Journal of Osteoporosis最新文献_第5页

Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes. 老年墨西哥裔美国人2型糖尿病患者的血糖控制和骨转换

IF 1.9

Journal of Osteoporosis Pub Date : 2018-05-13 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7153021

Nahid J Rianon, Scott M Smith, MinJae Lee, Hannah Pervin, Paul Musgrave, Gordon P Watt, Shahla Nader, Sundeep Khosla, Catherine G Ambrose, Joseph B McCormick, Susan P Fisher-Hoch

{"title":"Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes.","authors":"Nahid J Rianon, Scott M Smith, MinJae Lee, Hannah Pervin, Paul Musgrave, Gordon P Watt, Shahla Nader, Sundeep Khosla, Catherine G Ambrose, Joseph B McCormick, Susan P Fisher-Hoch","doi":"10.1155/2018/7153021","DOIUrl":"https://doi.org/10.1155/2018/7153021","url":null,"abstract":"Altered bone quality, caused by underlying metabolic changes of type 2 diabetes (T2D), has been hypothesized to cause altered bone strength and turnover leading to increased fracture risk in T2D patients. Current understanding about changes in bone turnover markers in T2D patients is mainly based on studies focused on Caucasian men and women. However, Hispanic populations have the highest prevalence of both T2D and osteoporosis in the US. We investigated associations of glycemic control (in terms of glycated hemoglobin [HbA1c]) and bone turnover rate in 69 older (≥50 years) Mexican American Cameron County Hispanic Cohort (CCHC) participants with T2D. Multivariable analyses were conducted to assess the associations between HbA1c (%), serum osteocalcin (OC), and serum sclerostin. In agreement with published reports from other racial/ethnic populations, our study found that lower bone turnover (indicated by lower serum OC) occurred in Mexican American men with T2D who had poorer glycemic control. For the women in our study, we found no significant association between glycemic control and OC. In contrast, HbA1c was positively associated with sclerostin for women, with near significance (p = 0.07), while no association was found in men. We recommend screening Mexican American individuals with T2D, specifically those with poor glycemic control, for bone loss and fracture risk.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2018-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7153021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36189332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Corrigendum to "Potential Extensions of the US FRAX Algorithm". “美国FRAX算法的潜在扩展”的勘误。

IF 1.9

Journal of Osteoporosis Pub Date : 2018-04-02 eCollection Date: 2018-01-01 DOI: 10.1155/2018/3021801

Journal Of Osteoporosis

引用次数: 0

The Impact of Multifaceted Osteoporosis Group Education on Patients' Decision-Making regarding Treatment Options and Lifestyle Changes. 骨质疏松症群体教育对患者治疗选择和生活方式改变决策的影响。

IF 1.9

Journal of Osteoporosis Pub Date : 2018-03-26 eCollection Date: 2018-01-01 DOI: 10.1155/2018/9703602

Annesofie L Jensen, Gitte Wind, Bente Lomholt Langdahl, Kirsten Lomborg

{"title":"The Impact of Multifaceted Osteoporosis Group Education on Patients' Decision-Making regarding Treatment Options and Lifestyle Changes.","authors":"Annesofie L Jensen, Gitte Wind, Bente Lomholt Langdahl, Kirsten Lomborg","doi":"10.1155/2018/9703602","DOIUrl":"https://doi.org/10.1155/2018/9703602","url":null,"abstract":"Introduction: Patients with chronic diseases like osteoporosis constantly have to make decisions related to their disease. Multifaceted osteoporosis group education (GE) may support patients' decision-making. This study investigated multifaceted osteoporosis GE focusing on the impact of GE on patients' decision-making related to treatment options and lifestyle.Material and methods: An interpretive description design using ethnographic methods was utilized with 14 women and three men diagnosed with osteoporosis who attended multifaceted GE. Data consisted of participant observation during GE and individual interviews.Results: Attending GE had an impact on the patients' decision-making in all educational themes. Patients decided on new ways to manage osteoporosis and made decisions regarding bone health and how to implement a lifestyle ensuring bone health. During GE, teachers and patients shared evidence-based knowledge and personal experiences and preferences, respectively, leading to a two-way exchange of information and deliberation about recommendations. Though teachers and patients explored the implications of the decisions and shared their preferences, teachers stressed that the patients ultimately had to make the decision. Teachers therefore refrained from participating in the final step of the decision-making process.Conclusion: Attending GE has an impact on the patients' decision-making as it can initiate patient reflection and support decision-making.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2018-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/9703602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36118031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

"Omics" Signatures in Peripheral Monocytes from Women with Low BMD Condition. 低骨密度女性外周血单核细胞的组学特征

IF 1.9

Journal of Osteoporosis Pub Date : 2018-03-18 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8726456

Bhavna Daswani, M Ikram Khatkhatay

{"title":"\"Omics\" Signatures in Peripheral Monocytes from Women with Low BMD Condition.","authors":"Bhavna Daswani, M Ikram Khatkhatay","doi":"10.1155/2018/8726456","DOIUrl":"https://doi.org/10.1155/2018/8726456","url":null,"abstract":"Postmenopausal osteoporosis (PMO) is a result of increased bone resorption compared to formation. Osteoclasts are responsible for bone resorption, which are derived from circulating monocytes that undertake a journey from the blood to the bone for the process of osteoclastogenesis. In recent times, the use of high throughput technologies to explore monocytes from women with low versus high bone density has led to the identification of candidate molecules that may be deregulated in PMO. This review provides a list of molecules in monocytes relevant to bone density which have been identified by \"omics\" studies in the last decade or so. The molecules in monocytes that are deregulated in low BMD condition may contribute to processes such as monocyte survival, migration/chemotaxis, adhesion, transendothelial migration, and differentiation into the osteoclast lineage. Each of these processes may be crucial to the overall route of osteoclastogenesis and an increase in any/all of these processes can lead to increased bone resorption and subsequently low bone density. Whether these molecules are indeed the cause or effect is an arena currently unexplored.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2018-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8726456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36083210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Femoral Neck Mechanoresponse to Hip Extensors Exercise: A Case Study 髋关节伸肌运动的股骨颈机械反应:一个案例研究

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-11 DOI: 10.1155/2017/5219541

S. Martelli, H. Mokhtarzadeh, P. Pivonka, P. Ebeling

{"title":"The Femoral Neck Mechanoresponse to Hip Extensors Exercise: A Case Study","authors":"S. Martelli, H. Mokhtarzadeh, P. Pivonka, P. Ebeling","doi":"10.1155/2017/5219541","DOIUrl":"https://doi.org/10.1155/2017/5219541","url":null,"abstract":"Physical activity is recommended to prevent age-related bone loss. However, the proximal femur mechanoresponse is variable, possibly because of a muscle-dependant mechanoresponse. We compared the proximal femur response with the femoral strain pattern generated by the hip extensor muscles. A healthy participant underwent a six-month unilateral training of the hip extensor muscles using a resistance weight regularly adjusted to the 80% of the one-repetition maximum weight. DXA-based measurements of the areal Bone Mineral Density (aBMD) in the exercise leg were adjusted for changes in the control leg. The biomechanical stimulus for bone adaptation (BS) was calculated using published models of the musculoskeletal system and the average hip extension moment in elderly participants. Volumetric (ΔvBMD) and areal (ΔaBMD) BMD changes were calculated. The measured and calculated BMD changes consistently showed a positive and negative effect of exercise in the femoral neck (ΔaBMD = +0.7%; ΔvBMD = +0.8%) and the trochanter region (ΔaBMD = −4.1%; ΔvBMD = −0.5%), respectively. The 17% of the femoral neck exceeded the 75th percentile of the spatially heterogeneous BS distribution. Hip extensor exercises may be beneficial in the proximal femoral neck but not in the trochanteric region. DXA-based measurements may not capture significant aBMD local changes.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2017-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A Review on the Relationship between Aspirin and Bone Health 阿司匹林与骨骼健康关系的研究进展

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-09 DOI: 10.1155/2017/3710959

K. Chin

{"title":"A Review on the Relationship between Aspirin and Bone Health","authors":"K. Chin","doi":"10.1155/2017/3710959","DOIUrl":"https://doi.org/10.1155/2017/3710959","url":null,"abstract":"Aspirin is a cyclooxygenase inhibitor commonly used in primary prevention of cardiovascular diseases and cancers. Its users are elderly population susceptible to osteoporosis. It also inhibits the synthesis of prostaglandin E2 essential in bone remodeling. This prompts the question whether it can influence bone health among users. This review aimed to summarize the current literature on the use of aspirin on bone health. A literature search on experimental and clinical evidence on the effects of aspirin on bone health was performed using major scientific databases. In vitro studies showed that aspirin could enhance the survival of bone marrow mesenchymal stem cells, the progenitors of osteoblasts, and stimulate the differentiation of preosteoblasts. Aspirin also inhibited the nuclear factor kappa-B (NFκB) pathway and decreased the expression of receptor activator of NFκB ligand, thus suppressing the formation of osteoclast. Aspirin could prevent bone loss in animal models of osteoporosis. Despite a positive effect on bone mineral density, the limited human epidemiological studies revealed that aspirin could not reduce fracture risk. A study even suggested that the use of aspirin increased fracture risk. As a conclusion, aspirin may increase bone mineral density but its effect on fracture prevention is inconclusive. More data are needed to determine the effects of aspirin and bone health in human.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2017-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90800214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Nutritional Aspects of Bone Health and Fracture Healing. 骨骼健康和骨折愈合的营养方面。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-12-31 DOI: 10.1155/2017/4218472

Athanasios Karpouzos, Evangelos Diamantis, Paraskevi Farmaki, Spyridon Savvanis, Theodore Troupis

引用次数: 57

Corrigendum to "Predictors of Fracture Risk and Bone Mineral Density in Men with Prostate Cancer on Androgen Deprivation Therapy". 对“雄激素剥夺治疗前列腺癌患者骨折风险和骨密度的预测因素”的更正。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-07-12 DOI: 10.1155/2017/4982312

Katherine Neubecker, Beverley Adams-Huet, Irfan M Farukhi, Rosinda Castanon, Ugis Gruntmanis

引用次数: 0

Corrigendum to "Mikkeli Osteoporosis Index Identifies Fracture Risk Factors and Osteoporosis and Intervention Thresholds Parallel with FRAX". “Mikkeli骨质疏松指数识别骨折危险因素和骨质疏松症和干预阈值与FRAX平行”的勘误表。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-08-20 DOI: 10.1155/2017/3074151

Ville Juhana Waris, Joonas P Sirola, Vesa V Kiviniemi, Marjo T Tuppurainen, V Pekka Waris

引用次数: 1

Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner. 使用便携式杂散场核磁共振扫描仪监测OVX大鼠PTH(1-34)治疗后骨髓细胞变化。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-05-30 DOI: 10.1155/2017/7910432

Inbar Hillel, Itzhak Binderman, Yifat Sarda, Uri Nevo

{"title":"Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner.","authors":"Inbar Hillel, Itzhak Binderman, Yifat Sarda, Uri Nevo","doi":"10.1155/2017/7910432","DOIUrl":"https://doi.org/10.1155/2017/7910432","url":null,"abstract":"Osteoporosis is characterized by reduction in trabecular bone in conjunction with increased marrow cell adiposity. While these changes occur within weeks, monitoring of treatment efficacy as performed by DEXA is sensitive only to long-term changes. MRI is sensitive to bone marrow changes but is less affordable. In a recent study, we have shown that a stray-field NMR can monitor bone marrow cellular changes that are related to osteoporosis. Objectives. To demonstrate sensitivity of a low-field tabletop NMR scanner to bone marrow dynamics following hormonal treatment in rats. Methods. Two-month-old female rats (n = 36) were ovariectomized (OVX) and dosed for the ensuing 3 or 5 weeks with 20 mg/kg of PTH(1-34). Hind limbs femurs and tibiae were isolated and underwent ex vivo microradiography and histology and NMR relaxometry at 6 weeks (preventive experiment) and 11 weeks (therapeutic treatment experiment) after OVX. Results. OVX rats developed osteoporotic changes including adipogenic marrow compared to Sham and PTH treated rats. T2 and ADC NMR relaxation coefficients were found to correlate with marrow composition. Conclusions. This study suggests that stray-field NMR, an affordable method that is sensitive to the rapid cellular changes in bone marrow, may have a clinical value in monitoring hormonal treatment for osteoporosis.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7910432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35109323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1