"Medical & pharmaceutical journal "Pulse"最新文献

{"title":"NEW CORONOVIRUS INFECTION: CLINICAL AND PATHOGENETIC ASPECTS OF COVID-19 IN PREGNANT WOMEN","authors":"Allakhyarov D.Z., Petrov Yu.A., Chernavsky V.V.","doi":"10.26787/nydha-2686-6838-2021-23-8-57-62","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-57-62","url":null,"abstract":"This article presents reviews of literature sources on the clinical and pathogenetic aspects of the course of a new coronovirus infection in pregnant women, in order to analyze the features of the course of COVID-19 in pregnant women and to assess the impact of infection on the body of a woman and a fetus. Pregnancy is a special physiological condition, during which a number of changes occur in the body, not only in the hormonal status, but also in the immune system. The urgency of this problem is due to the high prevalence of new coronavirus infection among the population. On March 12, 2020, the World Health Organization (WHO), as a result of the dynamic development of the epidemic in many countries and continents, declared a global pandemic of the contagious disease COVID-19 caused by the SARS-CoV-2 virus. According to available studies, pregnant women are more susceptible to a more severe course of infectious diseases affecting the upper respiratory tract. According to various studies, a new coronavirus infection can lead to premature birth, miscarriage, and preeclampsia. Separate studies show increased mortality in pregnant women diagnosed with COVID-19. The SARS-CoV-2 virus does not have a direct teratogenic effect on the fetus, but it can indirectly lead to harmful effects on the developing organism. Special attention should be paid to the issue of vaccination of pregnant women against a new coronavirus infection, at the moment there is no accurate data on the effect of the vaccine on the body of the pregnant woman and the fetus. In this regard, the question of the impact of a new coronavirus infection on the course of pregnancy has become relevant.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132484202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEARNING OF THE RELATIONSHIP BETWEEN EXACERBATION OF CARDIOVASCULAR PATHOLOGY AND METEOROLOGICAL FACTORS","authors":"Klepikov O.V., Berezhnova T.A., Kulintsova Ya.V., Kolyagina N.M.","doi":"10.26787/nydha-2686-6838-2021-23-8-110-116","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-110-116","url":null,"abstract":"Relevance. The problem of weather dependence, including diseases of the circulatory system, is debatable, and, therefore, requires research in order to find ways to improve the provision of medical care to the population and improve its quality.\u0000Aim: to study the influence of meteorological factors on the treatment of the population with diseases of the cardiovascular system for medical care.\u0000Material and methods. The ratio of the average number of cases of requests for medical care on unfavorable days for meteorological factors to the average number of cases of requests per day for medical care during 2018 was calculated.\u0000Results. The average number of cases of requests for medical care on hot days when the air temperature rose above + 300C, which is abnormal for the territory of the city of Voronezh, due to such diagnoses as hypertension without heart failure, brain vascular lesions (specified), cerebrovascular disease, hypertension with heart failure, is 1.1-1.4 times higher than the average number of cases of requests per day for the same reasons (diagnoses) during the year. At the same time, low air temperatures, which are not typical for this area, can also act as a factor contributing to the exacerbation of diseases of the cardiovascular system.\u0000Conclusion. The assessment of the relationship between the treatment of patients with leading forms of cardiovascular diseases for medical care and meteorological indicators showed that with the advance of the case of the disease by 1 day with meteorological indicators, according to the results of the correlation analysis, statistically significant links of weak and medium strength were revealed.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114997346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF THE TREATMENT OF PATIENTS WITH DISEASES OF THE CARDIOVASCULAR SYSTEM FOR MEDICAL CARE IN UNFAVORABLE WEATHER FACTORS DAYS","authors":"Kolyagina N.M., Berezhnova T.A., Kulintsova Ya.V., Elistratova O.S., Drapalyuk M.A.","doi":"10.26787/nydha-2686-6838-2021-23-8-117-123","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-117-123","url":null,"abstract":"Relevance. The impact of weather factors on the occurrence of exacerbations of diseases in weather-dependent people is currently one of the actively studied problems of medicine. A number of authors draw attention to the need to correct the functional status of weather-dependent patients with cardiovascular diseases in unfavorable weather conditions.\u0000Aim: to assess the possible relationship between the manifestations of exacerbations of cardiovascular pathology and adverse weather factors.\u0000Material and methods. The materials of the regional center for Hydrometeorology and environmental monitoring were used, and a database was formed that includes information on the average daily, maximum and minimum atmospheric air temperatures, and atmospheric pressure for each day of 2018.\u0000Results. Meteorological risk factors for exacerbation of cardiovascular diseases in the Central European part of Russia include uncharacteristic heat (above +30 0C) or severe frost (below -20 0C), sudden changes in air temperature (by 8 0C or more, both in the direction of its increase and decrease), atmospheric pressure drops of more than 6 mm Hg during the day. It is established that the range of changes in meteorological indicators during the annual cycle is quite wide.\u0000Conclusions. Evaluation of the relationship between the treatment of patients with leading forms of cardiovascular diseases for medical care and meteorological indicators (average daily, maximum and minimum atmospheric air temperatures, atmospheric pressure) showed that with the advance of the case of the disease by 1 day (hypertensive disease without heart failure, brain vascular lesions, cerebrovascular disease, hypertensive disease with heart failure, angina pectoris), statistically significant links of weak and moderate strength were revealed.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131529980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KIDNEY FUNCTION DURING THE MYOCARDIAL INFARCTION WITH RECURRENT EPISODES OF ISCHEMIA IN YOUNG AND MIDDLE-AGED MEN","authors":"Gordienko A.V., Epifanov S.Yu., Tassybayev B.B.","doi":"10.26787/nydha-2686-6838-2021-23-8-49-56","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-49-56","url":null,"abstract":"Relevance. Changes in renal function and their significance in reinfarction and early postinfarction angina have not been insufficiently established.\u0000Aim. To evaluate renal function changes in men under 60 years old with recurrent myocardial infarction and early postinfarction angina to improve prevention and outcomes.\u0000Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction and/or early postinfarction angina - 110 patients; II - control, without it - 555 patients. A comparative assessment of renal function changes in first 48 hours (1) and the end of third week disease (2), also risk analysis of recurrent ischemia and poor outcome in selected groups were performed.\u0000Results. The study group was distinguished by high levels of creatinine1 (0.11±0.03 (mmol/l)), lower - glomerular filtration rate (74.2±20.6 (ml/min/1.73 m2)) from the control (0.10±0.02 (mmol/l) and 78.3±17.9 (ml/min/1.73 m2), respectively; p=0.04). In both groups, there was a deterioration in indicators (creatinine, I: 2.3%; II: 5.9%; glomerular filtration rate - I: -5.8 and -6.3%, respectively; p<0.0001) during the observation period. The risk of recurrent ischemia increases with creatinine1 levels≥0.11 mmol/l and a glomerular filtration rate1˂70 ml/min/1.73 m2. In the study group, the risk of poor outcome is high with normal renal function. In the control group, it increased at creatinine1 levels≥0.10 mmol/l, glomerular filtration rate1˂65 ml/min/1.73 m2.\u0000Conclusions. Patients with recurrent ischemia have higher creatinine levels than controls. In both groups, during the study, there was a slight increase in creatinine and a decrease in glomerular filtration rate. The above values of renal function indices should be used in the formation of groups at high risk of early recurrence of ischemia and poor outcomes, as well as for predictive modeling of these complications.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132313792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESULTS OF OPTIMIZATION OF THE MEDICAL CARE SERVICE FOR THE ADULT POPULATION OF THE PENZA REGION IN THE PROFILE \"MAXILLOFACIAL SURGERY\" IN 2021","authors":"Lebedev M.V., Kerimova K.I., Zakharova I.Yu.","doi":"10.26787/nydha-2686-6838-2021-23-8-131-137","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-131-137","url":null,"abstract":"The increase in the number of patients with pathology of the maxillofacial region necessitates improving the quality of medical care provided to the population in the field of \"Maxillofacial surgery\". Anatomical and physiological features of the maxillofacial region, the prevalence of pathology determine the implementation of organizational measures, the involvement of narrow specialists, the need for medical organizations in modern material and technical equipment. The indicators of medical care mainly depend on a full-fledged diagnosis, and are also determined by the availability, quality and speed of specialized medical care. In modern conditions of the development of the health care system, an integrated approach to the organization, the introduction of new methods of providing medical care and rehabilitation of patients is required. Optimization of the maxillofacial surgery service within a multidisciplinary medical organization, the introduction and development of an outpatient polyclinic link, the training of highly qualified personnel contribute to improving the quality of diagnosis, treatment and timely detection of pathology.\u0000This article presents the results of optimizing the service for providing medical care to patients with pathology of the maxillofacial region. In the Penza region, the full-fledged, high-quality functioning of the service is realized through the organization of the Center for Maxillofacial Surgery on the basis of the State Budgetary Healthcare Institution «Penza Regional Clinical Hospital named after N.N. Burdenko». The structure of the Center for Maxillofacial Surgery ensures the continuity and complementarity of specialists of a medical organization in the treatment and diagnostic process. Optimal conditions have been created for the diagnosis, treatment and rehabilitation of patients with pathology of the maxillofacial region, in order to provide the population with affordable and high-quality medical care, regardless of the category of citizens. The creation of the Center for Oral and Maxillofacial Surgery contributes to an increase in the structural efficiency and medical efficiency of the health care system of the Penza region. The results of the measures and innovations carried out can be used to eliminate the existing shortcomings in the organization of medical care for patients with pathology of the maxillofacial region in other regions.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131543997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HUMAN IMMUNODEFICIENCY VIRUS AND PREGNANCY: PATHOMORPHOLOGICAL FEATURES AND OBSTETRIC AND GYNECOLOGICAL TACTICS","authors":"Spiridenko G.Yu., Petrov Yu.A., Bragina T.V.","doi":"10.26787/nydha-2686-6838-2021-23-8-178-184","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-178-184","url":null,"abstract":"Currently, due to the increase in the incidence of HIV infection in women of reproductive age, the number of desired pregnancies in such patients has increased. This makes it necessary to study the pathological effect of the human immunodeficiency virus on the placenta, fetus and the female body as a whole. HIV belongs to retroviruses and contributes to the discoordination of a woman's immune mechanisms. Using the gp41 and gp120 glycoproteins, reverse transcriptase, integrase, and protease, the virus destroys CD4 cells and increases the viral load. It founded that the risk of infection of the fetus decreases from 45% to 1% with HIV infection before pregnancy and with antiretroviral therapy throughout its duration. Vertical infection is possible in the intrauterine, intranatal and postnatal periods, the main of which is the period of childbirth-up to 70%. Viral, maternal, placental, fetal, obstetric and neonatal factors contribute to an increased risk of transmission of the pathogen to the fetus. High viral load and antiretroviral therapy lead in the 3rd trimester of pregnancy to the development of chronic placental insufficiency due to the formation of focal and diffuse deciduitis, membranitis, intervillusitis and chorionamnionitis and damage to the hematoplacental barrier. Early diagnosis before 12 weeks of gestation, timely therapy with nucleoside and non-nucleoside reverse transcriptase inhibitors, as well as protease inhibitors during pregnancy, childbirth and in the postpartum period are the main aspects of preventing HIV infection and further disorders of the child's growth and development. The timely choice of the method of delivery, indications and contraindications to delivery through the natural birth canal helps to reduce the risk of infection in a particularly dangerous period - the intrapartum.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134310526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF THE PROBABLE RELATIONSHIP OF EXACERBATIONS OF CARDIOVASCULAR DISEASES WITH THE METEOROLOGICAL SITUATION","authors":"Berezhnova T.A., Kulintsova Ya.V., Maslov O.V., Kolyagina N.M., Ponomaryova E.Yu.","doi":"10.26787/nydha-2686-6838-2021-23-8-63-69","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-63-69","url":null,"abstract":"Relevance. The analysis of these scientific publications has shown the relevance of studying the problem of the influence of sudden changes in meteorological factors on the functioning of the cardiovascular system, exacerbation of its leading diseases – arterial hypertension, brain vascular lesions, cerebrovascular diseases, angina.\u0000Aim: to identify the probable relationship of exacerbations of diseases of the cardiovascular system with the meteorological situation.\u0000Material and methods. A sample of data on the daily number of cases of patients 'requests for medical care to the registry of the Voronezh City Polyclinic No. 18 for 2018 was conducted.\u0000Results. At a temperature below-200C, which was registered on 27.02.2018, the number of requests for medical care due to hypertension without heart failure is 88 cases, with a diagnosis of brain vascular damage (specified) – 15, with a diagnosis of cerebrovascular disease-16, hypertension with heart failure-2, angina-0. The difference in the average daily temperature of more than 8 0C was recorded in 204 of 365 days. Out of 365 days, the atmospheric pressure drop of more than 6 mm Hg per day was recorded 52 times.\u0000Conclusions. The most informative characteristic of the six meteorological indicators taken into account in the study is a sharp drop in atmospheric pressure during the day, with which the number of cases of patients with cardiovascular diseases seeking medical care is statistically significantly correlated.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133144082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF THE COURSE OF PREGNANCY, CHILDBIRTH AND PERINATAL OUTCOMES IN WOMEN WITH VIRAL HEPATITIS C","authors":"Bragina T.V., Petrov Yu.A., Spiridenko G.Yu.","doi":"10.26787/nydha-2686-6838-2021-23-8-14-20","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-14-20","url":null,"abstract":"This article presents data from a review of literature sources on the peculiarities of the course of pregnancy, childbirth and perinatal outcomes in women with viral hepatitis C. The current problem is due to the high prevalence of hepatitis C virus infection among the population, the possibility of a clinically asymptomatic course of the disease, the possibility of a transplacental route of transmission of the virus to the fetus. So, viral hepatitis C can be diagnosed during pregnancy as a result of the determination of immunoglobulins of classes M and G to the antigen of viral hepatitis C three times - in each trimester of pregnancy. Viral hepatitis C can have an adverse effect on the course of the gestational period, childbirth, and the neonatal period. Viral hepatitis C provokes the following complications: the threat of termination of pregnancy, preeclampsia of moderate severity and severe, fetoplacental insufficiency, which leads to chronic fetal hypoxia, intrauterine growth retardation of I and II degrees, and in the early neonatal period the development of cerebral ischemia of I and II degrees, moderate asphyxia or severe, impaired course of the adaptive reactions of the newborn, impaired neurological status of the newborn. This proves that the problem of the course of pregnancy against the background of viral hepatitis in a woman has not only important medical, but also social significance. The teratogenic effect of drugs used in the treatment of viral hepatitis C and the lack of drugs that are safe for use during pregnancy emphasize the integral role of pregravidar preparation to exclude or minimize the risk of complications during the gravidar period, childbirth, and unfavorable perinatal outcomes.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133775527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REGIONAL FEATURES OF DEATHS FROM CARDIOVASCULAR DISEASES IN THE CONTEXT OF REGIONAL PROGRAM TO REDUCE CARDIOVASCULAR MORTALITY","authors":"Ermolaev D.O., Ermolaeva Yu.N.","doi":"10.26787/nydha-2686-6838-2021-23-8-21-27","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-21-27","url":null,"abstract":"The relevance is determined by the high proportion of diseases of the circulatory system in the structure of the total mortality of the population, as well as the potential modifiability of external factors of pathology. The aim of the research is to study the regional epidemiology of mortality from diseases of the circulatory system in the context of a regional program to reduce it. Materials and methods - аn analysis of the structure and dynamics of mortality rates from diseases of the circulatory system and the peculiarities of the organization of medical care for the population of the Astrakhan Region with cardiovascular diseases for the 7-year period from 2014 to 2020, based on the data of the Medical Information and Analytical Center and the Office of the Federal State Statistics Service for the Astrakhan Region, was carried out. Results and discussion - diseases of the circulatory system rank first in the structure of total mortality in the Astrakhan region, which accounted for about half (48%) of all deaths in 2020. During the study period, an increase in mortality from diseases of the circulatory system was established by 2.8% with a sharp increase of 17.6% in 2020 compared to 2019, which is associated with the spread of coronavirus infection. At the same time, the proportion of deaths outside the hospital was 65% in 2020. It’s indicates both the late seeking of medical care and the shortcomings of dispensary observation of the category of citizens with the maximum risk of developing cardiovascular complications. In the structure of mortality from diseases of the circulatory system, ischemic heart disease is steadily leading, with an increase of 5.8% over the reporting period. The second place is occupied by cerebrovascular diseases, which showed a slight decrease by 3.3%. In addition to the infectious threats associated with the spread of the coronavirus COVID-19, it is necessary to take into account such a stable phenomenon as the progressive aging of the population when predicting the mortality rate for the coming years. Conclusion. Research findings can be used to adjust activities to health care organizations for patients with cardiovascular diseases at the regional level.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114265533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EISENMENGER'S SYNDROME AND PREGNANCY: ASPECTS OF ETIOPATHOGENESIS AND THERAPEUTIC TACTICS","authors":"Petrov Yu.A., Spiridenko G.Yu., Palieva N.V.","doi":"10.26787/nydha-2686-6838-2021-23-8-158-164","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-8-158-164","url":null,"abstract":"In the modern world, the problem of maintaining a woman's reproductive potential and preserving the resulting pregnancy comes to the fore. An important aspect remains the increasing number of concomitant extragenital diseases. The most common pathology of the cardiovascular and respiratory systems. A rare and often fatal complication is Eisenmenger's syndrome. Eisenmenger's syndrome is a pathological process that occurs due to bidirectional blood discharge or right-left blood discharge due to the presence of a message between the right and left parts of the heart, clinically manifested by severe pulmonary hypertension with diffuse cyanosis. It occurs against the background of an existing decompensated heart defect - a defect of the atrial septum, interventricular septum, open arterial duct, anomalies of the pulmonary veins. Previously, it was believe that the threat of developing Eisenmenger syndrome is an absolute indication for termination of pregnancy, and this pathology is not compatible with gestation. Currently, the effect of pregnancy on the cardiovascular system has been study and recommendations for the management of such patients have been develop. It found that due to an increase in the volume of circulating blood, cardiac output, a decrease in total peripheral resistance and blood pressure, there is an increase in the load on the cardiovascular system and a change in the pharmacokinetics of drugs, which leads to a revision of the treatment tactics used before pregnancy. The situation is aggravated by an increase in blood clotting factors, fibrinogen, platelet aggregation and a decrease in fibrinolysis factors, which, together with the restriction of taking low-molecular-weight heparins due to the tendency of patients with Eisenmenger syndrome to bleeding and thrombosis, causes difficulties in determining the tactics of patient management, emphasizing the importance and relevance of the problem.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127651904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}