Clinical Cancer Investigation Journal最新文献_第6页

Spindle Cell Squamous Cell Carcinoma of the Tongue: A Rare Variant at an Even Rarer Location 舌梭形细胞鳞状细胞癌:一种罕见的变异在一个更罕见的位置

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/gznnxp2qlt

B. Iqbal, A. Raj, Sushma G Gurwale, C. Gore, Madhuri Singh

引用次数: 2

Trıplet or Doublet Chemotherapy Regimens in Metastatic Gastric Cancer Trıplet或双重化疗方案转移性胃癌

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/rpfscains5

S. Yıldırım, C. Yılmaz

{"title":"Trıplet or Doublet Chemotherapy Regimens in Metastatic Gastric Cancer","authors":"S. Yıldırım, C. Yılmaz","doi":"10.51847/rpfscains5","DOIUrl":"https://doi.org/10.51847/rpfscains5","url":null,"abstract":"Chemotherapy is the most important treatment option for patients diagnosed at an advanced stage. Chemotherapy both prolongs survival and increases the quality of life. Today, there is still no definite information about whether doublet or triplet chemotherapy should be chosen in empirical therapy. Therefore, we designed our study to evaluate first-line treatment options in metastatic gastric cancer.Our study is retrospective and involves five centers in Turkey. Inclusion criteria were the presence of metastatic gastric adenocarcinoma pathology, not having received treatment for local gastric cancer (surgery, chemotherapy, or radiotherapy), having received chemotherapy (patients with two or more combinations of drugs were included in the study, and patients who received single-drug chemotherapy were not included) for metastatic disease and being HER-2 negative. The survival of the triplet chemotherapy group was significantly longer when compared with the patients who received oxaliplatin-based doublet chemotherapy (11.1 vs. 8.1 months p=0.007). When the patients who received triplet chemotherapy and those who received cisplatin-based doublet chemotherapy were compared, there was no statistically significant difference (11.13 vs. 10.57 months p=0.665).If chemotherapy will be chosen as the first-line treatment in metastatic gastric cancer, choosing triplet chemotherapy regimens if possible, and if doublet chemotherapy will be given for any reason, choosing cisplatin-based regimens may be more appropriate, especially for the patient population in Turkey.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70832838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes Mellitus as a Risk Factor for Different Types of Cancers: A Systematic Review 糖尿病是不同类型癌症的危险因素:一项系统综述

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/trrtsjqjys

Saud S Alharbi

引用次数: 2

A Systematic Mapping Study of Tumor Cell Released by Enzymes and Toxins 肿瘤细胞酶和毒素释放的系统定位研究

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/wpdou0f3sc

S. Saeed

{"title":"A Systematic Mapping Study of Tumor Cell Released by Enzymes and Toxins","authors":"S. Saeed","doi":"10.51847/wpdou0f3sc","DOIUrl":"https://doi.org/10.51847/wpdou0f3sc","url":null,"abstract":"Cancers, especially of the neural tissue, are often deemed a death sentence. However, neither the cellular and molecular mechanisms nor the underlying causes are fully defined. Despite what is currently known about various types of brain tumors, it remains poorly understood how they spread and cause collateral damage to other parts of the brain. This research focuses the cerebrospinal fluid (CSF) leakage and enzymes from brain cancer cases and various secreted proteins and enzymes within the following hypothesis responsible for the breach of the blood-brain barrier. This research investigated the role of CSF in brain cancer and BBB. The research provides evidence that the leakage typically occurs at the spine level, especially in the thoracic spine region and the cardsiothoracic connection at the base of the brain. The aim is to determine the various proteins and enzymes contained within the CSF and investigated how to evaluate and specifically examine: (a) protein, (b) identity of these proteins/enzymes, (c) sequence of proteins/enzymes, and (d) identify the genes encoding these proteins/enzymes. Furthermore, the evidence that the function of CSF is breached by the components released from the tumorous tissue identifies the precise foci of this leakage and various proteins and enzymes that may be responsible for this damage. These observations perform a novel role in the detection of enzymes and toxins released by tumor cells, and a new component recognizes the type of CSF, whether it is normal CSF and proteolysis components of CSF related to tumor cells.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70838661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Megakaryocytic Alterations in Thrombocytopenia: A Bone Marrow Aspiration Study 血小板减少症的巨核细胞改变:一项骨髓穿刺研究

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/jne8swydaw

B. Iqbal, Rajeshwari Ravishankar, Meesha Zaheer, S. S. Chandanwale, C. Gore

引用次数: 0

Another Concept of Cancer Interpretation in View of the Interaction between Plasma Radiation and DNA 从等离子体辐射与DNA相互作用的角度解读癌症的另一个概念

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/pms16qq3bk

M. M. Ahmed, S. Montaser, A. Elhadary, G. Elaragi

{"title":"Another Concept of Cancer Interpretation in View of the Interaction between Plasma Radiation and DNA","authors":"M. M. Ahmed, S. Montaser, A. Elhadary, G. Elaragi","doi":"10.51847/pms16qq3bk","DOIUrl":"https://doi.org/10.51847/pms16qq3bk","url":null,"abstract":"Several studies included our preceding works on different types and doses of plasma sources on both normal and cancerous cells. All previous research tried to discuss and interpret cancer treatment concepts given plasma and cell interaction. Plasma has an effective role and specification character on cancerous cells outcome via many investigations (genetically, immunologically, and biochemically measurements) lead us to numerous paths of different theories which may create a new approach for considerations. This study was designed using a plasma jet powered by a Tesla coil used for generating Cold Atmospheric Pressure Plasma Jet (CAPPJ) from dielectric barrier discharge. The subject samples were categorized into three groups, the first was the cancer cell line. The second was normal blood samples whereas, the third one was non-exposed blood cells cultivated in CAPPJ-exposed cultures. The Cytokinesis Blocked Micronucleus Test (CBMN), a cytome assay, the protein expression of the P53 and Bcl2 genes, the interleukins (IL-1β, IL-6, and IL-10), and tumor necrosis factor (TNF-α) were the variables used in the current investigation. Results indicated that the direct interaction between cells and CAPPJ is more efficient than cells cultivated in CAPPJ-exposed cultures. Cell viability and protein expression levels of Bcl2 and P53 genes in CAPPJ irradiated Breast Cancer Cell lines (BCC) were remarkably valuable. CAPPJ affects cells via not only free radicals and enhancement of several important pathways but may be via direct interaction with DNA.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Breastfeeding as a Protective Factor against Breast Cancer: A Systematic Review 母乳喂养作为预防乳腺癌的保护因素:一项系统综述

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/cyzvpnmb4r

Rawan Deham I Aledeilah, Omar Hussain Ali Alanazi, Bader Saad Faleh AlHarby, M. A. Al Issa, Sara Ali Saleh Al-Dhahry, A. K. Alanazi, H. Alanazi, S. N. Alanazi

{"title":"Breastfeeding as a Protective Factor against Breast Cancer: A Systematic Review","authors":"Rawan Deham I Aledeilah, Omar Hussain Ali Alanazi, Bader Saad Faleh AlHarby, M. A. Al Issa, Sara Ali Saleh Al-Dhahry, A. K. Alanazi, H. Alanazi, S. N. Alanazi","doi":"10.51847/cyzvpnmb4r","DOIUrl":"https://doi.org/10.51847/cyzvpnmb4r","url":null,"abstract":"Breast cancer accounts for 24.5% of all cancer cases and 14% of all cancer deaths in women globally. Breastfeeding is thought to lower the risk of breast cancer mainly through two mechanisms; differentiation of breast tissue and a decrease in the total number of ovulatory cycles throughout a woman's lifetime. The objective of this systematic review is to investigate the published literature that studied breastfeeding and its duration as a possible protective factor for the development of breast cancer. PubMed, Web of Science, Science Direct, EBSCO, and Cochrane library were searched. Study articles were screened by title and abstract using Rayyan QCRI then a full-text assessment was implemented. Fifteen studies published between 2000 and 2022 with a total of 27315 breast cancer patients were included. Most included studies reported that breastfeeding and its longer duration play a protective role against breast cancer. Only three studies reported no association between breastfeeding and breast cancer development. So, our systematic review found that breastfeeding, especially breastfeeding of longer duration, was considered a protective factor against breast cancer. Therefore, it was advised that data on breastfeeding duration should be gathered by researchers in order to possibly lower the incidence of breast cancer. If breastfeeding offers protection against breast cancer, a more thorough analysis of potential confounders may shed light on how this protection is achieved. This systematic review reported that breastfeeding, especially breastfeeding of longer duration, was considered a protective factor against breast cancer.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ewing's Sarcoma in a 58-Year-Old Man: Oncological Diagnosis in the Time of COVID-19 58岁男性尤因氏肉瘤:COVID-19时期的肿瘤学诊断

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/rqquqpcuny

Damian Mojsak, Michał Dębczyński, Beata Kuklińska, R. Mroz

{"title":"Ewing's Sarcoma in a 58-Year-Old Man: Oncological Diagnosis in the Time of COVID-19","authors":"Damian Mojsak, Michał Dębczyński, Beata Kuklińska, R. Mroz","doi":"10.51847/rqquqpcuny","DOIUrl":"https://doi.org/10.51847/rqquqpcuny","url":null,"abstract":"Ewing's sarcoma is a rare and extremely aggressive neoplasm with a tendency to recur even after radical surgery and a tendency to early metastasis. This cancer is characteristic of the pediatric population because the peak incidence of this type of cancer occurs in patients between 10 and 20 years of age, but about 30% of cases occur in older patients. We present a case of Ewing's sarcoma in a 58-year-old man with a foot tumor manifestation with a history of back and left leg pain. Due to a lung tumor in the chest X-ray, the patient was referred to the Pulmonology Department, however, the diagnosis was postponed for many months, which in the case of an aggressive tumor, such as Ewing's sarcoma, significantly worsened the initially unfavorable prognosis. The COVID-19 pandemic is having a strong impact on the healthcare systems of countries around the world. Reorganizing medical care and focusing on the pandemic has an impact on the diagnosis and treatment of other diseases. In the current situation, we observe an increase in the number of patients presenting at an advanced stage of the disease, which excludes the possibility of radical treatment. Fear of infection causes both patients to avoid diagnosing disease by focusing on acute symptomatic treatment. The discussed case shows the possible impact of the epidemiological situation of the COVID19 pandemic on the diagnosis and treatment of oncology.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70832906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Cancer Risk Prediction with Stochastic Gradient Boosting 随机梯度增强的乳腺癌风险预测

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/21qrrklo4y

Mehmet Kivrak

{"title":"Breast Cancer Risk Prediction with Stochastic Gradient Boosting","authors":"Mehmet Kivrak","doi":"10.51847/21qrrklo4y","DOIUrl":"https://doi.org/10.51847/21qrrklo4y","url":null,"abstract":"Breast cancer, which is an important public health problem worldwide, is one of the deadliest cancers in women. This study aims to classify open-access breast cancer data and identify important risk factors with the Stochastic Gradient Boosting Method. The open-access breast cancer dataset was used to construct a classification model in the study. Stochastic Gradient Boosting was used to classify the disease. Balanced accuracy, accuracy, sensitivity, specificity, and positive/negative predictive values were evaluated for model performance. The accuracy, balanced accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score metrics obtained with the Stochastic Gradient Boosting model were 100 %, 100 %, 100 %, 100 %, 100 %, and 100 %, and 100 % respectively. In addition, the importance of the variables obtained, the most important risk factors for breast cancer were a cave. points_mean, area_worst, and perimeter_worst, concave. points_worst respectively. According to the study results, with the machine-learning model Stochastic Gradient Boosting used, patients with and without breast cancer were classified with high accuracy, and the importance of the variables related to cancer status was determined. Factors with high variable importance can be considered potential risk factors associated with cancer status and can play an essential role in disease diagnosis.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70810363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic Metastasis from Hepatoid Adenocarcinoma of the Stomach Mimicking Hepatocellular Carcinoma: Diagnostic Challenge 模拟肝细胞癌的胃类肝腺癌的肝转移:诊断挑战

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Clinical Cancer Investigation Journal Pub Date : 2022-01-01 DOI: 10.51847/eddehtlu0r

R. Sukumaran, A. Mathews, N. Radhakrishnan

{"title":"Hepatic Metastasis from Hepatoid Adenocarcinoma of the Stomach Mimicking Hepatocellular Carcinoma: Diagnostic Challenge","authors":"R. Sukumaran, A. Mathews, N. Radhakrishnan","doi":"10.51847/eddehtlu0r","DOIUrl":"https://doi.org/10.51847/eddehtlu0r","url":null,"abstract":"Hepatoid adenocarcinoma (HAC) is a unique type of extrahepatic adenocarcinoma that histologically mimics the appearance of hepatocellular carcinoma (HCC). Hepatoid adenocarcinoma of the stomach has a poor prognosis with increased potential for liver metastasis. HCC and HAC share clinicopathological and immunohistochemical features. The diagnosis of metastatic hepatoid adenocarcinoma to the liver is challenging. It is often misdiagnosed as hepatocellular carcinoma. The diagnostic dilemma is more when the primary tumour is unknown and the first diagnosis is to be established on liver biopsy. Herein, we present the case of a 68-year-old male patient who presented with dysphagia and abdominal discomfort for a three-month duration. Imaging studies showed multiple hypodense lesions in both lobes of the liver. Serum AFP level was markedly elevated to a level of 83,000 ng/ml). A liver biopsy showed atypical polygonal cells in the trabecular pattern. The atypical cells were CK7 negative, CK 20 negative, Hep Par-1 positive and AFP positive. Features were suggestive of hepatocellular carcinoma. Endoscopy showed ulceroproliferative growth in the distal body and antrum of the stomach, a biopsy of which showed atypical cells of similar morphology. The cells were showing focal positivity for CK7, CK20, Hep Par-1 and AFP. On further evaluation, tumour cells in both locations showed positivity for SALL 4. Correlating clinical features, radiology, serum marker values and IHC profile, diagnosis of hepatoid adenocarcinoma of the stomach with liver metastasis was given.","PeriodicalId":44457,"journal":{"name":"Clinical Cancer Investigation Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0