Tzu Chi Medical Journal最新文献_第2页

Pathophysiology and potential treatment modalities in women with recurrent urinary tract infection. 女性复发性尿路感染的病理生理学和潜在的治疗方式。

IF 1.4

Tzu Chi Medical Journal Pub Date : 2025-04-07 eCollection Date: 2025-04-01 DOI: 10.4103/tcmj.tcmj_286_24

Wei-Ju Liao, Yuan-Hong Jiang, Jia-Fong Jhang, Sheng-Fu Chen, Yu Khun Lee, Cheng-Ling Lee, Tien-Lin Chang, Hann-Chorng Kuo

{"title":"Pathophysiology and potential treatment modalities in women with recurrent urinary tract infection.","authors":"Wei-Ju Liao, Yuan-Hong Jiang, Jia-Fong Jhang, Sheng-Fu Chen, Yu Khun Lee, Cheng-Ling Lee, Tien-Lin Chang, Hann-Chorng Kuo","doi":"10.4103/tcmj.tcmj_286_24","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_286_24","url":null,"abstract":"Urinary tract infection (UTI) of the urinary bladder is a common bacterial infection that predominantly affects women, with many experiencing recurrent episodes. Recurrent UTIs (rUTIs) are associated with significant physical, psychological, and social difficulties. Further, they are closely related to lower urinary tract dysfunction (LUTD). LUTD affects bladder function and structure, thereby contributing to urinary urgency, frequency, and incontinence, which, in turn, increases the risk of recurrent infections due to impaired urothelial defense mechanisms. The current study explored the pathophysiology of LUTD in women with rUTIs. Potential treatments for rUTIs include long-term prophylactic antibiotics, probiotics, D-mannose, vaccines, small molecule inhibitors, and stem cell therapy. Moreover, it evaluated the use of platelet-rich plasma (PRP) therapy as a treatment modality for LUTD. PRP has regenerative and anti-inflammatory properties. Hence, it can be a promising option for enhancing urothelial barrier integrity and reducing infection recurrence. Repeated intravesical PRP injections are effective in improving bladder symptoms and decreasing UTI recurrences by enhancing the proliferative ability of the urothelium in patients with rUTIs. Further, this review examined the potential predictors of successful PRP treatment outcomes such as cytokine and urothelial biomarker levels, which provided insights into patient selection and individualized treatment strategies. Identifying the predictive biomarkers of treatment responsiveness is essential for optimizing PRP therapy. Hence, to improve the clinical outcomes and quality of life of patients with rUTIs, future research should focus on refining the use of PRP, exploring combination therapies, and validating biomarkers.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 2","pages":"117-124"},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare APOE p.Gly4Glu: A putative disease-causing variant for early-onset Alzheimer's disease identified by next-generation sequencing. 罕见APOE p.Gly4Glu：通过下一代测序确定的早发性阿尔茨海默病的推定致病变异

IF 1.4

Tzu Chi Medical Journal Pub Date : 2025-04-07 eCollection Date: 2025-04-01 DOI: 10.4103/tcmj.tcmj_117_24

Chu-Ting Wu, Liang-Hsuan Hu, Hui-Ying Weng, Yen-Ming Liu, Yung-Feng Lin, Shih-Feng Tsai, Raymond Y Lo, Yung-Hao Ching

{"title":"Rare APOE p.Gly4Glu: A putative disease-causing variant for early-onset Alzheimer's disease identified by next-generation sequencing.","authors":"Chu-Ting Wu, Liang-Hsuan Hu, Hui-Ying Weng, Yen-Ming Liu, Yung-Feng Lin, Shih-Feng Tsai, Raymond Y Lo, Yung-Hao Ching","doi":"10.4103/tcmj.tcmj_117_24","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_117_24","url":null,"abstract":"Objectives: We aimed to identify the early-onset Alzheimer's disease (EOAD)-causing variants in the Eastern Taiwanese population.Materials and methods: Twenty-one patients diagnosed with EOAD in the memory clinic at Hualien Tzu Chi Hospital were enrolled during 2014-2018. We conducted whole-exome sequencing to identify the disease-causing variations and validated by Sanger sequencing. SIFT, PolyPhen-2, and AlphaFold were applied to predict the functional impact of the identified variants.Results: Two unrelated normolipidemic EOAD patients were carrying a rare heterozygous APOE variant (rs373985746, NC_000019.10:g. 44905879G>A, NM_001302688.2:c. 11G>A, and NP_001289617.1:p.Gly4Glu) with the allele frequency as 0.000206. Sanger sequencing uncovered the ∑ haplotypes in which the c.11G>A variation resided. SIFT predicted that the variant severely impacts protein structure and, maybe thus, function. AlphaFold predicted a dysfunctional conformation of the mutant APOE precursor a protein (p.Gly4Glu).Conclusion: Our data strongly suggest that the rare p.Gly4Glu variant is associated with EOAD but does not cause dyslipidemia.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 2","pages":"175-180"},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3-Hydroxy-3-methylglutaryl-CoA reductase variants strongly associated with low-density lipoprotein cholesterol levels and diabetes mellitus risk in a Taiwanese population: A Mendelian randomization study. 3-羟基-3-甲基戊二酰辅酶a还原酶变异与台湾人群低密度脂蛋白胆固醇水平和糖尿病风险密切相关：孟德尔随机研究。

IF 1.4

Tzu Chi Medical Journal Pub Date : 2025-04-07 eCollection Date: 2025-04-01 DOI: 10.4103/tcmj.tcmj_247_24

Lung-An Hsu, Ming-Sheng Teng, De-Min Duan, Kuan-Hung Yeh, Semon Wu, Yu-Lin Ko

{"title":"3-Hydroxy-3-methylglutaryl-CoA reductase variants strongly associated with low-density lipoprotein cholesterol levels and diabetes mellitus risk in a Taiwanese population: A Mendelian randomization study.","authors":"Lung-An Hsu, Ming-Sheng Teng, De-Min Duan, Kuan-Hung Yeh, Semon Wu, Yu-Lin Ko","doi":"10.4103/tcmj.tcmj_247_24","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_247_24","url":null,"abstract":"Objectives: 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a rate-limiting enzyme involved in cholesterol synthesis. The common HMGCR variants are associated with low-density lipoprotein cholesterol (LDL-C) levels. We aimed to identify novel HMGCR variants influencing the lipid profiles of Taiwanese and assess the causal links between LDL-C levels and diabetic risk based on HMGCR genotypes.Materials and methods: Genome-wide genotyping of 108,880 participants from Taiwan Biobank was used for the association studies and Mendelian randomization (MR) analysis.Results: Regional association and stepwise linear regression analyses showed HMGCR rs3064191, rs150454634, and rs13354746 variants were independently associated with total cholesterol (TC), LDL-C, and non-high-density lipoprotein cholesterol (non-HDL-C) levels with the former two variants in strong linkage disequilibrium with HMGCR rs3846662, a variant influencing exonal alternative splicing, and HMGCR rs191835914 (p.Y311S), an Asian-specific nonsynonymous mutation, respectively. Multivariate MR analyses showed significant associations between weighted genetic risk scores using LDL-C-determining HMGCR variants and using genome-wide association study identifying LDL-C-determining 47 variants and the prevalence of diabetes mellitus (DM) (P = 0.0011 and P = 1.66 × 10-8, respectively).Conclusion: The HMGCR variants exhibited significant associations with TC, LDL-C, and non-HDL-C levels as well as causally with DM risk in our Taiwanese population. HMGCR genotypes may play an important role and serve as a reference for the prevention and treatment of cardiovascular diseases in the clinical settings.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 2","pages":"181-188"},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary supplementation roles in concussion management: A systematic review. 膳食补充在脑震荡管理中的作用：一项系统综述。

IF 1.4

Tzu Chi Medical Journal Pub Date : 2025-04-07 eCollection Date: 2025-04-01 DOI: 10.4103/tcmj.tcmj_241_24

Andre Marolop Pangihutan Siahaan, Alvin Ivander, Bahagia Wilibrordus Maria Nainggolan, Ruth Hasian Nami Siagian, Lidya Veronika, Natanael Ramoti

{"title":"Dietary supplementation roles in concussion management: A systematic review.","authors":"Andre Marolop Pangihutan Siahaan, Alvin Ivander, Bahagia Wilibrordus Maria Nainggolan, Ruth Hasian Nami Siagian, Lidya Veronika, Natanael Ramoti","doi":"10.4103/tcmj.tcmj_241_24","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_241_24","url":null,"abstract":"Concussion, one of the most common types of mild traumatic brain injury, remains a global problem that poses substantial effects on individuals, families, and society. When dealing with concussion, clinicians primarily focus on symptomatic treatment and modified activity with no established therapies specifically addressing the underlying pathophysiological changes. In recent years, there has been a growing increase in attention to the effectiveness of dietary supplements (DS) and nutritional interventions as adjunctive therapy options for concussion. Hence, this review aims to comprehensively explore the existing human studies on using DS as adjunctive therapy in the management of concussion. This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. The search strategy was created based on the population, intervention, comparison, outcome framework. The findings are conveyed narratively and analyzed according to the timing of the intervention. DS administered within 7 days of onset were classified as acute interventions, while those given after this period were classified as nonacute interventions. After screening, we identified 21 reports for 19 studies involving 13 DS. Thirteen DS were included in this review. Notably, omega-3 polyunsaturated fatty acids were the most extensively studied and accounted for 23.81% of studies, followed by melatonin and pine bark extract (19.05% and 9.5%). At least 13 supplements were identified in clinical studies, with 77% demonstrating favorable outcomes. However, none of the interventions reviewed offer strong enough evidence to justify regular use in clinical practice.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 2","pages":"157-166"},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium-glucose co-transporter 2 inhibitors use and the risks of genital and urinary tract infection: What should we know? 钠-葡萄糖共转运蛋白2抑制剂的使用和生殖器和尿路感染的风险：我们应该知道什么？

IF 1.6

Tzu Chi Medical Journal Pub Date : 2025-04-04 eCollection Date: 2025-07-01 DOI: 10.4103/tcmj.tcmj_275_24

Du-An Wu, Bang-Gee Hsu, Yu-Li Lin

{"title":"Sodium-glucose co-transporter 2 inhibitors use and the risks of genital and urinary tract infection: What should we know?","authors":"Du-An Wu, Bang-Gee Hsu, Yu-Li Lin","doi":"10.4103/tcmj.tcmj_275_24","DOIUrl":"10.4103/tcmj.tcmj_275_24","url":null,"abstract":"Sodium-glucose co-transporter 2 (SGLT2) inhibitors have convincingly demonstrated efficacy in reducing cardiovascular (CV) and renal complications in patients with diabetes mellitus, chronic kidney disease, and heart failure. However, their use is also linked to the concern of some adverse events, the most common being genital and urinary tract infections (UTIs). This review summarizes the risks of genital and UTIs of SGLT2 inhibitors across large-scale clinical trials, meta-analyses, and real-world cohort studies. SGLT2 inhibitors are shown to significantly increase the risk of genital infections in clinical trials and real-world observational studies and marginally increase the risk of UTI in meta-analyses. We also discuss the potential pathogenesis of SGLT2 inhibitor-related infections and identify the susceptible risk factors. Since most genital and UTIs associated with SGLT2 inhibitors are mild and treatable and severe infections are rare, the use of SGLT2 inhibitors is highly recommended in patients who meet the inclusion criteria of clinical trials, where the CV and renal benefits outweigh the infection risks. For all users of SGLT2 inhibitors, preventive strategies, patient education, and careful monitoring are essential to minimize the infection risks. Furthermore, we address an unmet need regarding SGLT2 inhibitors among vulnerable populations, such as older adults, frail, and immunocompromised patients, underscoring the importance of observational studies from the real-world data. Future research should focus on identifying the high-risk groups, developing SGLT2 inhibitors with a lower infection profile and establishing effective prevention strategies to mitigate the risk of genital and UTIs associated with these medications.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 3","pages":"255-263"},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multitarget-based in silico screening from phytoactive compounds of Garcinia linii fighting toward severe acute respiratory syndrome coronavirus-2. 抗严重急性呼吸综合征冠状病毒-2的藤黄植物活性化合物的多靶点筛选

IF 1.6

Tzu Chi Medical Journal Pub Date : 2025-04-04 eCollection Date: 2025-07-01 DOI: 10.4103/tcmj.tcmj_226_24

Ting-Hsu Chen, Zi-Han Shen, May-Jywan Tsai, Ching-Feng Weng, Max K Leong

{"title":"Multitarget-based in silico screening from phytoactive compounds of Garcinia linii fighting toward severe acute respiratory syndrome coronavirus-2.","authors":"Ting-Hsu Chen, Zi-Han Shen, May-Jywan Tsai, Ching-Feng Weng, Max K Leong","doi":"10.4103/tcmj.tcmj_226_24","DOIUrl":"10.4103/tcmj.tcmj_226_24","url":null,"abstract":"Objectives: The recent global coronavirus disease 2019 (COVID-19) pandemic, resulting from infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), can cause severe and fatal pneumonia along with other life-threatening complications.Materials and methods: The rare and limited accessibility of approved therapeutic agents or vaccines is of great distress. Swiftly working on designing and identifying inhibitors against all possible viral key protein targets, seven key SARS-CoV-2 viral enzymes were selected as targets, particularly in the action on the virus-entry, viral replication, and immune evasion of COVID-19. Papain-like protease, main protease, RNA-dependent RNA polymerase, endoribonuclease (nsp15), receptor-binding domain-angiotensin-converting enzyme 2, transmembrane serine protease 2 (TMPRSS2), and 2'- O-ribose methyltransferase (2'MTase), which were subjected to an unbiased in silico screening against 22 small molecules originating from Garcinia linii concomitantly with Remdesivir, Nirmatrelvir, and Molnupiravir were approved by Food and Drug Administration as repurposing drugs against SARS-CoV-2 invasion.Results: The in silico results showed that natural bioactive compounds containing α-Tocopheryolquinone, 6β-Hydroxystigmast-4-en-3-one, Squalene, Rutin and Quercetin have a high binding affinity with seven selected viral protein targets concurrently with the preference of absorption, distribution, metabolism, excretion, and toxicity and drug-likeness.Conclusion: This study provides potential phytoactive compounds from G. linii through multi-target screen with molecular dynamic simulation for combating COVID-19 pandemics that need further experimental validation to confirm the prospective efficacy.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 3","pages":"275-284"},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary tumor with osteosarcomatous and chondrosarcomatous components: The differential diagnosis. 肺肿瘤伴骨肉瘤和软骨肉瘤成分：鉴别诊断。

IF 1.6

Tzu Chi Medical Journal Pub Date : 2025-04-04 eCollection Date: 2025-07-01 DOI: 10.4103/tcmj.tcmj_282_24

Pau-Yuan Chang, Bing-Ru Chung, Yen-Chang Chen

引用次数: 0

Endothelial dysfunction in chronic kidney disease: Mechanisms, biomarkers, diagnostics, and therapeutic strategies. 慢性肾脏疾病的内皮功能障碍：机制、生物标志物、诊断和治疗策略。

IF 1.4

Tzu Chi Medical Journal Pub Date : 2025-03-21 eCollection Date: 2025-04-01 DOI: 10.4103/tcmj.tcmj_284_24

Ji-Hung Wang, Yu-Li Lin, Bang-Gee Hsu

{"title":"Endothelial dysfunction in chronic kidney disease: Mechanisms, biomarkers, diagnostics, and therapeutic strategies.","authors":"Ji-Hung Wang, Yu-Li Lin, Bang-Gee Hsu","doi":"10.4103/tcmj.tcmj_284_24","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_284_24","url":null,"abstract":"Endothelial cells regulate vascular tone, blood flow, coagulation, and inflammation, with heterogeneous populations serving specific roles throughout the body. In the kidney, endothelial cells maintain vascular integrity and function, contribute to filtration, and support other renal structures. Nitric oxide (NO) is a key signaling molecule that maintains vascular tone and endothelial function. It is synthesized by nitric oxide synthase (NOS) isoforms, with endothelial NOS playing a central role in vascular health. Chronic kidney disease (CKD) is characterized by reduced NO bioavailability, driven by the accumulation of endogenous NOS inhibitors such as asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Uremic toxins, oxidative stress, and proinflammatory cytokines contribute to a prothrombotic and proinflammatory state, contributing to endothelial dysfunction and exacerbating cardiovascular (CV) risks in CKD. Biomarkers such as ADMA, SDMA, endothelial microparticles, and soluble adhesion molecules offer insights into vascular health, while invasive or noninvasive diagnostic techniques can assess endothelial function in CKD. Effective management strategies focus on enhancing NO bioavailability, controlling oxidative stress, reducing inflammation, and optimizing dialysis to minimize uremic toxin levels. Emerging therapeutic approaches, including antioxidant therapies and endothelial progenitor cell-based interventions, show promise in preserving vascular function. A multifaceted approach to managing endothelial dysfunction is critical for mitigating CV complications and improving patient outcomes in CKD.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 2","pages":"125-134"},"PeriodicalIF":1.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis. 胰石蛋白作为II型糖尿病微血管并发症的新生物标志物：一项系统综述和荟萃分析

IF 1.6

Tzu Chi Medical Journal Pub Date : 2025-03-05 eCollection Date: 2025-07-01 DOI: 10.4103/tcmj.tcmj_211_24

Nicolas Daniel Widjanarko, Nanny Natalia Mulyani Soetedjo, Maria Riastuti Iryaningrum, Erlangga Saputra Arifin, Steven Alvianto, Stevan Kristian Lionardi, Archie Fontana Iskandar, Kevin Axel Chandra

{"title":"Pancreatic stone protein as a novel biomarker of microvascular complications in type II diabetes mellitus: A systematic review and meta-analysis.","authors":"Nicolas Daniel Widjanarko, Nanny Natalia Mulyani Soetedjo, Maria Riastuti Iryaningrum, Erlangga Saputra Arifin, Steven Alvianto, Stevan Kristian Lionardi, Archie Fontana Iskandar, Kevin Axel Chandra","doi":"10.4103/tcmj.tcmj_211_24","DOIUrl":"10.4103/tcmj.tcmj_211_24","url":null,"abstract":"Objectives: Pancreatic stone protein (PSP) has been identified as an indicator of systemic stress and is elevated in individuals diagnosed with type 2 diabetes mellitus (T2DM), potentially serving as a prognostic marker for both the onset and progression of the disease.Materials and methods: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 guidelines. Articles were sourced from MEDLINE, ProQuest, Science Direct, Google Scholar, and Cochrane Library electronic databases. Studies included are all observational studies examining PSP/Reg1α serum levels in patients with T2DM. The quality of the study was evaluated using the Newcastle-Ottawa Scale, as well as Review Manager 5.4 to perform the meta-analysis.Results: Seven studies met the criteria for inclusion. Pooled analysis revealed significant differences in PSP values between T2DM individuals and healthy controls (standardized mean difference [SMD] = 2.14, 95% confidence interval CI: 1.05-1.92, P < 0.00001). Further subgroup analysis showed PSP was substantially higher in T2DM with complications (SMD = -1.57, 95% CI: -2.12 to -1.02, P < 0.00001) compared to T2DM without complications (SMD = -1.39, 95% CI: -2.17 to - 0.61) and newly diagnosed T2DM (SMD = -1.85, 95% CI: -2.96 to -0.74). Grading of Recommendations, Assessment, Development, and Evaluations demonstrated moderate quality of evidence.Conclusion: Our analysis revealed a progressive elevation in PSP values concomitant with the worsening T2DM disease state across the entire spectrum. PSP exhibits promising potential as a biomarker for predicting both disease initiation and subsequent clinical course.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 3","pages":"328-338"},"PeriodicalIF":1.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac computed tomography: Current practice, guidelines, applications, and prospects. 心脏计算机断层扫描：目前的实践、指南、应用和前景。

IF 1.4

Tzu Chi Medical Journal Pub Date : 2025-03-05 eCollection Date: 2025-04-01 DOI: 10.4103/tcmj.tcmj_125_24

Yu-Tai Shih, Jia-Hao Zhou, Jong-Kai Hsiao

{"title":"Cardiac computed tomography: Current practice, guidelines, applications, and prospects.","authors":"Yu-Tai Shih, Jia-Hao Zhou, Jong-Kai Hsiao","doi":"10.4103/tcmj.tcmj_125_24","DOIUrl":"https://doi.org/10.4103/tcmj.tcmj_125_24","url":null,"abstract":"Cardiac computed tomography (CT) has evolved significantly as a critical tool in diagnosing and managing cardiac diseases, greatly facilitated by technological advancements in multidetector systems, dose-reduction techniques, and sophisticated imaging algorithms. This article discusses the historical progression and technological evolution in cardiac CT (CCT), focusing on the impact of 64-multidetector row CT and dual-energy CT systems on improving spatial and temporal resolutions and reducing radiation exposure. It explores the role of these technologies in enhancing diagnostic accuracy, such as through detailed three-dimensional reconstructions and minimized imaging artifacts. Furthermore, it highlights the integration of machine learning to automate complex imaging analysis and photon-counting CT, which promises higher resolution and further dose reduction. Prospective studies and ongoing trials such as FASTTRACK coronary artery bypass grafting also underscore the potential of advanced CT technologies in refining procedural planning and execution. The continuous advancements in detector technology, computational techniques, and image reconstruction are poised to expand the applications and efficacy of CCT, cementing its role in modern cardiology.","PeriodicalId":45873,"journal":{"name":"Tzu Chi Medical Journal","volume":"37 2","pages":"145-151"},"PeriodicalIF":1.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0