technical support for real-time, non-invasive, and continuous health monitoring-treatment. However, existing devices have limitations, and future research should focus on developing novel flexible smart fibers based on the clinical needs of panvascular diseases.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div><p>Flexible fiber technology can revolutionize the panvascular medical paradigm.</p><p>Flexible fiber technology aids in promptly identifying panvascular disease indicators, enabling better personalized treatment.</p><p>Further developments include wireless design, miniaturization, multifunction, artificial intelligence-assisted diagnosis, virtual medicine, customized healthcare, etc., and the integration of monitoring-intervention closed-loop functions.</p></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1042 - 1072"},"PeriodicalIF":21.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42765-025-00542-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen-Inspired 3D Printing Electrospinning Biomimetic Patch for Abdominal Wall Defect Regeneration","authors":"Yinghua Tao,&nbsp;Peiyu Luo,&nbsp;Fengya Jing,&nbsp;Tao Liu,&nbsp;Xin Tan,&nbsp;Zhiyang Lyu,&nbsp;Katrien VeerleBernaerts,&nbsp;Tianzhu Zhang,&nbsp;Ruipeng Jia","doi":"10.1007/s42765-025-00547-4","DOIUrl":"10.1007/s42765-025-00547-4","url":null,"abstract":"<div><p>Repairing abdominal wall defects presents significant challenges, due to the high infection risk, poor biocompatibility, and insufficient mechanical strength associated with synthetic materials. To overcome these limitations, we developed a bioinspired multifunctional 3DPF patch by integrating 3D printing and electrospinning technologies. The core material of the patch is 4arm-PLGA-GPO (4A-GPO), synthesized by conjugating the Gly-Pro-Hyp (GPO) peptide sequence with 4arm-PLGA(4A), which significantly enhances bioactivity and mechanical properties. Additionally, the patch encapsulates basic fibroblast growth factor (bFGF) to stimulate cell proliferation and migration, while an antibacterial layer composes of emodin (EMO) and tobramycin to prevent infection. <i>In vivo</i> studies demonstrate the 3DPF patch effectively accelerates tissue repair by reducing fibrosis and adhesions, promoting angiogenesis and collagen deposition, and modulating the immune response. Transcriptomic analysis reveals that the patch downregulates IL-17 mediated inflammatory pathways while upregulating cell adhesion molecule-related pathways, synergistically facilitating microenvironment reconstruction. Furthermore, molecular docking studies suggest the patch interacts with key molecules such as VEGF and COL3, enhancing angiogenesis and matrix remodeling. In summary, this biomimetic patch, composed of bioactive materials with well-defined chemical compositions, integrates mechanical support, immune modulation, and antibacterial protection. by offering a comprehensive solution for abdominal wall repair, it holds significant potential for clinical translation in complex tissue engineering applications.</p></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"7 4","pages":"1177 - 1194"},"PeriodicalIF":21.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}