{"title":"Soil-transmitted Helminth Infection and Perinatal Outcomes in Pregnant Women in Primary Care Settings in South India: A Cohort Study.","authors":"Revathi Ulaganeethi, Gowri Dorairajan, Nonika Rajkumari, Suganya Jayaraman, Sadhana Subramanian, Ganesh Kumar Saya","doi":"10.4103/ijcm.ijcm_826_23","DOIUrl":"https://doi.org/10.4103/ijcm.ijcm_826_23","url":null,"abstract":"<p><strong>Background: </strong>Soil-transmitted helminth infections (STHs) in pregnancy have been linked to maternal anemia, low birth weight, and adverse perinatal outcomes. STH includes <i>Ascaris lumbricoides</i>, hookworm, and <i>Trichuris trichiura</i>. However, conflicting evidence exists regarding these effects. Hence, we aimed to assess the association of STH infections with perinatal outcomes.</p><p><strong>Methods and materials: </strong>A community-based cohort study was conducted among pregnant women in primary care settings in Puducherry, South India, during December 2019 to April 2021. Stool samples were collected for STH screening and confirmed using polymerase chain reaction. Information on perinatal outcomes and hemoglobin levels were extracted from case records. The association of pre-term birth, low birth weight, anemia, and miscarriages with STH infection was analyzed using the Chi-square test.</p><p><strong>Results: </strong>Among the 650 women enrolled, 58 (8.9%) had one of the STH infections. At the time of recruitment, 336 (52.0%) women had anemia. Twenty-four women (3.7%) had miscarriages, 14 (2.2%) had pre-term birth, and 65 (10.4%) had low-birth-weight (LBW) babies. All 14 pre-term babies had LBW, and out of 65 LBW, 40 were in mothers with anemia. Incidence of LBW, pre-term deliveries, and anemia were higher in women with STH than in those without STH (LBW: 12.3% vs 10.2%, <i>P</i> = 0.62; pre-term: 3.5% vs 2.1%, <i>P</i> = 0.5; and anemia: 54.4% vs 51.85, <i>P</i> = 0.7).</p><p><strong>Conclusion: </strong>Though the incidence of anemia, LBW, and pre-term delivery was higher in women with STH infections compared to those without STH, we did not find any significant association between the presence of STH infections and perinatal outcomes.</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 5","pages":"719-725"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transforming Disease Surveillance through Artificial Intelligence.","authors":"Purushottam A Giri, Manoj Kumar Gupta","doi":"10.4103/ijcm.ijcm_459_24","DOIUrl":"https://doi.org/10.4103/ijcm.ijcm_459_24","url":null,"abstract":"","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 5","pages":"663-664"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DASH Therapy and Hypertension: A Novel Approach to Manage Blood Pressure.","authors":"Ram Kumar Garg","doi":"10.4103/ijcm.ijcm_793_23","DOIUrl":"https://doi.org/10.4103/ijcm.ijcm_793_23","url":null,"abstract":"","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 5","pages":"775-776"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Spectrum of Thyroid Dysfunction During Pregnancy and Fetomaternal Outcome, A Study from the Premier Institute of Western India.","authors":"Ranesh Debbarma, Meenakshi Gothwal, Pratibha Singh, Garima Yadav, Purvi Purohit, Navdeep Kaur Ghuman, Neeraj Gupta","doi":"10.4103/ijcm.ijcm_207_23","DOIUrl":"https://doi.org/10.4103/ijcm.ijcm_207_23","url":null,"abstract":"<p><strong>Background: </strong>Thyroid dysfunction evaluation during pregnancy is important for the mother's health, obstetric outcomes, and the child's cognitive development. This study is conducted to know various thyroid disorders that can occur during antenatal and their impact on mother and fetus outcomes.</p><p><strong>Materials and methods: </strong>This observational research was conducted over two years at a tertiary center in Western Rajasthan, India. Seven hundred and seventy-two low-risk singleton pregnant patients who met the inclusive criteria were recruited. The estimation of T3, T4, and TSH was done along with a routine investigation in antenatal women. Antenatal having abnormal thyroid profiles were then analyzed for mother and fetus problems.</p><p><strong>Results: </strong>The prevalence of thyroid dysfunction in antenatal women is 16.5%. Subclinical hypothyroidism (SCH) was seen in 12.5% of cases, overt hypothyroidism in 3.36%, and subclinical hyperthyroidism in only 0.51% of cases. Anti-TPO was positive in 46 (41.44%) women with hypothyroidism and 1 (25%) with hyperthyroidism. Compared to euthyroid women, women with overt hypothyroid (19.23% vs 3.1%, <i>P</i> = 0.002) and subclinical hypothyroid (9.27% vs 3.1%, <i>P</i> = 0.003) were found to be associated with a higher risk of hypertensive disease. Concerning fetal outcomes. There was a high risk for preterm (12.37% v/s 4.9%, <i>P</i> = 0.004) and fetal growth retardation (FGR) in patients with SCH (7.21% v/s 3.1%, <i>P</i> = 0.04).</p><p><strong>Conclusion: </strong>Considering the significant influence of thyroid disorders on mother and fetus outcomes, the screening for thyroid during pregnancy should be considered universally, particularly in developing countries with high prevalent rates, such as India.</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 5","pages":"734-738"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum: Prevalence of Physical Nicotine Dependence and its Determinants among Tobacco users in the Rural Field Practice Area of a Tertiary Care Hospital in Tamil Nadu, India.","authors":"","doi":"10.4103/IJCM.IJCM_265_24","DOIUrl":"10.4103/IJCM.IJCM_265_24","url":null,"abstract":"<p><p>[This corrects the article on p. 170 in vol. 49, PMID: 38425948.].</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 3","pages":"560"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum: Cine Medicine in Indian Scenario: A SWOT Analysis.","authors":"","doi":"10.4103/IJCM.IJCM_267_24","DOIUrl":"10.4103/IJCM.IJCM_267_24","url":null,"abstract":"<p><p>[This corrects the article on p. 255 in vol. 49, PMID: 38665454.].</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 3","pages":"560"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum: Incidence of Sudden Cardiac Death in Low- and Middle-Income Countries: A Systematic Review of Cohort Studies.","authors":"","doi":"10.4103/IJCM.IJCM_266_24","DOIUrl":"10.4103/IJCM.IJCM_266_24","url":null,"abstract":"<p><p>[This corrects the article on p. 279 in vol. 49, PMID: 38665450.].</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 3","pages":"560"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhaya Indrayan, Aman Mishra, Binukumar Bhaskarapillai
{"title":"Simplified Sample Size Formulas for Detecting a Medically Important Effect.","authors":"Abhaya Indrayan, Aman Mishra, Binukumar Bhaskarapillai","doi":"10.4103/ijcm.ijcm_787_23","DOIUrl":"10.4103/ijcm.ijcm_787_23","url":null,"abstract":"<p><p>The sample size is just about the most common question in the minds of many medical researchers. This size determines the reliability of the results and helps to detect a medically important effect when present. Some studies miss an important effect due to inappropriate sample size. Many postgraduate students and established researchers often contact a statistician to help them determine an appropriate sample size for their study. More than 80 formulas are available to calculate sample size for different settings and the choice requires some expertise. Their use is even more difficult because most exact formulas are quite complex. An added difficulty is that different books, software, and websites use different formulas for the same problem. Such discrepancy in the published formulas confounds a biostatistician also. The objective of this communication is to present uniformly looking formulas for many situations together at one place in their simple but correct form, along with the setting where they are applicable. This will help in choosing an appropriate formula for the kind of research one is proposing to do and use it with confidence. This communication is restricted to the sample size required to detect a medically important effect when present - known to the statisticians as the test of hypothesis situation. Such a collection is not available anywhere, not even in any book. The sample size formulas for estimation are different and not discussed here.</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 3","pages":"464-471"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muralidhar P Tambe, Malangori A Parande, Mangesh B Nanaware, Nandkumar M Salunke, Trayambak Dutta, Manish Mahajan
{"title":"Post-Marketing Surveillance of the World's First Novel Cocktail of Rabies Monoclonal Antibodies: TwinRab™ in Real -World Setting.","authors":"Muralidhar P Tambe, Malangori A Parande, Mangesh B Nanaware, Nandkumar M Salunke, Trayambak Dutta, Manish Mahajan","doi":"10.4103/ijcm.ijcm_562_23","DOIUrl":"https://doi.org/10.4103/ijcm.ijcm_562_23","url":null,"abstract":"<p><p>Rabies presents with a high fatality rate, which imposes a significant global public health challenge, and therefore the use of post-exposure prophylaxis (PEP) is crucial for prevention. Monoclonal antibodies (mAbs) have emerged as a promising substitute for rabies immunoglobulins (RIGs) due to their high efficacy and standardized manufacturing process. A prospective, open-label, post-marketing surveillance study (PMS) was conducted at Byramjee Jeejeebhoy Medical College (BJMC), Pune. The study included patients aged more than 2 years who had recently sustained Category III-suspected rabid animal bite exposures. These patients were administered TwinRabTM at a dosage of 40 IU/kg in and around the wound as intralesional transfer, along with the anti-rabies vaccine (ARV). Adverse events (AEs) grading was performed with reference to the Food and Drug Administration (FDA) toxicity grading. In this study, 215 subjects received the TwinRabTM mAb with a 100% completion rate. Out of 215 patients, three (1.3%) patients in the range of 18 to 65 years of age showed solicited local AEs, which were resolved after the appropriate treatment intervention, but causality assessment was non-assessable. The overall tolerability assessment showed positive ratings from doctors (91.63%) and patients (67.91%) for the mAb cocktail. The PMS demonstrated the safety of TwinRabTM in patients who experienced Category III-suspected rabid animal bites, thereby supporting its potential as an alternative option for post-exposure prophylaxis in the management of animal bites for the prevention of rabies.</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 2","pages":"443-447"},"PeriodicalIF":0.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nursing Intervention Strategies and Their Effectiveness on Restless Leg Syndrome and Psycho-Social Problems in Chronic Kidney Disease Patients.","authors":"Prabhjot Kaur, Surinder Jaspal, Tejinder Kaur","doi":"10.4103/ijcm.ijcm_914_22","DOIUrl":"https://doi.org/10.4103/ijcm.ijcm_914_22","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease is a global health problem affecting 843.6 million people with 1 million deaths and the 12<sup>th</sup> leading non-communicable cause of death worldwide. Insomnia is a disturbing problem found in chronic kidney disease patients, leading to physiological problems like fatigue, edema, and restless leg syndrome most of the time. The objective of this study was to assess the effectiveness of nursing intervention strategies on physiological and psycho-social problems.</p><p><strong>Materials and methods: </strong>A quantitative research approach with quasi-experimental pre-test and post-test design was used to assess the effectiveness of nursing intervention strategies on physiological and psycho-social problems among 30 chronic kidney disease patients, 15 in control and experimental each, admitted in a selected hospital of Punjab. Convenience sampling was used to assign the samples, and data were collected through an interview schedule by using standardized scales. IEC number: 2017/08/5051.</p><p><strong>Results: </strong>The result of the study showed that the baseline restless leg syndrome mean score was 9.67, whereas the psycho-social problem baseline mean score was 79.80, and after post-test, the mean score was reduced to 7.67 in physiological and 66.87 in psycho-social problems in the experimental group. Intervention was found to be effective in reduction of physiological and psycho-social symptoms of chronic kidney disease patients significantly (<i>P</i> ≤ 0.05).</p><p><strong>Conclusions: </strong>The study showed that nursing intervention strategies were effective in reduction of physiological and psycho-social symptoms.</p>","PeriodicalId":45040,"journal":{"name":"Indian Journal of Community Medicine","volume":"49 2","pages":"367-374"},"PeriodicalIF":0.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}