Case Reports in Gastrointestinal Medicine最新文献

{"title":"Drug-Induced Liver Failure Following Topical Minoxidil: A Case Report.","authors":"Katrin Premke, Matthias Kästner, Carlos Fritzsche, Andreas Erbersdobler, Micha Loebermann","doi":"10.1155/crgm/1040092","DOIUrl":"10.1155/crgm/1040092","url":null,"abstract":"<p><strong>Introduction: </strong>Drug-induced liver failure (DILI) is one of the causes of acute liver injury (13%-20%), encompassing both predictable and idiosyncratic reactions. While the latter are rare, it can lead to severe liver damage in vulnerable patients. Although topical minoxidil is a widely used treatment for androgenetic alopecia, cases of liver failure linked to its use are extremely uncommon and have not been widely described. This case report discusses the potential for severe liver injury following topical minoxidil application.</p><p><strong>Case presentation: </strong>A 21-year-old female with no significant medical history presented with jaundice, elevated liver enzymes, and impaired liver function three and a half weeks after starting topical minoxidil for alopecia areata. Laboratory tests revealed significantly elevated transaminases, bilirubin, and disturbed coagulation. A liver biopsy revealed centrilobular necrosis, which indicated drug-induced liver damage. After discontinuation of minoxidil, the patient's condition improved rapidly, with a marked decrease in liver enzymes and disappearance of clinical symptoms.</p><p><strong>Conclusions: </strong>This is the first evidence of severe drug-induced liver failure associated with topical minoxidil. It underscores the potential for hepatotoxicity even with over-the-counter drugs that are thought to have minimal systemic absorption. The rapid improvement after discontinuation of the drug and exclusion of differential diagnoses suggests a causal relationship. In cases of severe liver failure of unclear origin, all substances should be considered in the case history.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"1040092"},"PeriodicalIF":0.5,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12614736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound With Fine Needle Biopsy Confirming a Diagnosis of Immune Checkpoint Inhibitor-Related Type 3 Autoimmune Pancreatitis.","authors":"Dana Ley, Kusum Sharma, Saqib Walayat, Mark R Albertini, Rashmi M Agni, Deepak V Gopal","doi":"10.1155/crgm/5519015","DOIUrl":"10.1155/crgm/5519015","url":null,"abstract":"<p><strong>Introduction: </strong>Immune checkpoint inhibitor-related pancreatitis, also known as type 3 autoimmune pancreatitis (AIP), is uncommon and has a widely ranging clinical presentation. We present the biopsy findings of a case consistent with type 3 AIP-an entity recently described in the literature, the pathologic findings of which have not been well characterized.</p><p><strong>Case report: </strong>A 71-year-old male with metastatic mucosal melanoma of the urethra was treated with immune checkpoint inhibitor (ICI) therapy (nivolumab/relatlimab) and developed vague epigastric discomfort. He was found to have an elevated lipase, which increased to > 20x the upper limit of normal. Subsequent imaging showed new infiltrative masses in the pancreatic head and distal body/tail. Endoscopic ultrasound with fine needle biopsy (FNB) was performed. This showed T-lymphocyte predominant infiltrates, in the acini and septal areas, with concomitant acinar, duct, and venular damage, including both CD4 and CD8 lymphocytes, which were considered consistent with type 3 AIP. He was treated successfully with prednisone.</p><p><strong>Discussion: </strong>On biopsy, there was no evidence of malignancy or features of type 1 or type 2 AIP. Histologic findings included moderate infiltration and damage to the pancreatic parenchyma, ductal, and vascular structures by CD4 and CD8 lymphocytes, pointing to immune-mediated pancreatic injury, and supportive of ICI-mediated injury to the pancreas of this patient. The clinical presentation of type 3 AIP ranges from asymptomatic lipase elevation to asymptomatic pancreatitis to acute symptomatic pancreatitis. There may be no clear temporal relationship to treatment initiation. Type 3 AIP typically presents along with other immune-related adverse events. Endoscopic ultrasound with FNB contributed to diagnostic certainty in this case and changed our patient's management, allowing for appropriate treatment of his immune-related adverse event.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"5519015"},"PeriodicalIF":0.5,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12595219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Presentation of Colonic Sarcoidosis and Current Diagnostic Challenges.","authors":"Rangesh Modi, Cameron Dandridge, Nada Attia, Edwin McDonald","doi":"10.1155/crgm/5549338","DOIUrl":"10.1155/crgm/5549338","url":null,"abstract":"<p><p>We present a case of a Hispanic woman in her 70s who presented with nonspecific lower abdominal pain leading to a diagnosis of hepatic and colonic sarcoidosis. She had elevated liver function tests (LFTs), and imaging ruled out ischemia and cholangitis but revealed a cecal and ascending colon wall thickening with fat stranding. Infectious and autoimmune causes of elevated LFTs were excluded. A liver biopsy showed noncaseating granulomas, indicating hepatic sarcoidosis. Despite no bloody diarrhea, a colonoscopy was performed due to nonspecific abdominal pain and imaging-based evidence of colitis. A colonoscopy revealed diffuse areas of severely erythematous, hyperemic, and ulcerating mucosa in the ascending colon. Biopsies confirmed abundant noncaseating granulomas in the background of inflammation. Stool testing, imaging, and staining of biopsies excluded infectious or ischemic etiologies of colitis. The presence of hepatic sarcoidosis, along with age and symptom profile, prompted a diagnosis of colonic sarcoidosis rather than Crohn's colitis. Prednisone and methotrexate improved her symptoms and LFTs within 3 months of initiation.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"5549338"},"PeriodicalIF":0.5,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12595241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Presentation of Post-Transplant Lymphoproliferative Disorder (PTLD) and Acute Cellular Rejection (ACR) in a Liver Transplant Recipient: A Therapeutic Conundrum.","authors":"Ankit Mishra, Matthew Kubina, Dhiraj K Peddu, Benjamin L Viglianti, Anamarija M Perry, Priya Kathuria, Hellan Kwon, Shannon A Carty, Patricia Bloom","doi":"10.1155/crgm/1627234","DOIUrl":"10.1155/crgm/1627234","url":null,"abstract":"<p><p>We report a 64-year-old liver transplant recipient who developed early nondestructive post-transplant lymphoproliferative disorder (PTLD) and severe acute cellular rejection (ACR) concurrently. Hepatic lymphadenopathy led to a liver biopsy demonstrating early PTLD. Immunosuppression (IS) was reduced for early PTLD, which led to acute liver injury requiring high-dose steroids. However, subsequent augmentation in immunosuppression for ACR led to progression of PTLD, requiring rituximab treatment. This case highlights the complexity of managing conflicting liver transplant complications and underscores the importance of a multidisciplinary approach. In our case, prioritizing the treatment of rejection preserved the allograft function. Long-term follow-up showed complete resolution of both rejection and PTLD.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"1627234"},"PeriodicalIF":0.6,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12588761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Idiopathic Secretory Diarrhoea With a Profound Sustained Response to Somatostatin Analogues: A Case Report.","authors":"Geovanny Gandy, Alexander James Anthony Prudence, Miriam Tania Levy","doi":"10.1155/crgm/7006260","DOIUrl":"10.1155/crgm/7006260","url":null,"abstract":"<p><strong>Background: </strong>Chronic secretory diarrhoea is a diagnostic challenge with a broad differential and significant impact on patient's quality of life. While common causes include microscopic colitis, bile acid diarrhoea, and laxative use, rarer aetiologies such as vasoactive intestinal peptide (VIP)-secreting neuroendocrine tumours (VIPomas) must be considered when standard investigations fail.</p><p><strong>Case presentation: </strong>We present a 35-year-old woman with a two-year history of progressively worsening, fasting-persistent, high-volume watery diarrhoea leading to severe electrolyte abnormalities and weight loss requiring resuscitation in intensive care. Extensive biochemical, endoscopic, and radiological investigations-including faecal analysis, colonoscopy, neuroendocrine markers, multiphase CT, endoscopic ultrasound, and Ga-68 Dotatate PET imaging-failed to identify an underlying cause. Serum VIP levels remained within the normal range. Despite the absence of a definitive diagnosis, empirical treatment with the somatostatin analogue octreotide led to rapid and sustained symptom resolution. The patient was subsequently maintained on long-acting lanreotide with complete remission. Notably, diarrhoea recurred upon cessation of therapy, again resolving with reinitiation. After 4 years, the patient self-ceased lanreotide without symptom recurrence, and follow-up imaging remained unremarkable.</p><p><strong>Discussion: </strong>This case highlights a diagnostic dilemma: clinical and biochemical features were highly suggestive of a VIPoma, yet no tumour was identified despite repeated advanced imaging and biochemical workup. The patient's remarkable therapeutic response to somatostatin analogue therapy, in the absence of confirmed neuroendocrine neoplasia, suggests that somatostatin analogues may have a broader role in the management of idiopathic secretory diarrhoea than currently appreciated.</p><p><strong>Conclusion: </strong>We present a rare case of chronic secretory diarrhoea with suspected but unproven VIPoma, demonstrating sustained and reproducible response to somatostatin analogue therapy. This case supports the consideration of therapeutic trials of somatostatin analogues in refractory secretory diarrhoea of unknown origin.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"7006260"},"PeriodicalIF":0.5,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12585831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Hepatic Perivascular Epithelioid Tumor (PEComa) With High Risk of Malignancy: A Case Report.","authors":"Luis Enrique Quiroga-Hernández, Kharen Alessandra Verjel-Avila, Jerónimo Andrade-Restrepo, Alonso Vera-Torres, Rafael Enrique Andrade-Pérez, Rocío Del Pilar López-Panqueva","doi":"10.1155/crgm/6695278","DOIUrl":"10.1155/crgm/6695278","url":null,"abstract":"<p><p>Perivascular Epithelioid Tumors (PEComas) are predominantly present in uterine or gastric tissues. Liver presentations are uncommon and primary hepatic presentations are extremely rare. This is the case of a 31-year-old female patient, with previous diagnosis of hepatic abscess, the patient presented with a one-month history of abdominal pain and bilious emesis. Abdominal MR reported a lesion suggestive of hepatic adenoma. The team performed a partial hepatectomy, and histopathologic and immunohistochemical (IHC) studies reported a PEComa with high risk of confirmed malignant behavior metastatic workup. A complete left laparoscopic hepatectomy was performed due to positive surgical margins. Careful complete histologic and IHC studies are required for diagnosis. IHC reveals coexpression of melanocytic and muscle markers. These studies are usually performed after hepatectomy, the leading management strategy. Long-term follow-up and validated risk stratification scales for hepatic PEComas are needed. This report underscores the critical role of accurate diagnosis and the absence of precise information for management and prognosis of hepatic PEComas.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"6695278"},"PeriodicalIF":0.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12575044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Manifestation of Disseminated Gastrointestinal Kaposi Sarcoma in a Newly Diagnosed HIV Patient: A Case Report.","authors":"Masood Muhammad Karim, Shazaf Masood Sidhu, Abdul Hadi Shahid, Asad Diwan Muhammad, Abdullah Bin Khalid","doi":"10.1155/crgm/6919033","DOIUrl":"10.1155/crgm/6919033","url":null,"abstract":"<p><strong>Background: </strong>Kaposi sarcoma (KS) is a multifocal angioproliferative disorder linked to Human Herpesvirus-8 (HHV-8), presenting in four forms: classic, endemic, iatrogenic, and AIDS-related. AIDS-related KS remains prevalent among HIV-positive individuals despite widespread use of antiretroviral therapy. Gastrointestinal (GI) involvement is the most common extracutaneous manifestation, primarily affecting the upper GI tract. It is often asymptomatic and typically requires endoscopic evaluation. While commonly associated with advanced HIV, GI KS can occasionally precede an HIV diagnosis. Despite its strong link to HHV-8, disseminated KS may develop in HHV-8-negative patients with late HIV diagnoses, raising concerns about AIDS progression. Management primarily includes highly active antiretroviral therapy (HAART), while liposomal doxorubicin is reserved for extensive disease to ensure symptom control, lesion regression, and improved survival.</p><p><strong>Case presentation: </strong>This case report describes a rare presentation of disseminated GI KS in an HHV-8-negative patient newly diagnosed with HIV, indicating potential AIDS progression. The patient exhibited violaceous cutaneous lesions and GI symptoms, including abdominal pain and dysphagia. Endoscopy revealed esophageal masses and ulcer-like lesions in the stomach and duodenum, with histology and IHC confirming KS despite negative HHV-8 status. Management included HAART and liposomal doxorubicin, with close IRIS monitoring. The patient remained hemodynamically stable and was discharged on HAART, chemotherapy, and prophylactic antifungal and antibiotic therapies following negative cultures and stable clinical status.</p><p><strong>Conclusion: </strong>This case highlights the need for vigilance in the atypical manifestation of HHV-8-negative disseminated GI KS in an undiagnosed HIV-positive patient, emphasizing the clinical presentation, diagnostic approach, and disease management. The patient's stabilization underscores the importance of early recognition, comprehensive diagnostic evaluation, and a multidisciplinary approach in managing complex cases.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"6919033"},"PeriodicalIF":0.5,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Management of Acute Gastrointestinal Bleeding From a Gastric Lipoma: A Case Report, Literature Review, and Treatment Recommendation With Reference to ESGE Guidelines.","authors":"Ján Csomor, Petr Hříbek, Kateřina Košťálová, Jiří Soukup, Štěpán Suchánek, Petr Urbánek","doi":"10.1155/crgm/6874807","DOIUrl":"10.1155/crgm/6874807","url":null,"abstract":"<p><strong>Background: </strong>Acute gastrointestinal bleeding from a gastric lipoma is a very rare but severe condition, about 50 cases of which have been reported in the worldwide literature at the time of writing. It largely occurs from a lesion larger than 4 cm localized in the antrum of the stomach.</p><p><strong>Objective: </strong>We report the case of a patient with severe comorbidities presenting with melena and, on examination, a large subepithelial lesion in the gastric antrum, with a small ulceration and visible vessel at the summit. After stabilization and endoscopic hemostasis, the lesion was successfully treated by endoscopic submucosal dissection and a diagnosis of a large gastric antral lipoma was confirmed. We have collected similar case reports published worldwide and made a careful review of the literature and ESGE guidelines; we present these here with the aim of helping to find the best modality of treatment for future patients with large gastric lipoma.</p><p><strong>Conclusion: </strong>We present, to the best of our knowledge, the first case of acute gastrointestinal bleeding from a gastric lipoma in the Czech Republic, discuss the existing literature on similar cases, and make recommendations for the treatment of this condition in line with the relevant ESGE guidelines.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"6874807"},"PeriodicalIF":0.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Bilateral Massive Pneumothorax, Pneumomediastinum, Pneumoperitoneum, and Diffuse Subcutaneous Emphysema During Colonoscopy: Multidisciplinary Collaboration: Case Report.","authors":"Li-Li Liu, Mai-Qiao Yang, Rui Wu, Bing-Xing Li","doi":"10.1155/crgm/6444675","DOIUrl":"10.1155/crgm/6444675","url":null,"abstract":"<p><p>While colonoscopy is generally considered to be a safe procedure, serious complications such as intestinal perforation may also occur. Herein, we describe an extremely rare clinical case of acute colonic perforation during colonoscopy treatment. A 55-year-old female patient with good health presented to our hospital with abdominal pain for 2 months. While undergoing endoscopic submucosal dissection (ESD) of a colonic polyp, the patient developed sudden abdominal distension and dyspnea. An emergency computed tomography (CT) scan was performed and demonstrated bilateral massive pneumothorax, pneumomediastinum, pneumoperitoneum, and generalized subcutaneous emphysema (SCE). The patient underwent gas extraction, bilateral intercostal pneumothorax drainage, and conservative medical management. The patient had a favorable postoperative course and was discharged home on day 14. This case report highlights the clinical rarity of gas extravasation complications during colonoscopy and underscores the importance of multidisciplinary collaboration for accurate diagnosis and effective management, thereby avoiding surgical procedures.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"6444675"},"PeriodicalIF":0.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12473745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Pancreatitis Not Otherwise Specified (AIP-NOS): The Importance of Gastroenterology Consultation When Clinical Findings Are Concerning for Pancreatic Cancer.","authors":"Cooper Alden Josephs, Daniel Mullady, Taylor Templeton-Jager, Nicholas Fuerstenau, Steve Xie","doi":"10.1155/crgm/8916499","DOIUrl":"10.1155/crgm/8916499","url":null,"abstract":"<p><p><b>Introduction:</b> Autoimmune pancreatitis (AIP) and pancreatic cancer are top differentials of obstructive jaundice originating from the pancreas. <b>Case Description/Methods:</b> The patient's findings were concerning for malignant biliary obstruction, but a thorough workup determined that the patient had AIP-NOS. She underwent EBS and was discharged on a steroid taper. Follow-up demonstrated complete resolution of symptoms, laboratory markers, and imaging. <b>Conclusion:</b> Adequate pancreatic tissue is not always obtained with 22-gauge needles. Biliary stenting is justifiable in AIP with significant hyperbilirubinemia. It is important to consider AIP for with a pancreatic head mass and obstructive jaundice to optimize outcome.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"8916499"},"PeriodicalIF":0.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}