{"title":"Vasculitis","authors":"G. Spickett","doi":"10.1093/med/9780198789529.003.0013","DOIUrl":"https://doi.org/10.1093/med/9780198789529.003.0013","url":null,"abstract":"The term vasculitis implies inflammation affecting predominantly the blood vessels. The effects of the process depend on the location of the inflammatory change and the size and type of the vessel involved. It is unclear why there is selectivity for vessels of a certain type, size, or location. This chapter covers the presentation, immunogenetics, immunopathology, diagnosis, treatment, and testing for a range of primary vasculitides.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124037459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmunity in liver disease","authors":"G. Spickett","doi":"10.1093/med/9780198789529.003.0008","DOIUrl":"https://doi.org/10.1093/med/9780198789529.003.0008","url":null,"abstract":"This chapter covers the presentation, immunogenetics, immunopathology, diagnosis, treatment, and testing for a range of liver diseases. Primary biliary cirrhosis, autoimmune hepatitis, and primary sclerosing cholangitis are described.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122097407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Secondary immunodeficiency and other host defence syndromes","authors":"G. Spickett","doi":"10.1093/MED/9780198789529.003.0002","DOIUrl":"https://doi.org/10.1093/MED/9780198789529.003.0002","url":null,"abstract":"Many disease states have been associated with immune dysfunction of varying degrees of severity and significance. This chapter discusses individual immunological abnormalities, along with the classification of secondary immunodeficiency. Individual viruses, bacterial causes, fungal and parasitic infections, and oncological causes are all outlined, along with age, metabolic disorders, diabetes, drugs, and other injuries.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"48 5 Suppl 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128207161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmunity in gastrointestinal disease","authors":"G. Spickett","doi":"10.1093/MED/9780198789529.003.0007","DOIUrl":"https://doi.org/10.1093/MED/9780198789529.003.0007","url":null,"abstract":"This chapter covers issues of autoimmunity in gastrointestinal disease. It features the clinical presentation, immunology, and testing for diagnosis and management. It features autoimmune enteropathy, achalasia, eosinophilic gastroenteritis, Crohn’s disease, ulcerative colitis, Whipple’s disease, Coeliac disease, sclerosing mesenteritis, pancreatitis, and irritable bowel syndrome. Differential diagnoses are also highlighted where appropriate.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"34 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114106306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmune haematological disorders","authors":"G. Spickett","doi":"10.1093/MED/9780198789529.003.0009","DOIUrl":"https://doi.org/10.1093/MED/9780198789529.003.0009","url":null,"abstract":"This chapter covers the presentation, immunogenetics, immunopathology, diagnosis, treatment, and testing for a range of haematological disorders. Immune thrombocytopaenia, haemolytic anaemia, neutropenia, paroxysmal nocturnal haemglobinuria, aplastic anaemia, pure red cell aplasia, acquired haemophilia, and others are described.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130064106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmunity associated with cardiac, respiratory, and renal disease","authors":"G. Spickett","doi":"10.1093/MED/9780198789529.003.0006","DOIUrl":"https://doi.org/10.1093/MED/9780198789529.003.0006","url":null,"abstract":"This chapter covers autoimmunity associated with various cardiac, respiratory, and renal diseases. It features the clinical presentation, immunology, and testing for diagnosis and management. Myocarditis, cardiomyopathy, eosinophilic syndromes, recurrent pericarditis and rheumatic fever are all described, with over ten detailed topics on various respiratory and renal diseases.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123544882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmune eye disease","authors":"G. Spickett","doi":"10.1093/MED/9780198789529.003.0011","DOIUrl":"https://doi.org/10.1093/MED/9780198789529.003.0011","url":null,"abstract":"The eye has a number of interesting immunological properties that alter the propensity for immune-mediated disease, including the curious feature that antigen injected into the anterior chamber induces tolerance rather than immunity. In addition, the eye has no true lymphatics, relatively poor vascularity, and, as the retina is an extension of the CNS, there is a blood–retinal barrier that limits passage of molecules in either direction. Ocular involvement is a common feature of many connective tissue and vasculitic diseases.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133448436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmune skin disorders","authors":"G. Spickett","doi":"10.1093/MED/9780198789529.003.0010","DOIUrl":"https://doi.org/10.1093/MED/9780198789529.003.0010","url":null,"abstract":"This chapter covers the presentation, immunogenetics, immunopathology, diagnosis, treatment, and testing for a range of skin disorders. The skin is a very easy organ in which to investigate autoimmune disease, due to its accessibility for biopsy. It covers fourteen separate skin disorders.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"671 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131885986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality and managerial issues","authors":"G. Spickett","doi":"10.1093/med/9780198789529.003.0022","DOIUrl":"https://doi.org/10.1093/med/9780198789529.003.0022","url":null,"abstract":"Clinical and laboratory services do not operate in isolation but are integrated into the clinical and managerial framework of a hospital, and in the UK into a nationwide network (the NHS). This provides a constraint in both managerial and financial terms and also provides a legal framework in which services are delivered. It is essential that no matter where the patient is treated the right diagnosis is reached and the appropriate treatment is given. This chapter describes quality and managerial issues related to immunology and allergy, and gives an overview of the structure of the NHS.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"142 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120816723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Connective tissue disease","authors":"G. Spickett","doi":"10.1093/MED/9780198789529.003.0012","DOIUrl":"https://doi.org/10.1093/MED/9780198789529.003.0012","url":null,"abstract":"This chapter covers the presentation, immunogenetics, immunopathology, diagnosis, treatment, and testing for a range of connective tissue diseases. It covers a range of rheumatic disorders, from rheumatoid arthritis to Raynaud’s phenomenon, and also covers the undifferentiated diseases, overlap syndromes, and mixed connective tissue disease.","PeriodicalId":448046,"journal":{"name":"Oxford Handbook of Clinical Immunology and Allergy","volume":"48 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114060522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}