Roman A Bontsevich, Oxana M Zarudskaya, Anna V Adonina
{"title":"Doctors' preferences in the choice of antibacterial drugs in pregnant women (PIKAP study).","authors":"Roman A Bontsevich, Oxana M Zarudskaya, Anna V Adonina","doi":"10.1177/09246479251327814","DOIUrl":"https://doi.org/10.1177/09246479251327814","url":null,"abstract":"<p><p>BackgroundThe use of rational and safe antibiotic therapies for pregnant women remains an important issue within the medical community.ObjectiveTo analyze the preferences in the choice of antimicrobial drugs (AMD) among obstetricians-gynecologists of Central Russia in treatment of infectious diseases in pregnancy.MethodsThis is anonymous survey of obstetrician and gynecology specialists conducted in Central Russia between September 1st, and November 30th, 2017. Study included five healthcare facilities (ambulatory and in-patient), located in regional center, city Belgorod. Questionnaire contained six open-ended questions to evaluate AMD preferences in treatment of Chlamydia trachomatis, Mycoplasma hominis or genitalium, Ureaplasma species, acute cystitis, pyelonephritis, and other conditions, such as placental insufficiency, fetal growth restriction. Descriptive statistics was used including absolute and relative frequencies, minimum and maximum values, mean, frequency of prescribing AMD, and their proportion in the total number prescribed.ResultsA total of 52 responses were included in final analysis. There was significant rate of 15.4% of prescribing pregnancy unsafe (fluoroquinolones, tetracyclines) or non-rational AMD or deviation from existing clinical protocols and guidelines.ConclusionsThere were large variations in provider's AMD preference between healthcare facilities.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"9246479251327814"},"PeriodicalIF":0.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre Constant Ntoutoume Nzoghe, Rim Lakhmiri, Sophie Coniquet, Landry Missounga, Solange Ntsame, Yahia Cherrah, Samira Serragui
{"title":"Fluconazole-induced Stevens-Johnson syndrome at Libreville University Hospital - Gabon: A case report.","authors":"Pierre Constant Ntoutoume Nzoghe, Rim Lakhmiri, Sophie Coniquet, Landry Missounga, Solange Ntsame, Yahia Cherrah, Samira Serragui","doi":"10.1177/09246479251325475","DOIUrl":"https://doi.org/10.1177/09246479251325475","url":null,"abstract":"<p><p>BackgroundStevens-Johnson syndrome (SJS), a rare and severe toxic epidermal necrolysis, is reported here for the first time at the University Hospital Center of Libreville (CHUL), suspected to be related to fluconazole administration.ObjectiveTo inform clinicians about the risks associated with fluconazole in immunocompromised patients and the related healthcare expenses.Case presentationThe patient is a 39-year-old immunocompromised woman who received a single dose 400 mg of fluconazole. Two weeks later, she developed a rash affecting approximately 10 % of her body surface, confirmed as SJS. During clinical examinations, no signs of infection, such as fever, dizziness, or chills, were present, suggesting a drug-induced SJS reaction.ResultsCausality assessment assigned an intrinsic score of I6 and extrinsic score of B2 according to the French method, and a probable temporal relationship was confirmed using the world Health Organization (WHO) method. The ALDEN scale identified fluconazole as the probable cause (score = 4). No additional risk factors were identified (SCORTEN = 0, predicted mortality: 3.2 %). Economically, the total direct medical cost of hospitalization amounted to 605,700 CFA francs, or 923.38 €.ConclusionImmunocompromised HIV-positive patients treated with 400 mg of fluconazole are likely to develop SJS and incur costs.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"9246479251325475"},"PeriodicalIF":0.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors affecting patient safety culture and adverse drug reaction reporting among healthcare professionals in an Indonesian public hospital: A cross-sectional study.","authors":"Baiq Khuwailida Kartikasari, Samira Samirah, Yunita Nita, Arie Sulistyarini, Elida Zairina","doi":"10.1177/09246479251323834","DOIUrl":"https://doi.org/10.1177/09246479251323834","url":null,"abstract":"<p><strong>Background: </strong>Pharmacovigilance is a global effort to protect patients and public health by detecting and responding to adverse drug reactions (ADRs). However, underreporting is a major obstacle in reporting ADRs. An effective reporting culture is one way to overcome the challenges in ADR reporting.</p><p><strong>Objectives: </strong>This study aimed to determine the factors affecting the patient safety culture related to adverse drug reaction reporting among healthcare professionals in a public hospital in Indonesia.</p><p><strong>Methods: </strong>This observational cross-sectional study was conducted by Dr. R. Soedjono Selong Hospital, East Lombok, Indonesia. Data were collected using the Hospital Survey on Patient Safety Culture 2.0, conducted by the Agency for Healthcare Research and Quality, and a researcher-developed questionnaire.</p><p><strong>Results: </strong>Among the 238 healthcare professionals who responded, 60.9% had previously reported ADRs. Age, education, working period, knowledge, perception, facilities, policies, and environment were significantly associated with patient safety culture and ADR reporting. The working period and age emerged as the most influential factors in patient safety culture and ADR reporting, respectively.</p><p><strong>Conclusion: </strong>Age, education, working period, knowledge, perception, facilities, policy, and environment significantly affected the patient safety culture and ADR reporting.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"9246479251323834"},"PeriodicalIF":0.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of chemotherapy-mediated cardiotoxicity in patients with cancer by cardiac troponin I: A systematic review and meta-analysis.","authors":"Yang Liu, Huanglong Liu","doi":"10.1177/09246479241302586","DOIUrl":"10.1177/09246479241302586","url":null,"abstract":"<p><p>BackgroundCardiac damage is a significant risk of chemotherapy. Elevated circulating cardiac troponin I was suggested as a marker for early detection of cardiac damage.ObjectiveWe aim to assess the predictive value of cardiac troponin I for chemotherapy-induced cardiotoxicity in cancer patients.MethodsWe searched PubMed, Web of Science, Embase, and CNKI. Nine prospective studies involving 2033 cancer patients (pts) were included in the meta-analysis. Troponin I (TnI) levels in patients who underwent chemotherapy were categorized into cardiac troponin I (cTnI) positive and negative groups based on the cutoff concentrations described in the included studies. The cumulative effects of chemotherapy-induced cardiotoxicity between the cTnI-positive and cTnI-negative patients were represented as a summarized risk difference (RD) value with a 95% confidence interval. Subgroup analysis and sensitivity analysis were employed to address heterogeneities. Stata software (version 12.0) was utilized for the analysis.ResultscTnI-positive pts represented significant cardiotoxicity compared to cTnI-negative pts, as a decline in left ventricular ejection fraction (LVEF): RD = 0.279 [95% CI (0.248-0.311), <i>p</i> = 0.000, I<sup>2</sup> = 81.3%, 8 trials], heart failure (HF): RD = 0.117, [95% CI (0.090-0.144), <i>p</i> = 0.000, I<sup>2</sup> = 77.8%, 6 trials], arrhythmias: RD = 0.057 [95% CI (0.028-0.086), <i>p</i> = 0.000, I<sup>2</sup> = 0.0%, 3 trials], and cumulative events: RD = 0.318 [95% CI (0.272-0.364), <i>p</i> = 0.000, I<sup>2</sup> = 73.5%, 3 trials]. No statistically significant difference in cardiac death, acute pulmonary edema, and acute coronary syndromes between cTnI-positive pts and cTnI-negative pts was identified.ConclusionsAn increase in circulating troponin I serve as a potential biomarker that reflecting the high risk of early cardiotoxicity in cancer patients who have undergone chemotherapy. The presence of intrinsic unadjusted confounding factors in the reports suggests the need for further study to address this question.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"26-48"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Moving forward with Sage: 2025, a year to enjoy enhancements and innovation for research integrity, independence and freedom in health research.","authors":"Liliya Eugenevna Ziganshina","doi":"10.1177/09246479241312735","DOIUrl":"https://doi.org/10.1177/09246479241312735","url":null,"abstract":"","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":"36 1","pages":"3-4"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tien Dat Trinh, Quyen An Tran, Thanh Luan Nguyen, Thi Hong Hanh Nguyen, Ryo Watanabe, Kanami Tsuno
{"title":"Burnout status of Japanese healthcare workers and the association with medical errors: A 1-year follow-up.","authors":"Tien Dat Trinh, Quyen An Tran, Thanh Luan Nguyen, Thi Hong Hanh Nguyen, Ryo Watanabe, Kanami Tsuno","doi":"10.1177/09246479241301257","DOIUrl":"10.1177/09246479241301257","url":null,"abstract":"<p><p>BackgroundBurnout and medical errors are the most prevalent issues affecting health and life outcomes among healthcare professionals.ObjectiveThis study aimed to investigate the longitudinal association between burnout and medical errors in healthcare workers in Japan.MethodsWe conducted a prospective cohort study involving 539 healthcare workers from January 2017 to January 2018. Burnout was evaluated using the Maslach Burnout Inventory-General Survey (MBI-GS), which included exhaustion, cynicism, and professional efficacy dimensions. Medical errors during the previous year were measured by self-assessment at follow-up. Multivariate modified Poisson regressions estimated the association between baseline burnout and follow-up medical errors.ResultsIn the age and sex-adjusted model, overall burnout was significantly associated with medical errors (<i>p</i> = 0.008). Participants with high burnout levels exhibited a greater risk of medical errors than those with low or moderate levels (RR = 1.19, 95% CI: 1.05-1.35). Exhaustion and cynicism correlated significantly with medical errors (<i>p</i> < 0.05). High or moderate levels of exhaustion and cynicism were associated with elevated risks of medical errors (RR = 1.31 [95% CI: 1.10-1.55]; 1.25 [1.02-1.53]), (RR = 1.31 [95% CI: 1.13-1.53]; 1.20 [1.03-1.41]), compared to low-level counterparts, respectively.ConclusionHealthcare workers who experience burnout may be at an increased risk for medical errors.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"14-25"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-marketing regulatory actions in Portugal-A retrospective analysis between 2013 and 2023.","authors":"Vítor Silva, João Joaquim, Cristiano Matos","doi":"10.1177/09246479241301250","DOIUrl":"10.1177/09246479241301250","url":null,"abstract":"<p><p>BackgroundThe safety of medicines is a critical public health concern that requires continuous monitoring and evaluation throughout a drug's lifecycle, including post-authorization. Over the past decade, Portugal has undergone significant changes in its pharmaceutical sector, driven by regulatory actions from the National Authority of Medicines and Health Products (INFARMED, I.P.), which ensures the safety, effectiveness, and quality of medicines.ObjectiveThis study aimed to analyze the regulatory actions taken due to safety concerns in Portugal from 2013 to 2023.MethodsA retrospective analysis was conducted using safety alerts published by INFARMED, I.P. between January 2013 and December 2023. The analysis focused on changes in marketing status, drugs involved, causes of regulatory actions, and yearly patterns.ResultsDuring the study period, 602 safety and quality alerts were issued, being 41 from safety and 561 from quality. The highest number of regulatory actions occurred in 2018, with 172 cases (28.57%). Generic drugs accounted for the majority, with 432 cases (72.19%). Batch recalls (76.65%) corresponded to the main regulatory action related to quality. Quality alerts were often related to impurities or stability (65.42%), non-conformity with GMP standards (11.76%), and labeling or packaging problems (10.70%). Unfavorable risk-benefit ratios were the cause of 100% of safety-related alerts.ConclusionsThe findings highlight the importance of robust surveillance systems and continuous evaluation of manufacturing and regulatory processes to enhance drug safety. Collaboration between regulators, the pharmaceutical industry, and healthcare professionals is essential to ensure that the benefits of medicines consistently outweigh the risks associated with their use.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"49-56"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pattern, severity, and preventability of adverse drug reactions from a Northern Indian tertiary care facility: A retrospective analysis.","authors":"Yangshen Lhamo, Kalpana Purohit, Sunita Singh, Deepti Chopra, Mani Bharti","doi":"10.1177/09246479241304316","DOIUrl":"10.1177/09246479241304316","url":null,"abstract":"<p><p>BackgroundOver the years, it has been observed that adverse drug reaction (ADR) is a major cause of mortality and morbidity and a major cause of concern for all healthcare professionals. ADR is a leading cause for hospitalisation and increases the financial burden of the patient. Thus, it is imperative that we need steps and strategies to decrease the burden of ADRs and effectively reduce the cost of therapy to treat ADR.ObjectiveThis study evaluated the pattern, severity, and preventability of ADRs in a tertiary care hospital.MethodsA retrospective observational study of all the ADR reports due to medications submitted to the ADR monitoring centre in a Northern Indian tertiary care hospital from October 2017 to December 2019. Causality assessment of the ADRs was done using the WHO-UMC causality assessment scale, and the severity was assessed using the modified Hartwig scale. Furthermore, the preventability of the ADR was assessed using the Schumock and Thornton scale.ResultsA total of 252 ADRs were reported. A maximum number of the ADRs (33%) were due to antimicrobials followed by analgesics (16%) and antihypertensives (10%). Amongst the analgesics, a majority of ADRs were associated with Diclofenac (16 ADRs). Amlodipine was associated with maximum ADRs (10) amongst the antihypertensives. The ADRs of gastrointestinal systems (34.5%) were most common among all system organ class (SOCs) followed by skin and subcutaneous tissue disorders (32%). Majority of ADRs were probable and mild in severity. According to the Schumock and Thornton preventability scale 69% were not preventable while 12% were definitely preventable.ConclusionsAntimicrobials were associated with majority of ADRs with gastrointestinal system being the most commonest organ involved. It was also observed that most of the ADRs were not preventable but some were definitely preventable. The awareness regarding preventability of ADRs needs to be emphasised and further studies to elaborate on the preventability of ADRs needs to be carried out.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"5-13"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nasser Alkhushaym, Maha Aldhafeeri, Meshaal Hamad, Bander Almutairi, Mamun Mahmud, Maha Alenizi, Abdulkhaliq J Alsalman
{"title":"Prevalence of bleeding in patients on single or dual antiplatelet therapy combined with vitamin K antagonists or direct oral anticoagulants.","authors":"Nasser Alkhushaym, Maha Aldhafeeri, Meshaal Hamad, Bander Almutairi, Mamun Mahmud, Maha Alenizi, Abdulkhaliq J Alsalman","doi":"10.1177/09246479241311428","DOIUrl":"https://doi.org/10.1177/09246479241311428","url":null,"abstract":"<p><strong>Background: </strong>Patients with atrial fibrillation often require anticoagulation therapy to prevent stroke and thromboembolism. However, anticoagulants can have serious side effects, such as bleeding, particularly when combined with antiplatelet therapy.</p><p><strong>Objective: </strong>The aim of this study is to estimate the prevalence of major bleeding in patients receiving either dual or triple antithrombotic therapy.</p><p><strong>Method: </strong>This study is a single-center retrospective chart review utilizing the hospital electronic health record. The prevalence and percentage of bleeding events were reported for each antithrombotic regimen.</p><p><strong>Results: </strong>Of the 539 patients receiving oral anticoagulants, 202 were using oral anticoagulants in combination with either single or dual antiplatelet therapy. Out of 35 patients using triple antithrombotic therapy, four (11.4%) experienced major bleeding. Based on the analysis of 73 patients using anticoagulants in combined with clopidogrel, the results showed that one patient (1.3%) suffered bleeding. Among the 94 patients treated with anticoagulants plus aspirin, seven (7.4%) experienced major bleeding events.</p><p><strong>Conclusion: </strong>The combination of anticoagulants and antiplatelet agents is associated with an elevated bleeding risk. Patients receiving triple antithrombotic therapy experience high prevalence of bleeding. Nonetheless, the group receiving anticoagulant and clopidogrel alone exhibited low prevalence of bleeding risk.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"9246479241311428"},"PeriodicalIF":0.9,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shreya K Gowda, Arpita N Rout, Ashutosh Panigrahi, Chandrashekar Sirka
{"title":"A case report on azathioprine induced anagen effluvium, plica polonica, and bicytopenia in a patient of vitiligo.","authors":"Shreya K Gowda, Arpita N Rout, Ashutosh Panigrahi, Chandrashekar Sirka","doi":"10.1177/09246479241311431","DOIUrl":"https://doi.org/10.1177/09246479241311431","url":null,"abstract":"<p><strong>Background: </strong>Anagen effluvium is described as abrupt hair loss during the anagen phase due to reduced follicular mitotic activity. Chemotherapeutic medicines, toxic metals, and sporadically bismuth, levodopa, colchicine, and cyclosporine are often implicated in etiology. Plica polonica is a rare disorder that develops when the scalp hair mats completely and abruptly, resulting in an extended stiff mass of hair that resembles dreadlocks.</p><p><strong>Objective: </strong>We are describing this case because it is unusual to see plica polonica linked with azathioprine-induced pancytopenia in the literature and since the source of the condition was cuticular damage to the hair shaft as a result of the medication rather than carelessness or excessive bathing of the patient's hair.</p><p><strong>Case description: </strong>A 32-year-old lady presented to dermatology OPD, with vitiligo over bilateral forearm and lips for 6 months. She was started on azathioprine 50 mg daily for the past 1 month, and then she complained of sudden onset of extensive hair loss on attempting to comb her hair associated with matting of rest of uncombable hairs, multiple oral ulcers, and mild grade fever for 15 days. The possibility of systemic lupus erythematosus and azathioprine-induced anagen effluvium and neutropenic ulcers was thought.</p><p><strong>Results: </strong>We started on injectable granulocyte colony-stimulating factor for 3 days, and antibiotics and antifungals for 1 week. Improvement in clinical (oral ulcers, fever) and hematological profiles were noted.</p><p><strong>Conclusion: </strong>Although azathioprine is not often associated with the development of anagen effluvium, it is probable that the patient's abrupt pancytopenia caused damage to the hair shaft, which resulted in hair loss, and cuticular damage to the hair shaft, which led to the formation of Plica.</p>","PeriodicalId":45237,"journal":{"name":"INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE","volume":" ","pages":"9246479241311431"},"PeriodicalIF":0.9,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}