Clinics and Practice最新文献

{"title":"\"Walking a Day in My Shoes\": A Clinical Shadowing Program to Enhance Medical Students' Understanding of Chronic Disease Management Beyond Clinical Settings.","authors":"Aidan Hilton, Waseem Jerjes","doi":"10.3390/clinpract15050094","DOIUrl":"10.3390/clinpract15050094","url":null,"abstract":"<p><strong>Aims/background: </strong>Medical education is largely clinical and biomedical with little emphasis being put upon the social determinants of health (SDH) and patient-centredness. A programme entitled \"Walking a Day in My Shoes\" was devised as a pilot cohort study with the view of evaluating the impact of a clinical shadowing experience upon the empathy, SDH awareness, and patient-centredness of medical students.</p><p><strong>Methods: </strong>A prospective cohort study, involving 28 final-year London-area medical students, employing a three-phase teaching programme comprising preparation, observation, and reflection was carried out. Students' confidence in the management of non-medical barriers, SDH awareness, and empathy before and after shadowing were measured using pre- and post-shadowing questionnaires. Qualitative analysis of patient feedback and journals also occurred.</p><p><strong>Results: </strong>Statistically significant improvements were observed in students' empathy (mean score increase from 6.8 to 8.9, <i>p</i> < 0.001), understanding of SDH (advanced comprehension rose from 35% to 93%), confidence in addressing non-clinical barriers (from 39% to 86%), and awareness of logistical challenges (from 31% to 81%). Qualitative analysis highlighted key themes, including systemic barriers (transportation, polypharmacy, and social isolation) and students' increased awareness of the emotional toll of chronic illness. Patients expressed high satisfaction, with 97% agreeing that the programme improved students' understanding of chronic disease management. These findings suggest the programme's practicality and scalability in medical education.</p><p><strong>Conclusions: </strong>This pilot cohort study demonstrated the significant enhancement of the students' empathy, perception of SDH, and patient-centredness preparation through immersive shadowing. The findings support the use of experiential learning programmes as curricular interventions.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Ancient Greek Physicians in the Development of Tracheostomy: Pioneering Airway Interventions and Early Thoracic Surgery.","authors":"Vasileios Leivaditis, Francesk Mulita, Nikolaos G Baikoussis, Elias Liolis, Andreas Antzoulas, Levan Tchabashvili, Konstantinos Tasios, Dimitrios Litsas, Manfred Dahm","doi":"10.3390/clinpract15050093","DOIUrl":"10.3390/clinpract15050093","url":null,"abstract":"<p><p>Tracheostomy, a critical airway intervention, has a long and complex history that dates back to antiquity. While the earliest references to the procedure appear in Egyptian and Indian medical texts, its development within ancient Greek medicine remains a subject of historical debate. This study explores the evolution of tracheostomy in ancient Greece, analyzing its theoretical foundations, historical accounts, and surgical advancements. Despite Hippocratic opposition, which largely discouraged invasive airway procedures due to the risk of fatal complications, later physicians such as Asclepiades, Aretaeus, and Antyllus made significant contributions to refining airway management techniques. The anatomical studies of Galen further advanced the understanding of respiratory physiology, including early concepts of artificial ventilation. Additionally, this study examines archaeological evidence, such as a marble relief discovered in Abdera, which may depict an early attempt at tracheostomy, providing valuable insight into the practical application of airway interventions in antiquity. By comparing ancient Greek surgical techniques with modern tracheostomy practices, this research highlights the continuity of medical knowledge and innovation. It underlines the role of ancient Greek physicians in shaping the principles of thoracic surgery, offering a broader understanding of how early medical practices have influenced contemporary airway management. The findings contribute to the historical perspective on tracheostomy, emphasizing the timeless pursuit of life-saving surgical advancements and the evolving relationship between theoretical medical knowledge and practical surgical application.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Job Demands and Resources Perceived by Dentists in a Digital Dental Workplace and Perceived Effects on Job Satisfaction and Stress: A Qualitative Study.","authors":"Julia Sofie Gebhardt, Volker Harth, David A Groneberg, Stefanie Mache","doi":"10.3390/clinpract15050092","DOIUrl":"10.3390/clinpract15050092","url":null,"abstract":"<p><p><b>Background:</b> Digitalisation is becoming increasingly integrated into the field of dentistry; therefore, it is crucial to understand both the challenges it introduces and the opportunities it provides. By doing so, the research will offer insights into how digital tools can affect the work environment and contribute to the overall well-being and performance of dental professionals. <b>Objectives:</b> The present study aims to explore how dentists perceive the demands and resources within a digitalised dental practice. <b>Methods:</b> The present study adopted a qualitative design, incorporating guideline-based interviews. A total of 30 interviews were conducted with dentists from various German dental practices, with a focus on key topics such as job demands, job resources, digital stress factors, job satisfaction, and support needs in the context of digital dentistry. The interview data were analysed using qualitative content analysis. <b>Results:</b> The findings highlight that digital systems in dental practices offer benefits such as reduced errors and time savings, but also pose challenges, especially for less experienced users. While they improve efficiency, precision, and professional development, they can also lead to negative effects like dependence on technology, loss of manual skills, technical failures, and increased stress, particularly during the adaptation phase. These results suggest that successful integration of digital technologies requires adequate support to overcome initial learning curves and ensure long-term benefits. <b>Conclusions:</b> The results of the study underline the importance of effective implementation, comprehensive staff training, and technological reliability to maximise the benefits of digital tools and minimise their drawbacks. Maintaining a balance between digital stressors and resources is crucial to promoting a healthy work environment. Future research should focus on the long-term effects of training programmes and the integration of digital technologies into dental practices to increase their effectiveness in terms of job satisfaction and reduce potential risks.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous Pemphigoid Overlapping Psoriasis Vulgaris: A Rare Case Report and Literature Review.","authors":"Maria-Alexandra Timofte, Constantin Căruntu, Beatrice Bălăceanu-Gurău, Irina Mărgăritescu, Călin Giurcăneanu, Mara Mădălina Mihai","doi":"10.3390/clinpract15050091","DOIUrl":"10.3390/clinpract15050091","url":null,"abstract":"<p><p>Bullous pemphigoid (BP) is a rare autoimmune disease, primarily affecting elderly individuals, that significantly impacts the patient's quality of life. In contrast, psoriasis vulgaris (PV) is a common, chronic, immune-mediated skin condition recognized as a systemic T-cell-mediated disorder. We aim to present the case of a patient suffering from a dermatologic association of BP and PV, which unveiled hepatitis C viral infection as a potential trigger and led to complex therapeutic challenges. A literature review is also included, exploring previous cases of overlapping BP and PV, along with a discussion of the unique pathogenic mechanisms and an analysis of the available therapeutic options. The patient, a 53-year-old male with a seven-year history of PV, presented with tense bullae overlying the psoriatic papules and plaques, with a generalized distribution. The presence of hepatitis C infection was considered a potential trigger for the concurrent presentation of BP and PV. Recent GWASs have demonstrated a potential causal relationship between PV and the subsequent development of BP, suggesting shared genetic susceptibility and immune pathways. However, the exact mechanisms driving this transition remain incompletely understood. Our case is particularly relevant as it exemplifies how environmental triggers-such as chronic hepatitis C infection-together with chronic cutaneous inflammation may act as cofactors in this process, possibly through the 'epitope spreading' phenomenon. This case underlines the importance of identifying triggering factors in patients with overlapping autoimmune diseases and reinforces the need for future research to further elucidate the pathogenic link between genotype and phenotype, in order to improve personalized therapeutic strategies.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study of Biostimulation with Low-Power Diode Laser After Dental Extractions.","authors":"Yolanda Collado Murcia, Pia Lopez-Jornet, Francisco Parra Perez","doi":"10.3390/clinpract15050090","DOIUrl":"10.3390/clinpract15050090","url":null,"abstract":"<p><p><b>Introduction:</b> The objective of the present work is to assess the efficacy of photobiomodulation (PBM) with respect to pain, inflammation, and healing after tooth extractions as compared with a sham treatment. <b>Method:</b> A single-blinded, randomized clinical study conducted in a private dental clinic in Murcia, it included 124 patients who needed a tooth extraction, excluding those with medical conditions that could affect healing (such as non-controlled diabetes, immunosuppression, or hemorrhagic disorders). Group I (Experimental): extraction and PBM session with a diode laser (power: 0.5 W, energy 15 J/cm² for 10-30 s at 1 mm from the tissue). Group II (Sham treatment): tooth extraction and application of inactive PBM. <b>Results:</b> Pain and inflammation decreased similarly in both groups over time. Anxiety decreased in both groups without significant differences (<i>p</i> = 0.776; <i>p</i> = 0.246). There was no evidence that the treatment or location of the extraction had an influence on healing. Suturing the socket increased the likelihood of good healing (<i>p</i> = 0.048), while long procedures reduced it (<i>p</i> = 0.040). <b>Conclusions:</b> PBM is a non-invasive and safe therapy. This study did not show significant differences with respect to the sham treatment. More research is needed with a standardized methodology to better assess its efficacy.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Prenatal Vitamin D Deficiency in Early Allergic Rhinitis in Neonates in Greece: Insights from a Cross-Sectional Study at the \"Tzaneio\" General Hospital.","authors":"Artemisia Kokkinari, Evangelia Antoniou, Eirini Orovou, Maria Tzitiridou-Chatzopoulou, Maria Dagla, Georgios Iatrakis","doi":"10.3390/clinpract15050089","DOIUrl":"10.3390/clinpract15050089","url":null,"abstract":"<p><p><b>Background:</b> The role of vitamin D deficiency (VDD) in both mothers and neonates has been suggested as a possible factor in the development of allergic conditions in early infancy, however limited research has investigated this link in relation to allergic rhinitis (AR). This study investigates whether VDD in the mother-newborn dyad is associated with the onset of AR in neonates within the first three days after birth. The aim is to contribute to the understanding of neonatal allergic outcomes related to vitamin D status, which may inform future preventive strategies. This study investigates the role of vitamin D in the early onset of allergic rhinitis (AR) in neonates, specifically within the first three days of life. Although AR typically develops after years of allergen exposure and is rare in children under two, we aimed to explore its occurrence at this early stage. While no clear link was found between vitamin D and early AR onset, further research is needed to explore vitamin D levels at later ages and over longer time frames to clarify the relationship. <b>Methods:</b> A cross-sectional study was conducted between September 2019 and January 2022 in a single hospital. The study involved 248 infants born at ≥37 weeks of gestation and their mothers, who were of Greek nationality. The study included mother-infant pairs who met the inclusion criteria. Chi-square tests were applied to analyze the association between maternal or neonatal VDD and the presence of AR in neonates within the first three days after birth. In addition, multiple regression analysis was used to control other potential factors contributing to AR. <b>Results:</b> The results showed an unclear relationship between VDD and the onset of AR in neonates within the first three days of life. Although several factors were analyzed, the effect of VDD on the development of AR remained unclear. <b>Conclusions:</b> The findings highlight the lack of clarity regarding the effect of maternal and neonatal VDD on the incidence of AR in the immediate neonatal period. Few studies to date have specifically examined the role of VDD in neonatal AR. Further research with larger sample sizes is needed to verify these associations and to guide potential interventions aimed at reducing allergic outcomes in neonates.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Sport Specialization in a Pediatric Population: A Rapid Review of Injury, Function, Performance, and Psychological Outcomes.","authors":"Emily J Luo, Jake Reed, John Kyle Mitchell, Emilie Dorrestein, Lulla V Kiwinda, Steph Hendren, Zoe W Hinton, Brian C Lau","doi":"10.3390/clinpract15050088","DOIUrl":"10.3390/clinpract15050088","url":null,"abstract":"<p><p><b>Background</b>: Early sport specialization, involving intensive focus on a single sport for greater than 8 months per year at a prepubescent age, has become increasingly common in young athletes. While early sport specialization is often regarded as essential for success, there is growing concern that the potential risks to young athletes may outweigh the perceived benefits. Although numerous studies have explored early sport specialization, there has been no summative review on the topic in regard to the comprehensive impact on outcomes in these athletes. This study aims to systematically review the literature to determine the impacts of early specialization on injury, function, performance, sport success, and psychological outcomes. <b>Methods</b>: A review of Medline (PubMed) was conducted to search for studies relating to early sport specialization in pediatric patients (time of specialization < 18 years old) and outcomes. Extracted information included injury outcomes with a focus on overuse injuries, functional outcomes, performance outcomes, sport success, and psychological outcomes. For studies that reported relevant statistics, <i>p</i> < 0.05 was considered statistically significant. All studies were described qualitatively. <b>Results</b>: An initial search resulted in a total of 826 studies. After applying inclusion and exclusion criteria, 93 studies were included. A total of 62,327 athletes were included in the study. The average age of study participants was 15.9 years, with an average age at specialization of 11.6 years. Early sport specialization was associated with increased risk of injury, worse functional and physical performance, decreased or no benefit to sport success, and poor psychological outcomes. <b>Conclusions</b>: Early sport specialization was associated with increased risk of injury and negative impacts on functional and physical performance measures. There was also no clear advantage regarding sport success. Early sport specialization was linked to harmful effects on athlete psychological well-being. Late specialization, multisport participation, and following training volume guidelines can aid in mitigating these risks.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Psychometric Validation of Tinnitus Qualities and Impact Questionnaire.","authors":"Vinaya Manchaiah, Gerhard Andersson, Eldré W Beukes, Marc A Fagelson, De Wet Swanepoel, Eithne Heffernan, David Maidment","doi":"10.3390/clinpract15050087","DOIUrl":"10.3390/clinpract15050087","url":null,"abstract":"<p><p><b>Background:</b> To develop and validate the Tinnitus Qualities and Impact Questionnaire (TQIQ), a new tool for evaluating the perceived qualities of tinnitus sound. <b>Method:</b> The study was part of two clinical trials on internet-based tinnitus interventions, using cross-sectional (<i>n</i> = 380) and pretest-posttest data (<i>n</i> = 280). Participants completed various questionnaires online, including the newly developed TQIQ and measures of tinnitus severity (Tinnitus Functional Index; TFI), anxiety (Generalized Anxiety Disorder 7; GAD-7), depression (Patient Health Questionnaire 9; PHQ-9), insomnia (Insomnia Severity Index; ISI), and health-related quality of life (EQ-5D-5L Visual Analog Scale; VAS). The psychometric properties of the TQIQ were assessed, including construct validity, internal consistency reliability, floor and ceiling effects, interpretability, and responsiveness to treatment. <b>Results:</b> Exploratory factor analysis resulted in two factors that accounted for 57% of the variance-internal and external tinnitus qualities. Overall, 92% convergent validity predictions were confirmed; TQIQ total scores strongly (≥0.6) or moderately (0.30 to 0.59) correlated with the TFI, GAD-7, PHQ-9, and ISI. The known-groups validity prediction was confirmed as individuals with an overall TFI score > 50 (severe) obtained significantly higher TQIQ scores. All internal consistency reliability statistics were within the required range (Cronbach's α > 0.8). Floor and ceiling effects were negligible. ROC established clinically important cut-off scores, enhancing the interpretability of tinnitus severity classification. Finally, 89% convergent validity predictions were confirmed; TQIQ and TFI change scores were moderately correlated, indicating good responsiveness of the former to treatment. <b>Conclusions:</b> The TQIQ has adequate psychometric properties, providing a standardized measure for the assessment of characteristics of tinnitus sound in clinical practice.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Post-Tonsillectomy Hemorrhage Rate After Different Tonsillectomy Techniques: Systematic Review and Meta Analysis.","authors":"Mazyad M Alenezi, Faisal A Al-Harbi, Albaraa Nasser M Almoshigeh, Sultan S Alruqaie, Nada M Alshahrani, Alwaleed Mohammed Alamro, Abdulmalik Abdulaziz Aljulajil, Rayan Abduallah Alsaqri, Lama A Alharbi","doi":"10.3390/clinpract15050085","DOIUrl":"10.3390/clinpract15050085","url":null,"abstract":"<p><p><b>Introduction</b>: Post-tonsillectomy hemorrhage is a serious complication that varies according to the surgical technique used, potentially compromising patient safety and recovery. Even though several techniques were frequently used, including cold steel dissection, coblation, monopolar diathermy, and bipolar diathermy, there were certain discrepancies in hemorrhage rates in the literature. This meta-analysis aims to compare the rates of primary and secondary hemorrhage among these surgical techniques, with a focus on guiding clinical decision-making. <b>Methodology</b>: A total of 12 studies, published between 2005 and 2024, were selected from the PubMed, Web of Science, Scopus, and Cochrane Library databases, comprising 1684 participants from both pediatric and adult groups. Primary and secondary hemorrhage rates, surgical techniques, and study characteristics were extracted as data. Therefore, the aim of performing this meta-analysis with random-effects models was to calculate pooled estimates for hemorrhage rates and the heterogeneity index (I²). The techniques studied included cold steel dissection, coblation, monopolar diathermy, and bipolar diathermy. <b>Results</b>: The pooled primary hemorrhage rate across all techniques was 1.0% (95% Cl: 0.5-1.4%), with insignificant heterogeneity (I² = 0.0%, <i>p</i> < 0.665). By contrast, pooled secondary hemorrhage occurred at a rate of 5.8% (95% CI: 3.9-7.6%). Cold steel tonsillectomy was associated with the lowest secondary hemorrhage rate of 3.7% (95% CI: 0.8-6.6%, I² = 43.558%, <i>p</i> = 0.115), while bipolar diathermy had the highest secondary hemorrhage rate of 8.6% (95% CI: 2.3-15.0%, I² = 86.448%, <i>p</i> < 0.001). <b>Conclusions</b>: This meta-analysis underscores the considerable variability in rates of post-tonsillectomy hemorrhage frequency among various surgical techniques. Cold steel dissection appears to be the safest regarding secondary hemorrhage, while coblation likely minimizes primary bleeding. Bipolar diathermy comes across as the technique with the highest risk for primary hemorrhage and requires special caution during its use. Such results emphasize the need for careful selection of the surgical technique concerning patients' particular conditions and the need to enhance care periods to reduce the bearing of any hemorrhagic complications.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis.","authors":"Paula Alexandra Vulciu, Luminita Pilat, Maria-Daniela Mot, Voicu Dascau, Calin Daniel Popa, Norberth-Istvan Varga, Maria Puschita","doi":"10.3390/clinpract15050086","DOIUrl":"10.3390/clinpract15050086","url":null,"abstract":"<p><p><b>Background:</b> Heart failure (HF) is a leading cause of mortality across the globe, prompting ongoing research into novel biomarkers for improved risk stratification and patient management. <b>Methods:</b> This cross-sectional study aimed to investigate the relationship between two promising biomarkers, tetranectin and paraoxonase 1, and the severity of heart failure in a cohort of 87 patients with cardiovascular risk factors. Participants were categorized into three groups based on their New York Heart Association (NYHA) classification: no HF (Control), NYHA class I (G1), and NYHA class II-IV (G2). <b>Results:</b> Our analysis revealed a stepwise decrease in both TETRA and PON1 levels with increasing HF severity, with the Control group exhibiting the highest levels and the G2 group the lowest. Interestingly, a significant positive correlation between TETRA and PON1 was observed only in the Control group, suggesting a potential interplay between these biomarkers in healthy individuals that may be disrupted with the onset of HF. Furthermore, both TETRA and PON1 were positively associated with left ventricular ejection fraction (LVEF) and negatively associated with diastolic dysfunction, indicating their potential involvement in both systolic and diastolic cardiac function. <b>Conclusions:</b> These findings suggest that TETRA and PON1 may serve as valuable biomarkers for assessing HF severity and prognosis. Further research is warranted to validate these findings in larger, prospective studies and to explore their clinical utility in guiding treatment decisions.</p>","PeriodicalId":45306,"journal":{"name":"Clinics and Practice","volume":"15 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}