Journal of Osteoporosis最新文献_第9页

Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D 2 (300,000 IU). 维生素d2负荷剂量(300,000 IU)后Dickkopf-1 (DKK1)和Sclerostin的变化

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-11-24 DOI: 10.1155/2014/682763

A Sankaralingam, R Roplekar, C Turner, R N Dalton, G Hampson

{"title":"Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D 2 (300,000 IU).","authors":"A Sankaralingam, R Roplekar, C Turner, R N Dalton, G Hampson","doi":"10.1155/2014/682763","DOIUrl":"https://doi.org/10.1155/2014/682763","url":null,"abstract":"Background. Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain. Aim. We hypothesize that supraphysiological concentrations of 1,25 (OH)2 vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin and DKK1. Subjects and Methods. We measured serum sclerostin and DKK1 in 34 patients (21 F, 13 M) aged mean (SD) 61.3 (15.6) years with vitamin D deficiency/insufficiency treated with a loading dose of vitamin D2 (300,000 IU) intramuscularly. Blood samples were taken at baseline and serially up to 3 months. Results. Serum 1,25 (OH)2 vitamin D increased markedly at 3 months (mean (SD) baseline 116 (63), 3 months : 229 (142) pmol/L, P < 0.001). There was a significant correlation between sclerostin and DKK1 at baseline (r = 0.504, P = 0.002) and at 3 months (r = 0.42, P = 0.013). A significant inverse correlation was observed between sclerostin and eGFR at 3 months (r = -0.494, P = 0.007). Sclerostin increased significantly at 3 months (P = 0.033). In a multilinear regression analysis with % change in sclerostin and DKK1 as dependent variable, a positive significant association was observed with % change in 1,25 (OH)2 vitamin D (P = 0.038), independent of changes in PTH and following correction for confounders such as age, gender, BMI, BMD and eGFR. Conclusions. Supraphysiological concentration in 1,25 (OH)2 vitamin D achieved following a loading dose of vitamin D increases sclerostin and may inhibit Wnt signalling. This may have detrimental effects on bone. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/682763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32943171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Incidence of fractures after cardiac and lung transplantation: a single center experience. 心肺移植术后骨折的发生率:单中心经验。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-04-22 DOI: 10.1155/2014/573041

Aileen Hariman, Charles Alex, Alain Heroux, Pauline Camacho

{"title":"Incidence of fractures after cardiac and lung transplantation: a single center experience.","authors":"Aileen Hariman, Charles Alex, Alain Heroux, Pauline Camacho","doi":"10.1155/2014/573041","DOIUrl":"https://doi.org/10.1155/2014/573041","url":null,"abstract":"Osteoporotic fractures are well-known complications of organ transplantation. Fracture rates up to 35% have been previously reported following heart and lung transplantations. Our institutional pretransplant protocols include DXA scans, vitamin D screening, and appropriate antiresorptive therapy. We aimed to assess the incidence of fragility fractures following cardiac or lung transplantation. In a retrospective study 210 electronic medical records of patients who underwent LT (110 men, 100 women) and 105 HT (88 men, 17 women) between 2005 and 2010 were analyzed. Both clinical and radiographic fractures were recorded. DXA scans were obtained immediately after transplant. 17 out of 210 LT patients (8.0%) had fractures after transplantation and 9 out of 105 HT patients (8.6%) had fractures. The median time to the first fracture was 12 months and the mean time was 18 months for both LT and HT. In the HT recipients, the median femoral neck T score was statistically lower in the fracture group versus the nonfracture group. Similar results were seen in the LT patients. Conclusion. Our findings demonstrate a much lower incidence of fractures in heart and lung transplant recipients in comparison with earlier reports. Comprehensive bone care and early initiation of antiresorptive therapy are possible contributors to these improved outcomes. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/573041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32369873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model. 芦笋甲醇提取物对去卵巢小鼠骨吸收的影响。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-06-05 DOI: 10.1155/2014/348189

Babita Balakrishnan, Shubhada Vivek Chiplunkar, Madhavi Manohar Indap

{"title":"Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model.","authors":"Babita Balakrishnan, Shubhada Vivek Chiplunkar, Madhavi Manohar Indap","doi":"10.1155/2014/348189","DOIUrl":"https://doi.org/10.1155/2014/348189","url":null,"abstract":"Marine molluscs are widely distributed throughout the world and many bioactive compounds exhibiting antiviral, antitumor, antileukemic, and antibacterial activity have been reported worldwide. The present study was designed to investigate the beneficial effect of methanol extract of Euchelus asper (EAME) on estrogen deficiency induced osteoporosis in ovariectomised mice model. Forty-two female Swiss albino mice were randomly assigned into Sham operated (Sham) group and six ovariectomised (OVX) subgroups such as OVX with vehicle (OVX); OVX with estradiol (2 mg/kg/day); OVX with EAME of graded doses (25, 50, 100, and 200 mg/kg/day). Bone turnover markers like serum alkaline phosphatase (ALP), serum acid phosphatase (ACP), serum calcium, and histological investigations of tibia and uterus were analysed. Metaphyseal DNA content of the femur bone was also studied. Antiosteoclastogenic activity of EAME was examined. Administration of EAME was able to reduce the increased bone turnover markers in the ovariectomised mice. Histomorphometric analysis revealed an increase in bone trabeculation and restoration of trabecular separation by EAME treatment. Metaphyseal DNA content of the femur of the OVX mice was increased by EAME administration. EAME also showed a potent antiosteoclastogenic behaviour. Thus, the present study reveals that EAME was able to successfully reduce the estrogen deficiency induced bone loss. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/348189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32481995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Whole body bone tissue and cardiovascular risk in rheumatoid arthritis. 类风湿关节炎的全身骨组织和心血管风险。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-04-08 DOI: 10.1155/2014/465987

Claudiu Popescu, Violeta Bojincă, Daniela Opriş, Ruxandra Ionescu

{"title":"Whole body bone tissue and cardiovascular risk in rheumatoid arthritis.","authors":"Claudiu Popescu, Violeta Bojincă, Daniela Opriş, Ruxandra Ionescu","doi":"10.1155/2014/465987","DOIUrl":"https://doi.org/10.1155/2014/465987","url":null,"abstract":"Introduction. Atherosclerosis and osteoporosis share an age-independent bidirectional correlation. Rheumatoid arthritis (RA) represents a risk factor for both conditions. Objectives. The study aims to evaluate the connection between the estimated cardiovascular risk (CVR) and the loss of bone tissue in RA patients. Methods. The study has a prospective cross-sectional design and it includes female in-patients with RA or without autoimmune diseases; bone tissue was measured using whole body dual X-ray absorptiometry (wbDXA); CVR was estimated using SCORE charts and PROCAM applications. Results. There were 75 RA women and 66 normal women of similar age. The wbDXA bone indices correlate significantly, negatively, and age-independently with the estimated CVR. The whole body bone percent (wbBP) was a significant predictor of estimated CVR, explaining 26% of SCORE variation along with low density lipoprotein (P < 0.001) and 49.7% of PROCAM variation along with glycemia and menopause duration (P < 0.001). Although obese patients had less bone relative to body composition (wbBP), in terms of quantity their bone content was significantly higher than that of nonobese patients. Conclusions. Female patients with RA and female patients with cardiovascular morbidity have a lower whole body bone percent. Obese female individuals have higher whole body bone mass than nonobese patients. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/465987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32325510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates. 加拿大品牌和通用双膦酸盐体外崩解时间的差异。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-10-02 DOI: 10.1155/2014/420451

Wojciech P Olszynski, Jonathan D Adachi, K Shawn Davison

{"title":"Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates.","authors":"Wojciech P Olszynski, Jonathan D Adachi, K Shawn Davison","doi":"10.1155/2014/420451","DOIUrl":"https://doi.org/10.1155/2014/420451","url":null,"abstract":"The objective of this study was to compare the disintegration times among Canadian-marketed brand (alendronate 70 mg, alendronate 70 mg plus vitamin D 5600 IU, and risedronate 35 mg) and generic (Novo-alendronate 70 mg and Apo-alendronate 70 mg) once-weekly dosed bisphosphonates. All disintegration tests were performed with a Vanderkamp Disintegration Tester. Disintegration was deemed to have occurred when no residue of the tablet, except fragments of insoluble coating or capsule shell, was visible. Eighteen to 20 samples were tested for each bisphosphonate group. The mean (±standard deviation) disintegration times were significantly (P < 0.05) faster for Apo-alendronate (26 ± 5.6 seconds) and Novo-alendronate (13 ± 1.1 seconds) as compared to brand alendronate (147 ± 50.5 seconds), brand alendronate plus vitamin D (378 ± 60.5 seconds), or brand risedronate (101 ± 20.6 seconds). The significantly faster disintegration of the generic tablets as compared to the brand bisphosphonates may have concerning safety and effectiveness implications for patients administering these therapies. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/420451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Treatment for Osteoporosis among Women in Japan: Associations with Patient Characteristics and Patient-Reported Outcomes in the 2008-2011 Japan National Health and Wellness Surveys. 日本女性骨质疏松症的治疗:2008-2011年日本国家健康调查中患者特征和患者报告结果的关联

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-12-23 DOI: 10.1155/2014/909153

Masayo Sato, Jeffrey Vietri, Jennifer A Flynn, Saeko Fujiwara

{"title":"Treatment for Osteoporosis among Women in Japan: Associations with Patient Characteristics and Patient-Reported Outcomes in the 2008-2011 Japan National Health and Wellness Surveys.","authors":"Masayo Sato, Jeffrey Vietri, Jennifer A Flynn, Saeko Fujiwara","doi":"10.1155/2014/909153","DOIUrl":"https://doi.org/10.1155/2014/909153","url":null,"abstract":"This study was conducted to identify characteristics associated with treatment for osteoporosis among women aged 50 years and older in Japan and to explore differences among patients according to treatment regimen. Data were provided by a large annual survey representative of Japanese aged 18 and older; all measures were by self-report. Women aged 50 and older who reported diagnosed osteoporosis (N = 900) were compared based on current treatment status using bivariate statistics and logistic regression. Approximately 1 in 3 women in this study reporting diagnosed osteoporosis were currently untreated. Factors associated with current treatment for osteoporosis included having ≥1 physician visit in the prior 6 months (OR = 5.4, P < 0.001), self-rated moderate or severe osteoporosis (OR = 2.8, P < 0.001), completion of menopause (OR = 1.6, P < 0.05), and family history of osteoporosis (OR = 1.5, P < 0.05), while longer duration of osteoporosis diagnosis (OR = 0.9, P < 0.05) and arthritis (OR = 0.7, P < 0.05) were associated with lower odds of treatment. These findings suggest that diagnosed patients are not being actively managed in the longer term, and efforts need to be made to ensure that patients stay engaged with their healthcare providers. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/909153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32975423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Osteoporosis health beliefs of women with increased risk of the female athlete triad. 女性骨质疏松症健康信念与女性运动员三位一体风险增加。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-03-09 DOI: 10.1155/2014/676304

Vu H Nguyen, Ze Wang, Stephanie M Okamura

{"title":"Osteoporosis health beliefs of women with increased risk of the female athlete triad.","authors":"Vu H Nguyen, Ze Wang, Stephanie M Okamura","doi":"10.1155/2014/676304","DOIUrl":"https://doi.org/10.1155/2014/676304","url":null,"abstract":"Women with increased risk of the female athlete triad (Triad) are more susceptible to osteoporosis compared to other women. The study included 65 women with increased risk of the Triad who had their osteoporosis health beliefs measured to assess their concern for the disease. Participants were female collegiate cross-country runners at different levels of competition, including National Association of Intercollegiate Athletics (NAIA) and National Collegiate Athletic Association (NCAA) Divisions III, II, and I. Although these participants have an increased risk of the Triad and are more susceptible to osteoporosis, on a scale of 1 to 5, results showed that they had low to moderate perceived susceptibility to osteoporosis with a mean score as high as 2.81 and moderate perceived severity of osteoporosis with a mean score as high as 3.38. A statistically significant difference in perceived susceptibility to osteoporosis was found between female collegiate cross-country runners in the NAIA and those in the NCAA DIII. Reasons that could explain relatively low levels of concern for osteoporosis in female collegiate cross-country runners and reasons for significant differences in perceived susceptibility to osteoporosis are given, and recommendations for health education and intervention to help care for this population are provided. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/676304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32265246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comorbidity and healthcare expenditure in women with osteoporosis living in the basque country (Spain). 巴斯克地区骨质疏松症妇女的合并症和保健支出(西班牙)。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-10-01 DOI: 10.1155/2014/205954

Roberto Nuño-Solinis, Carolina Rodríguez-Pereira, Edurne Alonso-Morán, Juan F Orueta

{"title":"Comorbidity and healthcare expenditure in women with osteoporosis living in the basque country (Spain).","authors":"Roberto Nuño-Solinis, Carolina Rodríguez-Pereira, Edurne Alonso-Morán, Juan F Orueta","doi":"10.1155/2014/205954","DOIUrl":"https://doi.org/10.1155/2014/205954","url":null,"abstract":"Objectives. This study aimed to establish the prevalence of multimorbidity in women diagnosed with osteoporosis and to report it by deprivation index. The characteristics of comorbidity in osteoporotic women are compared to the general female chronic population, and the impact on healthcare expenditure of this population group is estimated. Methods. A cross-sectional analysis that included all Basque Country women aged 45 years and over (N = 579,575) was performed. Sociodemographic, diagnostic, and healthcare cost data were extracted from electronic databases for a one-year period. Chronic conditions were identified from their diagnoses and prescriptions. The existence of two or more chronic diseases out of a list of 47 was defined as multimorbidity. Results. 9.12% of women presented osteoporosis and 85.04% of them were multimorbid. Although multimorbidity in osteoporosis increased with age and deprivation level, prevalence was higher in the better-off groups. Women with osteoporosis had greater risk of having other musculoskeletal disorders but less risk of having diabetes (RR = 0.65) than chronic patients without osteoporosis. People with poorer socioeconomic status had higher healthcare cost. Conclusions. Most women with osteoporosis have multimorbidity. The variety of conditions emphasises the complexity of clinical management in this group and the importance of maintaining a generalist and multidisciplinary approach to their clinical care. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/205954","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury? 脊髓损伤患者的脂质谱与骨密度和骨形成有关吗?

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-08-21 DOI: 10.1155/2014/695014

Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi

{"title":"Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury?","authors":"Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi","doi":"10.1155/2014/695014","DOIUrl":"https://doi.org/10.1155/2014/695014","url":null,"abstract":"Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI. Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age. Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004, r = 0.33). HDL was negatively correlated with osteocalcin (P: 0.017, r = -0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD. Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/695014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Concern and risk perception: effects on osteoprotective behaviour. 关注和风险感知:对骨保护行为的影响。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-09-08 DOI: 10.1155/2014/142546

A L Barcenilla-Wong, J S Chen, L M March

{"title":"Concern and risk perception: effects on osteoprotective behaviour.","authors":"A L Barcenilla-Wong, J S Chen, L M March","doi":"10.1155/2014/142546","DOIUrl":"https://doi.org/10.1155/2014/142546","url":null,"abstract":"This study aimed to determine the effect that level of concern for osteoporosis, as well as self-perceived risk of osteoporosis and fracture, has on supplementation use, seeking medical advice, bone mineral density (BMD) testing, and antiosteoporosis medication (AOM) use. Study subjects were 1,095 female Australian participants of the Global Longitudinal study of Osteoporosis in Women (GLOW) untreated for osteoporosis at baseline. Study outcomes from self-administered questionnaires included calcium and vitamin D supplementation, self-reported seeking of medical advice regarding osteoporosis, BMD testing, and AOM use in the last 12 months at the late assessment. Logistic regression was used in the analysis. Concern significantly increased the likelihood of seeking medical advice and, however, had no significant impact on screening or treatment. Heightened self-perceived risks of osteoporosis and fracture both significantly increased the likelihood of seeking medical advice and BMD testing while elevated self-perceived risk of fracture increased AOM use. Supplementation use was not significantly associated with concern levels and risk perception. Concern and risk perceptions to osteoporosis and fracture were significantly associated with certain bone-protective behaviours. However, the disconnect between perceived osteoporosis risk and AOM use illustrates the need to emphasize the connection between osteoporosis and fracture in future education programs. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/142546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32713708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11