Melanoma ManagementPub Date : 2017-09-01Epub Date: 2017-07-31DOI: 10.2217/mmt-2017-0012
Thomas J Sharpe
{"title":"Survivor and patient advocate: an interview with T.J. Sharpe.","authors":"Thomas J Sharpe","doi":"10.2217/mmt-2017-0012","DOIUrl":"https://doi.org/10.2217/mmt-2017-0012","url":null,"abstract":"<p><p><b>T.J. Sharpe speaks to Sebastian Dennis-Beron, Commissioning Editor:</b> T.J. Sharpe is a stage IV melanoma patient who shares his journey through cancer in the Patient #1 Blog [1]. He was diagnosed in August 2012 with melanoma tumors in multiple organs; since then, he has undergone six surgeries and four immunotherapy treatments over two different clinical trials. The initial failures and subsequent significantly positive response have been chronicled in his blog posts since January 2013. His story is about life with a serious illness, and the mental and emotional hurdles a patient must clear. He writes how a cancer patient's challenges mirror those many face, and portrays life through the optimistic prism of a patient who is on the long, winding road toward overcoming melanoma's long odds and deadly consequences. He also shares the latest melanoma and oncology research breakthroughs and advocacy events, and initiatives to help others avoid, detect or educate themselves on cancer. As part of his advocacy, he attends cancer and melanoma conferences, reporting on the latest medical breakthroughs through his blog to other cancer patients. He also partners with advocacy organizations, clinical trial groups and the pharmaceutical industry to bring awareness to cancer research and developments. His efforts have been recognized by several organizations, including the Melanoma Research Foundation, Melanoma International Foundation, Patient Power, Forbes, Merck, GlaxoSmithKline, the Drug Information Association and the Milken Institute's FasterCures. In December 2014, he was able to share his story on Capitol Hill in a special session promoting immunotherapy research to lawmakers. A South Jersey native, T.J. lives in Fort Lauderdale with his wife Jennifer and two young children, Josie and Tommy. He is active in health and wellness initiatives, including melanoma/cancer awareness runs and bike rides, and an avid yoga participant. He also serves on the Board of Directors of A Prom to Remember, a 501</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 3","pages":"157-160"},"PeriodicalIF":3.6,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2017-0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36470684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanoma ManagementPub Date : 2017-09-01Epub Date: 2017-07-26DOI: 10.2217/mmt-2017-0010
Cesar E Ochoa, Richard W Joseph
{"title":"Utility of ipilimumab in melanoma patients who progress on anti-PD-1 therapy.","authors":"Cesar E Ochoa, Richard W Joseph","doi":"10.2217/mmt-2017-0010","DOIUrl":"https://doi.org/10.2217/mmt-2017-0010","url":null,"abstract":"survival","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 3","pages":"143-145"},"PeriodicalIF":3.6,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2017-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36468075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When to consider alternatives to front-line immune therapies in metastatic melanoma.","authors":"Daniel Y Wang, Douglas B Johnson","doi":"10.2217/mmt-2017-0005","DOIUrl":"https://doi.org/10.2217/mmt-2017-0005","url":null,"abstract":"","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 2","pages":"71-74"},"PeriodicalIF":3.6,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2017-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10752702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Are we entering the era of combination therapy for melanoma?","authors":"Justine V Cohen, Ryan J Sullivan","doi":"10.2217/mmt-2016-0029","DOIUrl":"https://doi.org/10.2217/mmt-2016-0029","url":null,"abstract":"","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 1","pages":"5-8"},"PeriodicalIF":3.6,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2016-0029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36470213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanoma ManagementPub Date : 2017-03-01Epub Date: 2017-03-03DOI: 10.2217/mmt-2016-0025
Giuseppe Argenziano
{"title":"An interview with Giuseppe Argenziano: an insight into the field of dermoscopy.","authors":"Giuseppe Argenziano","doi":"10.2217/mmt-2016-0025","DOIUrl":"https://doi.org/10.2217/mmt-2016-0025","url":null,"abstract":"<p><p><b>Giuseppe Argenziano speaks to Sebastian Dennis-Beron, Commissioning Editor:</b> Giuseppe Argenziano is Full Professor and Head of the Dermatology Unit at the University of Campania, Naples, Italy. His main research field is dermato-oncology. He is an author of numerous scientific articles and books concerning dermoscopy, a new technique improving the clinicians detection of benign and malignant skin tumors. As a coordinator of a Skin Cancer Unit, he has established a successful tertiary, multidisciplinary, referral center particularly devoted to the diagnosis and management of patients with skin tumors. Over the past 20 years he has supervised over 100 foreign students and 40 residents in dermatology, established scientific collaborations with more than 200 colleagues from more than 30 nations, and organized more than 50 national and international scientific activities, courses and conferences (such as the Consensus Net Meeting on Dermoscopy and the First Congress of the International Dermoscopy Society). He is co-founder and past president of the International Dermoscopy Society; project leader for the development of a high diagnostic technology oncologic center at the Arcispedale Santa Maria Nuova IRCCS in Reggio Emilia; faculty member of the Master of Science in Dermoscopy and Preventive Dermato-oncology and has undertaken a short course in dermoscopy, two e-learning courses by the Medical University of Graz and by Cardiff University, respectively; and member of the Editorial Board of the Journal of the American Academy of Dermatology. Professor Argenziano has authored more than 400 full scientific articles and produced landmark primary publications and books in the field of dermoscopy. Over the past 20 years, he has been invited as speaker and/or chairman in more than 500 national and international conferences in the field of dermatology. His combined publications have received a sum total of more than 8000 citations with an h-index value of 46.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 1","pages":"9-11"},"PeriodicalIF":3.6,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2016-0025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36470214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanoma ManagementPub Date : 2017-03-01Epub Date: 2017-03-03DOI: 10.2217/mmt-2016-0033
Sebastian Dennis-Beron
{"title":"Welcome to the fourth volume of <i>Melanoma Management</i> and a look back at 2016.","authors":"Sebastian Dennis-Beron","doi":"10.2217/mmt-2016-0033","DOIUrl":"10.2217/mmt-2016-0033","url":null,"abstract":"","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 1","pages":"1-3"},"PeriodicalIF":3.6,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2016-0033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36470211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariah M Johnson, Sancy A Leachman, Lisa G Aspinwall, Lee D Cranmer, Clara Curiel-Lewandrowski, Vernon K Sondak, Clara E Stemwedel, Susan M Swetter, John Vetto, Tawnya Bowles, Robert P Dellavalle, Larisa J Geskin, Douglas Grossman, Kenneth F Grossmann, Jason E Hawkes, Joanne M Jeter, Caroline C Kim, John M Kirkwood, Aaron R Mangold, Frank Meyskens, Michael E Ming, Kelly C Nelson, Michael Piepkorn, Brian P Pollack, June K Robinson, Arthur J Sober, Shannon Trotter, Suraj S Venna, Sanjiv Agarwala, Rhoda Alani, Bruce Averbook, Anna Bar, Mirna Becevic, Neil Box, William E Carson, Pamela B Cassidy, Suephy C Chen, Emily Y Chu, Darrel L Ellis, Laura K Ferris, David E Fisher, Kari Kendra, David H Lawson, Philip D Leming, Kim A Margolin, Svetomir Markovic, Mary C Martini, Debbie Miller, Debjani Sahni, William H Sharfman, Jennifer Stein, Alexander J Stratigos, Ahmad Tarhini, Matthew H Taylor, Oliver J Wisco, Michael K Wong
{"title":"Skin cancer screening: recommendations for data-driven screening guidelines and a review of the US Preventive Services Task Force controversy.","authors":"Mariah M Johnson, Sancy A Leachman, Lisa G Aspinwall, Lee D Cranmer, Clara Curiel-Lewandrowski, Vernon K Sondak, Clara E Stemwedel, Susan M Swetter, John Vetto, Tawnya Bowles, Robert P Dellavalle, Larisa J Geskin, Douglas Grossman, Kenneth F Grossmann, Jason E Hawkes, Joanne M Jeter, Caroline C Kim, John M Kirkwood, Aaron R Mangold, Frank Meyskens, Michael E Ming, Kelly C Nelson, Michael Piepkorn, Brian P Pollack, June K Robinson, Arthur J Sober, Shannon Trotter, Suraj S Venna, Sanjiv Agarwala, Rhoda Alani, Bruce Averbook, Anna Bar, Mirna Becevic, Neil Box, William E Carson, Pamela B Cassidy, Suephy C Chen, Emily Y Chu, Darrel L Ellis, Laura K Ferris, David E Fisher, Kari Kendra, David H Lawson, Philip D Leming, Kim A Margolin, Svetomir Markovic, Mary C Martini, Debbie Miller, Debjani Sahni, William H Sharfman, Jennifer Stein, Alexander J Stratigos, Ahmad Tarhini, Matthew H Taylor, Oliver J Wisco, Michael K Wong","doi":"10.2217/mmt-2016-0022","DOIUrl":"10.2217/mmt-2016-0022","url":null,"abstract":"<p><p>Melanoma is usually apparent on the skin and readily detected by trained medical providers using a routine total body skin examination, yet this malignancy is responsible for the majority of skin cancer-related deaths. Currently, there is no national consensus on skin cancer screening in the USA, but dermatologists and primary care providers are routinely confronted with making the decision about when to recommend total body skin examinations and at what interval. The objectives of this paper are: to propose rational, risk-based, data-driven guidelines commensurate with the US Preventive Services Task Force screening guidelines for other disorders; to compare our proposed guidelines to recommendations made by other national and international organizations; and to review the US Preventive Services Task Force's 2016 Draft Recommendation Statement on skin cancer screening.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 1","pages":"13-37"},"PeriodicalIF":1.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/84/mmt-04-13.PMC5480135.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35365717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanoma ManagementPub Date : 2017-03-01Epub Date: 2017-02-21DOI: 10.2217/mmt-2016-0018
Richard Tyrell, Camila Antia, Sharon Stanley, Gary B Deutsch
{"title":"Surgical resection of metastatic melanoma in the era of immunotherapy and targeted therapy.","authors":"Richard Tyrell, Camila Antia, Sharon Stanley, Gary B Deutsch","doi":"10.2217/mmt-2016-0018","DOIUrl":"https://doi.org/10.2217/mmt-2016-0018","url":null,"abstract":"<p><p>Melanoma is the deadliest form of skin cancer and one of the few malignancies whose incidence is on the rise. The treatment of metastatic melanoma continues to be quite challenging, although in recent years, there has been significant progress. Current National Comprehensive Cancer Network guidelines list immunotherapy, chemotherapy, surgery and clinical trials as potential options for patients with metastatic disease but do not clearly recommend which is superior. Additionally, when utilizing combined modality treatment there are no clear guidelines for the optimal timing of surgery in the treatment of metastatic melanoma. In this paper we sought to compile the current evidence and on-going trials in order to provide a comprehensive review of the different options available and underway in regards to the treatment of metastatic melanoma. It is clear that with the responses now seen with systemic immunotherapies and targeted therapies, an expanded role for surgery is the logical next step.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 1","pages":"61-68"},"PeriodicalIF":3.6,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2016-0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36470217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hugo Arasanz, Alejandra Lacalle, Maria José Lecumberri, Ángela Fernández de Lascoiti, Idoia Blanco-Luquin, María GatoCañas, Leyre Pérez-Ricarte, Miren Zuazo, Grazyna Kochan, David Escors
{"title":"Immunotherapy in malignant melanoma: recent approaches and new perspectives.","authors":"Hugo Arasanz, Alejandra Lacalle, Maria José Lecumberri, Ángela Fernández de Lascoiti, Idoia Blanco-Luquin, María GatoCañas, Leyre Pérez-Ricarte, Miren Zuazo, Grazyna Kochan, David Escors","doi":"10.2217/mmt-2016-0019","DOIUrl":"10.2217/mmt-2016-0019","url":null,"abstract":"<p><p>Immunotherapy has radically transformed the management of metastatic malignant melanoma. Ipilimumab, a CTLA-4-targeted monoclonal antibody, was the first immunotherapeutic drug to reach a survival benefit compared with traditional chemotherapy. PD-1 targeted therapies, pembrolizumab and nivolumab, have demonstrated, in recent clinical trials, to be even more effective and safer. PD-1 and CTLA-4 blockade combination appears to improve the outcomes achieved so far, although increasing toxicity. However, many questions concerning the optimal timing of administration or the most adequate sequence of treatment are yet to be answered.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 1","pages":"39-48"},"PeriodicalIF":3.6,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094586/pdf/mmt-04-39.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36470216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanoma ManagementPub Date : 2017-03-01Epub Date: 2017-03-03DOI: 10.2217/mmt-2016-0023
Madalyn G Neuwirth, Edmund K Bartlett, Giorgos C Karakousis
{"title":"Lymph node dissection for melanoma: where do we stand?","authors":"Madalyn G Neuwirth, Edmund K Bartlett, Giorgos C Karakousis","doi":"10.2217/mmt-2016-0023","DOIUrl":"https://doi.org/10.2217/mmt-2016-0023","url":null,"abstract":"<p><p>The extent and timing of regional lymphadenectomy and its role in patients with clinically localized primary melanoma has been the subject of considerable debate. While therapeutic lymphadenectomy for clinically positive nodes is uniformly accepted, the benefit of regional lymphadenectomy in patients with clinically uninvolved lymph nodes potentially harboring micrometastatic disease is less clear. Efforts to better select patients for complete regional lymphadenectomy after sentinel lymph node biopsy are underway. The future holds the promise of more stringent selection criteria and perhaps the identification of subgroups of patients for which a therapeutic benefit may be realized. Moreover, novel sensitive radiological techniques for detecting <i>in vivo</i> micrometastatic nodal disease may improve surgical precision, further decreasing potential morbidities of lymphadenectomy.</p>","PeriodicalId":44562,"journal":{"name":"Melanoma Management","volume":"4 1","pages":"49-59"},"PeriodicalIF":3.6,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/mmt-2016-0023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36470215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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