MEDIS – International Journal of Medical Sciences and Research最新文献

{"title":"DEEP OSCILLATION® THERAPY - CAN IT BE EFFECTIVE IN PATIENTS WITH COVID-19 AND POST - COVID SYNDROME","authors":"G. Мratskova","doi":"10.35120/medisij010401m","DOIUrl":"https://doi.org/10.35120/medisij010401m","url":null,"abstract":"Treatment of patients with COVID-19, prevention of respiratory and other affected systems complications, prevention of multisystem damage and faster recovery possibilities and disease consequences overcoming is a particularly relevant topic today, when the number of people who have suffered from acute coronavirus infection is increasing. A tendency to shift the focus from acute manifestations to long-term morbidity and chronic involvement of various organs and systems is observed. In these subacute and chronic phases of illness, the application of physical modalities would be potentially effective. Traditionally, physical and rehabilitation medicine deals with patients with combined pathologies in order to reduce the duration of treatment and to speed up after-illness recovery. Deep Oscillation® therapy is a relatively new physical modality that is successfully applied to a number of diseases, including inflammatory pathologies of respiratory and musculoskeletal system, trauma, burns, fibrosis prevention, edema reduction, muscle relaxation etc. The purpose of this article is to make a review of the potential therapeutic effects of the Deep Oscillation® therapy application to patients suffering from COVID-19 and/or post-COVID-19 syndrome. Materials and methods: A review of the available literature was performed, including reports, articles, feedback letters regarding the application of Deep Oscillation® therapy. The search for scientific articles was conducted in the bibliographic database of Pub Med, Google Scholar, Elsevier. Results matching the following keywords were searched: Deep Oscillation® therapy, low-frequency and low-intensity electrostatic field, COVID-19, COVID-pneumonia, post-COVID-19 syndrome, long COVID, post-acute sequelae of SARS-CoV-2 infection, chronic COVID syndrome, diseases of the respiratory system, pneumonia, obstructive bronchitis, asthma, edema, lymphedema, musculoskeletal symptoms after COVID-19, chronic pain, myalgia, arthralgia, chronic back pain, fatigue. Results: The review made found evidence regarding the anti-inflammatory, anti-edematous, pain-reducing, and anti-fibrotic effects observed with the application of Deep Oscillation® in various diseases, including such of lungs. At this time, no research data were found regarding the application of Deep Oscillation® in patients with COVID-19 or after illness except for a brief communication in the form of a feedback letter regarding the therapy application in individual clinical cases of patients with COVID -19. Conclusion: The scientific studies carried out so far testify of established anti-inflammatory, -swelling and pain-reducing effects, fibrosis reduction possibilities, muscle spasm reduction, local microcirculation improvement and anti-lymphedematous effects of Deep Oscillation® application in various diseases, including lung diseases. These data suggest that a possible positive effect of the low-frequency electrostatic field can also be assumed in patients wi","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"911 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116404566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRAUMATIC DENTAL INJURIES: ETIOLOGY, PREVALENCE AND POSSIBLE OUTCOMES","authors":"Sanja Nashkova, C. Dimova","doi":"10.35120/medisij010427n","DOIUrl":"https://doi.org/10.35120/medisij010427n","url":null,"abstract":"Traumatic dental injuries are significant public health problem because of its frequency, impact on economic productivity and quality of life. It is not a disease and no individual is ever at zero risk of sustaining these potentially life-changing injuries. Traumatic dental injuries occur most frequently in children and young adults. Older adults also suffer from traumatic dental injuries but at significantly lower rates than individuals in the younger cohorts. Luxation injuries are the most common traumatic dental injuries in the primary dentition, whereas crown fractures are more commonly reported for the permanent teeth. Proper diagnosis, treatment planning and follow up are very important to assure a favorable outcome. The aim was to overview the etiology, prevalence and possible outcomes of dental trauma. An electronic search of Medline (PubMed), Cochrane, SSCI (Social Citation Index), SCI (Science Citation Index) databases from 2000 to the present, using the following search words: tooth injuries, tooth trauma, traumatized teeth, dental trauma, dentoalveolar trauma, oral trauma, epidemiology, etiology, prevalence, prevention, pulp necrosis, inflammatory resorption, ankylosis, cervical resorption, was performed. The current revision represents the best evidence based on the available literature and expert opinions. During last decade traumatic dental injuries were recognized as public dental health problem worldwide. Prevalence of traumatic dental injuries varies between countries. According to the existing data they are more prevalent in permanent than in primary dentition. All treatment procedures in case of dental trauma are directed to minimize undesired consequences despite that treatment of traumatic dental injuries in the young patient is often complicated and can continue during the rest of his/her life. The changing lifestyle and requirements of modern society lead to an emergence of new patterns of dental trauma. Successful treatment of traumatic injuries depends on timely action by the patient and a quick and accurate diagnosis by the dentist. Although most injuries are minor and of an urgent nature, displaced or missing teeth are true emergencies. The mismanagement of traumatic dental injuries has provided much information as well as questions for research that have resulted in the increased retention of teeth with as little treatment as possible. Maintaining pulp vitality when possible, utilizing the therapeutic effects of calcium hydroxide, and returning teeth to function as soon as possible are keys to predictable prognosis. It is the responsibility of the dentist to stay current on the latest techniques available to treat traumatic injuries. The charts included provide most of the potential emergency treatment possibilities, recommended follow-up treatment, and final treatment outcomes essential to providing the best care for our child patients. It is also the responsibility of the dentist to use evidence-based research when ","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128576239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MANAGING THE MOST COMMON COMPLICATIONS OF RADIATION THERAPY IN PATIENTS WITH HEAD AND NECK CANCER","authors":"Sonja Rogoleva Gjurovski","doi":"10.35120/medisij010451r","DOIUrl":"https://doi.org/10.35120/medisij010451r","url":null,"abstract":"Radiation therapy is widely used approach in treatment of head and neck cancer, unfortunately it leaves consequences that are influencing the patients’ life in a negative way. During and after the treatment with ionizing irradiation it affects not only the malignant area that is being treated, but also the surrounding tissues and organs that are located near the region that is targeted (oral mucosa, jaw bones, teeth, salivary glands, surrounding muscles and the temporomandibular joints), leaving changes in their structure and functions. Many of the patients that are treated, have not been prepared optimally for the radiation treatment, what also affects the post operative condition of their tissues and organs that are located nearby to the radiation treated area. The aim of this study was to define the most common postradiation complications in patients with head and neck cancer and to evaluate the efficiency of the solutions that are used to manage them. For this study were analyzed in details 37 published articles on the studied topic, the research was done online using the data bases NCBI, Cochrane Library, Medline, PubMed and Webmd. The inclusion criteria were: studies made in vivo; studies written in English; case reports on head and neck cancer patients; surveys on patients after radiation therapy; studies on patients with intraoral complications from after radiation therapy. Results showed that radiation induced complications in the head and neck cancer patients can be classified in three groups as early, intermediate and late changes. The most common changes were found in the tissues (mucosa, skin, subcutaneous connective tissues, salivary glands, the bone tissues and the teeth), resulting with: hyposalivation (xerostomia), mucositis, opportunistic infections, radiation caries, dysphagia, altered taste and difficulties with the chewing and swallowing. Many studies have shown that the percent of damage on the oral mucosa is strongly related to the radiation dose and the type of ionizing irradiation that patients are being treated with. Treatment consists of application of lubricants; usage of substitutes for saliva; and stimulants for the saliva production, with preparations like pilocarpine and cevimeline, and electro stimulation. The loss of the taste after the treatment can be partial or total. Mostly affected are the sour and bitter tastes, rarely the sweet and the salty taste, and very rare is total loss on all of the flavors. Fortunately in most of the studied cases has been show that the changes in the taste were reversible after a period of time, in some cases a few months and in others it can happen even up to a few years until it reaches total recovery. It is crucial to implement more solutions and to find new ways to manage the complications that follow after the irradiation, so the quality of the life in these patients can be spared in any possible way. Using the new approaches such as IMRT and VMAT on these patients, could als","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125091912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEALTH AND SOCIAL CARE FOR ADULTS WITH FUNCTIONAL DEPENDENCE IN CONDITIONS OF COVID 19 PANDEMIC","authors":"P. Stefanova","doi":"10.35120/medisij010431s","DOIUrl":"https://doi.org/10.35120/medisij010431s","url":null,"abstract":"The importance of Public Healthcare as a science originates from the measures in an integrated manner, targeted at the health of the public through prevention and extending life in good health. Home health care for elderly people with chronic illnesses and functional dependence is one of the priorities of the social politics of Bulgaria, through the creation of regulations for the interaction when organising and planning the support that supplies their health and social needs. in the competencies of nurses is the provision of health and social care for people with chronic diseases and functional dependence. The covid 19 pandemic has presented challenges in implementing nursing interventions. Due to the declared global pandemic on 19.03.2020 of COVID-19, many countries including Bulgaria, introduced strict measures for maximal isolation and social distancing with the aim of reducing transmission to the minimum. This presented an array of challenges for the teams, carrying out the activities for patronage care in the homes of the care receivers. Objective: To review and analyze the impact of the COVID 19 pandemic on changes in the daily activities of health care providers in the municipalities of Burgas region. Methods: documentary - research and analysis of information; sociological-anonymous survey; statistically. Results: developed and implemented additional module “Patronage Care +” with expansion of the target group of users and services provided; provided personal protective equipment and disinfectants to the multidisciplinary team providing care; not all project managers have provided antigenic tests for the teams; communication between the team and the GPs of the users - difficult; periodic briefings for compliance with anti-epidemic measures; Of the 41 nurses, 19.51% were quarantined with complaints and positive PSR tests - without hospitalization, and of the home nurses 26.23%. Vaccinated nurses - certainly 2 / project managers are not familiar /; ineffective medical waste management. Conclusion: The provisioning of health and social services and care is absolutely necessary for the maintenance of the quality of life of people with chronic illnesses with functional dependencies and under the existing pandemic situation; The care receivers are willing to accept alternative approaches for realizing the activities, providing them with quality of life even with their chronic ailments and degree of disability; The managers and coordinators of project “Patron care” have the capabilities and the resources to maintain the quality of the offered integrated health and social service; The absence of medical nurses in the teams of some municipalities in the Burgas region negatively affects the carrying out of activities of the project. The high percentage of nurses placed under quarantine and home nurses supports the tendency for lack of emergency and periodic instruction, i.e. unsatisfactory activity of the occupational medicine services.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123711981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 – GLOBAL CHALLENGE OF OUR TIME","authors":"Eli Dimitrovska, Marija Avramoska","doi":"10.35120/medisij010307d","DOIUrl":"https://doi.org/10.35120/medisij010307d","url":null,"abstract":"Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. The first diagnosed case of COVID 19 in Macedonia with a PCR diagnostic test was on February 27, 2020. The first diagnosed case of COVID 19 in Bitola with a PCR diagnostic test was on April 03, 2020. The purpose of this paper is to present our experiences in the fight against the new unknown disease, with special reference to clinical expressions and post-covid conditions. A great problem and challenge for the infectologists in Clinical Hospital, Bitola, were the therapeutic possibilities, especially in treatment of patients with multiple comorbid conditions. This paper covers patients who were treated in the Infectious Diseases department’s COVID-19 center at the Clinical Hospital, over a period of 2 years.The fight against the SARS-CoV 2 continues and we are already facing the new - seventh wave of the pandemic.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"05 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127191676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF THE ECONOMIC INDICATORS OF THE ACTIVITIES OF MULTI-PROFILE HOSPITALS FOR ACTIVE TREATMENT IN BULGARIA AND THEIR CHANGE AS A RESULT OF THE COVID-19 PANDEMIC","authors":"R. Yaneva","doi":"10.35120/medisij010349y","DOIUrl":"https://doi.org/10.35120/medisij010349y","url":null,"abstract":"The purpose of the present study is to perform a comparative analysis of the change in the economic indicators for the activity of the multi-profile hospitals for active treatment from the public health care system in Bulgaria before and during the COVID-19 pandemic. Methodology: The study used the following methods for processing and analyzing the received information: documentary method; system analysis method; comparative-analytical method; economical analysis; statistical methods – analysis of the dynamics of phenomena and graphic analysis. The need to determine and compare the economic indicators of hospitals of one group is, on the one hand, for managers of inpatient facilities to compare the hospital they manage with other hospitals of the same group, and on the other hand, the problem is particularly relevant for financing institutions - the National Health Insurance Fund, the Ministry of Health and Municipalities. Results and discussion: The main economic indicators for the activity of the medical institutions reflect the ratio of the expenses incurred by the medical institutions to the achieved results of the activity (patients passed, realized bed days, etc.), are used to evaluate the economic efficiency of the activity of the medical institutions and provide information about the “cost” of a particular type of medical care. For the observed five-year period before the COVID-19 pandemic, an increase in the average values of all economic indicators for the activity of the University and national multi-profile hospitals for active treatment, as well as the Municipal multi-profile hospitals for active treatment is characteristic - with the exception of the decrease in their value per drug day. At the Regional multi-profile hospitals for active treatment, there is a decrease in the values of the economic indicators “average cost per bed”, “average cost per food-day” and “average cost per medicine day” and a slight increase in the values of the indicators “average cost per single received patient” and “average cost per bed-day”. In the first year of the pandemic, 2020, in contrast to the previous year - 2019, there was an increase in the value of all economic indicators for the activity in the group of multi-profile hospitals for active treatment, most pronounced in the indicator “average cost per patient treated”. Conclusions: The healthcare crisis caused by the pandemic raises many questions about the adequacy of the healthcare system in the country, its capacity, opportunities and problems. In response to the crisis, the government of the Republic of Bulgaria is increasing public spending on healthcare in 2020 by approximately BGN 628 million.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125018083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RELATIONSHIP BETWEEN VISFATIN AND SOME BIOMARKERS OF BONE TURNOVER IN PATIENTS WITH CHRONIC KIDNEY DISEASE","authors":"P. Petrov, S. Staykova","doi":"10.35120/medisij010331p","DOIUrl":"https://doi.org/10.35120/medisij010331p","url":null,"abstract":"Chronic kidney disease (CKD) is a progressive disease that might result in an end stage renal disease (ESRD), raising cardiovascular morbidity and mortality. Life expectancy among patients with CKD could significantly be reduced as a result of an advanced atherosclerosis and followed by a premature death from cardiovascular disease (CVD). CVD is a condition of a subclinical systematic inflammation that involves cytokines produced by adipose tissue. Visfatin is an adipocytokine with potentially important effects on glucose metabolism and atherosclerosis. Therefore, it could be treated like a new marker of endothelial dysfunction (ED) in CKD patients. It has been suggested that visfatin levels could increase as CKD progresses, which could be due to either the chronic inflammation associated with CKD and/or the hypoxia resulting from tubular necrosis, anemia and reduced capillary blood flow. As CKD progresses, visfatin levels among these patients most often spell increased mortality caused by cardiovascular events. The current research has been conducted among a total of 80 subjects with CKD who were divided into two groups - pre-dialysis (30) and hemodialysis treatment (50) patients from the Nephrology and Dialysis Clinic at the UMHAT “Sveta Marina” Varna. Demographics indicators and levels of visfatin, iFGF-23 and iPTH were inevstigated.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116316699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIAGNOSTIC CONTRIBUTION OF CLOSED NEEDLE PLEURAL BIOPSY – A 10-YEAR RETROSPECTIVE ANALYSIS","authors":"J. Bushev, Biljana Noveska-Petrovska, Zoran Karatashev","doi":"10.35120/medisij010311b","DOIUrl":"https://doi.org/10.35120/medisij010311b","url":null,"abstract":"Determining the etiology of a pleural effusion can present a major problem for the clinician. Diagnostic evaluation of pleural effusions should include relevant history, clinical course, radiographic abnormalities, and take into account the patient’s desire and consent for further invasive investigations. The seventies were dominated by specific pleural effusions, but in the last three decades effusions of malignant etiology have dominated. Despite advances in diagnostics, about 20% of pleural effusions remain etiologically unexplained. Objective: we present data on the diagnostic contribution and complications when using a Ramel‘s needle (Wolf’s set) in investigating the nature of pleural effusions from an etiopathogenetic aspect. Methods: This retrospective study included 284 transparietal closed pleural biopsies performed between January 2011 and December 2020. Local anesthesia with 2% lidocaine was applied to the skin and subcutaneous tissue in all subjects (premedication with 1 mg of atropine or 10 mg of apaurin was sporadically applied); a chest radiograph was taken immediately before and within 4 to 12 hours after the procedure to rule out complications. The diagnostic positivity, accuracy and complication rate of the technique were evaluated. Results: 175 men and 109 women (median age 60 years, range 19–88) underwent transparietal pleural biopsy with a Ramel‘s needle, 96% of pleural effusions were unilateral (53% in the right hemithorax). Pleural tissue was obtained in 98%. The most common histological diagnosis included: malignancy (34.7%), nonspecific inflammation and mesothelial hyperplasia (32.3%), chronic inflammation with fibrosis (23.5%), granulomatous disease (4.3%), normal pleura and striated muscle (5.2%). Microbiological examination was performed in 24 samples (8.4%): Mycobacterium tuberculosis was present in 1 case, Escherichia Coli in one and Candida albicans in another patient. No pathogenic bacteria or fungi were identified in the rest of the examined. The procedure was well tolerated. Complications occurred in 7 (2.4%): pneumothorax in 4 patients (1.4%), vasovagal reaction in 2 cases (0.7%), local hematoma (0.3%). Conclusion: closed (percutaneous, blind) pleural biopsy with a Ramel‘s needle appears to be a simple technique, well tolerated, with a low complication rate and high diagnostic efficiency. Closed pleural biopsy has a relatively high sensitivity in the diagnosis of exudative pleural fluid, especially in tuberculous pleurisy and may provide an alternative technique in clinical practice. It can be applied to any unexplained pleural effusion, in cooperative patients with no coagulation abnormalities, in relation to standard biochemical, microbiological and cytological investigations, especially in hospital units without thoracoscopy. In our series, nonspecific inflammation was the most common histological diagnosis, and repeated biopsies significantly increased the diagnostic contribution.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126788120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IATROGENIC PNEUMOTHORAX","authors":"J. Bushev","doi":"10.35120/medisij010319b","DOIUrl":"https://doi.org/10.35120/medisij010319b","url":null,"abstract":"Iatrogenic (a subtype of traumatic) pneumothorax commonly occurs as a complication of transthoracic puncture biopsy (TTPB), central venous catheterization (especially the subclavian vein), thoracocentesis, positive pressure mechanical ventilation (PPMV), transbronchial (TBB) and pleural biopsy. The incidence has recently been increasing due to the increasing use of invasive diagnostic and therapeutic procedures. The aim of this reseacrh is to present the results and the efficiency in the care of iatrogenic pneumothorax in the pneumophtisiologist practice in general hospital. Material and methods: the analysis includes 290 hospital histories (mainly from the Pulmonology Department, in a much smaller number from other Internal Medicine or Surgery Department at the GOB “September 8”) for a 4-year period (January 2018 - December 2021) with final discharge diagnoses: pleural effusion, pyothorax, lung cancer, pulmonary infiltration, pleural mesothelioma and metastatic pleural fluid - ICD codes: J90, J91, J86.9, C34, C45.0 and C78.2. All underwent an invasive diagnostic or therapeutic procedure. The diagnosis of pneumothorax included a radiological examination (PA-posteroanterior proection and LL -profile chest X-ray). Results: from 290 diagnostic-therapeutic procedures, immediately and up to 24 hours after the intervention, a total of 24 (8.3%) pneumothoraxes were recorded, namely: 15 (27%) out of 54 after TTPB, 3 (4.8%) of 62 after TBB and 3 (2%) of 124 after thoracocenthesis and percutaneous biopsyes of the parietal pleura. In 2 (4%) of 49 cases after lavage of the pleural space, partial pneumothorax was recorded, 1 complete hematopneumothorax after catheterization of the subclavian vein. Thoracic drainage was performed in 12 (50%) (initially in 9, and in 3 after 24 hours due to progression of incomplete lung collapse). Of the remaining 12 patients, the pneumothorax was treated with exufflation in 4, and in 8 conservatively (with a procedure of forced expiration and respiratory exercises). No case requiring a surgical approach has been registered. Conclusion: a condition for successful care of iatrogenic pneumothorax is compliance with standards in the application of diagnostic procedures in pulmonology and related areas, careful observation and efficient application of modern attitudes in care of complications from invasive-interventional diagnostic-therapeutic procedures.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"206 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132665020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF AUTOIMMUNE STATUS WITH ASST, AUTOIMMUNE AND ATOPIC DISEASES IN CSU PATIENTS","authors":"Vesna Trajkova, N. Velickova","doi":"10.35120/medisij010355t","DOIUrl":"https://doi.org/10.35120/medisij010355t","url":null,"abstract":"Chronic spontaneous urticaria (CSU) is a mast cell-driven skin disease characterized by the recurrence of transient wheals, angioedema, or both for more than 6 weeks. Autoimmunity is thought to be one of the most frequent causes of CSU.CSU represents an important burden that compromises patient’s quality of life, interferes with routine daily activities. Aim of the study: The aim of this study is to make an association of autologous skin serum test (ASST), autoimmune diseases and atopic diseases with the autoimmune status in patients with HSU. Materials and methods: This study assessed 230 patients with CSU. The study is prospective, proceeding at the Department of Dermatology at City General Hospital “8mi Septemvri”, Skopje, in the period from January - November 2021. The study and the data collection were conducted with the approval of the institutional and ethical committee. Inform consent was obtained from all patients. Patients were divided in two groups according to their autoimmune status: patients with positive and patients with negative autoimmune status. Autoimmunity was defined in the case of a personal history of autoimmune disease or in the presence of at least one type of autoimmune antibodies (AAbs) (included anti- TPO, anti-nuclear antibodies (ANA) and rheumatoid factor (RF)).ASST was performed on untreated patients by the intradermal injection of 50 μL of the patient’s own serum into the volar part of the forearm. Anamnestic data on the course of the disease, accompanying autoimmune diseases and allergic diseases were taken. Results: Positive autoimmune status was confirmed in 40.28% of patients with HSU. Patients with a positive autoimmune status significantly more often than patients without an autoimmune status had a certain autoimmune disease (75.17% vs 10.59%):Hashimoto Tireoiditis39.31% vs10.59 %,Vitiligo13.79% ,Arthritis Rheumatica9.66 %,Morbus Crohn 5.52%, Hashimoto Tireoiditis + Vitiligo6.9% . Patients had a personal history of atopy (67.59% vs 55.29%), asthma (61.38% vs 44.71%), personal history for allergic rhinitis (57.24% vs 49.41%), positive ASST (86.9% vs 16.47%). To conclude, in this study, we obtained a high incidence of association of ASST, autoimmune diseases and atopic diseases with positive autoimmune status in CSU patients, thus providing additional evidence in the association of HSU with autoimmunity.","PeriodicalId":446210,"journal":{"name":"MEDIS – International Journal of Medical Sciences and Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125120962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}