Journal of Osteoporosis最新文献_第9页

Osteoporosis health beliefs of women with increased risk of the female athlete triad. 女性骨质疏松症健康信念与女性运动员三位一体风险增加。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-03-09 DOI: 10.1155/2014/676304

Vu H Nguyen, Ze Wang, Stephanie M Okamura

{"title":"Osteoporosis health beliefs of women with increased risk of the female athlete triad.","authors":"Vu H Nguyen, Ze Wang, Stephanie M Okamura","doi":"10.1155/2014/676304","DOIUrl":"https://doi.org/10.1155/2014/676304","url":null,"abstract":"Women with increased risk of the female athlete triad (Triad) are more susceptible to osteoporosis compared to other women. The study included 65 women with increased risk of the Triad who had their osteoporosis health beliefs measured to assess their concern for the disease. Participants were female collegiate cross-country runners at different levels of competition, including National Association of Intercollegiate Athletics (NAIA) and National Collegiate Athletic Association (NCAA) Divisions III, II, and I. Although these participants have an increased risk of the Triad and are more susceptible to osteoporosis, on a scale of 1 to 5, results showed that they had low to moderate perceived susceptibility to osteoporosis with a mean score as high as 2.81 and moderate perceived severity of osteoporosis with a mean score as high as 3.38. A statistically significant difference in perceived susceptibility to osteoporosis was found between female collegiate cross-country runners in the NAIA and those in the NCAA DIII. Reasons that could explain relatively low levels of concern for osteoporosis in female collegiate cross-country runners and reasons for significant differences in perceived susceptibility to osteoporosis are given, and recommendations for health education and intervention to help care for this population are provided. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"676304"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/676304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32265246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates. 加拿大品牌和通用双膦酸盐体外崩解时间的差异。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-10-02 DOI: 10.1155/2014/420451

Wojciech P Olszynski, Jonathan D Adachi, K Shawn Davison

{"title":"Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates.","authors":"Wojciech P Olszynski, Jonathan D Adachi, K Shawn Davison","doi":"10.1155/2014/420451","DOIUrl":"https://doi.org/10.1155/2014/420451","url":null,"abstract":"The objective of this study was to compare the disintegration times among Canadian-marketed brand (alendronate 70 mg, alendronate 70 mg plus vitamin D 5600 IU, and risedronate 35 mg) and generic (Novo-alendronate 70 mg and Apo-alendronate 70 mg) once-weekly dosed bisphosphonates. All disintegration tests were performed with a Vanderkamp Disintegration Tester. Disintegration was deemed to have occurred when no residue of the tablet, except fragments of insoluble coating or capsule shell, was visible. Eighteen to 20 samples were tested for each bisphosphonate group. The mean (±standard deviation) disintegration times were significantly (P < 0.05) faster for Apo-alendronate (26 ± 5.6 seconds) and Novo-alendronate (13 ± 1.1 seconds) as compared to brand alendronate (147 ± 50.5 seconds), brand alendronate plus vitamin D (378 ± 60.5 seconds), or brand risedronate (101 ± 20.6 seconds). The significantly faster disintegration of the generic tablets as compared to the brand bisphosphonates may have concerning safety and effectiveness implications for patients administering these therapies. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"420451"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/420451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Treatment for Osteoporosis among Women in Japan: Associations with Patient Characteristics and Patient-Reported Outcomes in the 2008-2011 Japan National Health and Wellness Surveys. 日本女性骨质疏松症的治疗:2008-2011年日本国家健康调查中患者特征和患者报告结果的关联

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-12-23 DOI: 10.1155/2014/909153

Masayo Sato, Jeffrey Vietri, Jennifer A Flynn, Saeko Fujiwara

{"title":"Treatment for Osteoporosis among Women in Japan: Associations with Patient Characteristics and Patient-Reported Outcomes in the 2008-2011 Japan National Health and Wellness Surveys.","authors":"Masayo Sato, Jeffrey Vietri, Jennifer A Flynn, Saeko Fujiwara","doi":"10.1155/2014/909153","DOIUrl":"https://doi.org/10.1155/2014/909153","url":null,"abstract":"This study was conducted to identify characteristics associated with treatment for osteoporosis among women aged 50 years and older in Japan and to explore differences among patients according to treatment regimen. Data were provided by a large annual survey representative of Japanese aged 18 and older; all measures were by self-report. Women aged 50 and older who reported diagnosed osteoporosis (N = 900) were compared based on current treatment status using bivariate statistics and logistic regression. Approximately 1 in 3 women in this study reporting diagnosed osteoporosis were currently untreated. Factors associated with current treatment for osteoporosis included having ≥1 physician visit in the prior 6 months (OR = 5.4, P < 0.001), self-rated moderate or severe osteoporosis (OR = 2.8, P < 0.001), completion of menopause (OR = 1.6, P < 0.05), and family history of osteoporosis (OR = 1.5, P < 0.05), while longer duration of osteoporosis diagnosis (OR = 0.9, P < 0.05) and arthritis (OR = 0.7, P < 0.05) were associated with lower odds of treatment. These findings suggest that diagnosed patients are not being actively managed in the longer term, and efforts need to be made to ensure that patients stay engaged with their healthcare providers. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"909153"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/909153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32975423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury? 脊髓损伤患者的脂质谱与骨密度和骨形成有关吗?

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-08-21 DOI: 10.1155/2014/695014

Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi

{"title":"Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury?","authors":"Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi","doi":"10.1155/2014/695014","DOIUrl":"https://doi.org/10.1155/2014/695014","url":null,"abstract":"Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI. Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age. Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004, r = 0.33). HDL was negatively correlated with osteocalcin (P: 0.017, r = -0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD. Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"695014"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/695014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Comorbidity and healthcare expenditure in women with osteoporosis living in the basque country (Spain). 巴斯克地区骨质疏松症妇女的合并症和保健支出(西班牙)。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-10-01 DOI: 10.1155/2014/205954

Roberto Nuño-Solinis, Carolina Rodríguez-Pereira, Edurne Alonso-Morán, Juan F Orueta

{"title":"Comorbidity and healthcare expenditure in women with osteoporosis living in the basque country (Spain).","authors":"Roberto Nuño-Solinis, Carolina Rodríguez-Pereira, Edurne Alonso-Morán, Juan F Orueta","doi":"10.1155/2014/205954","DOIUrl":"https://doi.org/10.1155/2014/205954","url":null,"abstract":"Objectives. This study aimed to establish the prevalence of multimorbidity in women diagnosed with osteoporosis and to report it by deprivation index. The characteristics of comorbidity in osteoporotic women are compared to the general female chronic population, and the impact on healthcare expenditure of this population group is estimated. Methods. A cross-sectional analysis that included all Basque Country women aged 45 years and over (N = 579,575) was performed. Sociodemographic, diagnostic, and healthcare cost data were extracted from electronic databases for a one-year period. Chronic conditions were identified from their diagnoses and prescriptions. The existence of two or more chronic diseases out of a list of 47 was defined as multimorbidity. Results. 9.12% of women presented osteoporosis and 85.04% of them were multimorbid. Although multimorbidity in osteoporosis increased with age and deprivation level, prevalence was higher in the better-off groups. Women with osteoporosis had greater risk of having other musculoskeletal disorders but less risk of having diabetes (RR = 0.65) than chronic patients without osteoporosis. People with poorer socioeconomic status had higher healthcare cost. Conclusions. Most women with osteoporosis have multimorbidity. The variety of conditions emphasises the complexity of clinical management in this group and the importance of maintaining a generalist and multidisciplinary approach to their clinical care. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"205954"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/205954","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Concern and risk perception: effects on osteoprotective behaviour. 关注和风险感知:对骨保护行为的影响。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-09-08 DOI: 10.1155/2014/142546

A L Barcenilla-Wong, J S Chen, L M March

{"title":"Concern and risk perception: effects on osteoprotective behaviour.","authors":"A L Barcenilla-Wong, J S Chen, L M March","doi":"10.1155/2014/142546","DOIUrl":"https://doi.org/10.1155/2014/142546","url":null,"abstract":"This study aimed to determine the effect that level of concern for osteoporosis, as well as self-perceived risk of osteoporosis and fracture, has on supplementation use, seeking medical advice, bone mineral density (BMD) testing, and antiosteoporosis medication (AOM) use. Study subjects were 1,095 female Australian participants of the Global Longitudinal study of Osteoporosis in Women (GLOW) untreated for osteoporosis at baseline. Study outcomes from self-administered questionnaires included calcium and vitamin D supplementation, self-reported seeking of medical advice regarding osteoporosis, BMD testing, and AOM use in the last 12 months at the late assessment. Logistic regression was used in the analysis. Concern significantly increased the likelihood of seeking medical advice and, however, had no significant impact on screening or treatment. Heightened self-perceived risks of osteoporosis and fracture both significantly increased the likelihood of seeking medical advice and BMD testing while elevated self-perceived risk of fracture increased AOM use. Supplementation use was not significantly associated with concern levels and risk perception. Concern and risk perceptions to osteoporosis and fracture were significantly associated with certain bone-protective behaviours. However, the disconnect between perceived osteoporosis risk and AOM use illustrates the need to emphasize the connection between osteoporosis and fracture in future education programs. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"142546"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/142546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32713708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A New Predictive Index for Osteoporosis in Men under 70 Years of Age: An Index to Identify Male Candidates for Osteoporosis Screening by Bone Mineral Density. 70 岁以下男性骨质疏松症的新预测指数：通过骨质密度确定男性骨质疏松症筛查对象的指数。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-03-03 DOI: 10.1155/2014/781897

Lee Oh Kim, Hyeon-Ju Kim, Mi Hee Kong

{"title":"A New Predictive Index for Osteoporosis in Men under 70 Years of Age: An Index to Identify Male Candidates for Osteoporosis Screening by Bone Mineral Density.","authors":"Lee Oh Kim, Hyeon-Ju Kim, Mi Hee Kong","doi":"10.1155/2014/781897","DOIUrl":"10.1155/2014/781897","url":null,"abstract":"Background. Bone mineral density (BMD) screening guidelines for osteoporosis in men seem to have remained unclear. We aimed to set up a predictive index for the osteoporosis(PIO) in men under 70 years of age and present the optimal cutoff value of it, so that clinicians might use it to identify male candidates who benefit from taking the BMD screening. Methods. Adult men under 70 years old who met certain criteria were included. With the determined significant predictors for osteoporosis, we created a new index that presumably best predicts the osteoporosis and compared the predictability of it to other variables. Lastly, the optimal cutoff value of the PIO was calculated. Results. A total of 359 men were included. Age, weight, and current smoking status turned out to be significant predictors for osteoporosis. The PIO was as follows: [age(years) + 10 (for current smoker)]/weight(kg). Compared to other variables, the PIO showed the greatest predictive performance with the optimal cutoff point being 0.87 at which sensitivity and specificity were 71.9% and 70.0%, respectively. Conclusion. A new predictive index appeared to predict the presence of osteoporosis fairly well and thus can be used with its cutoff point to identify men under 70 years of age who need BMD screening. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"781897"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32255129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving hip fracture care in ireland: a preliminary report of the irish hip fracture database. 改善爱尔兰髋部骨折护理:爱尔兰髋部骨折数据库的初步报告。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-12-08 DOI: 10.1155/2014/656357

Prasad Ellanti, Breda Cushen, Adam Galbraith, Louise Brent, Conor Hurson, Emer Ahern

{"title":"Improving hip fracture care in ireland: a preliminary report of the irish hip fracture database.","authors":"Prasad Ellanti, Breda Cushen, Adam Galbraith, Louise Brent, Conor Hurson, Emer Ahern","doi":"10.1155/2014/656357","DOIUrl":"https://doi.org/10.1155/2014/656357","url":null,"abstract":"Introduction. Hip fractures are common injuries in the older persons, with significant associated morbidity and mortality. The Irish Hip Fracture Database (IHFD) was implemented to monitor standards of care against international standards. Methods. The IHFD is a clinically led web-based audit. We summarize the data collected on hip fractures from April 2012 to March 2013 from 8 centres. Results. There were 843 patients with the majority being (70%) female. The 80-89-year age group accounted for the majority of fractures (44%). Most (71%) sustained a fall at home. Intertrochanteric fractures (40%) were most common. Only 28% were admitted to an orthopaedic ward within 4 hours. The majority (97%) underwent surgery with 44% having surgery within 36 hours. Medical optimization (35%) and lack of theatre space (26%) accounted for most of the surgical delay. While 29% were discharged home, 33% were discharged to a nursing home or other long-stay facilities. There was a 4% in-hospital mortality rate. Conclusions. Several key areas in both the database and aspects of patient care needing improvement have been highlighted. The implementation of similar databases has led to improved hip fracture care in other countries and we believe this can be replicated in Ireland. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"656357"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/656357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32943170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

The therapeutic effectiveness of the coadministration of weekly risedronate and proton pump inhibitor in osteoporosis treatment. 每周联合利塞膦酸钠与质子泵抑制剂治疗骨质疏松症的疗效观察。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-11-09 DOI: 10.1155/2014/607145

Mizue Tanaka, Soichiro Itoh, Taro Yoshioka, Kimihiro Yamashita

{"title":"The therapeutic effectiveness of the coadministration of weekly risedronate and proton pump inhibitor in osteoporosis treatment.","authors":"Mizue Tanaka, Soichiro Itoh, Taro Yoshioka, Kimihiro Yamashita","doi":"10.1155/2014/607145","DOIUrl":"https://doi.org/10.1155/2014/607145","url":null,"abstract":"This trial was conducted to investigate the long-term effects of proton pump inhibitor (PPI) coadministration on the efficacy of weekly risedronate treatment for osteoporosis. Ninety-six women over 50 years old with low bone mineral density (BMD) participated in this trial. Subjects were randomly divided into 2 groups: a 17.5 mg dose of sodium risedronate was administered weekly, with or without a daily 10 mg dose of sodium rabeprazole (n = 49 and 47 in the BP + PPI and BP groups, resp.). The following biomarkers were measured at the baseline and every 3 months: bone-specific alkaline phosphatase, N-terminal telopeptide of type I collagen corrected for creatinine, parathyroid hormone, BMD of the lumbar spine, and physical parameters evaluated according to the SF-36v2 Health Survey. Statistical comparisons of these parameters were performed after 6, 12, 18, and 24 months. The Δ values of improvement in physical functioning after 12 months and bodily pain after 6 and 12 months in the BP + PPI group were significantly larger than those in the BP group. These results suggest that PPI does not adversely affect bone metabolism. Alternatively, approved bone formation by concomitant PPI treatment may have had favorable effects on the improvement of bodily pain and physical functions. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"607145"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/607145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32849632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The combination therapy with zoledronic Acid and propranolol improves the trabecular microarchitecture and mechanical property in an rat model of postmenopausal osteoporosis. 唑来膦酸和心得安联合治疗可改善绝经后骨质疏松大鼠模型的骨小梁微结构和力学性能。

IF 1.9

Journal of Osteoporosis Pub Date : 2014-01-01 Epub Date: 2014-03-30 DOI: 10.1155/2014/586431

Deepak Kumar Khajuria, Rema Razdan, D Roy Mahapatra

{"title":"The combination therapy with zoledronic Acid and propranolol improves the trabecular microarchitecture and mechanical property in an rat model of postmenopausal osteoporosis.","authors":"Deepak Kumar Khajuria, Rema Razdan, D Roy Mahapatra","doi":"10.1155/2014/586431","DOIUrl":"https://doi.org/10.1155/2014/586431","url":null,"abstract":"We conducted the present study to investigate the therapeutic effects of propranolol (PRO), alone and in combination with the antiresorptive agent ZOL, in a rat model of postmenopausal osteoporosis. Female Wistar rats were OVX or sham-operated at 3 months of age. Twelve weeks after surgery, rats were randomized into six groups: (1) sham + vehicle, (2) OVX + vehicle, (3) OVX + ZOL (100 μ g/kg, i.v. single dose), (4) OVX + ZOL (50 μ g/kg, i.v. single dose), (5) OVX + PRO (0.1 mg/kg, s.c. 5 days per week), and (6) OVX + ZOL (50 μ g/kg, i.v. single dose) + PRO (0.1 mg/kg, s.c. 5 days per week) for 12 weeks. At the end of treatment study, various bone parameters were evaluated. With respect to improvement in the mechanical strength of the lumbar spine and the femoral mid-shaft, the combination treatment of ZOL and PRO was more effective than each drug administered as a monotherapy. Moreover, combination therapy using ZOL and PRO preserved the trabecular microarchitecture better than single-drug therapy using ZOL or PRO in OVX rats. These data suggest that combination therapy with ZOL plus PRO represents a potentially useful therapeutic option for patients with osteoporosis. ","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2014 ","pages":"586431"},"PeriodicalIF":1.9,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/586431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32319393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14