Journal of Clinical Neonatology最新文献_第5页

Role of modified sick neonatal score in predicting the neonatal mortality at limited-resource setting of central India 改良的患病新生儿评分在预测印度中部资源有限的新生儿死亡率中的作用

IF 0.2

Journal of Clinical Neonatology Pub Date : 2023-01-01 DOI: 10.4103/jcn.jcn_83_22

R. Meshram, Roshan Nimsarkar, Ayushi Nautiyal

{"title":"Role of modified sick neonatal score in predicting the neonatal mortality at limited-resource setting of central India","authors":"R. Meshram, Roshan Nimsarkar, Ayushi Nautiyal","doi":"10.4103/jcn.jcn_83_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_83_22","url":null,"abstract":"Background: The targets of Sustainable Development Goals cannot be achieved without reducing mortality of inborn as well as outborn neonates. Objective: The objective was to predict the mortality of neonates by applying Modified Sick Neonatal Score (MSNS). Material and Methods: Parameters of MSNS scoring system were applied to 450 neonates at the time of admission and followed up prospectively till discharge or death. The score and individual parameters were correlated with outcome. A receiver operating curve was plotted to determine the cutoff value for score to predict the mortality. Results: The common clinical diagnoses were respiratory distress (38%), sepsis (26%), and jaundice (14.44%). Sixty-two percent neonates were born at term and 38% were preterm while 55.56% neonates were low birth weight and 44.4% were weighted more than 2500 gms. Neonates who died were older at the time of admission, and duration of hospital stay was shorter compared to alive neonates (P < 0.001) with a mortality rate of 23.11%. The total MSNS for neonates who died was statistically significantly low, (mean ± standard deviation) 7.93 ± 2.70, compared to alive neonates, 12.02 ± 1.84 (P < 0.0001). With optimum cutoff score of ≤10, the sensitivity was 79.80% and the specificity was 82.37% while the positive predictive value and negative predictive value was 57.64% and 93.14% respectively with the area under curve was 0.89 (odds ratio-18.46, 95% confidence interval 10.3-33.64, P < 0.0001). Conclusion: The MSNS of ≤10 has a better sensitivity and specificity in predicting neonatal mortality and is easy to use with minimal resources to both preterm and term neonates.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"1 - 6"},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41654871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Invasive fungal infection presenting as early-onset neonatal sepsis: A case report from Northern Nigeria 侵袭性真菌感染表现为早发新生儿败血症:尼日利亚北部一例报告

IF 0.2

Journal of Clinical Neonatology Pub Date : 2023-01-01 DOI: 10.4103/jcn.jcn_98_22

U. Sanni, Taslim O. Lawal, A. Na'uzo, L. Audu

引用次数: 0

Impact of a short period of prone versus supine nursing in preterm neonates less than 32 weeks on weight gain: A prospective observational study 一项前瞻性观察研究:短时间俯卧与仰卧对32周以下早产儿体重增加的影响

IF 0.2

Journal of Clinical Neonatology Pub Date : 2023-01-01 DOI: 10.4103/jcn.jcn_89_22

H. Venkatesh, P. Mohanty

{"title":"Impact of a short period of prone versus supine nursing in preterm neonates less than 32 weeks on weight gain: A prospective observational study","authors":"H. Venkatesh, P. Mohanty","doi":"10.4103/jcn.jcn_89_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_89_22","url":null,"abstract":"Background: Postnatal growth depends on multiple factors such as gestational age, associated morbidities, and the nutrition and varies from one newborn to another. Preterm babies in neonatal intensive care unit are very much susceptible to growth faltering even after adequate nutrition and supplements. The positioning of preterm infants in neonatal intensive care has an impact on their survival and neurological outcome. Prone positioning is known to improve oxygenation, minute ventilation, and functional residual capacity. Quiet undisturbed sleep in preterms has helped them to conserve energy for growth. Objective: To determine the effect of prone versus supine position on weight gain in infants less than 32 weeks of gestational age. Design: Prospective observational study. Participants: Twenty-two neonates were recruited. Results: On day 1, in the prone position, 63.6% gained weight vs. 59.1% in the supine position (P = 0.425). On day 2, in prone, 72.7% has gained vs. 63.6% in supine (P = 0.359). On day 3, in prone, 68.2% gained weight vs. 63.6% in supine position (P = 0.426). Conclusion: Nursing a baby in a prone position has demonstrated weight gain over nursing in a supine position though not statistically significant.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"13 - 15"},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46280614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective validation of the Alexandria retinopathy of prematurity model in preterm infants in Saudi Arabia 沙特阿拉伯早产儿亚历山大视网膜病变模型的回顾性验证

IF 0.2

Journal of Clinical Neonatology Pub Date : 2023-01-01 DOI: 10.4103/jcn.jcn_87_22

L. Raffa, Omar Akeely, Saleh Alariefy, Faisal A Alharbi, Moussa A Alkhateeb, M. Khan

{"title":"Retrospective validation of the Alexandria retinopathy of prematurity model in preterm infants in Saudi Arabia","authors":"L. Raffa, Omar Akeely, Saleh Alariefy, Faisal A Alharbi, Moussa A Alkhateeb, M. Khan","doi":"10.4103/jcn.jcn_87_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_87_22","url":null,"abstract":"Background: In developing countries, data on the applicability of existing models to predict retinopathy of prematurity (ROP) are scarce. The study aimed to validate the Alexandria ROP (Alex-ROP) and high-grade Alex-ROP (Hg Alex-ROP) models retrospectively to identify treatable ROP in a cohort of preterm infants in Saudi Arabia. Materials and Methods: We reviewed and included the records of 281 infants born prematurely in 2015–2021. We recorded the infants' demographics, gestational age at birth (GA), birth weight (BW), and serial weight measurements (day 7, 14, 21, and 28). We determined whether the included met the Alex-ROP and Hg Alex-ROP detection criteria for treatable or any-stage ROP and calculated the specificity, sensitivity, negative and positive predictive values, and accuracy. Results: The median BW and GA was 1095 g (range: 426–1920 g) and 29 weeks (range: 23–36 weeks), respectively. ROP developed in 112 infants, of which 30 cases were treatable. The Alex-ROP sensitivity for correctly predicting any-stage ROP and treatable ROP was 77.7% and 80.0%, respectively, and its specificity for predicting any-stage ROP and treatable ROP was 49.7% and 41%, respectively. The Hg Alex-ROP had 36.6% and 50.0% sensitivity for detecting any-stage ROP and treatable ROP, respectively, and its specificity for detecting any-stage ROP and treatable ROP was 83.4% and 78.5%, respectively. Conclusion: Previously published accuracy parameters were not reproducible in this cohort and a significant number of children requiring treatment would have been missed if the Alex-ROP or Hg Alex-ROP were applied.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"7 - 12"},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44469756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Down syndrome with umbilical cord hematoma: Case report and review of literature 唐氏综合征并发脐带血肿1例报告并文献复习

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Journal of Clinical Neonatology Pub Date : 2023-01-01 DOI: 10.4103/jcn.jcn_103_22

A. Naeem, Sajjad Rahman, M. Abdulghani, Yahya Almalki

引用次数: 0

Risk factors for developing pressure ulcers in neonates and novel ideas for developing neonatal antipressure ulcers solutions 新生儿发生压疮的危险因素及开发新生儿抗压疮解决方案的新思路

IF 0.2

Journal of Clinical Neonatology Pub Date : 2023-01-01 DOI: 10.4103/jcn.jcn_84_22

A. Mallick, M. Bhandari, Bijit Basumatary, Shivani Gupta, K. Arora, A. Sahani

{"title":"Risk factors for developing pressure ulcers in neonates and novel ideas for developing neonatal antipressure ulcers solutions","authors":"A. Mallick, M. Bhandari, Bijit Basumatary, Shivani Gupta, K. Arora, A. Sahani","doi":"10.4103/jcn.jcn_84_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_84_22","url":null,"abstract":"Pressure Ulcers (PU) are highly prevalent iatrogenic occurrences among hospitalized adults and neonatal patients. These decubitus ulcers are progressive in nature and are mostly seen in patients that are immobile for prolonged periods, either by virtue of being bedridden or chair bound. The continual pressure on the skin surfaces disrupts blood supply from the subcutaneous regions and leads to the development of PUs. Several treatment and prevention protocols have been defined for adult patients. However, there is a dearth of literature available for critically ill pediatrics or neonates and often adult practices are used to treat pressure injuries in them. There is a significant physiological and anatomical difference between the skin of newborns and adults or even older children. The dermal layer of a preterm neonate is <60% of the thickness of an adult and has a much higher susceptibility for developing pressure ulcers. The immune system of premature infants lacks an efficient antigenic specificity, diversity or immunologic memory, making them prone to lethal infections. The study was performed using search engines like PubMed, EMBASE and Google Scholar, with the focus of the search strategy being the breadth rather than the details of the study. Selected keywords were used alone or in combination with each other to retrieve relevant articles. This review focuses on the risk of developing PUs in neonates, explains the currently available solutions of PU prevention in adults, emphasizes the need for neonatal specific solutions and presents novel ideas for developing antisore bed for neonates.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"27 - 33"},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42402601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Novel cord blood and urinary phytoestrogens levels in male neonates with normal external genitalia 外生殖器正常男性新生儿脐带血和尿液植物雌激素水平的变化

IF 0.2

Journal of Clinical Neonatology Pub Date : 2023-01-01 DOI: 10.4103/jcn.jcn_95_22

Che Salim, A. Zaman, Hana Azhari, S. Makpol, S. Ishak, Z. Latiff, Dayang Anita Abdul Aziz

{"title":"Novel cord blood and urinary phytoestrogens levels in male neonates with normal external genitalia","authors":"Che Salim, A. Zaman, Hana Azhari, S. Makpol, S. Ishak, Z. Latiff, Dayang Anita Abdul Aziz","doi":"10.4103/jcn.jcn_95_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_95_22","url":null,"abstract":"Objective: This was a new prospective study to determine the association between phytoestrogen levels in the cord blood and urine with normal and abnormal external genitalia in male newborns. Materials and Methods: One hundred and fifty-one term male newborns were enrolled. Cord blood and urine and medical photos of their external genitalia were obtained. Prematurity and multiple congenital anomalies or syndromic characteristics were excluded. Serum and urine levels of phytoestrogens (daidzein and genistein) were calculated using liquid chromatography/mass spectrometry. The normality of the appearance of the external genitalia of the males was determined by a consensus review by experts. Results: A total of 146 cord blood and 96 newborn urine samples were obtained; only two newborns had abnormal external genitalia. In the 144 babies with normal external genitalia, mean levels were determined to be as follows; serum daidzein 10.82 ng/ml, serum genistein 42.17 ng/ml, urine daidzein 69.91 ng/ml, and urine genistein 126.09 ng/ml. In the two babies with abnormal external genitalia, mean levels of each of the measured phytoestrogen were lower; however, there was no statistical significance between the two groups (P > 0.05). Conclusions: We successfully determined and developed a novel database on the levels of measurable phytoestrogens in serum and urine from male newborns with normal external genitalia. In the normal group, a higher concentration of serum and urinary phytoestrogens was correlated with the extension of the scrotal pigmentation above and proximal to the base of the penis. These data are useful to better understand the role of phytoestrogens in the development of male genitalia and for future research on newborns with abnormal external genitalia.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"16 - 21"},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47831732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and risk factors for admission hypothermia in neonates in a Tertiary Hospital in Jos, Nigeria 尼日利亚乔斯一家三级医院新生儿低温入院的患病率和危险因素

IF 0.2

Journal of Clinical Neonatology Pub Date : 2022-10-01 DOI: 10.4103/jcn.jcn_52_22

U. Diala, Patience Kanhu, D. Shwe, B. Toma

{"title":"Prevalence and risk factors for admission hypothermia in neonates in a Tertiary Hospital in Jos, Nigeria","authors":"U. Diala, Patience Kanhu, D. Shwe, B. Toma","doi":"10.4103/jcn.jcn_52_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_52_22","url":null,"abstract":"Background: Hypothermia on admission in neonatal units is a well-recognized contributor of neonatal mortality and morbidity. This study aimed to identify risk factors for hypothermia on admission in a resource-poor setting which will help provide targeted preventive interventions. Methods: A retrospective cross-sectional descriptive study was conducted from July 1, 2020 to January 31, 2022. A total of 567 neonates were included in the study, data were collected from the unit electronic database. The axillary temperature of each neonate was measured using a digital thermometer at the point of admission. Bivariate and multiple logistic regressions were used to assess associated risk factors. Results: The prevalence of admission hypothermia (AH) in the study population was 42.4% with mild and moderate hypothermia accounting for 46.3% and 53.7%, respectively. Maternal ages 20–29 years (adjusted odds ratio [aOR] 0.28, 95% confidence interval [CI] 0.09–0.93) and 30–39 years (aOR 0.27, 95% CI 0.08–0.88) and primary education (aOR 0.44, 95% CI 0.21–0.92) were associated with reduced risk of AH. Age <24 h (aOR 3.61, 95% CI 1.70–7.66), gestational age 28–32 weeks (aOR 3.90, 95% CI 1.41–10.79) and 33–36 weeks (aOR 2.835, 95% CI 1.52–5.28), admission weight <2.5 kg (aOR 2.01, 95% CI 1.18–3.43), and cold season (aOR 1.85, 95% CI 1.06–3.14) were associated with increased risk of AH. Mortality in those with AH was 3 folds (crude odds ratio 3.38, 95% CI 1.6–6.82). Conclusion: Hypothermia on admission is common in neonates in resource-poor settings. Training of newborn care-providers in maintaining thermoneutral environment and temperature at delivery and postnatal periods will be a cost-effective intervention in reducing neonatal mortality.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"195 - 201"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45789276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum 25-hydroxy Vitamin D and bilirubin levels in term neonates with hyperbilirubinemia: A cross-sectional, observational study 高胆红素血症足月新生儿血清25-羟基维生素D与胆红素水平的相关性：一项横断面观察性研究

IF 0.2

Journal of Clinical Neonatology Pub Date : 2022-10-01 DOI: 10.4103/jcn.jcn_61_22

H. Kumar, T. Bandyopadhyay, P. Kumari, A. Maria, Swati Upadhyay

{"title":"Association between serum 25-hydroxy Vitamin D and bilirubin levels in term neonates with hyperbilirubinemia: A cross-sectional, observational study","authors":"H. Kumar, T. Bandyopadhyay, P. Kumari, A. Maria, Swati Upadhyay","doi":"10.4103/jcn.jcn_61_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_61_22","url":null,"abstract":"Introduction: Neonatal jaundice is a common cause of hospital admission among neonates in the 1st week of life. The condition results from an imbalance between oxidative stress and antioxidant mechanisms. Considering the fact that the metabolism of both bilirubin and 25-hydroxy Vitamin D occurs in the liver and 25-hydroxy Vitamin D being a potent antioxidant, we hypothesized that there exists an association between 25-hydroxy Vitamin D and serum bilirubin levels. Methods: A total of 174 neonates were enrolled in the study and were further subclassified into 4 groups: Group A (no clinical jaundice), Group B (clinical jaundice with the value of serum bilirubin <10 mg/dl), Group C (clinical jaundice with the value of serum bilirubin >10 mg/dl but not in phototherapy range), and Group D (clinical jaundice with serum bilirubin value requiring initiation of phototherapy). 25-hydroxy Vitamin D and serum bilirubin levels along with parathyroid hormone, calcium, phosphorus, and alkaline phosphatase levels were estimated. Results: The mean 25-hydroxy Vitamin D levels were highest in Group A and lowest in Group D (21.92 ± 20.85 vs. 14.38 ± 8.52, P = 0.020) and vice versa for serum bilirubin levels (15.08 ± 0.93 vs. 4.28 ± 0.97, P < 0.001). There was a nonsignificant negative correlation between serum 25-hydroxy Vitamin D and bilirubin levels (correlation coefficient: −0.113 [−0.257–0.0364], P = 0.138). Conclusion: The present study suggests a lack of association between serum 25-hydroxy Vitamin D and bilirubin levels. However, the results need to be confirmed by further prospective studies to conclude that 25-hydroxy Vitamin D has no role in the pathogenesis of neonatal hyperbilirubinemia.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"206 - 211"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47286784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful management of a cutaneous abscess caused by Candida albicans in a very low birth weight neonate 成功的管理皮肤脓肿引起的白色念珠菌在一个非常低出生体重的新生儿

IF 0.2

Journal of Clinical Neonatology Pub Date : 2022-10-01 DOI: 10.4103/jcn.jcn_36_22

V. Vaddi, Medha Goyal, Dwayne Mascarenhas, A. Haribalakrishna

{"title":"Successful management of a cutaneous abscess caused by Candida albicans in a very low birth weight neonate","authors":"V. Vaddi, Medha Goyal, Dwayne Mascarenhas, A. Haribalakrishna","doi":"10.4103/jcn.jcn_36_22","DOIUrl":"https://doi.org/10.4103/jcn.jcn_36_22","url":null,"abstract":"Fungal sepsis is a sinister infection in the neonatal intensive care unit associated with significant mortality and neurodevelopment sequelae. Very low birth weight and very preterm neonates are often predisposed and manifestations range from mucocutaneous to invasive organ involvement. Prompt recognition and treatment with appropriate antifungal improve survival and neurodevelopmental outcomes. In this report, we describe a neonate with rare dermatological manifestation in the form of a cutaneous fungal abscess with urinary tract involvement. The diagnosis was based on budding yeast cells seen on pus smear examination and culture suggestive of Candida albicans. Risk factors included birth weight <1500 g, placement of central vascular catheter, endotracheal tube, parenteral nutrition, surgical intervention, and use of broad-spectrum antibiotics. Amphotericin B deoxycholate and incision and drainage of the abscess were done to manage the abscess successfully. This report highlights the consideration of Candida as an etiological agent for cutaneous abscesses, in case of preterms with risk factors for fungal infection. Evaluation for systemic dissemination is mandatory and management with appropriate antifungal agents is critical for survival.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"219 - 221"},"PeriodicalIF":0.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46650175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2