2010 IEEE International Conference on Nano/Molecular Medicine and Engineering最新文献_第3页

Submicron-fabrication of bovine serum albumin (BSA) matrix via two-photon photochemical crosslinking 双光子光化学交联亚微米制备牛血清白蛋白(BSA)基质

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749821

Jinye Xu, Jinping Cheng, S. Cheng, B. Chan

引用次数: 0

Rapidly dissolving silk protein microneedles for transdermal drug delivery 用于经皮给药的快速溶解丝蛋白微针

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749822

Xueqiu You, J. Pak, J. Chang

{"title":"Rapidly dissolving silk protein microneedles for transdermal drug delivery","authors":"Xueqiu You, J. Pak, J. Chang","doi":"10.1109/NANOMED.2010.5749822","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749822","url":null,"abstract":"This paper presents rapidly dissolving fibroin microneedles for the first time. A reverse PDMS microneedles mold was first created and drug-contained fibroin solution was poured into this reverse PDMS microneedles mold. Fibroin microneedles were successfully fabricated after drying and detaching the solidified fibroin structure from the PDMS mold. These fibroin microneedles serve as a matrix to incorporate drug molecules while maintaining the drug activity. The dimensions of the fabricated fibroin microneedles are 500 μm in length, 200 μm in diameter at the base, and 5 μm in radius at the tip. These fibroin matrix microneedles can dissolve within one minute under the skin to release the drug molecules and the dissolved fibroin in the skin generates noninflammatory amino acid degradation products usable in cell metabolic functions. The fibroin microneedles containing methylene blue as a drug were fabricated and their surface morphology, internal layered structure, mechanical property, and the dissolving characteristics were examined. These rapidly dissolving fibroin microneedles provide more benefit than conventional syringes for painless transdermal drug delivery.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133809873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

On chip superoxide dismutase assay for high-throughput screening of radioprotective activity of herbal plants 芯片上超氧化物歧化酶高通量筛选植物放射防护活性的研究

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749838

S. Park, Jiyeon Kim, Y. Tak, J. Song

{"title":"On chip superoxide dismutase assay for high-throughput screening of radioprotective activity of herbal plants","authors":"S. Park, Jiyeon Kim, Y. Tak, J. Song","doi":"10.1109/NANOMED.2010.5749838","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749838","url":null,"abstract":"With the advent of new technologies, human exposure to ionizing radiation has increased. Therefore, appropriate pharmacological interventions and modalities are needed to protect humans against the deleterious effects of ionizing radiation. In this work, we developed a photosensitive, high-throughput chip-based assay for exploring the antioxidant [superoxide dismutase (SOD)]/radioprotective potential of herbal plants. Red light absorption property of nitroblue tetrazolium (NBT) formazan was applied to chip-based SOD activity measurements of six herbal plant extracts in a high-throughput manner. SOD enzyme in the photochemical reaction scavenged free radicals (O•−2) to form a stable carryover product (O2 and H2O2). This in turn inhibited the development of NBT formazan in the reaction. Thus, the inhibition of NBT formazan production in reaction samples compared to their controls provides for measuresing the SOD activity of the respective samples. All herbal plant extracts showed higher SOD activities than amifostine. Pueraria root and scutellaria root had higher SOD activities whereas the apricot kernel displayed the lowest SOD activity among the herbal plant samples. In all test samples, gamma ray irradiation mildly reduced SOD activity. However, the reduction in SOD activity between 5 and 20 Gy irradiated samples was relatively remarkable for ponicirus fruit and citrus unshiu peel. The results indicate that the tested herbal plant extracts have the potential to be used as radioprotectors. Among the tested herbal extracts, pueraria root showed the highest antioxidant/radioprotective activity and can be considered as preferred radioprotector candidate.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115167562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Migratory response of human orbital fat-derived mesenchymal stem cell encapsulated in collagen gel 胶原凝胶包膜人眼眶脂肪源性间充质干细胞的迁移反应

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749841

H. Diao, C. Yu, B. Chan

引用次数: 0

A novel immunosensor platform based on inorganic BST film for point-of-care application 一种基于无机BST薄膜的新型免疫传感器平台

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749804

X. Fang, M. Tse, O. Tan, L. Sun

{"title":"A novel immunosensor platform based on inorganic BST film for point-of-care application","authors":"X. Fang, M. Tse, O. Tan, L. Sun","doi":"10.1109/NANOMED.2010.5749804","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749804","url":null,"abstract":"In this investigation, we present a novel label-free immunosensor platform based on inorganic barium strontium titanate (BST) thin film and interdigitated microelectrodes for clinical point-of-care application. The immunosensor is based on non-faradaic process, using DI water as electrolyte. As proof of concept, anti-human IgG, a common biomarker found and associated with many diseases was immobilized on the chemically modified BST film surface as sensing probe for human IgG detection. The BST immunosensor was also used for real clinical sample with pre-inactivated dengue virus as sensing probe to detect dengue antibody in human serum. Good linear correlations were observed for the measured electrical signals, AC impedances or current changes, versus the dilution of the human IgG concentration or the dengue serum samples. The measured signal changes in impedance/current without/with the presence of antibody were attributed to the surface conductivity change upon biomolecules immobilization and the dipole-induced interfacial polarization potential at the BST film/biomolecules interface. Promising specificity was proven with the interference tests by mixing human IgG solution with BSA and rabbit IgG. The performance of BST immunosensors exhibited good long-term stability with very low fluctuation/degradation even after storing dry at 4 °C for 60 days.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126070351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time stressing and force sensing on biological cells 生物细胞的实时应力和力传感

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749797

M. Han, Yan Liang Zhang, M. Y. Yu, C. Shee, W. T. Ang

{"title":"Real-time stressing and force sensing on biological cells","authors":"M. Han, Yan Liang Zhang, M. Y. Yu, C. Shee, W. T. Ang","doi":"10.1109/NANOMED.2010.5749797","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749797","url":null,"abstract":"Biological cells possess biochemical modules and physical shapes to maintain appropriate biological function. Different types of force and deformation are applied on cells to investigate the response and mechanical properties. In the biophysics field, studies use indentation deformation on cell membranes to examine the elastic-viscoelastic properties of biological cells. Experiments in different predefined profiles and frequencies are required to test the fidelity and predictive capability of cells creep function. The accuracy and the repeatability of the given stimulus are the significant factor in the experiments to obtain reliable measurements, which are very difficult to realize using manual operations. Automatic micromanipulation systems have substantial advantages over the conventional manual operations in aspects of reliability, accuracy and repeatability. In this paper, an automatic micromanipulation system is introduced and a series of experiments are conducted to stress zebrafish embryo in different sinusoidal profiles. The experimental results show that the system is able to stress the biological cell in desired stimulation and give consistent force outputs in realtime, meanwhile mechanical properties of the zebrafish embryo are also analyzed.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124958498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Strategies for drug-delivery and chemical sensing using biomédical microrobots 生物医学微型机器人的药物传递和化学传感策略

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749823

S. Pané, O. Ergeneman, K. M. Sivaraman, T. Luhmann, H. Hall, B. Nelson

引用次数: 7

PDMS stretchable platforms for the studies of mechanical compression on neurogenesis 用于神经发生机械压迫研究的PDMS可拉伸平台

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749799

Leyla Esfandiari, W. Tang

引用次数: 0

Magnetic bio-nanobeads and nanoelectrode based impedance biosensor for detection of avian influenza virus 用于禽流感病毒检测的磁性生物纳米球和纳米电极阻抗生物传感器

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749837

Ronghui Wang, Yanbin Li, X. Mao, T. Huang, Huaguang Lu

引用次数: 8

Force measurement study of engineered collagen-chitosan scaffold using Atomic Force Microscopy 工程胶原-壳聚糖支架的原子力显微镜测力研究

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2010-12-01 DOI: 10.1109/NANOMED.2010.5749831

Zhuxin Dong, U. Wejinya, Yanxia Zhu, K. Ye

引用次数: 4