Turkish Archives of Otorhinolaryngology最新文献

{"title":"Prospective Exploratory Evaluation of Audiovestibular Function in Patients Receiving Oral Isotretinoin Using Audiometry and Videonystagmography.","authors":"Fatih Yüksel, Cahit Yavuz, Mehmet Erkan Kahraman","doi":"10.4274/tao.2026.2026-4-9","DOIUrl":"10.4274/tao.2026.2026-4-9","url":null,"abstract":"<p><strong>Objective: </strong>To prospectively evaluate possible audiovestibular changes associated with short-term oral isotretinoin therapy using pure-tone audiometry and selected videonystagmography (VNG)-based vestibular assessments.</p><p><strong>Methods: </strong>Participants older than 18 years receiving oral isotretinoin therapy constituted the study group. All participants underwent detailed otorhinolaryngological examination, along with pure-tone audiometry and tympanometric analysis, prior to treatment initiation and after three months of therapy. Vestibular assessment included VNG-based spontaneous nystagmus analysis, gaze testing, positional testing, and oculomotor evaluations.</p><p><strong>Results: </strong>Thirty-three patients were included in the analysis (11 males and 22 females). The median age was 20.0 years (interquartile range: 3.0). Comparison of pre- and post-treatment audiometric data demonstrated no significant changes across frequencies ranging from 250 to 8000 Hz, nor in pure-tone average, high-frequency average, or low-frequency average pure-tone average, high-frequency average, or low-frequency average values. A significant change was observed at 6000 Hz in the right ear; however, this finding was not clinically meaningful and likely reflected minor distributional variation between paired measurements. Selected VNG-based vestibular assessments, including spontaneous nystagmus, gaze, positional, and oculomotor testing, remained within normal limits throughout the study period.</p><p><strong>Conclusion: </strong>Within the limitations of this exploratory pilot study, short-term oral isotretinoin therapy did not demonstrate clinically significant abnormalities in audiometric measurements or selected VNG-based vestibular assessments.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"137-143"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Multiclass Classification of Benign Vocal Fold Lesions Using Acoustic, Clinical, and Patient-Reported Features.","authors":"Ebru Karakaya Gojayev, Zahide Çiler Büyükatalay, Arjin Öksüz, Gürsel Dursun","doi":"10.4274/tao.2026.2026-6-14","DOIUrl":"10.4274/tao.2026.2026-6-14","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate a multiclass random forest classifier for distinguishing among five types of benign vocal fold lesions using acoustic and phonatory parameters, patient-reported outcomes (PROs), demographic characteristics, and occupational voice demands.</p><p><strong>Methods: </strong>This retrospective study included 217 adults with confirmed diagnoses of vocal fold nodules, vocal fold polyps, intracordal cysts, Reinke's edema, or sulcus vocalis at a tertiary otolaryngology center. Features included five acoustic parameters (fundamental frequency, jitter, shimmer, maximum phonation time, s/z ratio), three PRO instruments, the voice handicap index, voice-related quality of life, and reflux symptom index (RSI), and demographic and occupational variables. A class-weighted random forest classifier was evaluated using stratified five-fold cross-validation with bootstrap-derived 95% confidence intervals; multinomial logistic regression and linear support vector machine served as comparators.</p><p><strong>Results: </strong>The random forest classifier outperformed the comparator models, achieving accuracy of 0.576, balanced accuracy of 0.476, macro-F1 of 0.479, and a macro-averaged area under the receiver operating characteristic curve of 0.76. The highest class-level F1 scores were observed for sulcus vocalis (0.703) and vocal fold polyps (0.625); intracordal cysts showed the lowest recall (0.111), reflecting acoustic overlap with vocal fold polyps. Top 2 accuracy was approximately 74%. Fundamental frequency, RSI, and maximum phonation time were the highest-ranked predictors.</p><p><strong>Conclusion: </strong>A multidimensional random forest framework incorporating acoustic measures, PROs, and occupational voice demand demonstrated potential for classifying benign vocal fold lesions. Acoustic parameters alone may not adequately distinguish among these lesions, and the inclusion of patient-reported data may improve model performance. A top 2 accuracy of 74% supports utility as a pre-endoscopic decision-support tool.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"180-185"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental Value of Multimodality Imaging for Preoperative Localization in Primary Hyperparathyroidism: A Stepwise Strategy for Focused Parathyroidectomy.","authors":"Erdoğan Özgür, Özden Savaş, Asuman Feda Bayrak, Gamze Çapa Kaya, Çağla Atakan, Özden Özdemir Başer, Nuri Karabay","doi":"10.4274/tao.2026.2026-8-4","DOIUrl":"10.4274/tao.2026.2026-8-4","url":null,"abstract":"<p><strong>Objective: </strong>Accurate preoperative localization of the affected parathyroid gland is important for focused parathyroidectomy in primary hyperparathyroidism, yet no single imaging modality is uniformly reliable. This study evaluated the incremental localization benefit of combining ultrasonography (US), ^99mTc-sestamibi scintigraphy (MIBI), and four-dimensional computed tomography (4D-CT) and assessed agreement between imaging-measured and histopathological adenoma size.</p><p><strong>Methods: </strong>This retrospective, single-center study included 118 patients with histopathologically confirmed parathyroid adenoma who underwent parathyroidectomy between 2015 and 2025. Imaging-based localization was compared with the surgically confirmed location of the adenoma. Sensitivity, positive predictive value, and incremental localization accuracy were calculated. Size agreement was assessed using Bland-Altman analysis, and US sensitivity was examined according to gland location.</p><p><strong>Results: </strong>Site-level sensitivity was 71.8% for US, 72.8% for MIBI, 66.7% for CT, and 60.0% for 4D-CT, with no significant pairwise differences (all p>0.05). Adding MIBI to US significantly increased localization accuracy from 71.7% to 84.1% (n=113, McNemar p<0.001); adding 4D-CT to US+MIBI further raised accuracy from 73.5% to 79.4% in a smaller cohort (n=34), though this increment was not statistically significant (p=0.50). US sensitivity fell sharply with anatomical difficulty, from 80.9% for inferior glands to 61.1% for superior and 16.7% for ectopic glands. US also systematically underestimated adenoma size, particularly for larger lesions (bias -10.8 mm; 95% limits of agreement -50.1 to 28.5 mm).</p><p><strong>Conclusion: </strong>Combining US with MIBI improved localization accuracy. The addition of 4D-CT yielded a further, statistically non-significant increase in the smaller cohort studied. These findings support a stepwise approach to preoperative imaging for focused parathyroidectomy.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"64 3","pages":"186-195"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible Horizontal Semicircular Canalith Jam Mimicking Acute Vestibular Syndrome: Diagnosis and Treatment with Head-Shaking and Gufoni Maneuvers.","authors":"Ajay Kumar Vats, Sudhir Kothari, Pradeep Vundavilli","doi":"10.4274/tao.2026.2026-3-24","DOIUrl":"10.4274/tao.2026.2026-3-24","url":null,"abstract":"<p><p>A 72-year-old man presented with a 3-day history of positional rotational vertigo that progressed to continuous vertigo with one episode of vomiting, mimicking acute vestibular syndrome (AVS). Bedside examination revealed spontaneous right-beating horizontal nystagmus and findings consistent with a peripheral pattern on the head impulse, nystagmus, test of skew (HINTS) examination: a positive head impulse test (HIT), unidirectional nystagmus, and no skew deviation. Head shaking with the head flexed forward by 30° reversed the nystagmus to left-beating, and the HIT became positive on rightward impulses. The head yaw test subsequently elicited apogeotropic horizontal positional nystagmus, which converted to a geotropic pattern after repeated head yaw testing and head shaking. Following the Gufoni maneuver, nystagmus and vertigo resolved within one hour. This case demonstrates reversible right horizontal semicircular canal (HSC) canalith jam, a rare benign paroxysmal positional vertigo (BPPV) variant caused by otoconial obstruction of endolymph flow, producing persistent nystagmus and fluctuating sequential labyrinthine hypofunction. Head-shaking maneuver induced a previously unreported bidirectional switch between sustained excitatory and inhibitory cupular deflections within the same canal. Simple bedside maneuvers enabled rapid diagnosis and cure without imaging or drugs. Clinicians should consider HSC canalith jam in AVS with peripheral HINTS when history suggests BPPV.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"64 3","pages":"196-199"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Burkitt Lymphoma of the Maxillary Sinus in an Immunocompetent Adult: A Case Report.","authors":"Konstantinos Chaidas, Artemis Zarkadi, Nikolaos Tepelenis, Sotirios Papouliakos","doi":"10.4274/tao.2026.2026-4-18","DOIUrl":"10.4274/tao.2026.2026-4-18","url":null,"abstract":"<p><p>Primary Burkitt lymphoma (BL) of the maxillary sinus is rare, particularly in immunocompetent adults, and only a few cases have been reported in the literature. Its clinical presentation may mimic benign conditions, such as chronic rhinosinusitis or neuropathic facial pain, potentially resulting in diagnostic delay. We present the case of a 38-year-old male with a five-month history of isolated left-sided facial pain. Comprehensive clinical, radiological, and histopathological evaluation established the diagnosis of BL, and the patient subsequently received systemic chemotherapy. This case highlights the importance of considering BL in the differential diagnosis of persistent or atypical sinonasal symptoms, particularly those unresponsive to empirical treatment. Prompt biopsy and histopathological and immunohistochemical evaluation are essential for establishing the diagnosis and initiating appropriate treatment without delay.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"200-203"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Neck Infection Complicated by Internal Carotid Pseudoaneurysm: A Diagnostic and Therapeutic Challenge.","authors":"Burcu Vural Camalan, Tuğçe Güneş Küçük, Sadık Ahmet Uyanık, Samet Özlügedik","doi":"10.4274/tao.2026.2025-12-4","DOIUrl":"10.4274/tao.2026.2025-12-4","url":null,"abstract":"<p><p>Parapharyngeal infections may result in a pseudoaneurysm of the internal carotid artery, a rare but potentially fatal condition. Early recognition and multidisciplinary management are crucial to avoid catastrophic outcomes. We present a case of a twenty-two-year-old man with a parapharyngeal abscess complicated by an internal carotid artery pseudoaneurysm. The patient presented with painful left neck swelling, fever, dysphagia, and hoarseness. Examination revealed oropharyngeal asymmetry, ipsilateral vocal cord paralysis, and shoulder weakness findings consistent with jugular foramen syndrome. Imaging demonstrated a parapharyngeal abscess with a surrounding hematoma encasing the distal internal carotid artery, which appeared aneurysmal and was confirmed as pseudoaneurysm. Despite appropriate antibiotic therapy, the patient's neck pain progressively worsened, and repeat imaging demonstrated enlargement of the lesion. Urgent endovascular coil embolization was successfully performed. The patient was discharged on the second postoperative day and remained neurologically stable at six-month follow-up, with radiological improvement. Carotid pseudoaneurysm secondary to deep neck infection is exceedingly rare. Infection may spread from the parapharyngeal space to the carotid sheath, causing progressive arterial wall erosion. Early identification is crucial, as rupture carries high mortality without intervention. Recent evidence supports endovascular management as a safe and effective alternative to open surgery, particularly for lesions involving the skull base or petrous segment, where surgical exposure is hazardous. This case underscores that deep neck infections presenting with cranial neuropathies or opioid-refractory pain warrant prompt vascular imaging, and that endovascular occlusion represents a safe and effective treatment when collateral circulation is sufficient.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"204-208"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Sinonasal Tumors: A 17-Year Single Center Experience.","authors":"Hakan Kara, Kağan Avcı, Vedat Emre Alayoğlu, Furkan Olgun, Yakup Bahadır Öcal, Levent Aydemir, Şenol Çomoğlu, Meryem Nesil Keleş Türel","doi":"10.4274/tao.2026.2026-6-32","DOIUrl":"10.4274/tao.2026.2026-6-32","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated demographic characteristics, histopathological distribution, surgical approaches, residual disease, complications, and recurrence patterns in patients surgically treated for benign sinonasal tumors.</p><p><strong>Methods: </strong>Medical records of patients who underwent surgery for benign sinonasal tumors at a single tertiary center between January 2007 and December 2024 were retrospectively reviewed. Patients with less than three months of follow-up were excluded. Demographic, histological, surgical, complication, residual disease, follow-up, and recurrence data were analyzed according to tumor type.</p><p><strong>Results: </strong>A total of 368 patients were included. The median age was 42.5 years, and 260 patients (70.7%) were male. The most common histological groups were sinonasal papilloma (34.2%), osseous lesions (22.6%), and juvenile nasopharyngeal angiofibroma (19.0%). Surgical approach differed significantly by tumor type (p<0.001), with endoscopic surgery used most frequently overall (74.5%). Residual disease also differed significantly among tumor types (p=0.011) and was most common in osseous lesions. Complications occurred in 17.4% of patients; complication types varied significantly across tumor groups (p=0.035). Recurrence data were available for 326 patients, and recurrence occurred in 40 patients (12.3%), most frequently in juvenile nasopharyngeal angiofibroma (23.4%; p=0.010).</p><p><strong>Conclusion: </strong>Histological subtype was associated with surgical approach, residual disease, complication pattern, and recurrence. These findings support individualized surgical planning and histology-specific follow-up in benign sinonasal tumors.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"154-162"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Videofluoroscopic Analysis of Swallowing Biomechanics in Parkinson's Disease.","authors":"Maria Inês Rebelo Gonçalves, Isabella Christina Oliveira Neto, Henrique Lederman, Guilherme Maia Zica","doi":"10.4274/tao.2026.2026-5-6","DOIUrl":"10.4274/tao.2026.2026-5-6","url":null,"abstract":"<p><strong>Objective: </strong>To quantitatively assess maximum hyoid displacement, laryngeal displacement, pharyngeal constriction, and upper esophageal sphincter opening in patients with Parkinson's disease and compare these measures with those of controls with normal videofluoroscopic swallowing findings.</p><p><strong>Methods: </strong>This retrospective observational study included 32 videofluoroscopic swallowing examinations: 16 from patients with Parkinson's disease and 16 from controls. Thin liquid, paste, and solid consistencies were evaluated. Measurements were obtained using ImageJ after image calibration, and between-group comparisons were performed using Student's t-test or the Mann-Whitney U test according to data distribution.</p><p><strong>Results: </strong>The groups had similar mean ages. Patients with Parkinson's disease demonstrated significantly reduced laryngeal displacement across all consistencies and poorer pharyngeal constriction with thin liquids, as indicated by a larger residual pharyngeal area. No significant between-group differences were observed in maximum hyoid displacement or upper esophageal sphincter opening.</p><p><strong>Conclusion: </strong>In this sample, Parkinson's disease was primarily associated with impaired laryngeal displacement and pharyngeal constriction, potentially affecting airway protection and pharyngeal clearance. Quantitative videofluoroscopic analysis may help identify biomechanical swallowing alterations in this population.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"144-153"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Post-Tonsillectomy Hemorrhage: A 10-Year Retrospective Cohort Study at a Tertiary Military Hospital in Thailand.","authors":"Juthamard Moungthong, Anisong Pilakasiri","doi":"10.4274/tao.2026.2026-3-26","DOIUrl":"10.4274/tao.2026.2026-3-26","url":null,"abstract":"<p><strong>Objective: </strong>Tonsillectomy is one of the most frequently performed surgical procedures worldwide, and several patient-and procedure-related factors have been associated with post-tonsillectomy hemorrhage (PTH). Severe hemorrhage may require reoperation under general anesthesia to achieve hemostasis. The aim of this retrospective cohort study was to identify pre-, intra-, and postoperative factors associated with PTH.</p><p><strong>Methods: </strong>Records of 549 patients who underwent tonsillectomy at a tertiary military hospital in Thailand between 2010 and 2020 were reviewed, with PTH ascertained by detailed manual chart review.</p><p><strong>Results: </strong>The mean age was 26.89±15.69 years. PTH occurred in 56 patients (10.2%), most commonly on postoperative day 6. Multivariate logistic regression identified the following independent risk factors: male sex [p=0.039; adjusted odds ratio (aOR) 2.11, 95% confidence interval (CI) 1.04-4.30], age<19 years (p=0.016; aOR 7.96, 95% CI 1.46-43.27), age 19-45 years (p=0.024; aOR 5.74, 95% CI 1.26-26.11), surgeon experience <15 years (p=0.023; aOR 2.85, 95% CI 1.16-7.01), elevated mean arterial pressure (MAP) (p=0.002; aOR 1.04 per mmHg, 95% CI 1.02-1.07), intravenous (IV) antibiotic prescription (p=0.036; aOR 2.03, 95% CI 1.05-3.92), and a day-1 pain score >5 (p=0.037; aOR 2.25, 95% CI 1.05-4.81). As the >45-year reference group had few events, the age odds ratios were imprecise; a Firth-penalized pediatric estimate was 6.33 (95% CI 1.52-37.37), and a pooled age <45 versus ≥45 contrast gave aOR 5.07 (95% CI 1.56-26.00).</p><p><strong>Conclusion: </strong>Male sex, age under 45 years, and surgeon experience less than 15 years were the principal independent predictors of PTH; elevated postoperative MAP, a day-1 pain score above 5, and IV antibiotic prescription further characterized higher-risk patients.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"171-179"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic ACTH-Secreting Pituitary Adenoma of the Maxillary Sinus: A Rare Cause of Cushing's Syndrome.","authors":"Georgina Wordsworth, Tuğba Karagöz, Kathryn Lonnen, Warren Bennett, Timothy Bates","doi":"10.4274/tao.2026.2025-5-3","DOIUrl":"10.4274/tao.2026.2025-5-3","url":null,"abstract":"<p><p>We describe a rare case of Cushing's syndrome caused by an ectopic adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma located in the maxillary sinus and outline the diagnostic and therapeutic challenges. A 41-year-old woman presented with an eight-year history of progressive weight gain, fatigue, type 2 diabetes mellitus, and hypertension, leading to a diagnosis of Cushing's syndrome. Inferior petrosal sinus sampling confirmed an ectopic ACTH source. Fluorodeoxyglucose-positron emission tomography demonstrated a 12-mm lesion in the right maxillary sinus, which was successfully removed via an endonasal approach. Postoperatively, cortisol levels normalized and her symptoms resolved. The patient remains in remission 2.5 years following surgery. This case highlights the importance of considering ectopic ACTH-secreting adenomas in patients with Cushing's syndrome without a sellar mass and emphasizes the need for thorough diagnostic evaluation to ensure accurate tumor localization and optimal surgical management.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":" ","pages":"209-213"},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}