V.F.Snegirev Archives of Obstetrics and Gynecology最新文献

{"title":"Experience of using extracorporeal membrane oxygenation for total abruption of a normally located placenta in severe preeclampsia","authors":"A. Lazareva, I. B. Fatkullina, A. Yashchuk, K. N. Zolotukhin","doi":"10.17816/2313-8726-2022-9-4-247-254","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-4-247-254","url":null,"abstract":"INTRODUCTION: Premature abruption of a normally located placenta is a sudden and challenging problem to manage, and is a leading cause of maternal and perinatal mortality. Here, we reviewed the case of a pregnant woman with multiple organ failure and premature placental abruption involving the successful use of extracorporeal membrane oxygenation (ECMO) in the treatment of respiratory distress syndrome. \u0000AIM: We aimed at assessing the feasibility of using ECMO in the treatment of severe lung damage in a patient with multiple organ failure. \u0000CLINICAL CASE: We reviewed the clinical findings of the course of multiple organ failure and lung damage in a puerpera with severe preeclampsia. Moreover, we analyzed her life history, diseases, and diagnostic and treatment methods were analyzed. \u0000The described clinical case shows the possibility of the successful use of ECMO in patients with severe lung damage and respiratory distress syndrome in multiple organ failure resulting from severe obstetric complications. Currently, this is the first case involving ECMO in the treatment of the consequences of acute total abruption of a normally located placenta with favorable outcomes in the Republic of Bashkortostan.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131425703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of reconstructive plastic robot-assisted surgery in patients with isthmocele after cesarean section","authors":"D. V. Bryunin, N.S. Mikhaelyan, A. A. Bakhvalova, I. Khokhlova, T. A. Dzhibladze, I. Gadaeva, Y. Chushkov, E. Svidinskaya, A. Asambaeva, Anatolii I. Ishchenko","doi":"10.17816/2313-8726-2022-9-4-221-229","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-4-221-229","url":null,"abstract":"BACKGROUND: According to several Russian researchers, the number of cesarean deliveries in different regions of Russia varies from 15.2% to 42%. The incidence of complications inconsistency of the uterine scar (isthmocele) after surgery is 10%15%. \u0000AIM: This study aimed to assess the efficiency and safety of robot-assisted surgery in the correction of isthmoceles after cesarean section in patients of reproductive age. \u0000MATERIALS AND METHODS: The study involved seven patients aged 2734 years with signs of isthmoceles after urgent or elective cesarean section 12 months to 6 years prior to hospitalization. A comprehensive dynamic examination (echography, magnetic resonance imaging, and office hysteroscopy), surgical treatment with the da Vinci Si robotic complex, and outpatient monitoring in the early and long-term period (1, 6, 12, 24, and 36 months) were performed. \u0000RESULTS: The patients were satisfied with the results of surgical treatment during outpatient monitoring due to the improved quality of life resulting from the reduction of pathological symptoms. The control echography (1, 6, and 12 months later) showed normal myometrial thickness (911 mm) and adequate blood flow in the metroplasty area in all patients. The niche was not visualized during office hysteroscopy 6-months after the metroplasty. Three patients became pregnant 1620 months after the reconstructive uteroplasty and ended with a timely operative delivery. Two patients were followed up for their pregnancies at 12 and 29 weeks of gestation, while two women continued taking oral contraceptives and planned their next pregnancy at least a year later. \u0000CONCLUSIONS: The use of the da Vinci Si robotic system for surgical correction of isthmoceles provides volumetric three-dimensional visualization of anatomical structures, reduces the duration of surgery and intraoperative blood loss, minimizes the number of intraoperative and postoperative complications, and contributes to accelerated postoperative rehabilitation of patients.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124854906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effect of antiviral therapy for grade II cervical intraepithelial neoplasia","authors":"O. P. Vinogradova, N. Andreeva, O. V. Epifanova, O. Artemova","doi":"10.17816/2313-8726-2022-9-4-239-246","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-4-239-246","url":null,"abstract":"BACKGROUND: The production of many molecular markers at different grades of cervical intraepithelial neoplasia is currently being studied to predict the outcome of the disease and build an individual prognosis. However, no clear criteria for the course of neoplasia are available at this time. \u0000AIM: This study aimed to assess the efficiency of the antiviral immunomodulator Allokin-alpha (Alloferon) in the treatment of cervical intraepithelial neoplasia of moderate severity from the perspective of long-term follow-up. \u0000DESIGN: Prospective study. \u0000MATERIALS AND METHODS: We examined 86 women of reproductive age with grade II cervical intraepithelial neoplasia (CIN II) associated with human papillomavirus (HPV). In the CIN II group, all patients underwent excision of the affected area. According to the study design, 43 women were followed up after excision (Group 1a), while 43 participants were treated surgically and used the study drug (Group 1b). By cytological and colposcopic examination, the efficiency of the chosen therapy was assessed after 3, 12, and 18 months. However, the main criteria for the efficiency of treatment were the absence of HPV or a decrease in the viral load below significant values and the absence of recurrence of the pathological process. \u0000RESULTS: The combination of excision and the use of Allokin-alpha (Alloferon) showed significant advantages over monosurgical treatment. \u0000CONCLUSIONS: The data obtained indicate high HPV elimination and reduced probability of recurrence after excisional treatment in patients with CIN II when using Allokin-alpha (Alloferon).","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114899453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic significance of autoantibody combination in fetal growth restriction with early and late manifestation","authors":"Diana I. Yakubova, I. Ignatko, A. D. Megrabyan, T.M. Silaeva, I. Bogomazova","doi":"10.17816/2313-8726-2022-9-4-203-211","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-4-203-211","url":null,"abstract":"BACKGROUND: Fetal growth restriction (FGR) is one of the current problems in modern obstetrics and perinatology, which is associated with a large number of adverse perinatal outcomes. \u0000AIM: This study aimed to assess the diagnostic significance of the combination of autoantibodies (AAB) in the early and late FGR manifestation. \u0000MATERIALS AND METHODS: The study involved 117 pregnant women, classified into Group 1 (90 women with FGR) and Group 2 (27 women with a physiological course of pregnancy). Pregnant women with FGR were divided into two subgroups depending on the time of manifestation, i.e. FGR subgroups with early and late manifestation (45 patients each), respectively. Upon hospital admission, all patients of the study groups had blood sampling to determine autoimmune AABs using the ELI-P-test. \u0000RESULTS: An isolated increase in AABs to human chorionic gonadotropin (hCG) antigen, TrM (AAB markers of changes in vascular and hemostasis system), S100 protein, antineutrophil cytoplasm antibodies (ANCA), and KiMS (AABs to the cytoplasmic antigen of glomerular kidney cells) were observed in the early FGR manifestation when comparing the abnormal AAB spectrum in the early and late FGR manifestation, while a statistically significant isolated increase in the level of AABs to DNA and insulin was found in the late FGR manifestation. \u0000CONCLUSIONS: The study revealed the diagnostic significance of AAB combinations, as well as the combinations of increased AAB levels to hCG, S100, ANCA, and KiMS and an increase in AABs to DNA, collagen, and S100 protein in the early and late FGR manifestation, respectively.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129586878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and morphological features of endometrial pathologies during the perimenopausal period","authors":"Fidan T. Aliyeva, D. V. Bryunin, N. B. Paramonova, A. A. Bakhvalova, T. A. Dzhibladze, V. Zuev, Farakh T. Aliyeva","doi":"10.17816/2313-8726-2022-9-4-213-219","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-4-213-219","url":null,"abstract":"BACKGROUND: Disorders leading to pathological (most commonly, hyperplastic) processes in the endometrium often occur during the perimenopausal period, in addition to the natural changes associated with a physiological decrease in the function of hormone-producing and hormone-dependent organs. \u0000AIM: This study aimed to investigate the clinical and morphological features of endometrial pathological processes during the perimenopausal period. \u0000MATERIALS AND METHODS: We examined 73 perimenopausal women with various endometrial pathologies. The mean age of the examined patients was 47.80.3 (4551) years. All patients with perimenopausal endometrial pathologies underwent clinical, functional, endoscopic, and morphological examination. \u0000RESULTS: Endometrial polyps, endometrial hyperplasia, chronic endometritis, and endometrial adenocarcinoma were present in 54.8%, 30.1%, 12.4%, and 2.7% of perimenopausal patients examined, respectively. \u0000The most common clinical manifestations of endometrial pathologies in the perimenopause were polymenorrhea, acyclic menorrhagia, and menorrhagia in 42.4%, 39.7%, and 27.4% of patients, respectively. Moreover, a glandular fibrous endometrial polyp was diagnosed in 61.3% of patients with polymenorrhea and 50% of patients with acyclic bloody discharge and menorrhagia. \u0000CONCLUSIONS: The revealed variety of clinical signs, including their absence in some cases, as well as the diversity of hysteroscopic and morphological endometrial pathologies in perimenopausal women, up to the detection of endometrial cancer, confirmed the need for both ultrasound screening and mandatory hysteroscopy with separate diagnostic endometrial curettage in echo signs of intrauterine pathologies for timely diagnosis and adequate treatment.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121125868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newborns in the early neonatal period in a group of mothers at high obstetric and perinatal risk","authors":"P. Samchuk, I.Kh. Tsaroeva, A. I. Ishchenko, E. L. Azoeva","doi":"10.17816/2313-8726-2022-9-3-163-171","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-3-163-171","url":null,"abstract":"AIM: We aimed at assessing the status of newborns in the early neonatal period in a group of mothers at high prenatal risk for preeclampsia (PE), fetal growth restriction (FGR), preterm birth (PTB), and fetal chromosomal abnormalities (FCA). \u0000MATERIALS AND METHODS: We prospectively analyzed the status of 435 singletons. Mothers in the first-trimester underwent prenatal screening with risk assessment. Group 1 (study group, n=231) included high-risk subgroups for FCA (subgroup 1A, n=67), maternal PE (subgroup 1B, n=66), FGR (subgroup 1C, n=46), and PTB (subgroup 1D, n=52). We excluded risk combinations. Group 2 (controls) included 204 children of low-risk women. \u0000RESULTS: Group 1 had a higher incidence of mild-to-moderate asphyxia compared with group 2 (p 0.05) and was more frequent in 1B, 1C, and 1D subgroups. Moreover, the frequency of severe asphyxia was similar between the groups (p 0.05). Intrauterine growth restriction (IUGR) and developmental delay were more frequent in group 1 than in group 2 (p 0.05). Moreover, group 1 children required monitoring and treatment more frequently that in group 2 (p 0.05). The frequency of infectious complications in group 1 and 1A, 1B, and 1C subgroups was equally higher than that of group 2 (p 0.05), while respiratory distress syndrome predominated in group 1 (subgroup 1D) and was not observed in group 2. The discharge rate was 95.7% in group 1 and 84.0% in group 2 (p 0.05). On days 3 to 5, 16% and 3.4% of children in groups 1 and 2, respectively, were transferred to the second stage of aftercare (p 0.05). \u0000CONCLUSIONS: In the early neonatal period, children born to high-risk mothers, as opposed to those born to low-risk mothers, were significantly more likely to have asphyxia, IUGR, infectious complications, and indications for continued treatment in the second stage of nursing.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127509786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological pattern and misdiagnosis in polycystic ovarian syndrome","authors":"E. A. Sosnova, T. S. Gracheva, T. Demura, M. Krot","doi":"10.17816/2313-8726-2022-9-3-143-151","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-3-143-151","url":null,"abstract":"INTRODUCTION: Polycystic ovarian syndrome (PCOS) is currently one of the most common diseases in women. Ovarian dysfunction (irregular menstrual cycle and anovulation), hyperandrogenism, and polycystic ovarian morphology are the most frequent manifestations of the syndrome. Its main macroscopic sign is bilateral enlargement of the ovaries with multiple cystic and atretic follicles. Moreover, an ovarian biopsy is usually performed in addition to clinical examination allowing for an accurate diagnosis and management. \u0000AIM: In this study, we sought to analyze the morphological verification of PCOS. \u0000MATERIALS AND METHODS: We analyzed 121 patients admitted to Moscow hospitals for surgical treatment diagnosed of PCOS by pathologists. Initially, PCOS was diagnosed at the outpatient examination. Thus, 121 women of reproductive age were included in the study after excluding tubal-peritoneal factors, male infertility factors, and menstrual dysfunction. Intraoperatively, all patients (n=121) were sampled for histological examination. \u0000The patients were referred to different gynecological hospitals: a municipal clinical hospital (group 1, n=54), a research center (group 2, n=48) and a commercial clinic (group 3, n=19). We processed data using parametric and non-parametric me thods in the STATISTICA Base software package. Arithmetic means, standard deviations, medians, and percentiles were equally determined. Confidence intervals for the arithmetic mean were determined using on the Student-t distribution. Moreover, we determined the 95% confidence intervals to the frequencies and the significance of differences in frequencies between the groups using binomial distribution and the Chi-square test, respectively. \u0000Some indicators exhibited significantly different distributions from the norm; therefore, non-parametric Mann-Whitney (p2) and Wilcoxon criteria were further applied. Differences were considered significant at p 0.05. \u0000RESULTS: Histological findings in 121 (100%) women of reproductive age with a clinical diagnosis of PCOS after surgical treatment were analyzed. After primary analysis, the clinical diagnosis was not confirmed in 78 (64%) patients, and histological findings of PCOS or PCOS that could not be excluded were obtained for only 43 (36%) women. Re-examination of histological samples from these 43 women let to the identifying of two groups of patients: group 1 with a typical histological pattern of PCOS (n=6, 14%) and group 2 with the so-called PCOS-like conditions (n=37, 86%). \u0000CONCLUSIONS: Significant differences were found between the morphological pattern of true PCOS and PCOS-like conditions. Thus, the final diagnosis should made clinically and through imaging, as well as through mandatory morphological examination of ovarian biopsy specimens after surgical treatment.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114796585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for premature placental abruption: a retrospective observational comparative study","authors":"Irina S. Rudakova, E. Shifman, G. Tikhova","doi":"10.17816/2313-8726-2022-9-3-153-161","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-3-153-161","url":null,"abstract":"AIM: This study aimed to determine the risk factors for premature placental abruption (PPA). \u0000MATERIALS AND METHODS: A retrospective comparative study was conducted at the Republican Perinatal Center of Petrozavodsk. The study group included 106 patients with a confirmed diagnosis of PPA from 2007 to 2017. The control group (comparison) included 106 women without PPA and abnormal placenta. \u0000RESULTS: The statistical data analysis revealed the following risk factors of PPA: lack of higher education in the patient (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.280.90); smoking (OR: 3.41, 95% CI: 1.298.97); chronic liver disease (OR: 7.29, 95% CI: 1.6033.06); uterine abnormalities (OR: 8.57, 95% CI: 1.0569.79); and pelvic inflammatory disease (OR: 6.12, 95% CI: 2.5614.62). The effect of chronic hypertension, chronic kidney disease, and anemia on the occurrence of PPA in our study was not significant. \u0000CONCLUSION: An increased risk of PPA was found in patients who smoke without higher education with chronic liver disease, uterine abnormalities, and pelvic inflammatory diseases.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125735824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction of iron deficiency in patients with abnormal uterine bleeding","authors":"L. Ozolinya, Tat’yana N. Savchenko, E. D. Golovko","doi":"10.17816/2313-8726-2022-9-3-173-180","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-3-173-180","url":null,"abstract":"INTRODUCTION: Iron deficiency (ID) occurring latently or as iron deficiency anemia (IDA) is common in gynecology, particularly in patients with abnormal uterine bleeding (AUB). \u0000AIM: We aimed at exploring the efficiency of a medication containing ferrous sulfate and multivitamins for the correction of latent ID and treatment of mild IDA in AUB patients. \u0000MATERIALS AND METHODS: We performed a comprehensive clinical, laboratory, and instrumental examination of 60 women aged 35 to 50 years with AUB, revealing many gynecological pathologies (endometrial polyps or hyperplasia, ade nomyosis, and uterine myoma). The examined patients with AUB were divided into two groups: women with latent ID (group 1, n=38) and women with IDA (group 2, n=22). Moreover, all the patients had extragenital pathology in addition to gynecological diseases. As a treatment, ferrous sulfate with multivitamins was prescribed for 13 months. \u0000RESULTS: Before treatment, the hemoglobin level in the examined patients ranged from 95 to 130 g/L, with an average of 127.11.8 g/L in group 1 and 100.32.1 g/L in group 2. Serum iron concentrations in the examined groups were 9.80.2 and 6.91.3 mol/L, respectively. After treatment, the average levels of hemoglobin and serum iron increased significantly and reached normal levels in all those examined. Hemoglobin was 143.31.8 g/L in group 1 and 122.51.5 g/L in group 2, whereas serum iron was 14.90.2 mol/L in group 1 and 13.51.0 mol/L in group 2. Furthermore, a significant increase to normal values was observed in other indicators of complete blood count and biochemical analysis. \u0000CONCLUSIONS: The results of the study reveal a high clinical efficiency of ferrous sulfate and multivitamins in the treatment of ID in patients with AUB.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127723301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of preeclampsia: The significance of first-trimester biochemical screening of pregnancy-associated plasma protein A and human chorionic gonadotropin in predicting recurrence","authors":"S. A. Galeeva, I. B. Fatkullina, Eugeny M. Gareev, N. A. Tadzhiboeva, Natal’ya A. Stetsenko, A. Lazareva, D. G. Sitdikova","doi":"10.17816/2313-8726-2022-9-3-181-188","DOIUrl":"https://doi.org/10.17816/2313-8726-2022-9-3-181-188","url":null,"abstract":"AIM: We aimed at assessing the significance of first-trimester biochemical screening of pregnancy-associated plasma protein A (РАРР-А) and human chorionic gonadotropin (hCG) in predicting the recurrence of preeclampsia (PE) in pregnant women with early and late history of gestational PE. \u0000MATERIALS AND METHODS: A retrospectively included 94 labor histories and prenatal medicals records of pregnant women (20202021). Moreover, their first-trimester biochemical screening parameters (РАРР-А and hCG) with a gestational PE history were performed to predict the recurrence of PE. They were divided into three groups (two study groups and a control group). Groups 1 and 2 included 31 labor histories each with late- and early-onset PE, respectively. Group 3 (controls) consisted of 32 labor histories with uncomplicated pregnancies. \u0000RESULTS: In the groups with a gestational PE history and recurrence, a significant decrease in РАРР-А levels was found at 1114 weeks of gestation. We equally observed high levels of first-trimester hCG in late-onset PE, most probably due moderate degrees of PE recurrence and not gestational age. However, severe degrees of recurrence prevailed in early-onset PE. \u0000CONCLUSIONS: A decrease in РАРР-А levels measured at 1114 weeks of gestation is a significant predictor of recurrence of PE in the group of pregnant women with a gestational PE history.","PeriodicalId":448378,"journal":{"name":"V.F.Snegirev Archives of Obstetrics and Gynecology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128928124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}