Fatigue-Biomedicine Health and Behavior最新文献

{"title":"Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors.","authors":"Daniel L Hall,&nbsp;Michael H Antoni,&nbsp;Emily G Lattie,&nbsp;Devika R Jutagir,&nbsp;Sara J Czaja,&nbsp;Dolores Perdomo,&nbsp;Suzanne C Lechner,&nbsp;Jamie M Stagl,&nbsp;Laura C Bouchard,&nbsp;Lisa M Gudenkauf,&nbsp;Lara Traeger,&nbsp;MaryAnn Fletcher,&nbsp;Nancy G Klimas","doi":"10.1080/21641846.2015.1039289","DOIUrl":"https://doi.org/10.1080/21641846.2015.1039289","url":null,"abstract":"<p><strong>Objective: </strong>Persistent fatigue and depressive symptoms are both highly prevalent among patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) as well as breast cancer survivors. This study aimed to assess and directly compare perceptions of fatigue as highly interfering in one's daily functioning in both patient populations to better understand their relationships with depressed mood.</p><p><strong>Methods: </strong>Participants were 95 female CFS/ME patients and 67 females who were approximately 5 years post-treatment for stage 0-III breast cancer presenting with clinically elevated fatigue severity. Self-report measures were obtained on participants' fatigue-related interference in daily functioning and fatigue severity as well as depressed mood. Hierarchical regression was used to test effects controlling for relevant demographic, psychosocial, and medical covariates.</p><p><strong>Results: </strong>CFS/ME patients endorsed greater depressed mood and fatigue interference than did fatigued breast cancer survivors, <i>p's</i><.001. These factors were significantly positively correlated among CFS/ME patients (β=.36, <i>p</i><.001), but not the fatigued breast cancer survivors (β=.18, <i>p</i>=.19).</p><p><strong>Conclusions: </strong>CFS/ME patients reported elevated fatigue symptoms and depression relative to fatigued breast cancer survivors. In the former group, greater depressed mood was highly and significantly associated with greater fatigue-related inference in daily activities. Potential targets for cognitive behavioral interventions are discussed.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"3 3","pages":"142-155"},"PeriodicalIF":2.8,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2015.1039289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33909551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.","authors":"David Benjamin Fischer,&nbsp;Arsani Hany William,&nbsp;Adam Campbell Strauss,&nbsp;Elizabeth R Unger,&nbsp;Leonard Jason,&nbsp;Gailen D Marshall,&nbsp;Jordan D Dimitrakoff","doi":"10.1080/21641846.2014.906066","DOIUrl":"https://doi.org/10.1080/21641846.2014.906066","url":null,"abstract":"<p><p>Chronic fatigue syndrome (CFS) remains an incompletely characterized illness, in part due to controversy regarding its definition, biological basis and diagnosis. Biomarkers are objective measures that may lead to improvements in our understanding of CFS by providing a more coherent and consistent approach to study, diagnosis and treatment of the illness. Such metrics may allow us to distinguish between CFS subtypes - each defined by characteristic biomarkers - currently conflated under the single, heterogeneous condition of CFS. These delineations, in turn, may guide more granular, focused, and targeted treatment strategies based on more precise characterizations of the illness. Here, we review potential CFS biomarkers related to neurological and immunological components of the illness, and discuss how these biomarkers may be used to move the field of CFS forward, emphasizing clinical utility and potential routes of future research.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"2 2","pages":"93-109"},"PeriodicalIF":2.8,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2014.906066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32425105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and chronic hypoxia: implications for cerebral function and exercise tolerance.","authors":"Stuart Goodall,&nbsp;Rosie Twomey,&nbsp;Markus Amann","doi":"10.1080/21641846.2014.909963","DOIUrl":"https://doi.org/10.1080/21641846.2014.909963","url":null,"abstract":"<p><strong>Purpose: </strong>To outline how hypoxia profoundly affects neuronal functionality and thus compromise exercise-performance.</p><p><strong>Methods: </strong>Investigations using electroencephalography (EEG) and transcranial magnetic stimulation (TMS) detecting neuronal changes at rest and those studying fatiguing effects on whole-body exercise performance in acute (AH) and chronic hypoxia (CH) were evaluated.</p><p><strong>Results: </strong>At rest during very early hypoxia (<1-h), slowing of cerebral neuronal activity is evident despite no change in corticospinal excitability. As time in hypoxia progresses (3-h), increased corticospinal excitability becomes evident; however, changes in neuronal activity are unknown. Prolonged exposure (3-5 d) causes a respiratory alkalosis which modulates Na⁺ channels, potentially explaining reduced neuronal excitability. Locomotor exercise in AH exacerbates the development of peripheral-fatigue; as the severity of hypoxia increases, mechanisms of peripheral-fatigue become less dominant and CNS hypoxia becomes the predominant factor. The greatest central-fatigue in AH occurs when S_aO₂ is ≤75%, a level that coincides with increasing impairments in neuronal activity. CH does not improve the level of peripheral-fatigue observed in AH; however, it attenuates the development of central-fatigue paralleling increases in cerebral O₂ availability and corticospinal excitability.</p><p><strong>Conclusions: </strong>The attenuated development of central-fatigue in CH might explain, the improvements in locomotor exercise-performance commonly observed after acclimatisation to high altitude.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"2 2","pages":"73-92"},"PeriodicalIF":2.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2014.909963","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32979594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis.","authors":"Leonard A Jason,&nbsp;Madison Sunnquist,&nbsp;Abigail Brown,&nbsp;Meredyth Evans,&nbsp;Suzanne D Vernon,&nbsp;Jacob Furst,&nbsp;Valerie Simonis","doi":"10.1080/21641846.2013.862993","DOIUrl":"https://doi.org/10.1080/21641846.2013.862993","url":null,"abstract":"<p><strong>Background: </strong>Considerable controversy has transpired regarding the core features of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS). Current case definitions differ in the number and types of symptoms required. This ambiguity impedes the search for biological markers and effective treatments.</p><p><strong>Purpose: </strong>This study sought to empirically operationalize symptom criteria and identify which symptoms best characterize the illness.</p><p><strong>Methods: </strong>Patients (<i>n</i>=236) and controls (<i>n</i>=86) completed the DePaul Symptom Questionnaire, rating the frequency and severity of 54 symptoms. Responses were compared to determine the threshold of frequency/severity ratings that best distinguished patients from controls. A Classification and Regression Tree (CART) algorithm was used to identify the combination of symptoms that most accurately classified patients and controls.</p><p><strong>Results: </strong>A third of controls met the symptom criteria of a common CFS case definition when just symptom presence was required; however, when frequency/severity requirements were raised, only 5% met criteria. Employing these higher frequency/severity requirements, the CART algorithm identified three symptoms that accurately classified 95.4% of participants as patient or control: fatigue/extreme tiredness, inability to focus on multiple things simultaneously, and experiencing a dead/heavy feeling after starting to exercise.</p><p><strong>Conclusions: </strong>Minimum frequency/severity thresholds should be specified in symptom criteria to reduce the likelihood of misclassification. Future research should continue to seek empirical support of the core symptoms of ME and CFS to further progress the search for biological markers and treatments.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"2 1","pages":"40-56"},"PeriodicalIF":2.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2013.862993","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32101988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology.","authors":"Abigail A Brown,&nbsp;Leonard A Jason","doi":"10.1080/21641846.2014.928014","DOIUrl":"https://doi.org/10.1080/21641846.2014.928014","url":null,"abstract":"<p><strong>Objectives: </strong>The present study sought to validate a comprehensive self-report measure of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptomatology to aid in clinical and research assessment.</p><p><strong>Method: </strong>Exploratory factor analysis (EFA) was used to establish the underlying factor structure of the DePaul Symptom Questionnaire (DSQ) (Jason, Evans, et al., 2010) using a well-characterized sample of individuals (92.6% met the Fukuda et al. criteria (1994) and/or the Clinical Canadian Criteria (Carruthers et al., 2003)), and this structure was then tested on a less stringently recruited sample of individuals utilizing a confirmatory factor analysis (CFA). Convergent and discriminant validity of the DSQ were also examined utilizing alternative measures of symptomatology and functioning.</p><p><strong>Results: </strong>A 3-factor solution was found using EFA (Neuroendocrine, Autonomic & Immune Dysfunction; Neurological/Cognitive Dysfunction; Post-Exertional Malaise) and the fit of this factor structure was adequate for the second sample.</p><p><strong>Discussion: </strong>The DSQ is a valid measure of ME/CFS symptomatology. The emergent factors were consistent with previous literature on symptom clusters, and convergent and discriminant validity were established.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"2 3","pages":"132-152"},"PeriodicalIF":2.8,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2014.928014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34574067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A metagenomic approach to investigate the microbial causes of myalgic encephalomyelitis/chronic fatigue syndrome: moving beyond XMRV.","authors":"Ruth R Miller,&nbsp;Jennifer L Gardy,&nbsp;Patrick Tang,&nbsp;David M Patrick","doi":"10.1080/21641846.2013.812831","DOIUrl":"https://doi.org/10.1080/21641846.2013.812831","url":null,"abstract":"Three years ago, a novel association between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the murine retrovirus XMRV was published.[1] Since then, 191 papers have been published on the subject (NCBI PubMed, accessed 6 November 2012), largely disproving the initial association, a trend confirmed by a recent multicentre blinded trial which definitively concluded that there is no association between ME/CFS and XMRV.[2] It is therefore time to revisit the investigation of ME/CFS aetiology. Metagenomics offers a promising new opportunity for hypothesis discovery in microbial associations with ME/CFS, and we describe herein the technical basis of this approach and its advantages in aetiological agent investigation.","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"1 4","pages":"185-189"},"PeriodicalIF":2.8,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2013.812831","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31899593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue and Circadian Activity Rhythms in Breast Cancer Patients Before and After Chemotherapy: A Controlled Study.","authors":"Lianqi Liu,&nbsp;Michelle Rissling,&nbsp;Ariel Neikrug,&nbsp;Lavinia Fiorentino,&nbsp;Loki Natarajan,&nbsp;Michelle Faierman,&nbsp;Georgia Robins Sadler,&nbsp;Joel E Dimsdale,&nbsp;Paul J Mills,&nbsp;Barbara A Parker,&nbsp;Sonia Ancoli-Israel","doi":"10.1080/21641846.2012.741782","DOIUrl":"https://doi.org/10.1080/21641846.2012.741782","url":null,"abstract":"<p><p>BACKGROUND: Breast cancer (BC) patients often experience cancer-related fatigue (CRF) before, during, and after their chemotherapy. Circadian rhythms are 24-hour cycles of behavior and physiology that are generated by internal pacemakers and entrained by zeitgebers (e.g., light). A few studies have suggested a relationship between fatigue and circadian rhythms in some clinical populations. METHODS: One hundred and forty-eight women diagnosed with stage I-III breast cancer and scheduled to receive at least four cycles of adjuvant or neoadjuvant chemotherapy, and 61 controls (cancer-free healthy women) participated in this study. Data were collected before (Baseline) and after four cycles of chemotherapy (Cycle-4). Fatigue was assessed with the Short Form of Multidimensional Fatigue Symptom Inventory (MFSI-SF); circadian activity rhythm (CAR) was recorded with wrist actigraphy (six parameters included: amplitude, acrophase, mesor, up-mesor, down-mesor and F-statistic). A mixed model analysis was used to examine changes in fatigue and CAR parameters compared to controls, and to examine the longitudinal relationship between fatigue and CAR parameters in BC patients. RESULTS: More severe CRF (total and subscale scores) and disrupted CAR (amplitude, mesor and F-statistic) were observed in BC patients compared to controls at both Baseline and Cycle-4 (all p's<0.05); BC patients also experienced more fatigue and decreased amplitude and mesor, as well as delayed up-mesor time at Cycle-4 compared to Baseline (all p's<0.05). The increased total MFSI-SF scores were significantly associated with decreased amplitude, mesor and F-statistic (all p's<0.006). CONCLUSION: CRF exists and CAR is disrupted even before the start of chemotherapy. The significant relationship between CRF and CAR indicate possible underlying connections. Re-entraining the disturbed CAR using effective interventions such as bright light therapy might also improve CRF.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"1 1-2","pages":"12-26"},"PeriodicalIF":2.8,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2012.741782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31240971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.","authors":"Emily G Lattie,&nbsp;Michael H Antoni,&nbsp;Mary Ann Fletcher,&nbsp;Sara Czaja,&nbsp;Dolores Perdomo,&nbsp;Andreina Sala,&nbsp;Sankaran Nair,&nbsp;Shih Hua Fu,&nbsp;Frank J Penedo,&nbsp;Nancy Klimas","doi":"10.1080/21641846.2013.843255","DOIUrl":"https://doi.org/10.1080/21641846.2013.843255","url":null,"abstract":"<p><strong>Background: </strong>The onset of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) typically involves reductions in <i>activities of daily living</i> and <i>social interactions</i> (jointly referred to as \"illness burden\"). Emotional distress has been linked to increased reported symptoms, and stress management skills have been related to lower fatigue severity in CFS patients. Symptom severity and illness burden are highly correlated. The ability to manage stress may attenuate this relationship, allowing individuals to feel less burdened by the illness independent of the severity of their symptoms.</p><p><strong>Purpose: </strong>This study aimed to evaluate if perceived stress management skills affect illness burden via emotional distress, independent of ME/CFS symptom severity.</p><p><strong>Methods: </strong>A total of 117 adults with ME/CFS completed measures of perceived stress management skills, emotional distress, ME/CFS symptom severity and illness burden.</p><p><strong>Results: </strong>Regression analyses revealed that greater perceived stress management skills related to less social and fatigue-related illness burden, via lower emotional distress. This relationship existed independent of the association of symptom severity on illness burden, and was stronger among those not currently employed.</p><p><strong>Conclusions: </strong>Ability to manage stress is associated with a lower illness burden for individuals with ME/CFS. Future studies should evaluate the efficacy of psychosocial interventions in lowering illness burden by targeting stress management skills.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"1 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2013.843255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31905104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}