Clinics and Practice最新文献_第9页

How to Evaluate the Efficacy of Manipulations in Spine Disorders-A Comprehensive Review of New and Traditional Outcome Measures. 如何评估脊柱疾病手法治疗的疗效--全面回顾新的和传统的疗效测量方法。

IF 1.7

Clinics and Practice Pub Date : 2024-07-29 DOI: 10.3390/clinpract14040119

Giacomo Farì, Carlo Mariconda, Laura Dell'Anna, Francesco Quarta, Danilo Donati, Cristiano Sconza, Vincenzo Ricci, Giustino Varrassi, Valeria Coco, Alessandro Manelli, Ennio Spadini, Maria Teresa Giglio, Andrea Bernetti

{"title":"How to Evaluate the Efficacy of Manipulations in Spine Disorders-A Comprehensive Review of New and Traditional Outcome Measures.","authors":"Giacomo Farì, Carlo Mariconda, Laura Dell'Anna, Francesco Quarta, Danilo Donati, Cristiano Sconza, Vincenzo Ricci, Giustino Varrassi, Valeria Coco, Alessandro Manelli, Ennio Spadini, Maria Teresa Giglio, Andrea Bernetti","doi":"10.3390/clinpract14040119","DOIUrl":"10.3390/clinpract14040119","url":null,"abstract":"Spine pain (SP) is the most common musculoskeletal disorder that causes transitional forms of motor disability. Considering its affordability and safety, manipulative therapy (MT) stands as one of the primary therapeutic approaches for SP and the related dysfunctional consequences. However, it is still difficult to assess and quantify the results of this treatment since there is a lack of objective evaluation tools in the available scientific literature. Thus, the purpose of this comprehensive review is to summarize the main outcomes used to evaluate the effectiveness of spine manipulations, focusing on their strengths and weaknesses. An extensive review of the PubMed, Cochrane, and Embase databases was performed to identify the literature of the last ten years regarding MT and the related assessment tools. A total of 12 studies met the inclusion criteria. The analyzed literature indicates that a wide range of outcome measures have been used to assess the effectiveness of spine MT. Pain is the main aspect to be investigated but it remains difficult to elucidate since it is strongly linked to various dimensions such as self-perception and psychological aspects. Therefore, it seems necessary to include new tools for evaluating the effects of spine MT, with the aim of exploiting new technologies and taking into consideration the SP biomechanical and biopsychosocial aspects.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1478-1495"},"PeriodicalIF":1.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting Pulmonary Sclerosing Pneumocytoma. 重新审视肺硬化性肺细胞瘤

IF 1.7

Clinics and Practice Pub Date : 2024-07-22 DOI: 10.3390/clinpract14040116

Claudia Manini, Simone Vezzini, Antonella Conte, Giuseppe Sciacca, Alessandro Infantino, Poliana Santos-Pereira, José I López

{"title":"Revisiting Pulmonary Sclerosing Pneumocytoma.","authors":"Claudia Manini, Simone Vezzini, Antonella Conte, Giuseppe Sciacca, Alessandro Infantino, Poliana Santos-Pereira, José I López","doi":"10.3390/clinpract14040116","DOIUrl":"10.3390/clinpract14040116","url":null,"abstract":"Pulmonary sclerosing pneumocytoma (PSP) is a quite rare tumor outside Eastern countries. This rarity, together with a wide histological appearance, makes its correct identification a diagnostic challenge for pathologists under the microscope. Historically, PSP was considered a vascular-derived neoplasm (sclerosing hemangioma), but its immunohistochemical profile clearly supports its epithelial origin. No specific molecular fingerprint has been detected so far. This short narrative revisits the clinical, histological, immunohistochemical, and molecular aspects of this tumor, paying special attention to some controversial points still not well clarified, i.e., clinical aggressiveness and metastatic spread, multifocality, the supposed development of sarcomatoid change in a subset of cases, and tumor associations with lung adenocarcinoma and/or well-differentiated neuroendocrine hyperplasia/tumors. The specific diagnostic difficulties on fine-needle aspiration cytology/biopsy and perioperative frozen sections are also highlighted. Finally, a teaching case of tumor concurrence of lung adenocarcinoma, neuroendocrine lesions, and PSP, paradigmatic of tumor association in this context, is also presented.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1440-1450"},"PeriodicalIF":1.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Social Constraints, Psychosocial Adjustment and Optimism among Dialysis Patients. 透析患者的社会限制、社会心理适应和乐观情绪调查。

IF 1.7

Clinics and Practice Pub Date : 2024-07-19 DOI: 10.3390/clinpract14040115

Eirini Zorba, Georgia Fasoi, Eirini Grapsa, Afroditi Zartaloudi, Maria Polikandrioti, Victoria Alikari, Areti Stavropoulou, Chrysoula Dafogianni, Orchan Impis, Georgia Gerogianni

{"title":"Investigation of Social Constraints, Psychosocial Adjustment and Optimism among Dialysis Patients.","authors":"Eirini Zorba, Georgia Fasoi, Eirini Grapsa, Afroditi Zartaloudi, Maria Polikandrioti, Victoria Alikari, Areti Stavropoulou, Chrysoula Dafogianni, Orchan Impis, Georgia Gerogianni","doi":"10.3390/clinpract14040115","DOIUrl":"10.3390/clinpract14040115","url":null,"abstract":"Background: Social constraints are perceived as unsupportive behaviors, leading to inadequate psychosocial adjustment, while optimism can help people recover from distress and reduce any negative effects of chronic disease. The aim of this study was to investigate social constraints, psychosocial adjustment and optimism among patients on dialysis.Methods: In this study, 402 patients undergoing dialysis in Greece completed the following questionnaires: (i) the Social Constraints Scale (SCS) for the assessment of social constrains, (ii) the Psychosocial adjustment to illness scale (PAIS-SR) for the assessment of psychosocial adjustment, and (iii) the LOT-R scale for the assessment of optimism. A Mann-Whitney test was used for the comparison of continuous variables between two groups. Spearman correlation coefficients (rho) were used to explore the association of two continuous variables. Multiple linear regression analysis was used with the SCS scale.Results: Greater difficulty in psychosocial adjustment in the domestic, vocational, extended family and social environments, sexual relationships, and health care as well as greater psychological distress were significantly associated with a greater occurrence of social constraints (p < 0.001). Additionally, greater optimism was significantly associated with fewer social constraints and lower difficulty in adjusting to their disease (p < 0.001).Conclusions: Greater difficulty in all dimensions of psychosocial adjustment is associated with more social constraints, while optimism is associated with fewer social constraints and better disease adjustment.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1430-1439"},"PeriodicalIF":1.7,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Relationship between Chronic Liver Cirrhosis and Parkinsonism: A Comparative Analysis and a Suggested Diagnostic Scheme. 慢性肝硬化与帕金森病的关系研究：比较分析与诊断方案建议》。

IF 1.7

Clinics and Practice Pub Date : 2024-07-11 DOI: 10.3390/clinpract14040110

Tal Sigawi, Omer Hamtzany, Noa Hurvitz, Yuval Ishay, Roy Dayan, David Arkadir, Yaron Ilan

{"title":"Investigating the Relationship between Chronic Liver Cirrhosis and Parkinsonism: A Comparative Analysis and a Suggested Diagnostic Scheme.","authors":"Tal Sigawi, Omer Hamtzany, Noa Hurvitz, Yuval Ishay, Roy Dayan, David Arkadir, Yaron Ilan","doi":"10.3390/clinpract14040110","DOIUrl":"10.3390/clinpract14040110","url":null,"abstract":"Aim: Neurological manifestations are common in patients with chronic liver diseases. This study aimed to depict the association between liver cirrhosis and Parkinson's disease (PD) and propose a clinically relevant diagnostic scheme. Methods: We examined patients' medical records with PD and chronic liver impairment secondary to cirrhosis or liver metastases for temporal correlations between liver insult and Parkinsonian signs. Results: Thirty-five individuals with PD and chronic liver impairment were included due to either cirrhosis or liver metastases. In all 22 patients with PD and liver metastases, the diagnosis of PD preceded the diagnosis of cancer. Conversely, patients with cirrhosis were often diagnosed with liver impairment before diagnosing PD. Age at diagnosis did not account for this difference. Conclusions: This study reinforces the potential clinical association between cirrhosis and PD. We also provide a diagnostic scheme that may guide therapeutic interventions and prognostic assessments.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1375-1382"},"PeriodicalIF":1.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Thyroidectomy and Lobectomy on Patients' Health-Related Quality of Life, Eastern Region, Saudi Arabia. 甲状腺切除术和甲状腺叶切除术对患者健康相关生活质量的影响，沙特阿拉伯东部地区。

IF 1.7

Clinics and Practice Pub Date : 2024-06-29 DOI: 10.3390/clinpract14040101

Zainab Ali AlOsaif, Hassan Mohammed Al Bisher, Hend Abdelmonem Elshnawie, Mohammed Taha Al-Hariri

{"title":"The Impact of Thyroidectomy and Lobectomy on Patients' Health-Related Quality of Life, Eastern Region, Saudi Arabia.","authors":"Zainab Ali AlOsaif, Hassan Mohammed Al Bisher, Hend Abdelmonem Elshnawie, Mohammed Taha Al-Hariri","doi":"10.3390/clinpract14040101","DOIUrl":"10.3390/clinpract14040101","url":null,"abstract":"Introduction: The thyroid gland is a crucial endocrine organ that can be susceptible to various pathological conditions, often necessitating total thyroidectomy or lobectomy. It is a common surgical procedure in Saudi Arabia. Thus, it is essential to recognize the impact of thyroid surgery on patients' health-related quality of life (HRQoL).Aim: The aim of this study was to evaluate HRQoL among patients with benign and malignant thyroid diseases who underwent thyroidectomy in the eastern region of Saudi Arabia.Methods: This cross-sectional study was conducted at King Fahad Hospital of University in Khobar, Kingdom of Saudi Arabia from January 2018 to May 2018. The data collection method used was divided into two parts. Part I included the patients' socio-demographic characteristics and the clinical characteristics of their thyroid surgery. Part II was a HRQoL questionnaire (SF-36, version 1.0).Results: The sample included 100 thyroidectomy patients ≥18 years. The study findings revealed that the overall scores for post-thyroidectomy patients showed a significant improvement in HRQoL, and HRQoL was not significantly associated with benign or malignant thyroid diseases.Conclusion: Especially when the surgery is performed by a high-volume endocrine surgeon, thyroidectomy may lead to significant improvements in HRQoL among patients, including the elderly and younger adults, with benign and malignant thyroid disorders. There was no difference in HRQoL between patients who underwent total thyroidectomy or thyroid lobectomy. Also, HRQol among thyroidectomy patients is associated with their educational and occupational statuses.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1251-1263"},"PeriodicalIF":1.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-to-Treatment Delays and Their Prognostic Implications in Pharyngeal Cancer-An Exploratory Analysis in Western Romania. 咽癌治疗时间延迟及其预后影响--罗马尼亚西部的探索性分析。

IF 1.7

Clinics and Practice Pub Date : 2024-06-29 DOI: 10.3390/clinpract14040103

Andreea Mihaela Kiș, Roxana Buzatu, Lazar Chisavu, Marioara Poenaru, Claudia Borza, Andrada Iftode, Oana Silvana Sarau, Cristina Adriana Dehelean, Simona Ardelean

{"title":"Time-to-Treatment Delays and Their Prognostic Implications in Pharyngeal Cancer-An Exploratory Analysis in Western Romania.","authors":"Andreea Mihaela Kiș, Roxana Buzatu, Lazar Chisavu, Marioara Poenaru, Claudia Borza, Andrada Iftode, Oana Silvana Sarau, Cristina Adriana Dehelean, Simona Ardelean","doi":"10.3390/clinpract14040103","DOIUrl":"10.3390/clinpract14040103","url":null,"abstract":"Background: Diagnosis and treatment for pharyngeal cancer are decisive in determining prognosis. Diagnosis delays are frequent, representing a significant cause of avoidable mortality, and an important factor in subpar survival across the continuous HNC care delivery.Methods: The present study represents a retrospective analysis of medical records from Western Romania, which included 180 patients, to evaluate the impact of time-to-treatment delay on patients diagnosed with pharyngeal cancer. The data analyses were performed using the Kaplan-Meier method R (version 3.6.3) packages, including tidyverse, final-fit, mcgv, survival, stringdist, janitor, and Hmisc.Results: The mean days from diagnosis until the end of treatment were higher for the nasopharynx group. Cox regression analysis regarding diagnosis to treatment duration categories showed an increased risk mortality by 3.11 times (95%CI: 1.51-6.41, p = 0.0021) with a Harrell's C-index of 0.638 (95%CI: 0.552-0.723). The hypopharynx and oropharynx locations increased risk mortality by 4.59 (95%CI: 1.55-13.55) and 5.49 times (95%CI: 1.79-16.81) compared to the nasopharynx location.Conclusions: The findings of this study led to the conclusion that it seems there is a trend of mortality risk for oropharynx and hypopharynx cancers due to delays in the time to treatment over 70 days, standing as a basis for further research as there is an imperative need for prospective multicenter studies.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1270-1284"},"PeriodicalIF":1.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Atypical Case of Extrapulmonary Sarcoidosis with Severe Hypercalcemia as Initial Presentation, Successfully Treated with Glucocorticoids. 一个以严重高钙血症为首发症状的非典型肺外肉样瘤病例，使用糖皮质激素治疗后获得成功。

IF 1.7

Clinics and Practice Pub Date : 2024-06-29 DOI: 10.3390/clinpract14040102

Sushmita Mittal, Karolina Pogorzelski, Christopher Huxel, Chokkalingam Siva, Deepthi Rao

{"title":"An Atypical Case of Extrapulmonary Sarcoidosis with Severe Hypercalcemia as Initial Presentation, Successfully Treated with Glucocorticoids.","authors":"Sushmita Mittal, Karolina Pogorzelski, Christopher Huxel, Chokkalingam Siva, Deepthi Rao","doi":"10.3390/clinpract14040102","DOIUrl":"10.3390/clinpract14040102","url":null,"abstract":"Background: Sarcoidosis is a multisystemic disease that is histologically characterized by non-caseating granulomas in one or more organs. Although hypercalcemia is commonly seen in sarcoidosis, clinically significant hypercalcemia as the initial presentation of sarcoidosis is exceedingly rare. Long-standing hypercalcemia can lead to several complications and needs to be adequately managed to prevent irreversible damage. Currently, there are no standard treatment guidelines for sarcoidosis-induced hypercalcemia, although glucocorticoids have often been used as first-line therapy.Case report: We describe a 55-year-old male patient who presented with dull right upper quadrant abdominal pain and a 30-pound weight loss over one month. He was found to have severe hypercalcemia, which was treated with intravenous (IV) normal saline and intramuscular calcitonin. Imaging studies revealed hypodense lesions throughout the bilateral hepatic lobes, spleen, and bilateral kidneys, with no pathologic mediastinal, hilar, supraclavicular, or axillary lymphadenopathy or pulmonary parenchymal disease. A splenic biopsy confirmed extrapulmonary sarcoidosis. After initial discharge, the patient was re-admitted weeks later for severe hypercalcemia, which was successfully treated with the initiation of prednisone.Conclusions: In this report, we present an atypical case of isolated extrapulmonary sarcoidosis with severe hypercalcemia as the initial presentation, successfully treated with steroids.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1264-1269"},"PeriodicalIF":1.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuck Canal Endometriosis Following IVF Attempts in a Young Patient-Report of a Case. 年轻患者尝试体外受精后的纳克管子宫内膜异位症--病例报告。

IF 1.7

Clinics and Practice Pub Date : 2024-06-28 DOI: 10.3390/clinpract14040100

Maria Papadoliopoulou, Ioannis Margaris, Athanasios Giannakis, Menelaos G Samaras, Nikolaos V Michalopoulos, Panayiotis Kokoropoulos, Ioannis Panayiotides, Nikolaos Arkadopoulos

{"title":"Nuck Canal Endometriosis Following IVF Attempts in a Young Patient-Report of a Case.","authors":"Maria Papadoliopoulou, Ioannis Margaris, Athanasios Giannakis, Menelaos G Samaras, Nikolaos V Michalopoulos, Panayiotis Kokoropoulos, Ioannis Panayiotides, Nikolaos Arkadopoulos","doi":"10.3390/clinpract14040100","DOIUrl":"10.3390/clinpract14040100","url":null,"abstract":"Introduction: Endometriosis is a common benign condition affecting 10-15% of women of reproductive age. An unusual site of endometriosis is the canal of Nuck, which is a physiologically obliterated space in women spanning the area from the deep inguinal ring to the labia majora.Case presentation: A 37-year-old woman, with a past medical history of several in vitro fertilization attempts, presented with a right-sided painful inguinal mass. She was subsequently offered surgical exploration and excision of the lesion, which revealed the presence of endometrial glands and stroma.Discussion: Despite being a relatively common and benign pelvic condition, endometriosis can rarely manifest in the inguinal region, within the canal of Nuck. The treating physician should be cognizant of Nuck canal endometriosis, especially in young female patients presenting with an irreducible mass in the inguinal region and associated cyclic pain or infertility.Conclusion: When clinically and radiologically suspected, surgical excision is indicated to establish the diagnosis, provide symptomatic relief and guide further decision making.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1245-1250"},"PeriodicalIF":1.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Readmission in Young Adults with First-Episode Psychosis: A Multicentric Retrospective Study with a 12-Month Follow-Up. 青年首发精神病患者再入院的预测因素：随访 12 个月的多中心回顾性研究。

IF 1.7

Clinics and Practice Pub Date : 2024-06-24 DOI: 10.3390/clinpract14040099

Filippo Besana, Serena Chiara Civardi, Filippo Mazzoni, Giovanni Carnevale Miacca, Vincenzo Arienti, Matteo Rocchetti, Pierluigi Politi, Vassilis Martiadis, Natascia Brondino, Miriam Olivola

{"title":"Predictors of Readmission in Young Adults with First-Episode Psychosis: A Multicentric Retrospective Study with a 12-Month Follow-Up.","authors":"Filippo Besana, Serena Chiara Civardi, Filippo Mazzoni, Giovanni Carnevale Miacca, Vincenzo Arienti, Matteo Rocchetti, Pierluigi Politi, Vassilis Martiadis, Natascia Brondino, Miriam Olivola","doi":"10.3390/clinpract14040099","DOIUrl":"10.3390/clinpract14040099","url":null,"abstract":"Background: A significant number of young individuals are readmitted one or more times shortly after their first episode of psychosis. Readmission may represent a marker of psychopathological vulnerability. Our primary aim was to evaluate the impact of clinical and socio-demographic variables on readmission at 12-month follow-up. Secondly, our goal was to determine whether the use of Long-Acting Injection (LAI) antipsychotics provides notable benefits compared to oral medications in preventing subsequent readmissions.Subjects and methods: 80 patients hospitalised for the first time with a diagnosis of psychotic disorder (ICD-10 criteria) were retrospectively assessed through clinical records. The mean age was 21.7 years. Patients were predominantly male (n = 62, 77.5%), and 55 subjects had at least 8 years of education. 50% of the sample was \"NEET\" (not in education, employment, or training).Results: 35 patients (43.8%) were discharged with a LAI antipsychotic, while 45 (56.2%) recieved oral antipsychotic therapy. Substance use (p = 0.04) and oral antipsychotics at discharge (p = 0.003) were significantly associated with readmission at 1 year. We did not find any significant predictors of being discharged with LAI therapy.Conclusion: Our findings underlined the importance of identifying patients at risk of readmission in order to prevent future rehospitalization and promote appropriate prevention strategies. LAIs should be considered as a first-choice treatment for patients hospitalised for FEP since they proved to be effective in preventing relapse.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1234-1244"},"PeriodicalIF":1.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Higher Neutrophil Count Is Associated with Favorable Achievement of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia Who Received Second Generation Tyrosine Kinase Inhibitor as Frontline Treatment. 接受第二代酪氨酸激酶抑制剂前线治疗的慢性髓性白血病患者中性粒细胞计数越高，无治疗缓解率越高。

IF 1.7

Clinics and Practice Pub Date : 2024-06-21 DOI: 10.3390/clinpract14040097

Hiroshi Ureshino, Yusuke Takeda, Kazuharu Kamachi, Takaaki Ono, Noriyoshi Iriyama, Eiichi Ohtsuka, Emiko Sakaida, Shinya Kimura

{"title":"A Higher Neutrophil Count Is Associated with Favorable Achievement of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia Who Received Second Generation Tyrosine Kinase Inhibitor as Frontline Treatment.","authors":"Hiroshi Ureshino, Yusuke Takeda, Kazuharu Kamachi, Takaaki Ono, Noriyoshi Iriyama, Eiichi Ohtsuka, Emiko Sakaida, Shinya Kimura","doi":"10.3390/clinpract14040097","DOIUrl":"10.3390/clinpract14040097","url":null,"abstract":"Background: ABL1 tyrosine kinase inhibitor discontinuation securely became among the therapeutic goal for chronic myeloid leukemia chronic phase patients (CML-CP). To establish successful prognostic factors for treatment-free remission (TFR), it is necessary to diagnose the patients with high-risk molecular relapse, however, a biomarker for the achievement of TFR has not been completely elucidated. Recent investigations have determined that neutrophils function crucially in cancer immunology.Patients and methods: The research was a multicenter retrospective observational study to examine the correlation between TFR and neutrophil counts before TKI discontinuation. The investigation included patients having Philadelphia chromosome-positive CML-CP who attempted the discontinuation of TKIs after a durable deep molecular response between January 2012 and July 2021 at four institutions in Japan.Results: 118 CML-CP patients in total discontinued TKIs and an estimated 36-month TFR rate was 65.1%. 52 patients received second-generation TKIs as frontline. Higher neutrophil count (>3210/μL) at TKIs discontinuation was determined as an independent prognostic variable for TFR in patients who received second-generation TKIs as frontline [(HR, 0.235 (95%, confidence interval (CI) 0.078-0.711); p = 0.010].Conclusions: The neutrophil-mediated immunomodulation can be a significant component for the effective achievement of TFR in CML supported by our clinical observation.","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"14 4","pages":"1216-1224"},"PeriodicalIF":1.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0