MEDIS – International Journal of Medical Sciences and Research最新文献

{"title":"GMP AUDIT CHECKLIST – A VALUABLE MANAGEMENT TOOL IN PHARMACEUTICAL INDUSTRY","authors":"Edita Alili-Idrizi, Sihana Ahmeti-Lika, Dorentina Bexheti, E. Janevik","doi":"10.35120/medisij010301a","DOIUrl":"https://doi.org/10.35120/medisij010301a","url":null,"abstract":"Internal audit is an effective independent activity within a pharmaceutical industry quality management system. It ensures a thorough analyses and evaluation of the company activities and helps prevent, predict and detect mistakes and weaknesses in order to minimize losses. Internal audits help the organization achieve its goals and ensures all the involved parties that a program complies with regulatory and Good Manufacturing Practice (GMP) requirements. A successful audit, is carried out by quality auditor or audit team members, chosen carefully and properly trained. The auditor should gain as much information in advance before the auditing process begins that should help him to design tools useful in achieving the desired results. There are several sections recommended to be included in the GMP audit checklist: Quality management, Personnel, Facility and Equipment System, Documentation, Production System, Packaging and Labelling System, Storage System, and Laboratory Control System. A quality management system (QMS) is a formalized collection of processes, procedures, and documented policies, therefore the auditor looks to find out if the system complies with GMP requirements. As for the personnel, GMP audit checklist cover all the necessary procedures to ensure that the organization’s hiring and supervising practices are in compliance to GMP requirements, such as competences, trainings, dressing, and hygiene of the employees. Documentation ensures traceability of all development, manufacturing and testing activities, so the auditor needs to verify major types of documents that should be kept and recorded. The checklist includes questions addressing review of the layout, construction, size, location of the facility and main areas such as production area, storage, and laboratory, as well as the installation, operation, instructions, maintenance and cleaning of the equipment used in the manufacture. The production and process audit checklist include organization’s various stages of manufacturing such as weighing or measuring of raw materials, appropriate storage conditions for intermediates, In-Process sampling and controls, contamination control, process validation. Checklist points for internal audit of Packaging and Labelling System include elements ensuring the security and quality of packaging and as well elements that relate to labelling such as documentation, storage of starting materials and finished products, packaging and labelling operations. Internal auditing of storage system should prevent occurrence of mix-ups, damage, physical, chemical or microbial contamination. As for the Laboratory Control System, the GMP checklist questions aim to ensure that pharmaceutical products meet safety, efficacy, purity, and stability standards. The checklist is a good and critical tool to assist in conducting an in-depth and consistent audit and will serve as guideline for evaluation of compliance to standards and documentation, as well as for the ","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"284 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132278326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DISTAL RADIUS FRACTURES IN CHILDHOOD - OUR FIVE-YEAR EXPERIENCE","authors":"Rosen Staykov, N. Kolarov","doi":"10.35120/medisij010337s","DOIUrl":"https://doi.org/10.35120/medisij010337s","url":null,"abstract":"The most common fractures in children are those of the distal radius. There are relatively scanty publications devoted to this specific pathology in childhood. The timely diagnosis and proper treatment of the distal radius fractures are of undoubted significance. The purpose of the present communication is to share our recent practical experience with the management of the distal radius fractures in children. 2. Methodology. During the period between January 1, 2017 and December 31, 2021, 34 children at an average age of 10,85±3,00 years (between two and 17) with wrist joint injuries resulting in distal radius fractures were examined in the Clinic of Orthopedics and Traumatology, St. Anna Multiprofile Hospital of Varna. There were 21 boys at an average age of 11,43±3,39 years (between two and 17) and 13 girls at an average age of 9,92±2,38 years (between six and 12). Diagnosis was based on clinical and x-ray examinations. Therapeutic behavior included operative treatment, administration of analgesic means, immobilization, and, in some cases, subsequent rehabilitation. Surgery was accomplished under general anaesthesia in most cases. 3. Results. Mean age did not differ statistically reliably between both groups (t=1,524; p>0,05). The left radius fractures (13 in boys and 11 in girls) were statistically significantly more common than right radius ones (eight in boys and two in girls) (t=3,726; p<0,001). Most commonly, a closed reduction technique with or without internal fixation of the radius and ulna was made use of (in 15 boys and in seven girls) followed by reposition and fixation with one Kirschner wire (in one girl), with two Kirschner wires (in five boys and one girl), or with three ones (in five boys and two girls). An open reduction technique was applied in six boys and in six girls followed by reposition and fixation with one Kirschner wire (in one girl), with two Kirschner wires (in two boys and two girls), or with three ones (in two boys). It should be noted that internal fixation was not carried out in two boys and three girls. Control x-ray examination was performed in all the children. Cast immobilization for a period between 28 and 35 days, most often, for one month, was obligatorily done. Subsequently, Kirschner wires were removed in eight boys and in four girls. One complication was observed in a six-year old girl. It was caused by mechanical damage of the left wrist joint following the implantation of the internal orthopedic devices, i.e. three Kirschner wires. They were removed two months after the operation. Complete healing was achieved in all the children. 4. Conclusions. Based on these results of ours, the conclusion can be drawn that these surgical procedures along with the precise diagnosis and immobilization have proven to be safe and effective in the children with distal radius fractures. Obviously, modern strategies to successfully prevent the fractures in children should be developed.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114919793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHRONIC PAIN IN STUDENTS OF THE UNIVERSITY OF MONTENEGRO-ATTITUDES AND EXPECTATIONS","authors":"Emilija Nikolic, J. Marić","doi":"10.35120/medisij010325n","DOIUrl":"https://doi.org/10.35120/medisij010325n","url":null,"abstract":"Chronic pain is a significant health problem for university students. However, research on the impact of chronic pain on students is lacking, as well as the support they need to overcome the consequences of chronic pain. The goals of this research were to examine chronic pain in students of natural and social sciences at the University of Montenegro, to determine personal emotions, attitudes and expectations towards pain. Methods. Cross-sectional research was conducted among students from the first to the fifth year of the Faculty of Philosophy in Nikšić (Psychology, Teacher Education), the Faculty of Science and Mathematics in Podgorica (Mathematics, Physics and Physiotherapy) and the Control Group (outside the University). A total of 1,500 students and the control group completed online questionnaire, of which 990 participants met the conditions). Statistical differences between groups, female and male individuals were tested using the chi-square test and t-test.( p-value of <0.05 was considered statistically significant).Results. In the observed groups of students of natural and social sciences there are differences in experiencing and describing pain. Social science students showed passivity in dealing with chronic pain. They prefer to leave the decision on the method of treatment to the doctor, and a third of them just take pills. Conclusions. By applying the obtained questionnaire, we can be determined different attitudes of students of natural and social sciences towards chronic pain, therapeutic approaches, as well as expectations. Students of natural sciences had more education about pain, so the emotion, attitude and approach to solving the problem was simpler.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116504779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDENT ASSESSMENT FROM THE FACULTY OF “PUBLIC HEALTH, HEALTHCARE AND SPORTS” SOUTH-WEST UNIVERSITY “NEOPHIT RILSKY” ON THE ONLINE TRAINING","authors":"R. Doynovska","doi":"10.35120/medisij010343d","DOIUrl":"https://doi.org/10.35120/medisij010343d","url":null,"abstract":"The COVID-19 pandemic is having an unprecedented impact on human behavior and everyday life. One of the most characteristic post-COVID effects that has occurred is the increasingly imposed digital communication in all public and personal spheres. Higher education institutions stopped the face-to-face form of education and switched to online education. Digital literacy was required for university teachers and students to use online platforms. For large part of the students this process was easier due to their almost daily presence in the Internet space, use of various communicative social networks and applications. For the teachers, it became necessary to adapt the teaching material for application in an environment, to prepare in a short period of time to move to a different learning environment and to overcome the existing deficits for teaching in an online environment, to develop different forms of testing, to use webinars as a means of synchronous learning. The purpose of the present study is to examine the opinion of the students from the Faculty of Public Health, Health Care and Sport, South-West University „Neofit Rilski“-Blagoevgrad for the quality of online education. An anonymous survey was conducted among students of medical and non-medical specialties – nursing, midwifery, kinesiotherapy, speech therapy and social work. The results show that part of the students accept the online training as effective in terms of the theoretical material, but all of the them express a definite opinion about conducting hands-on training. Students expect from teachers more attractive methods, more time for direct dialogue and discussions. The technical problems in implementing online learning and the difficulties experienced by both students and teachers are reported. The technical problems in implementing online learning and the difficulties experienced by both students and teachers are reported. The obtained results show that both countries are facing a number of problems in the digital reality rethinking the traditional way of teaching.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128354630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIBROMYALGIA - CHARACTERISTICS AND PROOF OF PAIN","authors":"Darina Mineva","doi":"10.35120/medisij010213m","DOIUrl":"https://doi.org/10.35120/medisij010213m","url":null,"abstract":"Fibromyalgia is a disease that remains unrecognized due to ignorance and misinterpretation of symptoms. This article presents a clinical case from the medical practice of Fibromyalgia, while characterizing the pain syndrome and the necessary tests to prove the diagnosis. The clinical case concerned a patient with lumbar pain syndrome who did not respond to non-steroidal anti-inflammatory drugs. No connection has been established with the diseases provided for in the differential diagnosis, such as disc herniation, acute arterial insufficiency, rheumatoid arthritis. The laboratory tests performed are normal, except for a slight increase in AST of about 200 U / l, as well as high CRP values. No instrumental studies such as endophotonic emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRT) and electroencephalogram (EEG) were performed. The case describes a modified symptom in the elderly. Modified symptoms are experienced differently by patients. In this case, our own (from the doctor’s experience) paradigm was used for diagnosis. The paradigm consists of four main steps, which are: description of the specifics of each symptom; two aspects of the diagnosis: what is and what is not; the symptoms form a whole which represents the diagnosis with a logical connection and sequence and analysis of small deviations and nuances - a way of accurate diagnosis. The burning nature of the pain, the presence of painful nodules in the lumbar and scapular areas bilaterally, point to myositis. Various non-steroidal anti-inflammatory drugs have been administered in various forms (oral, topical and injectable), with no effect. As a last resort, a tricyclic antidepressant, amitriptyline, was included, which showed that the pain disappeared within a month. The presence of a mental component in the field of rheumatic disease, the effect of amitriptyline pain and the presence of sore spots at the predilection sites, led to the disease “Fibromyalgia”. Diagnosis of fibromyalgia is necessary to comply with two conditions clinical analysis of pain with the detection of painful points and instrumental nuclear magnetic resonance imaging to demonstrate dysfunction of the central nervous system and electroencephalogram for sleep disorders. To improve the diagnostic process, it is necessary in practice to apply tests of hormones and neurotransmitters.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132268359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE AND SIGNIFICANCE OF HARMFUL HABITS AND HERITABLE FACTORS IN THE DEVELOPMENT OF CHRONIC VASCULAR DISEASES","authors":"M. Mireva, M. Tsekov, E. Naseva","doi":"10.35120/medisij010255m","DOIUrl":"https://doi.org/10.35120/medisij010255m","url":null,"abstract":"Chronic Arterial Insufficiency of the Limb is a condition of chronical reduction of blood flow delivered from the arteries to a limb. It is also known as Peripheral Arterial Disease (PAD). The most commonly affected are the aorto-iliac segment and the arteries of the lower extremities. The most common causes are diabetes and / or atherosclerosis, but the bad habits and hereditarity are also important. The varicose disease is a process of superficial venous dilatation of the lower extremities. The most important reason of chronic venous disease is correlated with hereditary factors and the bad habbits. The secondary varicose is caused by malformations, traumatism and deep vein thrombosis. The lymphedema is a chronic disease, manifested by slowly progressing edema of the skin and skin. Due to the reduction of the transport function of the lymphatic system – the flow of lymph slows that leads to an increase in fluid in the intercellular space- edema. May affect any part of the body, but most often are affected one of the upper or lower limb. Purpose: evaluation of the bad habits and the hereditary factors as a reason for chronical vascular diseases. Methodology: for the purpose of this study a new anonymous questionnaires were created. Results: this study includes patients with chronical vascular diseases and was made in university hospital – clinic of Vascular surgery and in healthcare medical center. Conclusions: The bad habits and the hereditary factors are the main reason for development of chronical vascular diseases.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122167094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF PROPRIOCEPTIVE FACILITATION AND ITS APPLICATION AS AN INDISPENSABLE PART OF PRACTICAL PHYSIOTHERAPY","authors":"A. Nikolova, Steliyana Valeva, N. Bekir","doi":"10.35120/medisij010201n","DOIUrl":"https://doi.org/10.35120/medisij010201n","url":null,"abstract":"The essence of proprioceptive neuromuscular facilitation consists in the application of specific reinforcement techniques to enhance central arousal by volitional movements to improve active capacity of the affected muscle and muscles groups. This is a method of rising the muscle reaction and volitional impulses, which can be reached during stimulation of proprioceptive nerve endings. Proprioceptive neuromuscular facilitation consists is a philosophy and a concept treatment (Kabat, 1950) and for the first time the method was applied in physiotherapy practice in 1947. Dr. Kabat and Maggie Knott was the founders which started and continued to expand the development of techniques. Nowadays patients with traumatic as well as orthopaedic symptoms are treated with this concept successful. Development of PNF concept followed some specific techniques and patterns responsible to the neuromuscular facilitation. Movements are our natural way to interact with our environment. Interactions are directed by the mechanism of motor learning principles includes a progression from hands-on to hands-off treatment strategy. The mean goal is functional oriented activities and independence. The physiotherapy should be focussed always to mobilize the reserves to reach the highest point of function. Especially in the first and cognitive stage of motor control, the therapists manual facilitation will be a helpful tool in reaching this goal (Adler et. al, 2007).","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125419731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIDRADENITIS SUPPURATIVA","authors":"Vaska Spaskova","doi":"10.35120/medisij010243s","DOIUrl":"https://doi.org/10.35120/medisij010243s","url":null,"abstract":"Hidradenitis suppurativa (HS), or still known under the name Acne Inversa is a multifactor disease that has a chronic flow and starts with the capture of follicles of fibers located in intertriginous regions or anogenital regions. It is followed by recurrent, deep, sub connected and painful nodes, connected intertriginous sinus tracts and hypertrophic scars. Women are more versatile from men, according to 3:1 and more likely to develop axillary and genitofemoral lesions than a male population that develops changes that are localized in the perineal region. The disease itself is unpredictable flow and cannot be certain whether the period of menstruation, pregnancy or menopause may affect the deterioration of the patient’s condition. Usually, the bacterial infection that builds on the state itself is like a secondary phenomenon and most often isolate beta hemolytic streptococcus or staphylococcus. The pathogenesis of the disease is still unclear, but it is thought that the primary event that occurs is follicular occlusion occurring as a result of infundibular keratosis and epithelial hyperplasia. Features show that patients say that the same changes occur in other members of the family. Some genes from Secretase G family are thought to be responsible for the disease itself. On the other hand, there are autoimmune reasons for the very disease, both of the innate and the acquired immunity. However, this disease is classified as neutrophilic restriction. The simplest and most widely used instrument for HS classification in routine clinical practice. It classifies HS into three stages: Stage I: isolated, single or more painful abscesses, no scars and occurrence of cicatrix. Stage II: recurrent pain abscesses with scars, single or multiple but not so extensive. Stage III: diffuse, similar to plates, inflammatory, sick infiltrates or more mutual abscesses. Contracts of joints as a result of limited mobility associated with pain. Because the disease has more stages and treatment itself will be correlated with the stage of the disease. We should emphasize that the disease can also be worsened by some accompanying diseases from which the type 2 diabetes or some other endocrine and metabolic diseases should be distinguished in the first place. Always put the lifestyle and change in everyday habits as it is in the first place to reduce weight if it is increased as well as the cancellation of cigarette smoking. Primary in treatment is maintaining good personal hygiene with soaps that are antibacterial and pastures with mild disinfection. At the beginning of the disease, antibiotics are usually attached as local and systemic administration, most often from the group of tetracyclines. Anti-inflammatory preparations are given in order to reduce inflammation and drug reduction drugs. As antiseptics use salicylic solution, alcohol pine, camphor, ethyl alcohol or iodine. More recently, it goes to make drinks from iodine and potassium hypermangan. If it is not contra","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132649946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INFLUENCE OF COVID-19 PANDEMIC ON THE VACCINATION OF THE POPULATION WITH THE INFLUENZA VACCINE IN THE REPUBLIC OF NORTH MACEDONIA","authors":"Z. Mustafa, S. Memeti, Z. Karadzovski, Zorica Arsova Sarafinovska, Evgenija Mihajloska, Katerina Anchevska Netkovska, A. Grozdanova","doi":"10.35120/medisij010249m","DOIUrl":"https://doi.org/10.35120/medisij010249m","url":null,"abstract":"The implemented actions to minimize the spread of the COVID-19 pandemic had a powerful effect on the transmission of other respiratory viruses, particularly influenza viruses. Influenza is a disease of viral aetiology that causes epidemics and occasionally pandemics during the wintertime almost every year. Generally, it is a mild and self-limiting disease, but it can represent high morbidity and even mortality when affecting the elderly population or people with latent chronic diseases. The existing circumstances of a persistent and ongoing epidemic caused by the SARS-CoV-2 virus, increase the probability of having active coincidence with the anticipated annual epidemic of influenza. Thus, the key is a logistic strategy for clinical and viral diagnosis of the SARS-CoV-2 virus that will determine the importance of understanding the role of influenza vaccines in virus-induced COVID-19 disease. This paper aims to compare the potential impact of the COVID-19 pandemic on the vaccination coverage of the population with the influenza vaccine. The official data for seasonal influenza vaccination were used, obtained from the weekly reports on the influenza situation in the Republic of North Macedonia from the Institute of Public Health as well as the data from the national system “MojTermin” for total vaccinated individuals with influenza vaccine for the season 2020/2021 and 2021/2022 including the 5th week. The analyzed data for the season 2021/2022 show an increase of applied doses by 8.3% compared to the season 2020/2021 and an increase of 11.5% compared to the season 2019/2020. Regarding the target groups in the season 2021/2022, including the 5th week, the coverage of influenza vaccination in children aged 6 months to 5 years has a significant decrease of 87.9% compared to the season 2020/2021. There is an increase in coverage in health professionals by 24.3% compared to last season, in the chronically ill the decrease of the applied doses is by 11.4% compared to last season, and in the elderly, over 65 it is noticeable an increase in coverage by 100% compared to the 2020/2021 season. Furthermore, there is a significant decrease of 95.7% in the vaccines administered to pregnant women compared to last season. The reduced coverage of influenza vaccination is partly due to the ambiguities arising from the influenza immunization campaign, which emphasized the importance of receiving a vaccine to minimize the spread of the influenza virus as an additional threat to the presence of COVID-19. Although the influenza vaccine does not protect against COVID-19, influenza vaccination has been part of the public health strategy to flatten the disease curve caused by respiratory viruses that attack the respiratory system, to protect and preserve the health of healthcare professionals providing care to patients with COVID-19. Influenza vaccination is still the most efficient preventive measure against influenza infections at our disposal and it is recommended by th","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122901353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MICROBIOLOGICAL ISOLATES AND IT’S RESISTOTYPE FROM CLINIC OF VASCULAR SURGERY FOR THE FIRST QUATER OF 2022","authors":"Bogomila Chesmedzhieva, S. Stanev, T. Dermendzhiev","doi":"10.35120/medisij010207c","DOIUrl":"https://doi.org/10.35120/medisij010207c","url":null,"abstract":"One of the most common complications of surgical exposures is the surgical site infection (SSI). Although it varies between different surgical profiles, it can reach up to one third of all complications. In vascular surgery patients ischemic ulcers are very common, as well as factors, compromising the immune system such as diabetes, chronic kidney disease etc. One of the main surgical exposures in vascular surgery is inguinal, providing access to the femoral artery and its bifurcation. Although it allows a wide range of reconstructions, implanting different types of prosthetic materials, stents and providing anastomosis site, it contains lymph nodes, which can contaminate the reconstruction and cause SSI with severe consequences. Patients, prone to SSI due to concomitant diseases, are threatened by sepsis, limb loss and even death, which makes prevention of those type of complications essential. Aim: To investigate etiological spectrum of microbiological isolates and their resistance against most common antimicrobials among vascular surgery patients. Materials and methods: The study is retrospective, conducted in the period 01 January 2022 – 31 March 2022. All of the samples were obtained from patients of Clinic of Vascular Surgery. After isolation of pure culture from the samples, the strains were identified by MALDI TOF MS and Vitec – 2 Compact. Antibiotic resistance was determined with Bauer-Kirby disk diffusion method. Results: From all 419 of the patients, hospitalized in the Clinic of Vascular surgery for this period, 28 isolates from 26 (6,21%) patients were obtained, of which Gram-negative were 19 (67,86%) and Gram-positive - 9 (32,14%). From Gram-negative - enterobacteria – 14 (73,68%), and non-fermenting gram-negative bacteria (NFGNB) were 5 (26,32%). Only 3 (21,43%) from all enterobacteria were extended spectrum beta-lactamases producing strains (ESBLs). No strains, resistant to carbapenems (RCP) were isolated. Five (55,55%) of the Gram-positive isolates were Staphylococcus aureus, 4 (80%) of which were methicillin resistant Staphylococcus aureus (MRSA). Two of the Gram-positive species isolated were Enterococcus faecalis, of which 1 with a high-level aminoglycoside resistance (HLAR). No Vancomycin resistant enterococci (VRE) were discovered. There were no colistin-resistant Acinetobacter baumannii and Pseudomonas aeruginosa strains. Conclusion: From all 28 isolates 8 (28,57%) were with acquired types of antimicrobial resistance. With almost one third of the isolates that are problematic in terms of antibiotic susceptibility, treatment of those patients can be challenging. Prevention of in hospital contamination with polyresistant strains, associated with medical care it is crucial for reducing the number of severe complications, decreasing of hospital stay and cost for treatment.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132355695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}