Journal of Osteoporosis最新文献_第5页

"Omics" Signatures in Peripheral Monocytes from Women with Low BMD Condition. 低骨密度女性外周血单核细胞的组学特征

IF 1.9

Journal of Osteoporosis Pub Date : 2018-03-18 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8726456

Bhavna Daswani, M Ikram Khatkhatay

{"title":"\"Omics\" Signatures in Peripheral Monocytes from Women with Low BMD Condition.","authors":"Bhavna Daswani, M Ikram Khatkhatay","doi":"10.1155/2018/8726456","DOIUrl":"https://doi.org/10.1155/2018/8726456","url":null,"abstract":"Postmenopausal osteoporosis (PMO) is a result of increased bone resorption compared to formation. Osteoclasts are responsible for bone resorption, which are derived from circulating monocytes that undertake a journey from the blood to the bone for the process of osteoclastogenesis. In recent times, the use of high throughput technologies to explore monocytes from women with low versus high bone density has led to the identification of candidate molecules that may be deregulated in PMO. This review provides a list of molecules in monocytes relevant to bone density which have been identified by \"omics\" studies in the last decade or so. The molecules in monocytes that are deregulated in low BMD condition may contribute to processes such as monocyte survival, migration/chemotaxis, adhesion, transendothelial migration, and differentiation into the osteoclast lineage. Each of these processes may be crucial to the overall route of osteoclastogenesis and an increase in any/all of these processes can lead to increased bone resorption and subsequently low bone density. Whether these molecules are indeed the cause or effect is an arena currently unexplored.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2018 ","pages":"8726456"},"PeriodicalIF":1.9,"publicationDate":"2018-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8726456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36083210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Femoral Neck Mechanoresponse to Hip Extensors Exercise: A Case Study 髋关节伸肌运动的股骨颈机械反应:一个案例研究

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-11 DOI: 10.1155/2017/5219541

S. Martelli, H. Mokhtarzadeh, P. Pivonka, P. Ebeling

{"title":"The Femoral Neck Mechanoresponse to Hip Extensors Exercise: A Case Study","authors":"S. Martelli, H. Mokhtarzadeh, P. Pivonka, P. Ebeling","doi":"10.1155/2017/5219541","DOIUrl":"https://doi.org/10.1155/2017/5219541","url":null,"abstract":"Physical activity is recommended to prevent age-related bone loss. However, the proximal femur mechanoresponse is variable, possibly because of a muscle-dependant mechanoresponse. We compared the proximal femur response with the femoral strain pattern generated by the hip extensor muscles. A healthy participant underwent a six-month unilateral training of the hip extensor muscles using a resistance weight regularly adjusted to the 80% of the one-repetition maximum weight. DXA-based measurements of the areal Bone Mineral Density (aBMD) in the exercise leg were adjusted for changes in the control leg. The biomechanical stimulus for bone adaptation (BS) was calculated using published models of the musculoskeletal system and the average hip extension moment in elderly participants. Volumetric (ΔvBMD) and areal (ΔaBMD) BMD changes were calculated. The measured and calculated BMD changes consistently showed a positive and negative effect of exercise in the femoral neck (ΔaBMD = +0.7%; ΔvBMD = +0.8%) and the trochanter region (ΔaBMD = −4.1%; ΔvBMD = −0.5%), respectively. The 17% of the femoral neck exceeded the 75th percentile of the spatially heterogeneous BS distribution. Hip extensor exercises may be beneficial in the proximal femoral neck but not in the trochanteric region. DXA-based measurements may not capture significant aBMD local changes.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"17 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2017-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A Review on the Relationship between Aspirin and Bone Health 阿司匹林与骨骼健康关系的研究进展

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-09 DOI: 10.1155/2017/3710959

K. Chin

{"title":"A Review on the Relationship between Aspirin and Bone Health","authors":"K. Chin","doi":"10.1155/2017/3710959","DOIUrl":"https://doi.org/10.1155/2017/3710959","url":null,"abstract":"Aspirin is a cyclooxygenase inhibitor commonly used in primary prevention of cardiovascular diseases and cancers. Its users are elderly population susceptible to osteoporosis. It also inhibits the synthesis of prostaglandin E2 essential in bone remodeling. This prompts the question whether it can influence bone health among users. This review aimed to summarize the current literature on the use of aspirin on bone health. A literature search on experimental and clinical evidence on the effects of aspirin on bone health was performed using major scientific databases. In vitro studies showed that aspirin could enhance the survival of bone marrow mesenchymal stem cells, the progenitors of osteoblasts, and stimulate the differentiation of preosteoblasts. Aspirin also inhibited the nuclear factor kappa-B (NFκB) pathway and decreased the expression of receptor activator of NFκB ligand, thus suppressing the formation of osteoclast. Aspirin could prevent bone loss in animal models of osteoporosis. Despite a positive effect on bone mineral density, the limited human epidemiological studies revealed that aspirin could not reduce fracture risk. A study even suggested that the use of aspirin increased fracture risk. As a conclusion, aspirin may increase bone mineral density but its effect on fracture prevention is inconclusive. More data are needed to determine the effects of aspirin and bone health in human.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"47 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2017-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90800214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Nutritional Aspects of Bone Health and Fracture Healing. 骨骼健康和骨折愈合的营养方面。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-12-31 DOI: 10.1155/2017/4218472

Athanasios Karpouzos, Evangelos Diamantis, Paraskevi Farmaki, Spyridon Savvanis, Theodore Troupis

引用次数: 57

Corrigendum to "Predictors of Fracture Risk and Bone Mineral Density in Men with Prostate Cancer on Androgen Deprivation Therapy". 对“雄激素剥夺治疗前列腺癌患者骨折风险和骨密度的预测因素”的更正。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-07-12 DOI: 10.1155/2017/4982312

Katherine Neubecker, Beverley Adams-Huet, Irfan M Farukhi, Rosinda Castanon, Ugis Gruntmanis

引用次数: 0

Corrigendum to "Mikkeli Osteoporosis Index Identifies Fracture Risk Factors and Osteoporosis and Intervention Thresholds Parallel with FRAX". “Mikkeli骨质疏松指数识别骨折危险因素和骨质疏松症和干预阈值与FRAX平行”的勘误表。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-08-20 DOI: 10.1155/2017/3074151

Ville Juhana Waris, Joonas P Sirola, Vesa V Kiviniemi, Marjo T Tuppurainen, V Pekka Waris

引用次数: 1

Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner. 使用便携式杂散场核磁共振扫描仪监测OVX大鼠PTH(1-34)治疗后骨髓细胞变化。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-05-30 DOI: 10.1155/2017/7910432

Inbar Hillel, Itzhak Binderman, Yifat Sarda, Uri Nevo

{"title":"Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner.","authors":"Inbar Hillel, Itzhak Binderman, Yifat Sarda, Uri Nevo","doi":"10.1155/2017/7910432","DOIUrl":"https://doi.org/10.1155/2017/7910432","url":null,"abstract":"Osteoporosis is characterized by reduction in trabecular bone in conjunction with increased marrow cell adiposity. While these changes occur within weeks, monitoring of treatment efficacy as performed by DEXA is sensitive only to long-term changes. MRI is sensitive to bone marrow changes but is less affordable. In a recent study, we have shown that a stray-field NMR can monitor bone marrow cellular changes that are related to osteoporosis. Objectives. To demonstrate sensitivity of a low-field tabletop NMR scanner to bone marrow dynamics following hormonal treatment in rats. Methods. Two-month-old female rats (n = 36) were ovariectomized (OVX) and dosed for the ensuing 3 or 5 weeks with 20 mg/kg of PTH(1-34). Hind limbs femurs and tibiae were isolated and underwent ex vivo microradiography and histology and NMR relaxometry at 6 weeks (preventive experiment) and 11 weeks (therapeutic treatment experiment) after OVX. Results. OVX rats developed osteoporotic changes including adipogenic marrow compared to Sham and PTH treated rats. T2 and ADC NMR relaxation coefficients were found to correlate with marrow composition. Conclusions. This study suggests that stray-field NMR, an affordable method that is sensitive to the rapid cellular changes in bone marrow, may have a clinical value in monitoring hormonal treatment for osteoporosis.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2017 ","pages":"7910432"},"PeriodicalIF":1.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7910432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35109323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Corrigendum to "New and Emerging Therapies for Osteoporosis". “骨质疏松症的新疗法”的勘误。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-06-28 DOI: 10.1155/2017/4175180

E Michael Lewiecki, Manuel Diaz Curiel, Joao Lindolfo Borges, Annie Kung, Maria Luisa Brandi, Hans Peter Dimai

引用次数: 0

Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions. 小鼠慢性骨质疏松性疼痛:皮肤和深层肌肉骨骼疼痛部分独立于骨吸收，对药物干预差异敏感。

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 Epub Date: 2017-02-19 DOI: 10.1155/2017/7582716

Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S Stone

{"title":"Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions.","authors":"Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S Stone","doi":"10.1155/2017/7582716","DOIUrl":"https://doi.org/10.1155/2017/7582716","url":null,"abstract":"Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0.25 mg/kg, 5x/week for 5 weeks] versus acute treatment with intraperitoneal morphine [10 mg/kg] and pregabalin [100 mg/kg]) in a mouse model of ovariectomized or sham-operated mice 6 months following surgery. We observed reduced BMD associated with weight gain, referred cutaneous hypersensitivity, and deep musculoskeletal pain that persisted for 6 months. Chronic bisphosphonate treatment, 6 months after ovariectomy, reversed bone loss and hypersensitivity to cold, but other behavioral indices of osteoporotic pain were unchanged. While the efficacy of acute morphine on cutaneous pain was weak, pregabalin was highly effective; deep musculoskeletal pain was intractable. In conclusion, the reversal of bone loss alone is insufficient to manage pain in chronic osteoporosis. Additional treatments, both pharmacological and nonpharmacological, should be implemented to improve quality of life for osteoporosis patients.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"2017 ","pages":"7582716"},"PeriodicalIF":1.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7582716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34816948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Exercise Training in Treatment and Rehabilitation of Hip Osteoarthritis: A 12-Week Pilot Trial 运动训练治疗和康复髋关节骨关节炎:一项为期12周的试点试验

IF 1.9

Journal of Osteoporosis Pub Date : 2017-01-01 DOI: 10.1155/2017/3905492

K. Uusi-Rasi, R. Patil, S. Karinkanta, K. Tokola, P. Kannus, H. Sievänen

{"title":"Exercise Training in Treatment and Rehabilitation of Hip Osteoarthritis: A 12-Week Pilot Trial","authors":"K. Uusi-Rasi, R. Patil, S. Karinkanta, K. Tokola, P. Kannus, H. Sievänen","doi":"10.1155/2017/3905492","DOIUrl":"https://doi.org/10.1155/2017/3905492","url":null,"abstract":"Introduction. Osteoarthritis (OA) of the hip is one of the major causes of pain and disability in the older population. Although exercise is an effective treatment for knee OA, there is lack of evidence regarding hip OA. The aim of this trial was to test the safety and feasibility of a specifically designed exercise program in relieving hip pain and improving function in hip OA participants and to evaluate various methods to measure changes in their physical functioning. Materials and Methods. 13 women aged ≥ 65 years with hip OA were recruited in this 12-week pilot study. Results. Pain declined significantly over 30% from baseline, and joint function and health-related quality of life improved slightly. Objective assessment of physical functioning showed statistically significant improvement in the maximal isometric leg extensor strength by 20% and in the hip extension range of motion by 30%. Conclusions. The exercise program was found to be safe and feasible. The present evidence indicates that the exercise program is effective in the short term. However, adequate powered RCTs are needed to determine effects of long-term exercise therapy on pain and progression of hip OA.","PeriodicalId":45384,"journal":{"name":"Journal of Osteoporosis","volume":"8 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85386527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14