V.F.Snegirev Archives of Obstetrics and Gynecology最新文献

{"title":"The role of integrins in the formation of the placental increment (placenta accreta spectrum)","authors":"Viktoriya А. Efimova, E. E. Rudenko, A. Murashko, O. Lobanova","doi":"10.17816/2313-8726-2022-9-1-5-12","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-1-5-12","url":null,"abstract":"One of the most serious pregnancy complications is currently considered as a violation of cytotrophoblast invasion, particularly, a pathologically increased depth of invasion, leading to the formation of the placental increment (placenta accreta), ingrowth (placenta increta), and germination (placenta percreta). Cytotrophoblast invasion is regulated through subtle intercellular interactions, an important role among which is played by integrins, transmembrane glycoproteins that contribute to the immersion of cytotrophoblast in the endometrium and myometrium. The balance disturbance in the expression of 11, 51, and 64 integrins after normal implantation form a pathological extravillous trophoblast (EVT) phenotype by the blastocyst. This review examines the importance of integrins, collagens, and fibronectin in the formation of placental ingrowth (placenta accreta spectrum).","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125727731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of habitual pregnancy miscarriage of various origins","authors":"A. Unanyan, L. Pivazyan, A. A. Zakaryan, A. A. Siordiya, A. I. Ishchenko","doi":"10.17816/2313-8726-2022-9-1-13-21","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-1-13-21","url":null,"abstract":"Habitual pregnancy miscarriage is one of the serious problems of reproductive health in the modern world. Habitual miscarriage is defined as the spontaneous termination of two or more pregnancies before the fetus reaches viability from conception to 24 weeks of pregnancy. However, some differences of opinion are determined among specialists in habitual miscarriage. Some experts in their clinical practice for habitual miscarriages use the definition of three or more consecutive miscarriages. Habitual miscarriage occurrence varies from 0.5 to 2.3%, but the exact prevalence is very difficult to estimate, which depends on the used definition. The pathogenesis of habitual miscarriage is determined based on the age of the mother and the gestational age of the fetus. Habitual miscarriage can be caused by chromosomal errors, autoimmune disorders, endometrial dysfunction, endocrinopathies, hormonal and metabolic disorders, infections, and uterine anatomical defects. Currently available treatments target suspected risk factors for miscarriage, although the effectiveness of many medical interventions appears to be controversial. \u0000This study aimed to evaluate the effectiveness of treatments for habitual miscarriage of various origins, such as antiphospholipid syndrome, subclinical hypothyroidism, and idiopathic habitual miscarriage.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117022417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of correction methods for isthmic-cervical insufficiency: cohort study results","authors":"Svetlana V. Pesegova, E. Timokhina, A. Strizhakov","doi":"10.17816/2313-8726-2022-9-1-33-40","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-1-33-40","url":null,"abstract":"AIM: To assess the pregnancy outcomes in patients with isthmic-cervical insufficiency (ICN) and the effectiveness of modern methods of correction, namely cervical cerclage, obstetric discharge pessary, and progesterone preparations. \u0000MATERIALS AND METHODS: The retrospective analysis included 184 females with ICN, who were divided into three groups based on ICN correction methods: 1st group consisted of 82 (44.6%) females who were corrected by cervical cerclage; 2nd group with 67 (36.4%) females by obstetric pessary; and 3rd group with 35 (19.0%) females by progesterone therapy with ICN sign appearance. \u0000RESULTS: According to the obtained data, every second patient (53.3%) in our study had risk factors for ICN development due to the mechanical expansion of the cervical canal in cervical anamnesis. In most cases, ICN was diagnosed in 20 weeks and more, and the median period of correction was 21 [2022] weeks in 1st group, 24 [2226] weeks in 2nd group, and 22 [2022] weeks in 3rd group (p 0.001). The overall incidence of preterm birth (PTB) in 1st group was 48.8%, whereas 40.3% in 2nd group and 60% in 3rd group. The share of timely births accounted for 41.5% in 1st group, whereas 53.7% in 2nd group and 11.4% in 3rd group. \u0000CONCLUSION: Correction of ICN with cervical cerclage and obstetric pessary showed similar effectiveness and allowed prolonged pregnancy to more favorable terms. The correction group with only progesterone preparations noted a high frequency of premature pregnancy termination since this group initially included females with a higher risk of PTB and adverse factors for further prolonged pregnancy.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114298182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality assessment of medical care for females with stillbirth according to a questionnaire","authors":"Yulya S. Mysovskaya, D. Marshalov, E. Shifman, A. V. Kuligin, E. E. Zeulina","doi":"10.17816/2313-8726-2022-9-1-57-66","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-1-57-66","url":null,"abstract":"BACKGROUND: Death is a leading factor in post-traumatic stress disorder development. The adequacy of medical and psychological support for childbirth with a dead fetus plays a key role in severe psychological disorder prevention. \u0000MATERIALS AND METHODS: The authors have developed a questionnaire to assess the quality of obstetric, anesthesiological, and psychological assistance to females with death. The questionnaires of 173 respondents were analyzed. The duty factor or completeness of answers was 0.96. Of the cases, 55% of childbirth with a dead fetus occurred after 34 weeks of gestation, whereas the time interval from the moment of delivery to the questionnaire did not exceed 2 years in 60% of cases. \u0000RESULTS: The heavy emotional state was rated by 70% of females. Psychological assistance was recognized as unsatisfactory in 52% of cases. Most females (63%) wanted to be conscious at the time of the birth of a child and contact with him. This issue was not discussed with females in labor in 51% of cases. Neuroaxial methods of analgesia were used in 36% of cases in vaginal childbirth, whereas anesthesia was not performed in 40% of patients. Sedative therapy was needed by 76% of females in the postpartum period, which was prescribed only in 25% of cases. A third of respondents rated unsatisfactory medical care provided, and 94% of females believe that special training and seminars on communication with patients who have had a stillbirth are necessary for medical workers. \u0000CONCLUSION: The analysis of questionnaires filled out by women with stillbirth revealed several problems in the quality of medical care provided to them, wherein the most significant was the insufficient realization of the patients desire for contact with a dead child, insufficient anesthesia in childbirth, and sedation in the postpartum period, as well as unsatisfactory psychological care provided by doctors of an interdisciplinary team and a clinical psychologist, according to respondents.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114143300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Course of pregnancy and childbirth in comorbid patients with gestational diabetes mellitus","authors":"N. Zharkin, Kseniya O. Zabolotneva","doi":"10.17816/2313-8726-2021-8-4-213-219","DOIUrl":"https://doi.org/10.17816/2313-8726-2021-8-4-213-219","url":null,"abstract":"AIM: This study aimed to assess the course of pregnancy and childbirth in comorbid patients with gestational diabetes mellitus (GDM). \u0000MATERIALS AND METHODS: This retrospective analysis enrolled 168 individual cards of pregnant women and women in labor with GDM between 2018 and 2020. \u0000RESULTS: Analysis of the comorbid background of pregnant women revealed the presence of overweight and obesity in 48.2% of patients. Thus, these conditions were attributed as determinants in the development of GDM. In 58.7% patients, delivery was performed by cesarean section; however, in 11.3% of pregnant women, surgical delivery was performed for the first time; the main indication for it was a large fetus. \u0000CONCLUSION: Comorbid background in pregnant women contributes to GDM development, which causes a high percentage of obstetric complications and diabetic fetopathy. The risk strategy for this pathology involves predicting complications using continuous outpatient observation, timely treatment, and hospitalization in accordance with the degree of risk.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121091650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for treating pregnant women with hepatitis B and C","authors":"V. A. Kaptilnyy, D. Y. Reyshtat, M. Berishvili, M. N. Zholobova","doi":"10.17816/2313-8726-2021-8-4-177-184","DOIUrl":"https://doi.org/10.17816/2313-8726-2021-8-4-177-184","url":null,"abstract":"This multilateral review provides current knowledge regarding pregnancy and infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), as well as discusses modern methods to reduce mother-to-child transmission (MTCT) of these infections. Maternal HBV or HCV infection is associated with adverse outcomes of pregnancy and childbirth, including MTCT. In countries, including the United States, where postpartum HBV vaccination and immunoprophylaxis with hepatitis B immunoglobulin have been introduced, MTCT has generally decreased to approximately 5%. Unlike that for HBV infection, there is no available or recommended therapy to reduce the risk of MTCT of HBV infection, and the risk remains at 310%. MTCT of HCV can be minimized if do not use obstetric care and avoid birth injuries. Young women with HCV should be referred for treatment after childbirth, and newborns should be closely monitored to rule out infection. New, more affordable, and better tolerated HCV treatment regimens are now emerging that will help reduce the number of infected women and infants.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132554691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern aspects of the fascial structure of the pelvic floor (literature review)","authors":"I. Musin, A. Yashchuk, R. A. Kazikhinurov, A. R. Molokanova, Maksimova Yu. Serafima","doi":"10.17816/2313-8726-2021-8-4-199-206","DOIUrl":"https://doi.org/10.17816/2313-8726-2021-8-4-199-206","url":null,"abstract":"The pelvic floor fascia in women has attracted the attention of obstetricians-gynecologists, proctologists and rehabilitologists due to their possible role in the development of pelvic organ prolapse and the appearance of pelvic pain. The development and improvement of new surgical techniques entails a comprehensive study of previously known approaches. For instance, regarding fascial tissues, studying the actual use of fascial flaps in plastic and reconstructive surgeries is of particular interest. This necessitates an accurate definition of and knowledge about structure of the fascia and their variations. In addition, knowledge of the fascial structure of surgical methods for treating prolapse, such as the installation of mesh prostheses in the reconstruction of the pelvic floor in the absence of alternative methods of correction. Primarily postoperative pain, a more in-depth study of the fascial anatomy of the pelvic floor can help reduce these adverse outcomes. The morphological and physiological characteristics of the perineal fascia presented in the teaching materials and teaching aids are not descriptive in nature and are far from the descriptive practice of obstetricians-gynecologists in the selection of methods for surgical correction of genital prolapse. This work is a literature review compiled from the sources of the electronic national bibliographic database of scientific citation of the Russian Science Citation Index and the English-language text database of medical and biological publications PubMed, created by the National Center for Biotechnological Information of the USA. To search for data, such key queries as fascia, pelvic floor, pelvic floor anatomy, genitourinary diaphragm, chronic pelvic pain were used, both individually and collectively.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122804524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibility of use and effectiveness of oral hypoglyctic drugs in gestational diabetes mellitus: a literature review","authors":"Nadezhda E. Russkova, Anna V. Shumak, E. Timokhina","doi":"10.17816/2313-8726-2021-8-4-207-212","DOIUrl":"https://doi.org/10.17816/2313-8726-2021-8-4-207-212","url":null,"abstract":"Gestational diabetes mellitus (GDM) is a serious and frequent concern in pregnancy. Worldwide, the prevalence of GDM ranges from 8 to 20%. In 5% of cases, this pathology is accompanied by complications such as diabetic fetopathy, preeclampsia, neonatal hypoglycemia, and hyperbilirubinemia. Modern national and foreign guidelines for detecting hyperglycemia during pregnancy and diagnosing GDM recommend lifestyle changes and adherence to a carbohydrate-restricted diet as initial therapy. In the absence of positive dynamics against the background of non-drug therapy, the Russian Federation recommends only the use of insulin. \u0000A number of foreign guidelines consider the use of oral hypoglycemic agents (metformin and/or glibenclamide) during pregnancy as an alternative to injectable drugs. In this review, we compared the efficacy and safety of metformin and/or glibenclamide for treating GDM. Metformin and glibenclamide are reliable and safe for correcting the level of blood glucose in pregnant women, but the optimal therapeutic strategy includes their combined use or combined use with insulin.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130300456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of endometrial dysfunction in the combined pathology of uterus: a literature review","authors":"N. A. Burova, N. Zharkin, Olga Yu. Murzina, Y. Shatilova","doi":"10.17816/2313-8726-2021-8-4-191-198","DOIUrl":"https://doi.org/10.17816/2313-8726-2021-8-4-191-198","url":null,"abstract":"Currently, the concern of endometrial dysfunction is still relevant and is of increasing interest. This is because of new factors have been identified that affect the reproductive function in women. Chronic endometritis and endometriosis mainly affect women of childbearing age, which threatens normal cyclic transformation of the endometrium and tissue receptivity. This consequently affects the main function of the endometrium, which is to ensure successful implantation of the fertilized egg and the development of the chorion and embryo. A detailed understanding of the functioning of the endometrium with a combination of chronic endometritis and endometriosis will improve their diagnosis and treatment.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"993 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123095188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nursing profoundly premature newborns with artificial placentae: a review","authors":"Akinyemi Oyedele, Morakinyo Oyedele, A. Murashko","doi":"10.17816/2313-8726-2021-8-4-185-190","DOIUrl":"https://doi.org/10.17816/2313-8726-2021-8-4-185-190","url":null,"abstract":"Neonatal mortality and morbidity are substantial issues affecting the maternal healthcare sector. Extremely premature infants, notably those born before the 28-week mark, experience significant morbidity and mortality rates during neonatal care. This is a result of developmental immaturity and iatrogenic injury. Several attempts have been made to develop a womb-like environment to mimic uteroplacental physiology, but limited success has been noted over the last decade. This review aims to summarize the current literature on improved techniques implemented in creating an artificial placenta, the principles of these procedures, and their limitations. Our findings indicate that implementing techniques that closely mimic uteroplacental pathophysiology is crucial in decreasing the excessive neonatal mortality and morbidity rates seen in extremely premature infants.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128814803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}