FEATURES OF THE COURSE OF PREGNANCY, CHILDBIRTH AND PERINATAL OUTCOMES IN WOMEN WITH VIRAL HEPATITIS C

This article presents data from a review of literature sources on the peculiarities of the course of pregnancy, childbirth and perinatal outcomes in women with viral hepatitis C. The current problem is due to the high prevalence of hepatitis C virus infection among the population, the possibility of a clinically asymptomatic course of the disease, the possibility of a transplacental route of transmission of the virus to the fetus. So, viral hepatitis C can be diagnosed during pregnancy as a result of the determination of immunoglobulins of classes M and G to the antigen of viral hepatitis C three times - in each trimester of pregnancy. Viral hepatitis C can have an adverse effect on the course of the gestational period, childbirth, and the neonatal period. Viral hepatitis C provokes the following complications: the threat of termination of pregnancy, preeclampsia of moderate severity and severe, fetoplacental insufficiency, which leads to chronic fetal hypoxia, intrauterine growth retardation of I and II degrees, and in the early neonatal period the development of cerebral ischemia of I and II degrees, moderate asphyxia or severe, impaired course of the adaptive reactions of the newborn, impaired neurological status of the newborn. This proves that the problem of the course of pregnancy against the background of viral hepatitis in a woman has not only important medical, but also social significance. The teratogenic effect of drugs used in the treatment of viral hepatitis C and the lack of drugs that are safe for use during pregnancy emphasize the integral role of pregravidar preparation to exclude or minimize the risk of complications during the gravidar period, childbirth, and unfavorable perinatal outcomes.