Argentine Journal of Cardiology最新文献

{"title":"Cardiotoxicity Alerts during Treatment with Trastuzumab in Breast Cancer at Four-year Follow-up","authors":"D. Santos, M. Tettamanti, C. Chacon, J. Nadal, V. Costanzo, A. Nervo, Federico Losco, R. Chacón","doi":"10.7775/RAC.87.2.13799","DOIUrl":"https://doi.org/10.7775/RAC.87.2.13799","url":null,"abstract":"Background: Adjuvant treatment of HER2+ breast cancer includes adriamycin and trastuzumab, a monoclonal antibody that producescardiotoxicity. The actual epidemiologic impact of trastuzumab-related cardiotoxicity in unselected populations in Argentinaremains unknown.Objectives: The aim of this study was to evaluate the impact of trastuzumab-related cardiotoxicity during adjuvant treatment forbreast cancer in an unselected population after >12 months of completing therapy.Methods: Among 888 patients prospectively evaluated for breast cancer, 231 (38%) were HER2+ and received adjuvant therapy withadriamycin and trastuzumab. Left ventricular ejection fraction was evaluated before treatment, after completing adriamycin and thenevery 3 months during follow-up. Cardiotoxicity was defined as a decline in left ventricular ejection fraction >10%, according to the definitionof the American College of Cardiology and was compared with the definitions of the B-31 trial and the MD Anderson Cancer Center.Results: A decline in left ventricular ejection fraction >10% from baseline values occurred in 65% (n=150) of the patients during amean follow-up of 48±12 months. In the per group analysis, patients included in the B-31and MD Anderson Cancer Center vs. theAmerican College of Cardiology definitions presented greater percent fall in left ventricular ejection fraction during treatment: 20%vs. 20% vs. 16%, respectively (p <0.04) and ended treatment with left ventricular ejection fraction <50% in 42% vs. 41% vs. 33% ofcases, respectively (p=0.01).Conclusions: In the population treated with trastuzumab under cardio-oncology surveillance during 48±12 months:1- Left ventricular ejection fraction was significantly decreased in more than 60% of patients.2- Different guidelines show different cardiotoxicity risks which demands continuous cardio-oncological monitoring.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127116074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPICOR Study: What Does It Tell Us About Acute Coronary Syndrome in Argentina?","authors":"X. Roselló, H. Bueno","doi":"10.7775/AJC.87.1.14625","DOIUrl":"https://doi.org/10.7775/AJC.87.1.14625","url":null,"abstract":"1 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, España 2 CIBER de enfermedades Cardiovasculares (CIBERCV), Madrid, España 3 Servicio de cardiología, Hospital Universitario 12 de Octubre e Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12) 4 Facultad de Medicina. Universidad Complutense, Madrid, España Rev ARgent CARdiol 2019;87:1-3.http://dx.doi.org/10.7775/rac.es.v87.i1.14625 VER ARTÍCULO RELACIONADO: Rev Argent Cardiol 2019;87:6-13 http://dx.doi.org/10.7775/rac.es.v87.i1.14242","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"22 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114130250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal ECG Findings in Amateur Athletes: Comparison of the 2013 and 2017 Seattle Criteria","authors":"F. Ramognino, F. Ferraro, Eduardo S. Blumberg, Nicolás Caruso, C. Sánchez, G. Bortman","doi":"10.7775/RAC.87.2.14621","DOIUrl":"https://doi.org/10.7775/RAC.87.2.14621","url":null,"abstract":"Introduccion: La especificidad del electrocardiograma como metodo diagnostico de causas de muerte subita cardiaca en deportistasdepende de los criterios utilizados para discernir entre alteraciones fisiologicas y patologicas.Objetivos: Evaluar la prevalencia de hallazgos electrocardiograficos anormales en deportistas amateur al comparar los Criteriosde Seattle 2013 y 2017.Material y metodos: Fueron evaluados 853 deportistas. Se evaluaron genero y edad como variables predictoras independientes.Se realizo un seguimiento mediante metodos complementarios de diagnostico.Resultados: Presentaron electrocardiogramas anormales segun criterios 2013 29 deportistas y 17, segun criterios 2017, lo queconstituyo el 3,4% y el 2%, respectivamente. No se encontraron diferencias significativas entre generos ni por edad.Conclusiones: De los electrocardiogramas considerados anormales segun los criterios 2013, el 41,4% paso a considerarse normalal aplicarse los criterios redefinidos en 2017. Ni el genero ni la edad constituyen variables predictoras independientes. Enningun evaluado, se pudo demostrar cardiopatia en el seguimiento.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113956297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Pulmonary Embolism in Argentina. XX CONAREC Registry","authors":"I. Cigalini, D. Igolnikof, C. E. Scatularo, J. Jauregui, M. Bernal, S. G. Zamora, J. Bonorino, J. Thierer, E. Zaidel","doi":"10.7775/RAC.87.2.14603","DOIUrl":"https://doi.org/10.7775/RAC.87.2.14603","url":null,"abstract":"Background: Acute pulmonary embolism (PE) represents the third cause of cardiovascular mortality. However, there is lackof information about this entity in our country. Our aim was to describe baseline characteristics, clinical evolution and treatmentof patients with acute PE in Argentina.Methods: This was a prospective multicenter registry including patients with acute PE hospitalized in centers with cardiologyresidency from October 2016 to November 2017. Conventional analysis was performed for descriptive and comparativestatistics. A value of p<0.05 was considered significant. Cross audit was performed to 20% of participating centers.Results: We included 684 consecutive patients from 75 centers with an average age of 63.8 years and 388 (57%) women. Hospitaladmission was due to PE in 484 (71%) cases. The most frequent predisposing factors were obesity, recent hospitalization,transient rest and active cancer. Anticoagulation was indicated in 661 patients (97%) and reperfusion therapy was performedin 91 (13%). However, only 50 of the 102 patients who presented with hemodynamic instability received reperfusion therapy(49%). Global in-hospital mortality was 12%, mainly associated with acute PE (51%).Conclusions: Acute pulmonary embolism presents with high in-hospital mortality in our setting, mainly related to the embolicevent. We observed a low use of reperfusion therapies in patients with hemodynamic instability.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121045032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The female doctor and the female patient","authors":"Ana Salvati","doi":"10.7775/RAC.87.2.15011","DOIUrl":"https://doi.org/10.7775/RAC.87.2.15011","url":null,"abstract":"","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114060959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When a Measure is Consequential","authors":"J. Banchs","doi":"10.7775/RAC.87.2.14985","DOIUrl":"https://doi.org/10.7775/RAC.87.2.14985","url":null,"abstract":"","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134149898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Kinetic Glomerular Filtration Rate in Patients with Decompensated Heart Failure","authors":"Y. C. Costa, F. Delfino, V. Mauro, H. Trevisani, Enrique B. Fairman, Adrián Charask, Alesis Raffaeli, C. Barrero","doi":"10.7775/RAC.87.2.13811","DOIUrl":"https://doi.org/10.7775/RAC.87.2.13811","url":null,"abstract":"Background: The coexistence of decompensated heart failure (DHF) and acute renal failure (ARF) is associated with longerhospital stay and greater mortality.Objectives: The aim of this study was to evaluate whether kinetic glomerular filtration rate (KeGFR) estimated with Chen´sequation can predict the development of ARF or mortality during hospitalization in patients with DHF.Methods: We conducted a retrospective study of consecutive patients with estimated kinetic glomerular filtration rate usingserum creatinine levels on admission and at 24 hours. The primary endpoint was a composite of ARF or mortality, and aROC curve was built to find the cutoff value with the best sensitivity and specificity to predict events. Acute renal failure wasdefined according to the KDIGO guideline. Patients were followed-up throughout hospitalization and those with a history ofchronic renal failure were excluded from the study.Results: Among 813 patients, 190 were excluded due to chronic renal failure and 608 patients were analyzed. Median age was81 years (IQR 25-75%: 73-87) and 48% were men; 25.5% were diabetics, 76% had hypertension, 19.4% had history of priormyocardial infarction and 46.8% presented left ventricular systolic dysfunction defined as left ventricular ejection fraction<45%. Median creatinine level on admission was 1.05 mg/dl. The incidence of the composite event was 41.1%. Age, sex andcomorbidities were similar in patients with and without the composite event, but KeGFR was significantly lower in this groupof patients (median: 50.7 ml/min vs. 57.9 ml/min, p<0.01) and resulted an independent predictor of mortality. The analysis ofthe ROC curve revealed that a cutoff point of 60 ml/kg/min for KeGFR (AUC 0.60) had the best diagnostic accuracy to predictthe composite event and was present in 58.9% of the patients. Age, female sex, hypertension and diabetes were predictors ofthe composite event.Conclusions: Kinetic glomerular filtrate rate can be used as an independent predictor of the composite event, but has no clinicalrelevance due to its low specificity.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127806526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2018 Dr. Pedro Cossio Foundation Award","authors":"J. Lerman","doi":"10.7775/RAC.87.2.14606","DOIUrl":"https://doi.org/10.7775/RAC.87.2.14606","url":null,"abstract":"","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125418028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Ventricular Outflow Tract Stenting in Severe Tetralogy of Fallot: an Option to the Blalock-Taussig Shunt","authors":"A. Peirone, A. Contreras, Adolfo Ferrero Guadagnoli, Victor Francucci, I. Juaneda, Marcelo Cabrera, Irma Azar, Juan Díaz, E. Banille, E. Juaneda","doi":"10.7775/RAC.87.2.14669","DOIUrl":"https://doi.org/10.7775/RAC.87.2.14669","url":null,"abstract":"Introduccion: El manejo inicial de pacientes con tetralogia de Fallot (TOF) asociado a una anatomia desfavorable y flujo vascularpulmonar significativamente reducido es controversial y continua siendo un desafio clinico.Material y metodos: Estudio multicentrico, retrospectivo, observacional. Se incluyeron pacientes consecutivos (neonatos y lactantes menores) con diagnostico de TOF asistidos en cuatro centros diferentes de la ciudad de Cordoba, Argentina, que recibieron stent entracto de salida de ventriculo derecho (TSVD) como abordaje inicial de su cardiopatia congenita. La indicacion de intervencion paliativa inicial fue consensuada en reunion del equipo cardiovascular en cada centro participante. Una anatomia compleja (ramas pulmonares con Z score≤ -2,5), presentacion en shock cardiogenico o en crisis de cianosis, bajo peso o comorbilidades significativas (enterocolitisnecrotizante, prematurez, insuficiencia renal, convulsiones) inclinaron la decision hacia un abordaje percutaneo inicial.Resultados: Entreagosto de 2017 hasta mayo de 2018, 6 pacientes con TOF sintomaticos recibieron stent en TSVD. La edad mediafue 39,3 dias (9-87), el peso medio fue 3,60 kg (2,2-5,4) y el 66% eran de sexo femenino. Los stents utilizados fueron coronarios operifericos con un diametro que vario entre 4,0 y 6,0 mm. La saturacion periferica previa a la colocacion del stent fue de 66,4% (42-77) incrementado a 90,6% (86-96) previo al alta (p<0,001). No se registraron complicaciones durante la intervencion. El tiempo deinternacion fue de 7 dias (1-13) y el tiempo de seguimiento fue de 106,8 dias (4-292). No hubo mortalidad a los 30 dias.Conclusion: El implante de stent en TSVD en pacientes con TOF y anatomia desfavorable es una opcion razonable en neonatos ylactantes menores como alternativa a la realizacion de una anastomosis de Blalock-Taussig modificada o correccion primaria inicial.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131209917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Two Argentine Registries on Myocardial Infarction: the 2011 SCAR Registry and the 2015 AR GEN -IA M-ST Registry","authors":"Claudio C. Higa, Heraldo D´Imperio, Patricia Blanco, Adrián Charask, H. C. Arazi, F. Novo, E. Perna, J. Gagliardi","doi":"10.7775/ajc.87.1.14515","DOIUrl":"https://doi.org/10.7775/ajc.87.1.14515","url":null,"abstract":"Background: The aim of this study was to compare patients with ST-segment elevation myocardial infarction (STEMI) included incenters participating of two registries in Argentina.Methods: STEMI patients included in the 54 centers participating in the SCAR (2011) registry and in the ARGEN-IAM-ST (2015)registry were compared.Results: A total of 676 STEMI patients were analyzed: 222 in the SCAR registry and 454 in the ARGEN-IAM-ST registry. There wereno significant differences in age and sex. The use of fibrinolytic agents was significantly lower and the use of primary percutaneouscoronary intervention was significantly increased. The incidence of cardiogenic shock was 50% lower. There were no differences inmortality and reinfarction during hospitalization.Conclusions: The indication of primary percutaneous coronary intervention increased and the use of fibrinolytic agents decreased.Cardiogenic shock decreased significantly in the last 5 years without significant changes in in-hospital mortality.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123196684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}