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Evaluation of validity and reliability of quantitative Cervical Vertebral Maturation Index (QCVMI): A cross-sectional study 定量颈椎成熟指数(QCVMI)的效度和信度评价:一项横断面研究
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-06-24 DOI: 10.1016/j.ortho.2025.101035
Abinaya Somaskandhan, Selva Arockiam, Uma Maheswari, Devaki Vijayalakshmi
{"title":"Evaluation of validity and reliability of quantitative Cervical Vertebral Maturation Index (QCVMI): A cross-sectional study","authors":"Abinaya Somaskandhan,&nbsp;Selva Arockiam,&nbsp;Uma Maheswari,&nbsp;Devaki Vijayalakshmi","doi":"10.1016/j.ortho.2025.101035","DOIUrl":"10.1016/j.ortho.2025.101035","url":null,"abstract":"<div><h3>Objective</h3><div>Various methods have been employed to determine skeletal maturity, based on height, weight, frontal sinus development, dental calcification sexual maturation and biomarkers. This study aimed to evaluate the validity and reliability of the Quantitative Cervical Vertebral Maturation Index (QCVMI) in assessing skeletal maturity and compare it with established radiographic maturity indicators, including Fishman's Skeletal Maturity Index, Hassal and Farman's CVMI, Modified MP3 Method, Baccetti's CVMI and correlation between QCVMI and mandibular growth increments.</div></div><div><h3>Material and methods</h3><div>A cross-sectional study was conducted on 120 patients. Lateral cephalograms and hand-wrist radiographs were analysed using Digimizer software. Agreement analysis was performed using Bland-Altman plots, while inter- and intra-rater reliability was assessed using Intraclass Correlation Coefficients (ICC). Lin's Concordance Correlation Coefficient (CCC) and the Bradley-Blackwood test were used for comparative assessment. ROC curve analysis determined diagnostic accuracy, and Pearson correlation coefficients and regression analysis assessed the relationship between QCVMI and mandibular growth increments.</div></div><div><h3>Results</h3><div>QCVMI demonstrated excellent agreement with Fishman's SMI, very good agreement with the Modified MP3, and good agreement with Hassal and Farman's CVMI and Baccetti's CVMI. High intra- and inter-rater reliability confirmed its reproducibility. ROC analysis showed QCVMI had the highest diagnostic accuracy compared to Fishman's SMI. A strong correlation was observed between QCVMI and mandibular growth increments, indicating its predictive efficacy for growth spurts.</div></div><div><h3>Conclusion</h3><div>QCVMI is a valid and reliable skeletal maturity assessment tool, demonstrating strong agreement with established indicators while enhancing objectivity and reproducibility. It effectively predicts mandibular growth spurts, making it valuable for orthodontic treatment planning.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101035"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144351534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of propolis, fluoride and probiotic mouthwashes on streptococcus mutans and oxidative stress in fixed orthodontic patients: A triple-blind, randomized controlled trial with 9-month follow-up 蜂胶、氟化物和益生菌漱口水对固定正畸患者变形链球菌和氧化应激的比较评价:一项随访9个月的三盲、随机对照试验
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-05-15 DOI: 10.1016/j.ortho.2025.101017
Praveen Chandrashekaraiah , Reshma Benzigar , Ramya Shivananjan , Selva Arockiam , Nithya Nandhini , Sangeetha Ulaganathan
{"title":"Comparative evaluation of propolis, fluoride and probiotic mouthwashes on streptococcus mutans and oxidative stress in fixed orthodontic patients: A triple-blind, randomized controlled trial with 9-month follow-up","authors":"Praveen Chandrashekaraiah ,&nbsp;Reshma Benzigar ,&nbsp;Ramya Shivananjan ,&nbsp;Selva Arockiam ,&nbsp;Nithya Nandhini ,&nbsp;Sangeetha Ulaganathan","doi":"10.1016/j.ortho.2025.101017","DOIUrl":"10.1016/j.ortho.2025.101017","url":null,"abstract":"<div><h3>Background</h3><div>Fixed orthodontic appliances increase the risk of enamel demineralization due to plaque accumulation. While fluoride mouthwash is well established, propolis and probiotic formulations are emerging alternatives with antimicrobial and anti-inflammatory potential.</div></div><div><h3>Aim</h3><div>To compare the effects of propolis, fluoride, and probiotic mouthwashes on <em>Streptococcus mutans</em> levels and oxidative stress (8-OHdG) in patients undergoing fixed orthodontic treatment.</div></div><div><h3>Materials and methods</h3><div>Of 120 patients screened (March 2022–February 2023), 90 were randomized into three groups (<em>n</em> <!-->=<!--> <!-->30 each): propolis, fluoride, and probiotic. <em>S.</em> <em>mutans</em> was quantified at baseline, 30 days, 3-, 6- and 9-months using Q-PCR. Salivary 8-OHdG was measured using ELISA. Dietary and oral hygiene behaviours were monitored through a mobile app, interviews and 24-hour dietary recalls.</div></div><div><h3>Results</h3><div><em>S.</em> <em>mutans</em> levels (log10 CFU/mL) significantly decreased (<em>P</em> <!-->&lt;<!--> <!-->0.001) at 9 months: from 4.35<!--> <!-->±<!--> <!-->0.45 to 0.89<!--> <!-->±<!--> <!-->0.06 (propolis), 4.42<!--> <!-->±<!--> <!-->0.49 to 2.74<!--> <!-->±<!--> <!-->0.18 (fluoride), and 4.38<!--> <!-->±<!--> <!-->0.50 to 3.21<!--> <!-->±<!--> <!-->0.06 (probiotic). Ct values increased accordingly, confirming reduced bacterial load. Salivary 8-OHdG (ng/mL) declined significantly (<em>P</em> <!-->&lt;<!--> <!-->0.001): 3.8<!--> <!-->±<!--> <!-->0.8 to 0.32<!--> <!-->±<!--> <!-->0.14 (propolis), 3.9<!--> <!-->±<!--> <!-->0.7 to 1.32<!--> <!-->±<!--> <!-->0.18 (fluoride), 3.8<!--> <!-->±<!--> <!-->0.6 to 2.42<!--> <!-->±<!--> <!-->0.22 (probiotic).</div></div><div><h3>Conclusion</h3><div>Propolis mouthwash produced the greatest reductions likely due to the combined effect of standardized extract and essential oils added for taste. Fluoride remained effective for microbial control, while probiotics offered modest benefit. High compliance strengthened these findings. Further studies should isolate active components and assess long-term effects in broader settings.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101017"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retention of pubertal cervical vertebral maturation stages in adults (20–45 years). Limitations of cervical vertebral maturation in growth status assessment: A cross-sectional study 保留成人(20-45岁)的青春期颈椎成熟阶段。颈椎成熟在生长状态评估中的局限性:一项横断面研究
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-05-20 DOI: 10.1016/j.ortho.2025.101027
Erum Amin , Sajid Ali , Rana Faiza , Marium Jamil , Qasim Khalid , Umar Hussain , Nikoloas Pandis
{"title":"Retention of pubertal cervical vertebral maturation stages in adults (20–45 years). Limitations of cervical vertebral maturation in growth status assessment: A cross-sectional study","authors":"Erum Amin ,&nbsp;Sajid Ali ,&nbsp;Rana Faiza ,&nbsp;Marium Jamil ,&nbsp;Qasim Khalid ,&nbsp;Umar Hussain ,&nbsp;Nikoloas Pandis","doi":"10.1016/j.ortho.2025.101027","DOIUrl":"10.1016/j.ortho.2025.101027","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the retention of pubertal cervical vertebral maturation (CVM) stages in adults and assess the association of vertical and sagittal skeletal patterns on this retention.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted on pre-treatment records of 489 adult participants (286 females and 203 males) aged 20 to 45. Inclusion criteria were clear lateral cephalometric radiographs and the absence of systemic conditions or previous orthodontic treatment affecting skeletal maturation. Skeletal sagittal and vertical patterns were recorded. Associations between CVM stages and sex, skeletal sagittal, and vertical pattern were analysed using inverse probability weighting (IPW)-adjusted ordinal logistic regression for age.</div></div><div><h3>Results</h3><div>The mean age was 26.09 (4.84) years. CS4 was retained in 8.59% and CS5 in 19.63%. Age varied significantly across stages (<em>P</em> <!-->=<!--> <!-->0.01) with participants in CS5 being older. A significant sex difference was observed (<em>P</em> <!-->=<!--> <!-->0.01) with more males in CS6 and more females in CS5. Skeletal class was significantly associated with CVM stages (<em>P</em> <!-->=<!--> <!-->0.001) with Class III subjects more likely to exhibit less mature CVM stages. However, the vertical pattern was not significantly associated with CVM stages (<em>P</em> <!-->=<!--> <!-->0.63). Ordinal logistic regression showed that Class III participants had a significantly lower likelihood of attaining CS6 (OR<!--> <!-->=<!--> <!-->0.30, 95% CI: 0.16–0.54, <em>P</em> <!-->&lt;<!--> <!-->0.001) while vertical pattern and sex were not significant predictors after age adjustment.</div></div><div><h3>Conclusion</h3><div>A higher proportion of adults did not attain the post-pubertal CVM stage, especially in Class III malocclusion, raising concerns about CVM's reliability. Multiple growth indicators in combination with physical appearance should be used for skeletal maturation assessment.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101027"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orthodontic tooth movement in alveolar bone augmentation area: A systematic review of animal studies 牙槽骨增强区正畸牙齿移动:动物研究的系统回顾
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-05-30 DOI: 10.1016/j.ortho.2025.101031
Si-Min Wang , Jia He , Wen-Yu Chuo , Lin Wu
{"title":"Orthodontic tooth movement in alveolar bone augmentation area: A systematic review of animal studies","authors":"Si-Min Wang ,&nbsp;Jia He ,&nbsp;Wen-Yu Chuo ,&nbsp;Lin Wu","doi":"10.1016/j.ortho.2025.101031","DOIUrl":"10.1016/j.ortho.2025.101031","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review aims to evaluate the optimal timing for orthodontic tooth movement (OTM) following alveolar bone augmentation, the types of alveolar bone graft materials used, and the associated animal models.</div></div><div><h3>Material and methods</h3><div>A systematic search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and grey literature databases, covering studies from January 1st, 2014, to November 30th, 2024. Studies addressing combined alveolar bone augmentation and OTM were selected, with outcomes such as OTM rate, bone formation, and root resorption assessed through imaging or histological methods. A control group was required in animal experiments. There were no language restrictions. Article screening and data extraction were performed independently by two reviewers. The SYRCLE risk-of-bias tool was used to evaluate study quality.</div></div><div><h3>Results</h3><div>Fourteen animal studies were included, with subjects comprising dogs, rats, mice, and rabbits. The graft materials predominantly consisted of allografts, xenografts, and alloplasts. The applied orthodontic force ranged from 10<!--> <!-->g to 150<!--> <!-->g, with OTM performed at intervals of 0 to 3<!--> <!-->months. Methodologies included model measurements, imaging, and histological analyses.</div></div><div><h3>Conclusion</h3><div>OTM can be performed during the bone weaving stage, however, the use of alveolar bone grafts generally impedes OTM. Alloplasts are associated with less root resorption. Animal models should closely mirror human characteristics, considering factors such as sex, age, defect location and size, type of tooth movement, and force magnitude. Overall, the quality of the studies is suboptimal, and further well-designed animal and human studies are needed.</div><div>This systematic review has been registered with PROSPERO (CRD42025642198).</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101031"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four-year follow-up comparison of three pre-surgical infant orthopedic methods on mandibular arch morphology in unilateral cleft lip and palate: A retrospective study 三种术前矫形方法对单侧唇腭裂婴幼儿下颌弓形态的影响:回顾性研究
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-05-02 DOI: 10.1016/j.ortho.2025.101013
Puneet Batra , Ajay Kubavat , Dhruv Ahuja
{"title":"Four-year follow-up comparison of three pre-surgical infant orthopedic methods on mandibular arch morphology in unilateral cleft lip and palate: A retrospective study","authors":"Puneet Batra ,&nbsp;Ajay Kubavat ,&nbsp;Dhruv Ahuja","doi":"10.1016/j.ortho.2025.101013","DOIUrl":"10.1016/j.ortho.2025.101013","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of presurgical infant orthopedics (PSIO) on mandibular dimensions and inter arch relation at 4 years follow-up comparing three different PSIO methods (modified Grayson's technique, Dynacleft nasal elevator, OrthoAligner NAM with Dynacleft nasal elevator) to no-nasoalveolar molding (NAM) in infants with unilateral cleft lip and palate (UCLP).</div></div><div><h3>Methodology</h3><div>A retrospective cohort study was conducted on non-syndromic UCLP patients treated with either PSIO or no-PSIO between 2018 and 2019, with a 4-year follow-up. The cohort was divided into four groups of 13 patients each: group 1 received PSIO with the modified Grayson's technique, group 2 received PSIO with the Dynacleft nasal elevator, group 3 was treated with OrthoAligner NAM combined with Dynacleft nasal elevator, and group 4 received no PSIO. Mandibular transverse width and interarch relation were assessed using the Modified Huddart and Bodenham (MBH) index. Descriptive statistics, ANOVA, and the Chi-square test were used to compare mandibular dimensions and interarch relationships across the groups.</div></div><div><h3>Results</h3><div>A total of 52 patients (29 boys, 23 girls) were included in the study. Mandibular arch dimensions showed no significant differences across groups (<em>P</em> <!-->&gt;<!--> <!-->0.05), with inter-canine (Grayson: 26.31<!--> <!-->mm, Dynacleft: 27.42<!--> <!-->mm, OrthoAligner: 28.27<!--> <!-->mm, no-NAM: 27.15<!--> <!-->mm), anterior arch (33.36–33.50<!--> <!-->mm), inter-molar (36.50–36.77<!--> <!-->mm), and posterior arch widths (42.36–42.61<!--> <!-->mm). Crossbite and interarch occlusal relationships showed comparable distribution among all groups, with no significant variations (<em>P</em> <!-->&gt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>The study found no significant differences in mandibular transverse arch dimensions or inter arch occlusal relationships among different PSIO modalities, indicating that the choice of PSIO modality did not substantially impact arch width or occlusion interarch relation.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101013"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mandibular molar protraction using round Australian wire and miniscrew anchorage with modified corticision in an adult with first molar loss: A case report 使用圆形澳洲金属丝和微型支抗结合改良皮质修复第一磨牙缺失的成人下颌磨牙:1例报告
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-06-12 DOI: 10.1016/j.ortho.2025.101032
Qingjuan Shi , Qinglian Zhang , Hong Zheng, Yi Wang
{"title":"Mandibular molar protraction using round Australian wire and miniscrew anchorage with modified corticision in an adult with first molar loss: A case report","authors":"Qingjuan Shi ,&nbsp;Qinglian Zhang ,&nbsp;Hong Zheng,&nbsp;Yi Wang","doi":"10.1016/j.ortho.2025.101032","DOIUrl":"10.1016/j.ortho.2025.101032","url":null,"abstract":"<div><div>A 27-year-old adult female presented with the chief complaint of bilateral mandibular first molar absence and strongly preferred to use wisdom teeth rather than prosthetic replacements. Treatment was carried out using a round Australian wire fixed orthodontic technique. The second and third molars were mesially moved with a bilateral terminal helical loop combined with curved tip-back bends in Australian wire. Miniscrew anchorage was placed in the mandibular premolar area to assist in the protraction of the second and third molars. Additionally, a modified cortical drilling technique was employed to accelerate tooth movement. A neutral molar relationship was established while maintaining the patient's facial profile.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101032"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stabilization splint combined with multiloop edgewise archwire for treatment of skeletal Class III open bite malocclusion with temporomandibular disorders: A case report with a 6-year follow-up 稳定夹板联合多环侧弓丝治疗骨性III类开咬错伴颞下颌紊乱:6年随访1例
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-07-11 DOI: 10.1016/j.ortho.2025.101038
Chengjing Xu , Dongsheng Song , Jingzheng Yi , Shaotai Wang , Yue Sun , Yu Chen , Huan Jiang , Min Hu
{"title":"Stabilization splint combined with multiloop edgewise archwire for treatment of skeletal Class III open bite malocclusion with temporomandibular disorders: A case report with a 6-year follow-up","authors":"Chengjing Xu ,&nbsp;Dongsheng Song ,&nbsp;Jingzheng Yi ,&nbsp;Shaotai Wang ,&nbsp;Yue Sun ,&nbsp;Yu Chen ,&nbsp;Huan Jiang ,&nbsp;Min Hu","doi":"10.1016/j.ortho.2025.101038","DOIUrl":"10.1016/j.ortho.2025.101038","url":null,"abstract":"<div><div>This case report illustrates the treatment of a 17-year-old male patient characterized by an anterior open bite, skeletal Class III malocclusion, mandibular deviation, and severe temporomandibular joint symptoms. Given the complexity of the patient's condition, a strategic treatment approach was employed. Stabilization splint was used initially for a duration of 9 months to alleviate TMJ symptoms and repositioning the condyle. Through model analysis on the articulator pretreatment, we found a worsening of his V-shape open bite due to occlusal interference in molars. The patient refused the surgery, so the multiloop edgewise archwire treatment was provided to upright the molars and eliminate occlusal interference. After 26 months of treatment, a functional and aesthetic occlusion, and a relatively well-balanced facial profile were established. After a 6 years post-treatment follow-up, the results of this case have demonstrated long-term stability.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101038"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biocompatibility of direct printed clear aligners: A systematic review of in vitro studies 直接印刷透明对准器的生物相容性:体外研究的系统回顾
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-05-28 DOI: 10.1016/j.ortho.2025.101028
Claire-Adeline Dantagnan , Sylvie Babajko , Ali Nassif , André Porporatti , Jean-Pierre Attal , Elisabeth Dursun , Jean-François Nguyen , Julia Bosco
{"title":"Biocompatibility of direct printed clear aligners: A systematic review of in vitro studies","authors":"Claire-Adeline Dantagnan ,&nbsp;Sylvie Babajko ,&nbsp;Ali Nassif ,&nbsp;André Porporatti ,&nbsp;Jean-Pierre Attal ,&nbsp;Elisabeth Dursun ,&nbsp;Jean-François Nguyen ,&nbsp;Julia Bosco","doi":"10.1016/j.ortho.2025.101028","DOIUrl":"10.1016/j.ortho.2025.101028","url":null,"abstract":"<div><h3>Objective</h3><div>Three-dimensional printing of aligners has gained in popularity as an alternative to thermoformed aligners. Only few studies evaluate the biological effects of these new materials. This systematic review aims to investigate the residual monomers leaching from direct printed clear aligners and their possible toxic effects.</div></div><div><h3>Search methods</h3><div>A search was conducted on several databases in accordance with PRISMA guidelines. In vitro, in vivo and clinical studies in English were included. The risk of bias of in vitro studies was assessed by QUIN Tool, for in vivo studies with the SYRCLE tool and for clinical studies with the RoB-2 tool.</div></div><div><h3>Results</h3><div>In all, 524 articles were initially identified and nine were included in the qualitative analysis. All the included studies were in vitro research with a moderate risk of bias. Seven studies were focused on cell toxicity and two on monomer release. Although mixed results are described, 3D printed aligners could present a slight cytotoxicity. Compared with thermoformed aligners, direct printed aligners had higher cytotoxicity levels. No estrogenic effects and no trace of Bisphenol A (BPA) release were detected from printed aligners when investigated but a leaching of Urethane Dimethacrylate (UDMA) have been reported in all studies. Post-curing was an important step to obtain satisfactory biocompatibility of printed aligners.</div></div><div><h3>Conclusions</h3><div>There is no consensus on the absence of cytotoxic effects of direct printed aligners but the release of some potentially active monomers including UDMA requires further investigations on long-term effects on patients’ health.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101028"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment for adult female temporomandibular joint osteoarthritis-related severe retrognathia and anterior open bite using premolar extraction and customized lingual orthodontic appliance with vertical control for significant compensation: A case report 采用前磨牙拔牙和定制化舌正畸矫治器垂直控制显著补偿治疗成年女性颞下颌关节骨关节炎相关严重颌后突和前开咬1例
IF 1.8
International Orthodontics Pub Date : 2025-12-01 Epub Date: 2025-05-05 DOI: 10.1016/j.ortho.2025.101016
Qiang Zhou , Yue Zhang , Jin Ke , Yingjie Li
{"title":"Treatment for adult female temporomandibular joint osteoarthritis-related severe retrognathia and anterior open bite using premolar extraction and customized lingual orthodontic appliance with vertical control for significant compensation: A case report","authors":"Qiang Zhou ,&nbsp;Yue Zhang ,&nbsp;Jin Ke ,&nbsp;Yingjie Li","doi":"10.1016/j.ortho.2025.101016","DOIUrl":"10.1016/j.ortho.2025.101016","url":null,"abstract":"<div><div>This case report presents a satisfactory lingual appliance orthodontic treatment in a 21-year-old woman diagnosed with Angle Class I anterior open bite (AOB) malocclusion and severe high-angle skeletal Class II retrognathia, which was attributed to bilateral temporomandibular osteoarthritis (TMJOA) and disc perforation. Because of the absence of joint symptoms and presence of bilateral condyles in a stable state, no conservative or surgical treatments were performed for this patient. Four first premolars and four third molars were extracted before bonding of the customized lingual brackets. No miniscrews were used during the orthodontic process. Space closure was performed using the double cable method. Finally, the maxillary molars were found to have intruded and moved mesially during the space-closing process, which resulted in a 2.9° decrease in the mandibular plane angle. Owing to the counter-clockwise rotation of the mandible, the chin moved anteriorly and superiorly. In addition, the anterior teeth were largely retracted because of the advantage of this customized lingual appliance, resulting in significant changes in the nasolabial angle and chin contour. Two-year follow-up examinations further confirmed that no obvious relapse in occlusion and no further condylar resorption, even though bilateral anterior disc displacement without reduction was revealed. In conclusion, a patient with TMJOA-related severe chin retrognathia and AOB treated with a lingual appliance showed satisfactory improvement in facial profile and occlusion.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101016"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between nasal septum deviation and maxillary dimensions in an adult South Indian population: A retrospective observational cone-beam computed tomography study 南印度成年人鼻中隔偏曲与上颌尺寸的关系:一项回顾性观察锥束计算机断层扫描研究
IF 1.8
International Orthodontics Pub Date : 2025-09-01 Epub Date: 2025-04-15 DOI: 10.1016/j.ortho.2025.101008
Shifo Savio, Shweta Nagesh
{"title":"Association between nasal septum deviation and maxillary dimensions in an adult South Indian population: A retrospective observational cone-beam computed tomography study","authors":"Shifo Savio,&nbsp;Shweta Nagesh","doi":"10.1016/j.ortho.2025.101008","DOIUrl":"10.1016/j.ortho.2025.101008","url":null,"abstract":"<div><h3>Introduction</h3><div>Nasal septal deviation (NSD) is a common anatomical variation influencing nasal function and maxillary development. This study aims to evaluate the correlation between NSD and maxillary dimensions in a South Indian population using cone-beam computed tomography (CBCT). Additionally, it examines NSD severity and its effect on maxillary dimensions and malocclusion.</div></div><div><h3>Methods</h3><div>The retrospective cross-sectional study analysed CBCT data from patients with NSD aged above 18 years and of South Indian descent, collected between 2022 and 2024, who satisfied the inclusion and exclusion criteria. NSD severity was classified based on the Septal Deviation Angle (SDA) as mild (0–9°), moderate (10–15°), and severe (&gt; 15°). Maxillary parameters such as: palatal width (MPW), length (ML), palatal arch depth (PAD), intermolar width (MIMW), interpremolar width (MPMW) were measured. The association between NSD and maxillary parameters was analysed using the Pearson correlation coefficient. The analysis of variance (ANOVA) was employed to examine the transverse maxillary parameters among three groups with different severity levels.</div></div><div><h3>Results</h3><div>A total of 140 CBCTs scans were analysed based on the inclusion and exclusion criteria. A weak positive correlation was observed between SDA and PAD (<em>P</em> <!-->=<!--> <!-->0.038), DSW-PAD (<em>P</em> <!-->=<!--> <!-->0.040) and DSW-MPW (<em>P</em> <!-->=<!--> <!-->0.030). MPW was significantly reduced in moderate NSD patients compared to mild NSD (<em>P</em> <!-->=<!--> <!-->0.048). Class II malocclusion was most prevalent across all NSD severities (mild: 20%, moderate: 25%, severe: 15%).</div></div><div><h3>Conclusion</h3><div>The nasal septal deviation is associated with increased palatal depth and reduced palatal width, particularly in moderate NSD cases.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 3","pages":"Article 101008"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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