The Journal of The Korean Rheumatism Association最新文献_第10页

Coronary Artery Calcification Measured by Multi-Detector Computed Tomography in Systemic Sclerosis 多探测器计算机断层扫描在系统性硬化症中冠状动脉钙化的测量

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.181

M. Cho, Young-Eun Park, S. Baek, Joung-Wook Lee, Geun-Tae Kim, Jun-Hee Lee, K. Choo, Y. Jeong, S. H. Lee, Sung-il Kim

{"title":"Coronary Artery Calcification Measured by Multi-Detector Computed Tomography in Systemic Sclerosis","authors":"M. Cho, Young-Eun Park, S. Baek, Joung-Wook Lee, Geun-Tae Kim, Jun-Hee Lee, K. Choo, Y. Jeong, S. H. Lee, Sung-il Kim","doi":"10.4078/JKRA.2009.16.3.181","DOIUrl":"https://doi.org/10.4078/JKRA.2009.16.3.181","url":null,"abstract":"Objective: There is some controversy regarding the early onset or high incidence of coronary atherosclerosis in patients with systemic sclerosis (SSc). Measurements of the coronary calcification score (CCS) by multi-detector computed tomography (MDCT) is an accurate and non-invasive method for detecting coronary atherosclerosis, and a high level of CCS ( ≥ 160) can predict coronary events. This study examined the CCS using MDCT and evaluated the risk of coronary events in patients with SSc. Methods: The clinical and laboratory characteristics of 35 patients with SSc were examined. The CCS was measured by MDCT, and the risk of coronary events were evaluated by CCS and the Framingham risk score (FRS). Results: In 35 patients (2 males and 33 females, 20 with limited and 15 with diffuse type), the mean age was 52±12 years and the disease duration was 8±7 years. The mean CCS was 10.1±30.8, the CCS of 28 patients (80%) was 0, and all patients had a CCS ＜ 160. The CCS had no significant correlation with the clinical and laboratory characteristics. The FRS evaluated in 29 patients. Twenty eight patients were categorized into the low-risk group (FRS ＜ 10%) and only one was classified into the moderate-risk group (FRS=13%). Conclusion: These results suggest that the risk of coronary events due to coronary atherosclerosis might not be high in patients with SSc.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131511784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Myocardial Function of Postmenopausal Women with Fibromyalgia 评估绝经后纤维肌痛妇女的心肌功能

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.189

J. Kang, J. Lee, K. Cho, Tae-Ik Kim, H. Kwon, H. Kim, M. Kim, C. Hwang

引用次数: 1

Bucillamine-induced Nephropathy Bucillamine-induced肾病

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.197

Hyoun-Ah Kim, H. Yim, J. Sung, Jin-Woo Lee, C. Suh

{"title":"Bucillamine-induced Nephropathy","authors":"Hyoun-Ah Kim, H. Yim, J. Sung, Jin-Woo Lee, C. Suh","doi":"10.4078/JKRA.2009.16.3.197","DOIUrl":"https://doi.org/10.4078/JKRA.2009.16.3.197","url":null,"abstract":"Objective: Bucillamine is a disease-modifying antirheumatic drug that’s widely used in Korea and Japan, and it is reported to be a cause of proteinuria. However, the clinical course of the nephropathy associated with the use of bucillamine in rheumatoid arthritis patients has not been described in detail in Korea. Methods: We examined clinical records of 835 patients who were treated with bucillamine for rheumatoid arthritis at least 2 months at Ajou University Hospital from 2003 to 2008, and we found 23 patients (2.75%) with proteinuria. Each patient was followed up until the proteinuria had resolved. Results: At the time the proteinuria developed, the mean age of patients was 53.8±11.0 years. Only one patient had marked hypoalbuminemia (＜3.0 g/dL). The mean value of the random urine protein-creatinine ratio was 3.44±2.99. The proteinuria appeared 4∼18 months after the initiation of the treatment with bucillamine. Among the patients, renal biopsy was carried out in 18 patients, and pathological findings were 17 cases of membranous glomerulopathy and 1 case of focal segmental glomerulosclerosis. On the follow-up of the 18 patients, the proteinuria in all the patients had resolved completely without deterioration of renal function. But the time to resolution of the proteinuria was positively correlated with the length of bucillamine treatment after the onset of proteinuria (p＜0.001, r=0.744). Conclusion: Prevalence of proteinuria in patients receiving bucillamine was 2.75%, and bucillamine-induced nephropathy showed a good prognosis in Korea. The most important thing for resolving the bucillamine-induced proteinuria is to discontinue the bucillamine.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133460330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracranial Hypotension with Spontaneous CSF Leakage in a Patient with Systemic Lupus Erythematosus 系统性红斑狼疮患者自发性脑脊液漏并发颅内低血压1例

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.238

Juyoung Shin, Yune-Jung Park, S. Kim, Eui Sung Chung, Sun-Hee Ko, Chung-Hwa Park, Chan Joon Kim, J. Kim, C. Cho

{"title":"Intracranial Hypotension with Spontaneous CSF Leakage in a Patient with Systemic Lupus Erythematosus","authors":"Juyoung Shin, Yune-Jung Park, S. Kim, Eui Sung Chung, Sun-Hee Ko, Chung-Hwa Park, Chan Joon Kim, J. Kim, C. Cho","doi":"10.4078/JKRA.2009.16.3.238","DOIUrl":"https://doi.org/10.4078/JKRA.2009.16.3.238","url":null,"abstract":"Headaches are not only one of the 19 different neuropsychiatric syndromes in SLE but also the most common chief complaint of patients with neuropsychiatric lupus. Approximately 50% of patients with SLE are presumed to have neuropsychiatric phenomena during their illness. There’re no specific serological, radiological or histological biomarkers to confirm the clinical diagnosis of neuropsychiatric lupus. Therefore, physicians tend to try controlling lupus activity especially when the origins of the headache in patients with lupus are difficult to define. However, neuropsychiatric lupus can only be diagnosed after excluding other causes which is the point. A 47-year-old woman with lupus presented to the emergency department with the sudden onset of postural headache with nausea and vomiting. Through CSF tapping and CT myelography, intracranial hypotension with spontaneous CSF leakage was revealed. Her symptoms promptly improved after therapy using an epidural blood patch. Intracranial hypotension with spontaneous CSF leakage is rare disease, and it has never been reported in patients with SLE before. This case emphasizes the importance of finding out the origin of a headache in patients with lupus.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123880896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Term Use of Glucocorticoid Induced Osteoporotic Multiple Compression Fractures in Autoimmune Diseases 自身免疫性疾病患者长期使用糖皮质激素诱导骨质疏松性多发性压缩性骨折

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.228

Ye-Soo Park, W. Seo, J. Cho, Tae-Hwan Kim

引用次数: 0

A Case of Fatal DRESS Syndrome Caused by Dapsone in a Patient with Behcet's Syndrome 氨苯砜致白塞综合征患者致致命性DRESS综合征1例

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.253

C. Lee, S. Jang, S. Oh, H. Kim, Myeung-Su Lee

{"title":"A Case of Fatal DRESS Syndrome Caused by Dapsone in a Patient with Behcet's Syndrome","authors":"C. Lee, S. Jang, S. Oh, H. Kim, Myeung-Su Lee","doi":"10.4078/JKRA.2009.16.3.253","DOIUrl":"https://doi.org/10.4078/JKRA.2009.16.3.253","url":null,"abstract":"Dapsone has been used for several dermatological conditions such as immunobullous disease and ulticarial vasculitis. Dapsone is very useful drug for treating the mucocutaneous manifestations of Behcet’s disease. The widely recognized side effects of dapsone are headache, methemoglobinemia and hemolysis. The severer, but rarer side effect of dapsone is known as dapsone hypersensitivity syndrome, which consists of exfoliative dermatitis, hepatitis, lymphadenopathy and hemolytic anemia. When this is associated with eosinophilia, we can diagnose and treat this drug reaction with eosinophilia and systemic symptoms (DRESS). DRESS is a syndrome of fever, rash, and internal organ involvement that’s secondary to administering the offending medication. We describe here a 47-year-old woman who was hospitalized with fever, skin rash, hemolytic anemia, lymphadenopathy, eosinophilia, pleural effusion and life threatening hepatitis, which could lead to hepatic failure, within three weeks of starting of dapsone therapy for controlling her oral and genital ulcers. We diagnosed the woman as suffering with DRESS syndrome and we started treatment with corticosteroid. Three weeks after starting therapy, her symptoms almost completely resolved and she was discharged.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"212 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117286629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Renal Artery Thrombosis in a Patient with Systemic Lupus Erythematosus without Antiphospholipid Antibody Syndrome: A Case Study 无抗磷脂抗体综合征的系统性红斑狼疮患者肾动脉血栓形成一例

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.248

D. Kang, B. Kim, E. Jang, S. Shin, Jinseok Kim

{"title":"Renal Artery Thrombosis in a Patient with Systemic Lupus Erythematosus without Antiphospholipid Antibody Syndrome: A Case Study","authors":"D. Kang, B. Kim, E. Jang, S. Shin, Jinseok Kim","doi":"10.4078/JKRA.2009.16.3.248","DOIUrl":"https://doi.org/10.4078/JKRA.2009.16.3.248","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a multisystemic inflammatory autoimmune disease caused by various autoantibodies and immune complexes. SLE and antiphospholipid antibodies are associated with thrombotic manifestations. However, renal artery thrombosis which causes renal artery occlusion is uncommon even in SLE patients with antiphospholipid antibodies. A 27-year-old woman with SLE suddenly developed left flank pain and generalized edema. From the laboratory workup, the woman was negative for antiphospholipid antibody and nephroticrange proteinuria was detected. Computed tomography revealed renal artery thromboembolism and multiple renal infarctions with parenchymal perfusion defects in the left kidney. Renal biopsy showed WHO classification III and V lupus nephritis. Left flank pain, generalized edema and proteinuria were resolved and the thromboembolism resolved itself after a high dose of steroid and anticoagulation therapy. In SLE patients, sudden onset of unexplained flank pain is considered as a possible symptom of renal vessel thromboembolism even if the antiphospholipid antibody is negative.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134487470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Characteristics of Korean Patients with RA: A Single Center Cohort Study 韩国类风湿性关节炎患者的特征:一项单中心队列研究

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.204

Y. Kim, Chan-Bum Choi, Y. Sung, Hye-Soon Lee, S. Bae

{"title":"Characteristics of Korean Patients with RA: A Single Center Cohort Study","authors":"Y. Kim, Chan-Bum Choi, Y. Sung, Hye-Soon Lee, S. Bae","doi":"10.4078/JKRA.2009.16.3.204","DOIUrl":"https://doi.org/10.4078/JKRA.2009.16.3.204","url":null,"abstract":"Objective: The aim of this study is to describe the general characteristics and potential susceptibility genes of a large cohort of Korean rheumatoid arthritis (RA) patients. Methods: After giving consent, the patients were invited to undergo a structured interview and clinical examination that were performed by rheumatologists and a specially trained research nurse. When appropriate, the information obtained by interview was supplemented by information from the patient’s medical record. We reviewed the genetic studies for the subjects in the Hanyang RA cohort to investigate the genetic characteristics of Korean RA patients. Results: The mean age of the Hanyang RA cohort was 51.6±12.4 years, and 88.1% were women. The unemployment rate was 19.6%, and 52.2% of the patients had limitation of everyday life or their work life. The mean age at the time of disease onset was 41.0±12.9 years and the duration from disease onset to initiation of treatment was 23.6±57.1 months. The smoking rate of the Hanyang RA cohort was 16.8%, and 30.8% of the patients were exposed to passive smoking. Total joint arthroplastys were performed in 158 (10.3%) patients, and the most common operation site was the knee. On the review of the genetic studies for the Hanyang RA cohort, the representative susceptibility genes for the development of RA were HLA-DRB1, PADI4, STAT4 and TRAF1-C5. Conclusion: This data of Korean RA patients can be used as the preliminary data for important","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131421487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

IL-10 Inihibits VEGF Production in the Synovial Fibroblasts of RA Patients via Down-regulation of the ERK and AP-1 Pathways IL-10通过下调ERK和AP-1通路抑制RA患者滑膜成纤维细胞中VEGF的产生

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.213

Seon-Yeong Lee, M. Cho, Mi-Kyung Park, H. Oh, Sung-Hwan Park, Ho‐Youn Kim

{"title":"IL-10 Inihibits VEGF Production in the Synovial Fibroblasts of RA Patients via Down-regulation of the ERK and AP-1 Pathways","authors":"Seon-Yeong Lee, M. Cho, Mi-Kyung Park, H. Oh, Sung-Hwan Park, Ho‐Youn Kim","doi":"10.4078/JKRA.2009.16.3.213","DOIUrl":"https://doi.org/10.4078/JKRA.2009.16.3.213","url":null,"abstract":"Objective: Interleukin (IL)-10 has been demonstrated to have anti-inflammatory and anti-tumour activity. Because aberrant angiogenesis is a significant pathogenic component of tumor growth and chronic inflammation, we investigated the effect of IL-10 on the production of vascular endothelial growth factor (VEGF) by the synovial fibroblasts derived from the patients with rheumatoid arthritis (RA). Methods: Fibroblast-like synoviocytes (FLS) were cultured with transforming growth factor (TGF-β) alone or with IL-10. The level of VEGF was measured by RT-PCR and enzyme-linked immunosorbent assay (using the 24, 48 and 72 h culture supernatants). The FLSs were cultured with TGF-b for 48 hr in the presence of PD98059 (an ERK inhibitor), curcumin and SP600125 (a JNK and Ap-1 inhibitor, respectively). The level of VEGF in the supernatants was measured by ELISA. Cell viability was assessed using MTT assay. The expressions of VEGF, ERK, AP-1 and IL-10 in the synovial tissue were quantified by immunohistochemistry. Results: IL-10 exhibited the inhibitory effect on VEGF production when the FLSs were stimulated with TGF-β. ERK and AP-1 inhibitors inhibited the TGF-β induced VEGF production.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116328187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TNF Inhibitor Use during the Perioperative Period 围手术期TNF抑制剂的使用

The Journal of The Korean Rheumatism Association Pub Date : 2009-09-01 DOI: 10.4078/JKRA.2009.16.3.175

H. Ko, S. Park

引用次数: 0