Sajala Kafle, Nisha Jha, Yunima Sapkota, Pathiyil Ravi Shankar
{"title":"Knowledge of community pharmacists in the Kathmandu Valley, Nepal about the risks associated with medication use during pregnancy.","authors":"Sajala Kafle, Nisha Jha, Yunima Sapkota, Pathiyil Ravi Shankar","doi":"10.3233/JRS-210026","DOIUrl":"https://doi.org/10.3233/JRS-210026","url":null,"abstract":"<p><strong>Background: </strong>Community pharmacists are among the most accessible health care providers.</p><p><strong>Objective: </strong>This study evaluates the knowledge of community pharmacists about the risks associated with medication use during pregnancy.</p><p><strong>Methods: </strong>A cross-sectional study was carried out in March 2021 among the 344 community pharmacies in the Kathmandu Valley, Nepal. Convenience sampling was used for data collection using a structured and validated questionnaire.</p><p><strong>Results: </strong>The majority of participants were male: 264 (76.7%), 94.2% were between the age of 21 to 30 years, and 53.1% had work experience of less than one year. Over half had completed diploma in pharmacy. Less than 10 medicines were dispensed to pregnant women daily in 61.6% of the pharmacies. Only 28.8% of the community pharmacists always inquired about pregnancy status from women in the reproductive age group. The median knowledge score was significantly different among individuals with different work experience and qualifications (p < 0.001). There was also difference in median scores according to average number of medicines dispensed daily (p = 0.006). The knowledge score also differed according to average number of medicines dispensed to pregnant woman and inquiry by the pharmacist about pregnancy status (p < 0.001).</p><p><strong>Conclusion: </strong>Our study revealed that the median knowledge scores need improvement.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39830629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and persistence of patient-reported visual problems associated with serotonin reuptake inhibiting antidepressants.","authors":"David Healy, Dee Mangin, Jonathan Lochhead","doi":"10.3233/JRS-210018","DOIUrl":"https://doi.org/10.3233/JRS-210018","url":null,"abstract":"<p><strong>Background: </strong>The majority of antidepressants inhibit serotonin reuptake and include the selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and the serotonin reuptake inhibiting tricyclic antidepressants.</p><p><strong>Objective: </strong>The objective of this study was to investigate and describe the range and impact of reported adverse visual effects linked to serotonin reuptake inhibiting antidepressants.</p><p><strong>Methods: </strong>Using data from a global database of patient spontaneous reports of drug adverse events, we systematically identified eligible reports of visual problems linked to the use of serotonin reuptake inhibiting antidepressants. We analyzed these data using simple descriptive statistics to present the range and impact.</p><p><strong>Results: </strong>We identified 124 reports of visual problems. Reports originate from 18 countries and involve 11 different drugs. The most commonly reported symptoms were vision blurred/visual acuity reduced (n = 79, 63.7%), night blindness (n = 22, 17.7%), vitreous floaters (n = 21, 16.9%), photophobia (n = 19, 15.3%), diplopia (n = 15, 12.1%), palinopsia (n = 13, 10.5%), visual field defect (n = 12, 9.7%), photopsia (n = 11, 8.9%) and visual snow syndrome (n = 11, 8.9%). 74 patients indicated that the side effect was bad enough to affect everyday activities, 62 had sought health care, and 50 indicated that their work had been affected. 49 patients reported an enduring vision problem after discontinuation of treatment.</p><p><strong>Conclusions: </strong>The data suggest that serotonin reuptake inhibiting antidepressants can produce a range of adverse effects on vision that in some cases can be long-lasting after discontinuation of the drug. Further efforts are needed to understand the mechanisms involved, the incidence among those prescribed these medications, and identify any risk or mitigation factors.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/JRS-210018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39290026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aly Zaheer Pathan, Jennifer Barwell, Artemis Kastrissianakis, Kiran Awan, Anie Abila, Amelia Lim, Rucchira Wickramasinghe, Anuj Pathare, Susan Deakin
{"title":"Patients' perception of personal protective equipment during the SARS-Cov-2 pandemic.","authors":"Aly Zaheer Pathan, Jennifer Barwell, Artemis Kastrissianakis, Kiran Awan, Anie Abila, Amelia Lim, Rucchira Wickramasinghe, Anuj Pathare, Susan Deakin","doi":"10.3233/JRS-227032","DOIUrl":"https://doi.org/10.3233/JRS-227032","url":null,"abstract":"<p><strong>Background: </strong>Since the outbreak of the coronavirus (SARS-Cov-2), wearing personal protective equipment (PPE) has become necessary. Patients' ability to recognize staff is disrupted impacting on the relationship between healthcare worker and patient.</p><p><strong>Objective: </strong>Assess the patients' perspective of healthcare workers wearing PPE and its effect on communication.</p><p><strong>Methods: </strong>Admitted Orthopaedic patients during the first wave of SARS-Cov-2 were surveyed about the experience with staff wearing PPE. In response to feedback, individual badges with large pictures and names were introduced to wear over PPE. Patient views and response to the badges was collected from surveying admitted patients.</p><p><strong>Results: </strong>Patients encountered staff wearing face masks and felt this was appropriate in the context of the pandemic. 44% responded that they would prefer staff wearing badges with names, roles and pictures more visible. Following the introduction of badges, patients were better able to recognize staff roles and remember names. Hospital staff felt this was a positive change to help improve rapport while wearing PPE.</p><p><strong>Conclusion: </strong>Wearing PPE affects patients' ability to recognize individuals in a fast-paced environment such as an acute hospital. Introducing badges was an intervention based on patient feedback and an important adaptation to sustained PPE use to improve the patient's experience.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/51/jrs-33-jrs227032.PMC9844063.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10782286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Barriers to access to clinical trial data: Obstruction of a RIAT reanalysis of the treatment for adolescents with depression study.","authors":"Natalie Aboustate, Jon Jureidini","doi":"10.3233/JRS-210022","DOIUrl":"https://doi.org/10.3233/JRS-210022","url":null,"abstract":"<p><strong>Background: </strong>Public access to data has been a major step in attempting to reduce bias in scientific literature. Data to verify efficacy outcomes are now more accessible; however, little has been done to ensure public access to harms data from RCTs, which are equally important in ascertaining possible misreporting and protecting safety.</p><p><strong>Objective: </strong>The treatment for adolescents with depression study (TADS) has influenced most international practice guidelines for treating children and adolescents with depression, supporting first-line prescription of fluoxetine in combination with cognitive behavioural therapy (CBT). However, after over 30 publications by the TADS team, reporting on harms remains highly deficient and we aimed to redress this lack.</p><p><strong>Methods: </strong>In undertaking a restoring invisible and abandoned trials (RIAT) reanalysis of TADS' effectiveness and safety outcomes, we sought access to de-identified serious adverse events (SAE) data.</p><p><strong>Results: </strong>This paper describes our unsuccessful efforts to obtain more detailed SAE data from TADS' data custodians, highlighting several problematic blocks to comprehensive safety reporting.</p><p><strong>Conclusion: </strong>Comprehensive access to clinical trial data is necessary to ensure safe and fully informed guidelines for treating children and adolescents with depression.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39830626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Considerations on the sidelines of the second principle of the Rome Declaration: The challenge of the One Health concept on the health of the future.","authors":"Tommaso Di Paolo","doi":"10.3233/JRS-227003","DOIUrl":"https://doi.org/10.3233/JRS-227003","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic represented a global earthquake that made the review of health policies aimed at strengthening common governance necessary.</p><p><strong>Objective: </strong>The paper analyses the reasons for which the One Health approach has become fundamental in the control of pandemic phenomena, by arguing the necessity to place it at the basis not only of health policies but also of intersectoral policies.</p><p><strong>Methods: </strong>The documents of the world organizations published before and after the pandemic were analyzed and studied in order to unpack the close relationship between new lifestyles and the increase of health risks.</p><p><strong>Results: </strong>It emerged that the One Health approach is a paradigm that has been advanced for more than 30 years, but due to the inadequacy of local and world health policies, this approach was never translated into concrete actions to protect health, feeding problems at the cause of the COVID-19 pandemic.</p><p><strong>Conclusions: </strong>Having ascertained that the adoption of a One Health approach can no longer be postponed, this must be insisted on several interconnected sectors that establish the new concept of healthcare which, in addition to being interdisciplinary, necessarily takes on a global perspective.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond the garden: The complexity of \"global and individual living\" at the heart of the international commitment towards a healthy, more resilient and fairer society.","authors":"Luca Dimasi","doi":"10.3233/JRS-227004","DOIUrl":"https://doi.org/10.3233/JRS-227004","url":null,"abstract":"<p><strong>Background: </strong>The right to fully enjoy the highest possible state of health is certainly nothing new in the agenda of the world's governments, and yet today it becomes a top priority not just in the restructuring of the health care system, but also in the promotion of multi-sector policies aimed at fostering and safeguarding the potential of every individual to achieve what could be defined, in general terms, as \"common good\".</p><p><strong>Objective: </strong>The current paper aimed at singling out the most useful strategies to promoting and achieving a healthy, more resilient and fairer society.</p><p><strong>Methods: </strong>Starting from principles 1 and 14 of the Declaration of Rome, the aim was to analyse and develop the concepts of resilience and health, questioning their possible future variations against the background of the current health emergency and the increasingly radical widespread use of new technologies as universally-applied and cross-sectional tools for human progress.</p><p><strong>Results: </strong>The \"health for all\" objective can only be achieved if we act on three key aspects: 1. Adding life to years; 2. Adding life to life; 3. Adding years to life.</p><p><strong>Conclusions: </strong>Each individual should raise their health awareness as a key resource to leading a fulfilling existence and to developing the required qualities to fully tap into health possibilities - whether integral or residual - to tackle life.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rosa Manca, Francisco Bombillar, Chester Glomski, Alessandra Pica
{"title":"Obesity and immune system impairment: A global problem during the COVID-19 pandemic.","authors":"Rosa Manca, Francisco Bombillar, Chester Glomski, Alessandra Pica","doi":"10.3233/JRS-227007","DOIUrl":"https://doi.org/10.3233/JRS-227007","url":null,"abstract":"<p><strong>Background: </strong>The production of healthy and nutritious food, in an ecologically sustainable and safe way, has become one of the great ethical issues of our time. The recent G 20 urged the \"promotion and work on the social determinants of health to address other critical health issues such as food and nutrition\".</p><p><strong>Objective: </strong>The aim of this work is to analyze the current scientific literature regarding the role of obesity in the severe COVID-19 outcomes. In the light of the indications of the G20, the main causes of obesity are examined, and lifestyles are suggested with particular regard to proper nutrition in order to prevent/treat overweight since childhood.</p><p><strong>Methods: </strong>Multidisciplinary work, in which the biological and legal perspectives provide a meta-legal analysis of the obesity problem.</p><p><strong>Results: </strong>Unhealthy habits induce metabolic imbalance and increase in the body weight promoting obesity. This condition is the result of many factors (genetic predisposition, social position and \"junk food\" consumption) and is associated with a high risk of diseases, among them exacerbations from viral respiratory infections, including the current COVID-19 pandemic.</p><p><strong>Conclusions: </strong>The industrial food revolution changed our eating habits, leading to production of too much unhealthy food, absent in ancient diet, thus contributing to the onset of some disorders. The business of food industry should be downsized in favor of morally or ethically fair choices for consumers and for the well-being of society, together with an ethical food distribution, governmental food education programs, and balanced oversight of food production.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cynthia Ciwei Lim, Hanis Bte Abdul Kadir, Ngiap Chuan Tan, Andrew Teck Wee Ang, Yong Mong Bee, Puay Hoon Lee, Bandy Qiuling Goh, Alcey Li Chang Ang, Xiaohui Xin, Jia Liang Kwek, Amanda Yun Rui Lam, Jason Chon Jun Choo
{"title":"Non-steroidal anti-inflammatory drugs and risk of acute adverse renal outcomes in diabetes and diabetic kidney disease.","authors":"Cynthia Ciwei Lim, Hanis Bte Abdul Kadir, Ngiap Chuan Tan, Andrew Teck Wee Ang, Yong Mong Bee, Puay Hoon Lee, Bandy Qiuling Goh, Alcey Li Chang Ang, Xiaohui Xin, Jia Liang Kwek, Amanda Yun Rui Lam, Jason Chon Jun Choo","doi":"10.3233/JRS-200096","DOIUrl":"https://doi.org/10.3233/JRS-200096","url":null,"abstract":"<p><strong>Background: </strong>Individuals with diabetes mellitus (DM) may be susceptible to non-steroidal anti-inflammatory drug (NSAID)-induced acute kidney injury (AKI) but data on NSAID-related adverse renal events is sparse.</p><p><strong>Objective: </strong>We aimed to evaluate the risk of acute kidney injury and/or hyperkalemia after systemic NSAID among individuals with DM and diabetic chronic kidney disease (CKD).</p><p><strong>Methods: </strong>Retrospective cohort study of 3896 adults with DM with incident prescriptions between July 2015 and December 2017 from Singapore General Hospital and SingHealth Polyclinics. Laboratory, hospitalization and medication data were retrieved from electronic medical records. The primary outcome was the incidence of AKI and/ or hyperkalemia within 30 days after prescription.</p><p><strong>Results: </strong>AKI and/or hyperkalemia occurred in 13.5% of all DM and 15.8% of diabetic CKD. The association between systemic NSAID >14 days and 30-day risk of AKI and/or hyperkalemia failed to reach statistical significance in unselected DM (adjusted OR 1.62, 95% CI 0.99-2.65, p = 0.05) and diabetic CKD (adjusted OR 0.64, 95% CI 0.15-2.82, p = 0.64), but the odds of AKI and/or hyperkalemia were markedly and significantly increased when NSAID was prescribed with renin-angiotensin-aldosterone system (RAAS) blocker (adjusted OR 4.17, 95% CI 1.74-9.98, p = 0.001) or diuretic (adjusted OR 3.31, 95% CI 1.09-10.08, p = 0.04) and in the absence of diabetic CKD (adjusted OR 1.98, 95% CI 1.16-3.36, p = 0.01).</p><p><strong>Conclusion: </strong>NSAID prescription >14 days in individuals with DM with concurrent RAAS blockers or diuretics was associated with higher 30-day risk of AKI and/or hyperkalemia.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39315525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antibiotic misuse and improper practices in India: Identifying the scope to improve through a narrative review.","authors":"Brinal Pereira, Shruti Kulkarni","doi":"10.3233/JRS-210020","DOIUrl":"https://doi.org/10.3233/JRS-210020","url":null,"abstract":"<p><strong>Background: </strong>In India, antibiotic resistance is high and by 2050, two million people will be affected.</p><p><strong>Objective: </strong>To review antibiotic practices in India and the variables that impact them.</p><p><strong>Methods: </strong>For this narrative review, research articles on antibiotic awareness, perception and practices were retrieved from PubMed and Google Scholar using search terms such as 'India AND antibiotic use AND cross sectional AND awareness'. A total of 1730 results were found on 30 June 2020, of which 35 articles were eligible for summarizing the common antibiotic practices.</p><p><strong>Results: </strong>We found that there are deficiencies in the implementation of existing policies in India. Several issues such as overprescribing of antibiotics, use without prescription and non-adherence to treatment regimens are contributing to irrational antibiotic practices in the country.</p><p><strong>Conclusion: </strong>There is a need for policies at the institute level to help curb the problem of antibiotic resistance.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39614950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving communication at NHS Nightingale Hospital North West: Medical updates to next of kin.","authors":"Megan Woolford, James Todd","doi":"10.3233/JRS-227034","DOIUrl":"https://doi.org/10.3233/JRS-227034","url":null,"abstract":"<p><strong>Background: </strong>The Nightingale North West (NNW) was a UK temporary field hospital set up during the COVID-19 pandemic. Policies and standard operating procedures were undeveloped. Visitors were permitted only in exceptional circumstances, resulting in heightened anxiety for patients and next of kin (NOK).</p><p><strong>Objective: </strong>Recognising the importance of effective NOK communication, a quality improvement project (QIP) was undertaken to improve communication between doctors and NOK.</p><p><strong>Method: </strong>NOK satisfaction with communication received from doctors (scored 1-5) was the primary outcome measure and data was collected through standardised phone-calls.A wide four point (1-5) variability in satisfaction was identified.PDSA methodology was used to introduce interventions: (1) 'Gold standard' for frequency of NOK updates; (2) Record date of NOK update on the doctors' list.</p><p><strong>Results: </strong>Early post-intervention data showed reduced variability in satisfaction with 82% of NOK scoring '4' or '5'. Process measures demonstrated excellent uptake of interventions.</p><p><strong>Conclusion: </strong>Conclusions are limited by the project's short time-frame but there is a promising role for these interventions in enhancing doctor-NOK communication.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/46/jrs-33-jrs227034.PMC9844058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10782290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}