Characteristics of Korean Patients with RA: A Single Center Cohort Study

Y. Kim, Chan-Bum Choi, Y. Sung, Hye-Soon Lee, S. Bae
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引用次数: 9

Abstract

Objective: The aim of this study is to describe the general characteristics and potential susceptibility genes of a large cohort of Korean rheumatoid arthritis (RA) patients. Methods: After giving consent, the patients were invited to undergo a structured interview and clinical examination that were performed by rheumatologists and a specially trained research nurse. When appropriate, the information obtained by interview was supplemented by information from the patient’s medical record. We reviewed the genetic studies for the subjects in the Hanyang RA cohort to investigate the genetic characteristics of Korean RA patients. Results: The mean age of the Hanyang RA cohort was 51.6±12.4 years, and 88.1% were women. The unemployment rate was 19.6%, and 52.2% of the patients had limitation of everyday life or their work life. The mean age at the time of disease onset was 41.0±12.9 years and the duration from disease onset to initiation of treatment was 23.6±57.1 months. The smoking rate of the Hanyang RA cohort was 16.8%, and 30.8% of the patients were exposed to passive smoking. Total joint arthroplastys were performed in 158 (10.3%) patients, and the most common operation site was the knee. On the review of the genetic studies for the Hanyang RA cohort, the representative susceptibility genes for the development of RA were HLA-DRB1, PADI4, STAT4 and TRAF1-C5. Conclusion: This data of Korean RA patients can be used as the preliminary data for important
韩国类风湿性关节炎患者的特征:一项单中心队列研究
目的:本研究的目的是描述韩国类风湿性关节炎(RA)患者的一般特征和潜在易感基因。方法:征得患者同意后,邀请患者接受由风湿病学家和经过专门培训的研究护士进行的结构化访谈和临床检查。在适当的情况下,通过面谈获得的资料由病人的病历资料加以补充。我们回顾了汉阳RA队列中受试者的遗传研究,以调查韩国RA患者的遗传特征。结果:汉阳RA队列患者的平均年龄为51.6±12.4岁,女性占88.1%。失业率为19.6%,日常生活或工作生活受到限制的占52.2%。发病时平均年龄为41.0±12.9岁,发病至开始治疗的时间为23.6±57.1个月。汉阳RA队列的吸烟率为16.8%,其中30.8%的患者暴露于被动吸烟。158例(10.3%)患者行全关节置换术,最常见的手术部位为膝关节。回顾汉阳RA队列的遗传学研究,RA发生的代表性易感基因为HLA-DRB1、PADI4、STAT4和TRAF1-C5。结论:本资料可作为韩国RA患者的重要初步资料
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