Journal of Osteoporosis最新文献_第9页

Osteoporosis in healthy South Indian males and the influence of life style factors and vitamin d status on bone mineral density. 南印度健康男性骨质疏松症及生活方式因素和维生素d状况对骨密度的影响

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-11-11 DOI: 10.1155/2014/723238

Sahana Shetty, Nitin Kapoor, Dukhabandhu Naik, Hesarghatta Shyamasunder Asha, Suresh Prabu, Nihal Thomas, Mandalam Subramaniam Seshadri, Thomas Vizhalil Paul

{"title":"Osteoporosis in healthy South Indian males and the influence of life style factors and vitamin d status on bone mineral density.","authors":"Sahana Shetty, Nitin Kapoor, Dukhabandhu Naik, Hesarghatta Shyamasunder Asha, Suresh Prabu, Nihal Thomas, Mandalam Subramaniam Seshadri, Thomas Vizhalil Paul","doi":"10.1155/2014/723238","DOIUrl":"https://doi.org/10.1155/2014/723238","url":null,"abstract":"Objective. To study the prevalence of osteoporosis and vitamin D deficiency in healthy men and to explore the influence of various life style factors on bone mineral density (BMD) and also to look at number of subjects warranting treatment. Methods. Ambulatory south Indian men aged above 50 were recruited by cluster random sampling. The physical activity, risk factors in the FRAX tool, BMD, vitamin D, and PTH were assessed. The number of people needing treatment was calculated, which included subjects with osteoporosis and osteopenia with 10-year probability of major osteoporotic fracture >20 percent and hip fracture >3 percent in FRAX India. Results. A total of 252 men with a mean age of 58 years were studied. The prevalence of osteoporosis and osteopenia at any one site was 20% (50/252) and 58%, respectively. Vitamin D deficiency (<20 ng/dL) was seen in 53%. On multiple logistic regression, BMI (OR 0.3; P value = 0.04) and physical activity (OR 0.4; P value < 0.001) had protective effect on BMD. Twenty-five percent warranted treatment. Conclusions. A significantly large proportion of south Indian men had osteoporosis and vitamin D deficiency. Further interventional studies are needed to look at reduction in end points like fractures in these subjects. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"723238"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/723238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32882673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

Bone mineral density in gravida: effect of pregnancies and breast-feeding in women of differing ages and parity. 孕期骨矿物质密度:不同年龄和胎次妇女怀孕和母乳喂养的影响。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-11-20 DOI: 10.1155/2014/897182

Ehud Lebel, Yuri Mishukov, Liana Babchenko, Arnon Samueloff, Ari Zimran, Deborah Elstein

{"title":"Bone mineral density in gravida: effect of pregnancies and breast-feeding in women of differing ages and parity.","authors":"Ehud Lebel, Yuri Mishukov, Liana Babchenko, Arnon Samueloff, Ari Zimran, Deborah Elstein","doi":"10.1155/2014/897182","DOIUrl":"https://doi.org/10.1155/2014/897182","url":null,"abstract":"Changes of bone during pregnancy and during lactation evaluated by bone mineral density (BMD) may have implications for risk of osteoporosis and fractures. We studied BMD in women of differing ages, parity, and lactation histories immediately postpartum for BMD, T-scores, and Z-scores. Institutional Review Board approval was received. All women while still in hospital postpartum were asked to participate. BMD was performed by dual-energy X-ray absorptiometry (DXA) machine at femoral neck (FN) and lumbar spine (LS) by a single technician. Of 132 participants, 73 (55.3%) were ≤30 years; 27 (20.5%) were primiparous; 36 (27.3%) were grand multiparous; 35 (26.5%) never breast fed. Mean FN T-scores and Z-scores were higher than respective mean LS scores, but all means were within the normal limits. Mean LS T-scores and Z-scores were highest in the grand multiparas. There were only 2 (1.5%) outliers with low Z-scores. We conclude that, in a large cohort of Israeli women with BMD parameters assessed by DXA within two days postpartum, mean T-scores and Z-scores at both the LS and FN were within normal limits regardless of age (20-46 years), parity (1-13 viable births), and history of either no or prolonged months of lactation (up to 11.25 years). ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"897182"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/897182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32906573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D 2 (300,000 IU). 维生素d2负荷剂量(300,000 IU)后Dickkopf-1 (DKK1)和Sclerostin的变化

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-11-24 DOI: 10.1155/2014/682763

A Sankaralingam, R Roplekar, C Turner, R N Dalton, G Hampson

{"title":"Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D 2 (300,000 IU).","authors":"A Sankaralingam, R Roplekar, C Turner, R N Dalton, G Hampson","doi":"10.1155/2014/682763","DOIUrl":"https://doi.org/10.1155/2014/682763","url":null,"abstract":"Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain. Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2 vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin and DKK1. Subjects and Methods. We measured serum sclerostin and DKK1 in 34 patients (21 F, 13 M) aged mean (SD) 61.3 (15.6) years with vitamin D deficiency/insufficiency treated with a loading dose of vitamin D2 (300,000 IU) intramuscularly. Blood samples were taken at baseline and serially up to 3 months. Results. Serum 1,25 (OH)2 vitamin D increased markedly at 3 months (mean (SD) baseline 116 (63), 3 months : 229 (142) pmol/L, P < 0.001). There was a significant correlation between sclerostin and DKK1 at baseline (r = 0.504, P = 0.002) and at 3 months (r = 0.42, P = 0.013). A significant inverse correlation was observed between sclerostin and eGFR at 3 months (r = -0.494, P = 0.007). Sclerostin increased significantly at 3 months (P = 0.033). In a multilinear regression analysis with % change in sclerostin and DKK1 as dependent variable, a positive significant association was observed with % change in 1,25 (OH)2 vitamin D (P = 0.038), independent of changes in PTH and following correction for confounders such as age, gender, BMI, BMD and eGFR. Conclusions. Supraphysiological concentration in 1,25 (OH)2 vitamin D achieved following a loading dose of vitamin D increases sclerostin and may inhibit Wnt signalling. This may have detrimental effects on bone. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"682763"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/682763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32943171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Osteoporosis health beliefs of women with increased risk of the female athlete triad. 女性骨质疏松症健康信念与女性运动员三位一体风险增加。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-03-09 DOI: 10.1155/2014/676304

Vu H Nguyen, Ze Wang, Stephanie M Okamura

{"title":"Osteoporosis health beliefs of women with increased risk of the female athlete triad.","authors":"Vu H Nguyen, Ze Wang, Stephanie M Okamura","doi":"10.1155/2014/676304","DOIUrl":"https://doi.org/10.1155/2014/676304","url":null,"abstract":"Women with increased risk of the female athlete triad (Triad) are more susceptible to osteoporosis compared to other women. The study included 65 women with increased risk of the Triad who had their osteoporosis health beliefs measured to assess their concern for the disease. Participants were female collegiate cross-country runners at different levels of competition, including National Association of Intercollegiate Athletics (NAIA) and National Collegiate Athletic Association (NCAA) Divisions III, II, and I. Although these participants have an increased risk of the Triad and are more susceptible to osteoporosis, on a scale of 1 to 5, results showed that they had low to moderate perceived susceptibility to osteoporosis with a mean score as high as 2.81 and moderate perceived severity of osteoporosis with a mean score as high as 3.38. A statistically significant difference in perceived susceptibility to osteoporosis was found between female collegiate cross-country runners in the NAIA and those in the NCAA DIII. Reasons that could explain relatively low levels of concern for osteoporosis in female collegiate cross-country runners and reasons for significant differences in perceived susceptibility to osteoporosis are given, and recommendations for health education and intervention to help care for this population are provided. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"676304"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/676304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32265246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates. 加拿大品牌和通用双膦酸盐体外崩解时间的差异。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-10-02 DOI: 10.1155/2014/420451

Wojciech P Olszynski, Jonathan D Adachi, K Shawn Davison

{"title":"Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates.","authors":"Wojciech P Olszynski, Jonathan D Adachi, K Shawn Davison","doi":"10.1155/2014/420451","DOIUrl":"https://doi.org/10.1155/2014/420451","url":null,"abstract":"The objective of this study was to compare the disintegration times among Canadian-marketed brand (alendronate 70 mg, alendronate 70 mg plus vitamin D 5600 IU, and risedronate 35 mg) and generic (Novo-alendronate 70 mg and Apo-alendronate 70 mg) once-weekly dosed bisphosphonates. All disintegration tests were performed with a Vanderkamp Disintegration Tester. Disintegration was deemed to have occurred when no residue of the tablet, except fragments of insoluble coating or capsule shell, was visible. Eighteen to 20 samples were tested for each bisphosphonate group. The mean (±standard deviation) disintegration times were significantly (P < 0.05) faster for Apo-alendronate (26 ± 5.6 seconds) and Novo-alendronate (13 ± 1.1 seconds) as compared to brand alendronate (147 ± 50.5 seconds), brand alendronate plus vitamin D (378 ± 60.5 seconds), or brand risedronate (101 ± 20.6 seconds). The significantly faster disintegration of the generic tablets as compared to the brand bisphosphonates may have concerning safety and effectiveness implications for patients administering these therapies. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"420451"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/420451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Treatment for Osteoporosis among Women in Japan: Associations with Patient Characteristics and Patient-Reported Outcomes in the 2008-2011 Japan National Health and Wellness Surveys. 日本女性骨质疏松症的治疗:2008-2011年日本国家健康调查中患者特征和患者报告结果的关联

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-12-23 DOI: 10.1155/2014/909153

Masayo Sato, Jeffrey Vietri, Jennifer A Flynn, Saeko Fujiwara

{"title":"Treatment for Osteoporosis among Women in Japan: Associations with Patient Characteristics and Patient-Reported Outcomes in the 2008-2011 Japan National Health and Wellness Surveys.","authors":"Masayo Sato, Jeffrey Vietri, Jennifer A Flynn, Saeko Fujiwara","doi":"10.1155/2014/909153","DOIUrl":"https://doi.org/10.1155/2014/909153","url":null,"abstract":"This study was conducted to identify characteristics associated with treatment for osteoporosis among women aged 50 years and older in Japan and to explore differences among patients according to treatment regimen. Data were provided by a large annual survey representative of Japanese aged 18 and older; all measures were by self-report. Women aged 50 and older who reported diagnosed osteoporosis (N = 900) were compared based on current treatment status using bivariate statistics and logistic regression. Approximately 1 in 3 women in this study reporting diagnosed osteoporosis were currently untreated. Factors associated with current treatment for osteoporosis included having ≥1 physician visit in the prior 6 months (OR = 5.4, P < 0.001), self-rated moderate or severe osteoporosis (OR = 2.8, P < 0.001), completion of menopause (OR = 1.6, P < 0.05), and family history of osteoporosis (OR = 1.5, P < 0.05), while longer duration of osteoporosis diagnosis (OR = 0.9, P < 0.05) and arthritis (OR = 0.7, P < 0.05) were associated with lower odds of treatment. These findings suggest that diagnosed patients are not being actively managed in the longer term, and efforts need to be made to ensure that patients stay engaged with their healthcare providers. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"909153"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/909153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32975423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury? 脊髓损伤患者的脂质谱与骨密度和骨形成有关吗?

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-08-21 DOI: 10.1155/2014/695014

Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi

{"title":"Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury?","authors":"Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi","doi":"10.1155/2014/695014","DOIUrl":"https://doi.org/10.1155/2014/695014","url":null,"abstract":"Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI. Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age. Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004, r = 0.33). HDL was negatively correlated with osteocalcin (P: 0.017, r = -0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD. Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"695014"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/695014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Comorbidity and healthcare expenditure in women with osteoporosis living in the basque country (Spain). 巴斯克地区骨质疏松症妇女的合并症和保健支出(西班牙)。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-10-01 DOI: 10.1155/2014/205954

Roberto Nuño-Solinis, Carolina Rodríguez-Pereira, Edurne Alonso-Morán, Juan F Orueta

{"title":"Comorbidity and healthcare expenditure in women with osteoporosis living in the basque country (Spain).","authors":"Roberto Nuño-Solinis, Carolina Rodríguez-Pereira, Edurne Alonso-Morán, Juan F Orueta","doi":"10.1155/2014/205954","DOIUrl":"https://doi.org/10.1155/2014/205954","url":null,"abstract":"Objectives. This study aimed to establish the prevalence of multimorbidity in women diagnosed with osteoporosis and to report it by deprivation index. The characteristics of comorbidity in osteoporotic women are compared to the general female chronic population, and the impact on healthcare expenditure of this population group is estimated. Methods. A cross-sectional analysis that included all Basque Country women aged 45 years and over (N = 579,575) was performed. Sociodemographic, diagnostic, and healthcare cost data were extracted from electronic databases for a one-year period. Chronic conditions were identified from their diagnoses and prescriptions. The existence of two or more chronic diseases out of a list of 47 was defined as multimorbidity. Results. 9.12% of women presented osteoporosis and 85.04% of them were multimorbid. Although multimorbidity in osteoporosis increased with age and deprivation level, prevalence was higher in the better-off groups. Women with osteoporosis had greater risk of having other musculoskeletal disorders but less risk of having diabetes (RR = 0.65) than chronic patients without osteoporosis. People with poorer socioeconomic status had higher healthcare cost. Conclusions. Most women with osteoporosis have multimorbidity. The variety of conditions emphasises the complexity of clinical management in this group and the importance of maintaining a generalist and multidisciplinary approach to their clinical care. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"205954"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/205954","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Concern and risk perception: effects on osteoprotective behaviour. 关注和风险感知:对骨保护行为的影响。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-09-08 DOI: 10.1155/2014/142546

A L Barcenilla-Wong, J S Chen, L M March

{"title":"Concern and risk perception: effects on osteoprotective behaviour.","authors":"A L Barcenilla-Wong, J S Chen, L M March","doi":"10.1155/2014/142546","DOIUrl":"https://doi.org/10.1155/2014/142546","url":null,"abstract":"This study aimed to determine the effect that level of concern for osteoporosis, as well as self-perceived risk of osteoporosis and fracture, has on supplementation use, seeking medical advice, bone mineral density (BMD) testing, and antiosteoporosis medication (AOM) use. Study subjects were 1,095 female Australian participants of the Global Longitudinal study of Osteoporosis in Women (GLOW) untreated for osteoporosis at baseline. Study outcomes from self-administered questionnaires included calcium and vitamin D supplementation, self-reported seeking of medical advice regarding osteoporosis, BMD testing, and AOM use in the last 12 months at the late assessment. Logistic regression was used in the analysis. Concern significantly increased the likelihood of seeking medical advice and, however, had no significant impact on screening or treatment. Heightened self-perceived risks of osteoporosis and fracture both significantly increased the likelihood of seeking medical advice and BMD testing while elevated self-perceived risk of fracture increased AOM use. Supplementation use was not significantly associated with concern levels and risk perception. Concern and risk perceptions to osteoporosis and fracture were significantly associated with certain bone-protective behaviours. However, the disconnect between perceived osteoporosis risk and AOM use illustrates the need to emphasize the connection between osteoporosis and fracture in future education programs. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"142546"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/142546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32713708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A New Predictive Index for Osteoporosis in Men under 70 Years of Age: An Index to Identify Male Candidates for Osteoporosis Screening by Bone Mineral Density. 70 岁以下男性骨质疏松症的新预测指数：通过骨质密度确定男性骨质疏松症筛查对象的指数。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-03-03 DOI: 10.1155/2014/781897

Lee Oh Kim, Hyeon-Ju Kim, Mi Hee Kong

{"title":"A New Predictive Index for Osteoporosis in Men under 70 Years of Age: An Index to Identify Male Candidates for Osteoporosis Screening by Bone Mineral Density.","authors":"Lee Oh Kim, Hyeon-Ju Kim, Mi Hee Kong","doi":"10.1155/2014/781897","DOIUrl":"10.1155/2014/781897","url":null,"abstract":"Background. Bone mineral density (BMD) screening guidelines for osteoporosis in men seem to have remained unclear. We aimed to set up a predictive index for the osteoporosis(PIO) in men under 70 years of age and present the optimal cutoff value of it, so that clinicians might use it to identify male candidates who benefit from taking the BMD screening. Methods. Adult men under 70 years old who met certain criteria were included. With the determined significant predictors for osteoporosis, we created a new index that presumably best predicts the osteoporosis and compared the predictability of it to other variables. Lastly, the optimal cutoff value of the PIO was calculated. Results. A total of 359 men were included. Age, weight, and current smoking status turned out to be significant predictors for osteoporosis. The PIO was as follows: [age(years) + 10 (for current smoker)]/weight(kg). Compared to other variables, the PIO showed the greatest predictive performance with the optimal cutoff point being 0.87 at which sensitivity and specificity were 71.9% and 70.0%, respectively. Conclusion. A new predictive index appeared to predict the presence of osteoporosis fairly well and thus can be used with its cutoff point to identify men under 70 years of age who need BMD screening. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"781897"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32255129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0