AIMS Bioengineering最新文献_第3页

Cardiovascular disease prediction using hyperparameters-tuned LSTM considering COVID-19 with experimental validation 考虑COVID-19的超参数调优LSTM心血管疾病预测与实验验证

AIMS Bioengineering Pub Date : 2023-01-01 DOI: 10.3934/bioeng.2023017

Kuna Dhananjay Rao, Mudunuru Satya Dev Kumar, Paidi Pavani, Darapureddy Akshitha, Kagitha Nagamaleswara Rao, Hafiz Tayyab Rauf, Mohamed Sharaf

{"title":"Cardiovascular disease prediction using hyperparameters-tuned LSTM considering COVID-19 with experimental validation","authors":"Kuna Dhananjay Rao, Mudunuru Satya Dev Kumar, Paidi Pavani, Darapureddy Akshitha, Kagitha Nagamaleswara Rao, Hafiz Tayyab Rauf, Mohamed Sharaf","doi":"10.3934/bioeng.2023017","DOIUrl":"https://doi.org/10.3934/bioeng.2023017","url":null,"abstract":"<abstract> <p>Heart disease, globally recognized as a leading cause of death, has seen its impact magnified by the emergence of COVID-19. The heightened demand for early detection and diagnosis of heart disease has forced the development of innovative, intelligent systems. This research offers a novel approach by leveraging extended short-term memory networks (LSTM) and including COVID-19 as a significant parameter in cardiac arrest analysis. A comparative study is conducted between LSTM and other prevalent techniques, such as support vector machines (SVM), linear regression (LR), and artificial neural networks (ANN), focusing on accuracy and other prognostic criteria for heart disease. We aim to develop an intelligent system powered by LSTM to predict heart disease, thereby assisting healthcare professionals in making well-informed decisions about heart disease management, stroke prevention, and patient monitoring. Additionally, hyperparameter tuning has been performed to optimize the LSTM model's performance in cardiac arrest prediction. The results underscore that LSTM, especially when trained with COVID-19 as an input parameter, surpasses other established techniques in prediction accuracy. The proposed model underwent experimental testing, showcasing its proficiency in predicting cardiovascular disease.</p> </abstract>","PeriodicalId":45029,"journal":{"name":"AIMS Bioengineering","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135495426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and analysis of coagulation effect in vein using MEMS laminar flow for the early heart stroke diagnosis MEMS层流检测和分析静脉凝血效果在早期心梗诊断中的应用

IF 2.3

AIMS Bioengineering Pub Date : 2023-01-01 DOI: 10.3934/bioeng.2023001

Vasudeva Reddy Tatiparthi, M. Rao, Santosh Kumar, Hindumathi

{"title":"Detection and analysis of coagulation effect in vein using MEMS laminar flow for the early heart stroke diagnosis","authors":"Vasudeva Reddy Tatiparthi, M. Rao, Santosh Kumar, Hindumathi","doi":"10.3934/bioeng.2023001","DOIUrl":"https://doi.org/10.3934/bioeng.2023001","url":null,"abstract":"The primary objective of the research article is to describe the functionality of wrist watch which acts as a digital stethoscope to measure health constraints such as heart pulse through blood pressure. The second objective is the detection of blockages of an artery due to fatty, cholesterol-deposited, over a period when the blood is passing through due to stress and exercise, etc. Pressure and velocity are two inputs with their respective results of contrast and expansion of veins at the outputs. The major parameters in detecting the laminar flow are pressure and velocity. These parameters of a vein are analyzed by integrating valves in the vein. The movement of blood laminar flow in the vein is captured by a MEMS-based piezoelectric sensor by its functionality. The proposed design performance accuracy is estimated by modeling of vein's laminar flow when blood is circulating. The coagulation effect of the vein is used to measure heart stroke by placing MEMS along with the stent, as MEMS are tiny in size. The functionality of a digital Stethoscope works on the piezoelectric effect that generates an electrical signal when pressure is applied from the vein. The accuracy, functionality, and performance of the design can be analyzed by COMSOL multi-physics. Applications of MEMS include detection, prevention, and alert during the second heart stroke, and also used in the bionic eye and automotive electronics.","PeriodicalId":45029,"journal":{"name":"AIMS Bioengineering","volume":"81 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74243431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Enhancing public health strategies for tungiasis: A mathematical approach with fractional derivative 加强对通虫病的公共卫生战略:分数阶导数的数学方法

AIMS Bioengineering Pub Date : 2023-01-01 DOI: 10.3934/bioeng.2023023

Norliyana Nor Hisham Shah, Rashid Jan, Hassan Ahmad, Normy Norfiza Abdul Razak, Imtiaz Ahmad, Hijaz Ahmad

{"title":"Enhancing public health strategies for tungiasis: A mathematical approach with fractional derivative","authors":"Norliyana Nor Hisham Shah, Rashid Jan, Hassan Ahmad, Normy Norfiza Abdul Razak, Imtiaz Ahmad, Hijaz Ahmad","doi":"10.3934/bioeng.2023023","DOIUrl":"https://doi.org/10.3934/bioeng.2023023","url":null,"abstract":"<abstract> <p>In this study, we formulate a mathematical model in the framework of the Atangana-Baleanu fractional derivative in Caputo sense to study the transmission of tungiasis. In this formulation, interactions between the human host and the sand fleas are taken into consideration, including factors like infestation rate, incubation duration, and recovery rate. We calculate the basic reproduction parameter for the system, symbolized by $mathcal{R}_0$ with the help of the next-generation matrix technique. A novel numerical scheme for encapsulating the non-local and memory-dependent aspects of the system is conceptualized via the Atangana-Baleanu fractional derivative. We prove the existence and uniqueness of the solution of the model of the infection and establish stability of the steady-states of the model. In addition to this, numerical simulations are carried out to evaluate the efficiency of interventions like campaigns for better sanitation and treatment, and to investigate the influence of various management techniques on the prevalence of tungiasis. The outcomes of the numerical simulations give us information about the possible efficacy of different control strategies in lowering the incidence of tungiasis. This research gives quantitative tools to enhance decision-making processes in public health treatments and advances our understanding of the dynamics of the tungiasis.</p> </abstract>","PeriodicalId":45029,"journal":{"name":"AIMS Bioengineering","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135312433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real data-based optimal control strategies for assessing the impact of the Omicron variant on heart attacks 评估欧米克隆变异对心脏病发作影响的真正基于数据的最优控制策略

IF 2.3

AIMS Bioengineering Pub Date : 2023-01-01 DOI: 10.3934/bioeng.2023015

F. Evirgen, Fatma Özköse, Mehmet Yavuz, N. Özdemir

引用次数: 1

Signal transduction from ligand-receptor binding associated with the formation of invadopodia in an invasive cancer cell 在侵袭性癌细胞中，配体-受体结合的信号转导与侵足形成相关

IF 2.3

AIMS Bioengineering Pub Date : 2022-01-01 DOI: 10.3934/bioeng.2022017

Noorehan Yaacob, S. Shafie, Takashi Suzuki, M. A. Admon

引用次数: 0

Use of “natural therapy” technology in the framework of social and psychological rehabilitation of the elderly “自然疗法”技术在老年人社会心理康复框架中的应用

IF 2.3

AIMS Bioengineering Pub Date : 2022-01-01 DOI: 10.3934/bioeng.2022022

M. Anishchenko, Ellina G. Pozdniakova-Kyrbiatieva, Y. Mosaiev, O. Krasnokutskyi, Volodymyr V. Glazunov

{"title":"Use of “natural therapy” technology in the framework of social and psychological rehabilitation of the elderly","authors":"M. Anishchenko, Ellina G. Pozdniakova-Kyrbiatieva, Y. Mosaiev, O. Krasnokutskyi, Volodymyr V. Glazunov","doi":"10.3934/bioeng.2022022","DOIUrl":"https://doi.org/10.3934/bioeng.2022022","url":null,"abstract":"The article is devoted to the peculiarities of using “natural therapy” technology in the process of social and psychological rehabilitation of the elderly. The article analyzes the relevance of the problem of social isolation, maladaptation and loneliness of elderly people in different countries of the world, and in Ukraine in particular, leading to sustainable social and psychological dysfunctions and substantiates the need to overcome them. The author's methodology for evaluating the effectiveness of socio-psychological rehabilitation sessions with the elderly using the rehabilitation implements of natural therapy is proposed. The mechanisms and technologies of social and psychological rehabilitation of the elderly using the rehabilitation concept of natural therapy are proposed and have been tested. As part of the research, an experiment was conducted among 100 people, half of whom were engaged in an individual rehabilitation course using the technology of the ecological rehabilitation concept of natural therapy. The article describes the results of the proposed classes for the participants of the experimental group and presents proposals in the field of improving rehabilitation measures based on natural therapy in the framework of the social and psychological rehabilitation of the elderly.","PeriodicalId":45029,"journal":{"name":"AIMS Bioengineering","volume":"44 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72612952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surveillance of elderlies at home: sensors, portable medical imaging devices, medical data management on smart phone 监测家中老人：传感器、便携式医疗成像设备、智能手机医疗数据管理

IF 2.3

AIMS Bioengineering Pub Date : 2022-01-01 DOI: 10.3934/bioeng.2022026

J. Demongeot, K. Oshinubi

引用次数: 1

Computational simulations of the effects of social distancing interventions on the COVID-19 pandemic 社交距离干预措施对COVID-19大流行影响的计算模拟

IF 2.3

AIMS Bioengineering Pub Date : 2022-01-01 DOI: 10.3934/bioeng.2022016

S. Khoshnaw, A. S. Mohammed

{"title":"Computational simulations of the effects of social distancing interventions on the COVID-19 pandemic","authors":"S. Khoshnaw, A. S. Mohammed","doi":"10.3934/bioeng.2022016","DOIUrl":"https://doi.org/10.3934/bioeng.2022016","url":null,"abstract":"The spread of the COVID-19 pandemic has been considered as a global issue. Based on the reported cases and clinical data, there are still required international efforts and more preventative measures to control the pandemic more effectively. Physical contact between individuals plays an essential role in spreading the coronavirus more widely. Mathematical models with computational simulations are effective tools to study and discuss this virus and minimize its impact on society. These tools help to determine more relevant factors that influence the spread of the virus. In this work, we developed two computational tools by using the R package and Python to simulate the COVID-19 transmissions. Additionally, some computational simulations were investigated that provide critical questions about global control strategies and further interventions. Accordingly, there are some computational model results and control strategies. First, we identify the model critical factors that helps us to understand the key transmission elements. Model transmissions can significantly be changed for primary tracing with delay to isolation. Second, some types of interventions, including case isolation, no intervention, quarantine contacts and quarantine contacts together with contacts of contacts are analyzed and discussed. The results show that quarantining contacts is the best way of intervening to minimize the spread of the virus. Finally, the basic reproduction number R0 is another important factor which provides a great role in understanding the transmission of the pandemic. Interestingly, the current computational simulations help us to pay more attention to critical model transmissions and minimize their impact on spreading this disease. They also help for further interventions and control strategies.","PeriodicalId":45029,"journal":{"name":"AIMS Bioengineering","volume":"38 1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85396887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A new mathematical modelling and parameter estimation of COVID-19: a case study in Iraq 新冠肺炎数学模型与参数估计:以伊拉克为例

IF 2.3

AIMS Bioengineering Pub Date : 2022-01-01 DOI: 10.3934/bioeng.2022030

M. Yavuz, Waled Yavız Ahmed Haydar

{"title":"A new mathematical modelling and parameter estimation of COVID-19: a case study in Iraq","authors":"M. Yavuz, Waled Yavız Ahmed Haydar","doi":"10.3934/bioeng.2022030","DOIUrl":"https://doi.org/10.3934/bioeng.2022030","url":null,"abstract":"Mathematical modelling has been widely used in many fields, especially in recent years. The applications of mathematical modelling in infectious diseases have shown that situations such as isolation, quarantine, vaccination and treatment are often necessary to eliminate most infectious diseases. In this study, a mathematical model of COVID-19 disease involving susceptible (S), exposed (E), infected (I), quarantined (Q), vaccinated (V) and recovered (R) populations is considered. In order to show the biological significance of the system, the non-negative solution region and the boundedness of the relevant biological compartments are shown. The endemic and disease-free equilibrium points of the model are calculated, and local stability analyses of these equilibrium points are performed. The basic reproduction number is also calculated for the relevant model. Sensitivity analysis of this number is studied, and it has been pointed out which parameters affect this number and how they affect it. Moreover, using real data from Iraq, the model parameters are estimated using the least squares curve fitting method, and numerical simulations are performed by using these estimated values. For the solution of the model, the Adams-Bashforth type predictive-corrective numerical method is used, and with the help of numerical simulations, several predictions are achieved about the future course of COVID-19.","PeriodicalId":45029,"journal":{"name":"AIMS Bioengineering","volume":"22 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74191973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Spatial mechanistic modeling for prediction of 3D multicellular spheroids behavior upon exposure to high intensity pulsed electric fields 高强度脉冲电场作用下三维多细胞球体行为预测的空间机制建模

IF 2.3

AIMS Bioengineering Pub Date : 2022-01-01 DOI: 10.3934/bioeng.2022009

Annabelle Collin, Hadrien Bruhier, Jelena Kolosnjaj, M. Golzio, M. Rols, C. Poignard

{"title":"Spatial mechanistic modeling for prediction of 3D multicellular spheroids behavior upon exposure to high intensity pulsed electric fields","authors":"Annabelle Collin, Hadrien Bruhier, Jelena Kolosnjaj, M. Golzio, M. Rols, C. Poignard","doi":"10.3934/bioeng.2022009","DOIUrl":"https://doi.org/10.3934/bioeng.2022009","url":null,"abstract":"The objective of this work was to investigate the growth specificities of cancer cells spheroids subjected to pulsed electric field. Multicellular HCT-116-GFP spheroids were exposed to different electric field intensities and the volume of multicellular spheroids was monitored by fluorescence and bright field microscopy. Thanks to an advanced mathematical model, based on differential equations and well-adapted estimation strategies, our modeling enables us to characterize the multicellular spheroids growth after permeabilizing pulsed electric field. In particular, we identify the percentage of cells which are destroyed and the percentage of cells which exhibit an altered growth pattern for different magnitudes of the electric field. We also quantify the growth resumption upon reversible and partially irreversible electroporation. Our preliminary results provide a first quantification of the impact of electroporation on multicellular spheroids growth, and suggest a booming growth of partially irreversible electric pulses, leading to an accelerated regrowth.","PeriodicalId":45029,"journal":{"name":"AIMS Bioengineering","volume":"51 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87871149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2