Journal of Clinical and Experimental Hematopathology最新文献_第5页

Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan. 使用噻替派和丁胺磺胺治疗方案进行自体干细胞移植，成功治疗原发性睾丸淋巴瘤孤立性中枢神经系统复发。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-03-28 Epub Date: 2024-02-28 DOI: 10.3960/jslrt.23039

Yasuhiro Tanaka, Tomomi Sakai, Hiroko Tsunemine, Tomoo Ito, Nobuyoshi Arima

{"title":"Successful treatment of isolated central nervous system recurrence of primary testicular lymphoma by autologous stem cell transplantation using a conditioning regimen of thiotepa and busulfan.","authors":"Yasuhiro Tanaka, Tomomi Sakai, Hiroko Tsunemine, Tomoo Ito, Nobuyoshi Arima","doi":"10.3960/jslrt.23039","DOIUrl":"10.3960/jslrt.23039","url":null,"abstract":"Primary testicular lymphoma (PTL) frequently relapses in the central nervous system (CNS) despite prophylactic intrathecal chemotherapy, and the outcome for CNS recurrence of PTL is very poor. We report a case of isolated CNS recurrence of bilateral PTL. Our patient achieved complete response (CR) after rituximab-combination chemotherapy for PTL. Approximately five years later, isolated CNS recurrence of PTL occurred. Our patient achieved CR again after high-dose methotrexate therapy and autologous stem cell transplantation (ASCT) with a conditioning regimen of thiotepa and busulfan as a consolidation therapy. The secondary failure of platelet recovery, probably caused by busulfan, occurred after the platelet engraftment. Our patient has remained in CR for over three years. The treatment strategy for CNS recurrence of PTL is mainly whole-brain radiotherapy or high-dose methotrexate-based chemotherapy; however, CNS recurrence of PTL may occur again even after achieving CR. ASCT with a conditioning regimen of thiotepa and busulfan is the optimal consolidation therapy for secondary CNS lymphoma. To the best of our knowledge, this is the second reported case of a patient with isolated CNS recurrence of PTL successfully treated by ASCT with a conditioning regimen of thiotepa and busulfan as a consolidation therapy.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":" ","pages":"32-36"},"PeriodicalIF":1.5,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis. 在 IgG4 相关性唾液腺炎中，浆细胞通过 PDGF/PDGFR 信号激活成纤维细胞。

IF 0.9

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.24040

Takumi Kitaoka, Rintaro Ohe, Takanobu Kabasawa, Masayuki Kaneko, Nobuyuki Sasahara, Michihisa Kono, Kazushi Suzuki, Naoya Uchiyama, Rinako Ogawa, Mitsuru Futakuchi

{"title":"Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis.","authors":"Takumi Kitaoka, Rintaro Ohe, Takanobu Kabasawa, Masayuki Kaneko, Nobuyuki Sasahara, Michihisa Kono, Kazushi Suzuki, Naoya Uchiyama, Rinako Ogawa, Mitsuru Futakuchi","doi":"10.3960/jslrt.24040","DOIUrl":"10.3960/jslrt.24040","url":null,"abstract":"IgG4-related sialadenitis (IgG4-SA) is one of the IgG4-related disease. The histological features of IgG4-SA include dense lymphoplasmacytic infiltrates and fibrosis. This study aimed to reveal the involvement of plasma cells in the development of fibrosis and the mechanism underlying fibrosis in IgG4-SA. Hematoxylin-eosin staining, Azan staining, silver staining, and immunohistochemistry (IHC) were performed on IgG4-SA and chronic sialadenitis specimens, and theses samples were analyzed by image analysis software. Histological spatial analysis was used to analyze the localization of IHC-positive cells and the distances between these cells. In the IgG4-SA group, many secondary lymphoid follicles with germinal centers were found, and many collagen fibers developed around these germinal centers. Collagen fibers composed mainly of type I collagen was abundant at sites away from secondary lymphoid follicles, and reticular fibers composed of type III collagen was abundant near secondary lymphoid follicles. Many FAP+ fibroblasts and MUM1+ plasma cells were localized near secondary lymphoid follicles. Histological spatial analysis demonstrated that 90.4% of MUM1+ plasma cells accumulated within 20 µm of FAP+ fibroblasts. Multiple immunofluorescence assays revealed that MUM1+ plasma cells expressed platelet-derived growth factor (PDGF) β, and FAP+ fibroblasts expressed PDGF receptor (PDGFR) β and pSTAT3 in IgG4-SA. We have shown that fibrosis is localized around secondary lymphoid follicles and that fibroblasts are activated by plasma cells via PDGF/PDGFR signaling in IgG4-SA.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 3","pages":"223-231"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization. 通过G-带和荧光原位杂交鉴定与t(14;19)(q32;q13)/IGH::BCL3相关的多种B细胞肿瘤。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23053

Hitoshi Ohno, Fumiyo Maekawa, Masahiko Hayashida, Miho Nakagawa, Katsuhiro Fukutsuka, Mitsuko Matsumura, Kayo Takeoka, Wataru Maruyama, Naoya Ukyo, Shinji Sumiyoshi, Yasuhiro Tanaka, Hironori Haga

{"title":"Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization.","authors":"Hitoshi Ohno, Fumiyo Maekawa, Masahiko Hayashida, Miho Nakagawa, Katsuhiro Fukutsuka, Mitsuko Matsumura, Kayo Takeoka, Wataru Maruyama, Naoya Ukyo, Shinji Sumiyoshi, Yasuhiro Tanaka, Hironori Haga","doi":"10.3960/jslrt.23053","DOIUrl":"10.3960/jslrt.23053","url":null,"abstract":"We characterized 5 B-cell tumors carrying t(14;19)(q32;q13) that creates the IGH::BCL3 fusion gene. The patients' ages ranged between 55 and 88 years. Two patients presented with progression or recurrence of B-cell chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma (SLL), two with diffuse large B-cell lymphoma (DLBCL) of non-germinal center B-like phenotype, and the remaining one with composite angioimmunoblastic T-cell lymphoma and Epstein-Barr virus-positive DLBCL. The presence of t(14;19)(q32;q13) was confirmed by fluorescence in situ hybridization (FISH), showing colocalization of 3' IGH and 3' BCL3 probes on der(14)t(14;19) and 5' BCL3 and 5' IGH probes on der(19)t(14;19). One B-CLL case had t(2;14)(p13;q32)/IGH::BCL11A, and 2 DLBCL cases had t(8;14)(q24;q32) or t(8;11;14)(q24;q11;q32), both of which generated IGH::MYC by FISH, and showed nuclear expression of MYC and BCL3 by immunohistochemistry. The IGH::BCL3 fusion gene was amplified by long-distance polymerase chain reaction in 2 B-CLL/SLL cases and the breakpoints occurred immediately 5' of BCL3 exon 1 and within the switch region associated with IGHA1. The 5 cases shared IGHV preferentially used in B-CLL cells, but the genes were unmutated in 2 B-CLL/SLL cases and significantly mutated in the remaining 3. B-cell tumors with t(14;19)(q32;q13) can be divided into B-CLL/SLL and DLBCL groups, and the anatomy of IGH::BCL3 in the latter may be different from that of the former.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 1","pages":"21-31"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified. 结节外自然杀伤/T 细胞淋巴瘤与外周 T 细胞淋巴瘤并存，未作其他说明。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23049

Kenta Hayashino, Chikamasa Yoshida, Yoshiyuki Ayata, Ryouya Yukawa, Aya Komura, Makoto Nakamura, Yusuke Meguri, Kazuhiko Yamamoto, Wakako Oda, Kenji Imajo

{"title":"Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified.","authors":"Kenta Hayashino, Chikamasa Yoshida, Yoshiyuki Ayata, Ryouya Yukawa, Aya Komura, Makoto Nakamura, Yusuke Meguri, Kazuhiko Yamamoto, Wakako Oda, Kenji Imajo","doi":"10.3960/jslrt.23049","DOIUrl":"10.3960/jslrt.23049","url":null,"abstract":"We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, ascitic fluid appeared. Abdominal aspiration revealed neutrophil-predominant ascites and microbiological studies revealed Candida albicans. However, ascites did not improve when treated with micafungin for Candida peritonitis. Abdominal aspiration was re-performed, and atypical lymphoid cells that were positive for CD3 and CD56 were detected. EBV-DNA levels in whole blood were significantly elevated. Atypical lymphoid cells were positive for EBER by in situ hybridization and Southern blot analysis showed EBV terminal repeat monoclonal patterns. Bone marrow examination revealed the same atypical lymphoid cells. Therefore, the patient was diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL) with bone marrow involvement 3 months after the diagnosis of PTCL-NOS. Complications associated with PTCL-NOS and ENKTL are rare. PTCL-NOS, chemotherapy, sepsis, and prednisone might have led to immunodeficiency and reactivation of EBV, which might be one of the pathophysiologies for developing ENKTL. Our case indicates that measuring EBV-DNA in the blood is a simple and prompt examination to detect complications of EBV-associated lymphoma.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 1","pages":"52-58"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of solitary plasmacytoma in the liver 10 years after the onset of multiple bone lesions. 多发性骨病10年后肝脏单发浆细胞瘤复发。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23056

Jun Numata, Hiroko Tsunemine, Asuka Imai, Naokazu Nakamura, Tomomi Sakai, Tomoo Itoh, Nobuyoshi Arima

引用次数: 0

A lymph node lesion of hyper IL-6 syndrome mimicking plasmacytoma, IgG4-related disease, and Castleman disease. 高IL-6综合征的淋巴结病变，类似浆细胞瘤、igg4相关疾病和Castleman病。

IF 0.9

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.24039

Kenta Matsui, Hiroshi Imai, Toshiaki Kobayashi, Minoru Mizutani, Midori Filiz Nishimura, Yasuharu Sato, Kennosuke Karube, Manato Okada, Miki Usui, Keiki Kawakami, Tetsuya Murata

引用次数: 0

Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT. PET-CT 发现小腿骨髓局部复发的结节外 NK/T 细胞淋巴瘤。

IF 1.5

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.23046

Takahisa Nakamura, Hiro Tatetsu, Yusuke Higuchi, Shinya Endo, Shinya Shiraishi, Koichi Kawanaka, Daisuke Imakane, Miyu Sonoda, Rie Furuta, Takafumi Shichijo, Yumi Honda, Kennosuke Karube, Yoshiki Mikami, Kisato Nosaka, Masao Matsuoka, Jun-Ichirou Yasunaga

{"title":"Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT.","authors":"Takahisa Nakamura, Hiro Tatetsu, Yusuke Higuchi, Shinya Endo, Shinya Shiraishi, Koichi Kawanaka, Daisuke Imakane, Miyu Sonoda, Rie Furuta, Takafumi Shichijo, Yumi Honda, Kennosuke Karube, Yoshiki Mikami, Kisato Nosaka, Masao Matsuoka, Jun-Ichirou Yasunaga","doi":"10.3960/jslrt.23046","DOIUrl":"10.3960/jslrt.23046","url":null,"abstract":"Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma (NHL) with poor prognosis, particularly in relapsed or refractory patients. Thus, timely detection of relapse and appropriate disease management are crucial. We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abnormal uptake in the subcutaneous mass of the right medial thigh, lymph nodes, and descending colon (Lugano stage IV). After induction therapy, PET-CT revealed new abnormal uptake only in the left tibia. In both patients, CT-guided biopsy confirmed ENKTL recurrence. Moreover, PET-CT with whole-body coverage was useful for the timely assessment of relapse and detection of asymptomatic bone involvement. This approach allowed for modifications to treatment strategies in certain patients.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 1","pages":"45-51"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD30- and CD56-positive atypical intravascular lymphocytes of the uterine cervix, mimicking intravascular lymphoma: A case report and review of the literature. CD30和cd56阳性的宫颈非典型血管内淋巴细胞，模拟血管内淋巴瘤：1例报告和文献复习。

IF 0.9

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.24058

Daisuke Yamashita, Munemichi Otani, Hayato Maruoka, Takuya Aoki, Shigeo Hara

引用次数: 0

Epstein-Barr virus-positive plasmacytoma in an immunocompetent female: A case report. 一名免疫功能正常女性的 Epstein-Barr 病毒阳性浆细胞瘤：病例报告。

IF 0.9

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.24038

Hiyo Okuno, Motoha Miura, Naoki Oishi, Megumi Koshiishi-Yamada, Fumihiko Tanioka, Keita Kirito, Tetsuo Kondo

{"title":"Epstein-Barr virus-positive plasmacytoma in an immunocompetent female: A case report.","authors":"Hiyo Okuno, Motoha Miura, Naoki Oishi, Megumi Koshiishi-Yamada, Fumihiko Tanioka, Keita Kirito, Tetsuo Kondo","doi":"10.3960/jslrt.24038","DOIUrl":"10.3960/jslrt.24038","url":null,"abstract":"Plasmacytoma is defined as a plasma cell neoplasm forming a solitary osseous or extramedullary tumor without evidence of myeloma or organ damage related to a plasma cell neoplasm. Epstein-Barr virus (EBV) is associated with various B-cell neoplasms, particularly in patients with immune dysregulation; however, plasmacytoma is typically negative for EBV. Here, a case of EBV-positive sternal plasmacytoma in an immunocompetent female is presented. A 76-year-old female with no immunodeficiency presented with a tumor on the anterior thoracic wall. Imaging analysis revealed a 6.3 cm-sized tumor at the manubrium, and a needle biopsy was performed. The tumor in the bone was composed of a diffuse proliferation of plasmacytes with eccentric nuclei and a perinuclear halo. By immunohistochemistry and in situ hybridization, tumor cells were CD20-, CD3-, CD138+, κ+, λ-, EBER+, and the Ki67-labeling index was approximately 20%. Subsequent studies identified IgG κ monoclonal protein in serum but no evidence of plasma cell neoplasm-related organ damage, such as hypercalcemia, anemia, or renal dysfunction. No plasma cell neoplasm was detected in the bone marrow in the morphological and flowcytometric studies. Accordingly, the diagnosis was EBV-positive plasmacytoma. The patient was treated with local radiation therapy and achieved complete remission. EBV-positive plasmacytoma is rare in immunocompetent patients and should be carefully distinguished from plasmablastic lymphoma, another EBV-positive neoplasm with a plasma cell phenotype and an aggressive clinical course. This case also raises an important question: \"when to perform EBER in situ hybridization in diagnosing plasma cell neoplasm?\", which prompts further large case-series studies.","PeriodicalId":45936,"journal":{"name":"Journal of Clinical and Experimental Hematopathology","volume":"64 3","pages":"268-272"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142356093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer immune reaction and lymph node sinus macrophages: a review from human and animal studies. 抗癌免疫反应和淋巴结窦巨噬细胞：人类和动物研究综述。

IF 0.9

Journal of Clinical and Experimental Hematopathology Pub Date : 2024-01-01 DOI: 10.3960/jslrt.24017

Yukio Fujiwara, Hiromu Yano, Cheng Pan, Takuya Shiota, Yoshihiro Komohara

引用次数: 0