Innovative Surgical Sciences最新文献

{"title":"Orthoplastic surgery for interdisciplinary extremity reconstruction.","authors":"Anja M Boos, Heide Delbrück, Philipp Lichte, Benedikt Schäfer, Alexander Gombert, Christian Uhl, Frank Hildebrand, Justus P Beier","doi":"10.1515/iss-2025-0026","DOIUrl":"10.1515/iss-2025-0026","url":null,"abstract":"<p><strong>Objectives: </strong>Combined bone and soft tissue injuries and defects pose a challenge for the interdisciplinary orthoplastic surgical team. These conditions are not only encountered in young, healthy patients, but, due to various causes ranging from trauma over chronic osteomyelitis to tumor resection, also in patients with pre-existing vascular disease and even many years after the initial trauma.</p><p><strong>Methods: </strong>An efficient interdisciplinary treatment approach by orthopedic/trauma surgeons and plastic surgeons, and if necessary, vascular surgeons, who develop a joint strategy as early as possible is crucial for optimal functional restoration of form and function.</p><p><strong>Results: </strong>The goal of this orthoplastic approach is early definitive fracture stabilization or bony reconstruction combined with adequate soft tissue coverage and reconstruction of other injured structures such as vessels, nerves, and tendons, in order to begin rehabilitation as early as possible.</p><p><strong>Conclusions: </strong>The different steps of the orthoplastic surgical approach for interdisciplinary extremity reconstruction is described in the following manuscript and should encourage and provide a guideline for other orthoplastic teams, possibly leading to establishing specialized extremity reconstruction centers.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"11 1","pages":"3-13"},"PeriodicalIF":1.3,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of molecular cues to regenerate musculoskeletal tissues.","authors":"Carlos Julio Peniche Silva, Martijn van Griensven, Virginie Joris","doi":"10.1515/iss-2025-0033","DOIUrl":"10.1515/iss-2025-0033","url":null,"abstract":"<p><strong>Introduction: </strong>Musculoskeletal tissues, including bone, tendon, cartilage, and muscle, are vital for movement and structural support, yet, their repair after injury remains a significant clinical challenge. Their regeneration relies on complex molecular signaling that regulates inflammation, repair, and remodeling. Understanding these cues, offers opportunities to design targeted therapeutic strategies.</p><p><strong>Content: </strong>This review summarizes current evidence on molecular regulators of musculoskeletal tissue regeneration with emphasis on both shared and tissue-specific mechanisms across bone, tendon, cartilage and muscle. Key molecular cues include growth factors, cytokines, extracellular matrix-derived signals, and non-coding RNAs, particularly microRNAs. Critical pathways such as TGF-β, NF-κB, FGF, and YAP/TAZ can either promote healing or drive pathological fibrosis depending on their modulation. This review discusses therapeutic strategies targeting these molecular cues, including microRNA replacement therapies, small molecules, growth factor delivery, and pathway-specific inhibitors or activators.</p><p><strong>Summary and outlook: </strong>Understanding how these molecular cues and pathways function and interact to regulate healing and regeneration offers valuable insight into tissue-specific and cross-tissue repair strategies. These advances may support the development of targeted therapies to enhance musculoskeletal regeneration and functional recovery. Furthermore, future research should focus on integrating these molecular insights with biomaterial and mechanobiological approaches to develop next-generation regenerative interventions.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"11 1","pages":"83-94"},"PeriodicalIF":1.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling of inflammatory and anti-inflammatory cytokines in osteomyelitic bone tissue.","authors":"Lara F Lingens, Tekoshin Ammo, Tim Ruhl, Justus P Beier","doi":"10.1515/iss-2025-0023","DOIUrl":"10.1515/iss-2025-0023","url":null,"abstract":"<p><strong>Objectives: </strong>Osteomyelitis (OM) represents a major clinical challenge in reconstructive surgery. It is characterized by chronic infection, impaired healing, and high treatment costs. Despite the high relevance, the local immune and regenerative microenvironment of infected human bone tissue remains insufficiently characterized. This study aimed to evaluate cytokine concentrations in osteomyelitic bone tissue.</p><p><strong>Methods: </strong>Bone samples were collected intraoperatively from patients with sternal, vascular, and posttraumatic OM and compared to noninfected control tissue. Cytokine concentrations of IL-6, IL-8, MCP-1, osteopontin, and SPARC were quantified in tissue homogenates by enzyme-linked immunosorbent assays (ELISA). Bacterial pathogens were identified using routine clinical microbiological diagnostics, and cytokine profiles were compared across the OM subgroups.</p><p><strong>Results: </strong>Pathogen identification revealed <i>Staphylococcus epidermidis</i> as the most common isolate in sternal OM, while vascular OM exhibited a broader spectrum including <i>S. epidermidis</i>, <i>Corynebacterium striatum</i>, <i>Enterobacter cloacae</i>, and <i>Proteus mirabilis</i>. Posttraumatic OM showed both monomicrobial and polymicrobial infections. The concentrations of the examined cytokines were significantly elevated in OM. No significant differences were observed between OM subtypes for most cytokines, except for MCP-1, which was higher in sternal compared to vascular OM. Spearman analysis revealed strong positive correlations between IL-6, IL-8, and MCP-1, indicating a coordinated inflammatory response. Osteopontin correlated significantly with inflammatory cytokines, while SPARC correlated primarily with osteopontin but not with inflammatory cytokines.</p><p><strong>Conclusions: </strong>Cytokine profiling demonstrated simultaneous activation of inflammatory and regenerative processes in OM. The preserved regenerative marker profile across OM subtypes supports individualized surgical strategies even in chronic infections. Distinct correlation patterns between inflammatory and regenerative cytokines suggest differential regulation of immune and repair mechanisms within infected bone tissue.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"11 1","pages":"73-81"},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interdisciplinary lower extremity reconstruction in peripheral artery disease with AV-loops and latissimus dorsi flaps.","authors":"Simon Reß, Anja M Boos, Alexander Gombert, Christian Uhl, Benedikt Schäfer, Lara Lingens, Astrid Bülow, Heide Delbrück, Frank Hildebrand, Justus P Beier","doi":"10.1515/iss-2025-0032","DOIUrl":"10.1515/iss-2025-0032","url":null,"abstract":"<p><strong>Objectives: </strong>Extensive soft tissue defects of the lower leg can be effectively addressed by transplantation of various free microvascular flaps. A fundamental requirement for successful free microvascular flap coverage is the availability of adequate recipient arteries and veins. In cases where vascular conditions are compromised, such as in peripheral artery disease (PAD), achieving effective defect coverage through free microvascular flap transplantation poses significant challenges. One potential treatment option is the creation of an arteriovenous (AV) - loop to facilitate the attachment of a free flap.</p><p><strong>Methods: </strong>Our study comprises patients receiving AV-loops with free latissimus dorsi flaps between 2019 and 2021. A retrospective review was performed of all patients who underwent this operative procedure with a minimum follow-up time of 3 years. We conducted pre- and intraoperative flow measurements with ultrasound. Flap survival, autonomisation and patient satisfaction was analyzed clinically, with thermography and the Freiburg Index of Patient Satisfaction (FIPS). We focus on identifying which patients benefit from this approach, as well as exploring limitations related to the severity of peripheral arterial occlusive disease (PAOD).</p><p><strong>Results: </strong>Our study showed that this procedure can be used to cover defects safely and with a low flap loss rate, even in highly compromised vascular situations. It was also shown that even in PAOD, permanent patency of the pedicle vessel is not essential for the flap. In this study, with its associated limitations, we were unable to establish a reliable correlation between preoperative and intraoperative flow measurements and flap loss in the two-stage procedure we chose. Despite the high physical and psychological stress on the individual patients, the majority were satisfied with the procedure and the result.</p><p><strong>Conclusions: </strong>Defect coverage of the lower extremity using a loop and free muscle flap is a safe, reliable procedure with a high patient satisfaction.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"11 1","pages":"53-63"},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative outcomes of inguinal hernia repair performed by surgical residents in routine clinical practice: a retrospective single-center analysis.","authors":"Helga Oehler, Kim L Zerr, Hanan El Youzouri, Ursula Pession, Wolf O Bechstein, Armin Wiegering, Teresa Schreckenbach","doi":"10.1515/iss-2025-0028","DOIUrl":"10.1515/iss-2025-0028","url":null,"abstract":"<p><strong>Objectives: </strong>Inguinal hernia repair is one of the most common surgical procedures performed worldwide. As part of training, surgical residents perform these procedures, which raises questions about the safety and efficacy of their involvement compared to specialists. This study compares the postoperative outcome and complications of inguinal hernia repairs conducted by residents under supervision with those performed by board certified surgeons independent of the method of surgery.</p><p><strong>Methods: </strong>This retrospective cohort study was performed at a single tertiary care center. 388 patients undergoing inguinal hernia repair, aged 18 years and older were included. Data were collected from 2014 to 2020.</p><p><strong>Results: </strong>The techniques used for the hernia repair were open repair using the Lichtenstein technique (n=159) and the transabdominal preperitoneal (TAPP) mesh technique (n=228). The hernia repairs were mostly performed as an open procedure by residents (n=72; 45 %), whereas board-certified surgeons mostly operated laparoscopically (n=190; 83 %). Surgical trainees had significantly longer operation times when performing a laparoscopic procedure than attending surgeons (means: 94 vs.70 min; <i>p</i><0.001). However, there was no difference in operation time when an open procedure was performed (<i>p</i>=0.988). Univariate analyses revealed no influence of the level of training on overall postoperative morbidity (<i>p</i>=0.138) but showed that the TAPP technique was a protective factor for postoperative complications (<i>p</i><0.001).</p><p><strong>Conclusions: </strong>Resident participation in inguinal hernia repair is safe and does not increase postoperative complications. In the tertiary care center, residents primarily performed open repairs, while board-certified surgeons favored the minimally invasive approach. Both techniques proved to be safe under appropriate supervision. These findings highlight the feasibility of structured surgical training in routine clinical practice, ensuring patient safety while maintaining high educational standards.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"11 3","pages":"151-159"},"PeriodicalIF":1.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic insufficiency fractures in the elderly - what insights has the past year of research brought? A narrative review.","authors":"Kim Lydia Klepka, Christian Kleber, Yasmin Youssef","doi":"10.1515/iss-2025-0018","DOIUrl":"10.1515/iss-2025-0018","url":null,"abstract":"<p><p>Pelvic insufficiency fractures (PIFs) are low-energy fractures typically occurring in osteoporotic bone and are associated with significant morbidity, reduced quality of life, and increased mortality. PIF requires individualized, often interdisciplinary treatment strategies combining surgical, conservative, and systemic approaches. This narrative review aims to summarize recent findings on the diagnosis, management, and outcomes of PIFs and place them in the context of existing literature. For this purpose, a selective literature search was conducted in January 2025 to identify publications on the topic of PIFs. The search was performed on PubMed and clinical studies addressing the diagnosis, treatment, outcomes and complications of PIFs from January 2024 to 2025 were selected for evaluation. A total of 11 studies with a total of 27,672 patients were included in this review. The findings emphasise the significant morbidity, mortality and healthcare burden associated with these fractures. Conventional radiography frequently fails to detect this type of fracture, thus necessitating advanced imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) to ensure an early diagnosis. The treatment decision is determined by the stability of the fracture, presence and intensity of pain, and the patient's mobility levels. The treatment options, whether conservative or surgical, are adapted to these factors. The osteoporotic fracture (OF) Pelvis Score has emerged as a promising tool for guiding therapeutic strategies, though there is still potential for further development in the use of pharmaceutical treatment of underlying conditions such as osteoporosis. Despite the advances that have been made, the existing literature remains heterogeneous, underscoring the importance of conducting prospective studies and developing evidence-based guidelines. Interdisciplinary and orthogeriatric care is important for improving outcomes for this vulnerable patient group.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"10 4","pages":"181-189"},"PeriodicalIF":1.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12724486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in operative techniques for pancreatic surgery.","authors":"Johanna Strotmann, Verena Tripke","doi":"10.1515/iss-2025-0017","DOIUrl":"10.1515/iss-2025-0017","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreatic resections are one of the most complex operations in visceral surgery, characterized by high perioperative morbidity and mortality. Continuous evaluation and adjustment of surgical techniques and approaches are required to improve the quality of surgery and outcomes in this highly vulnerable collective of patients.</p><p><strong>Content: </strong>In this short narrative review we will discuss exemplary three recent advances in pancreatic surgery.</p><p><strong>Summary and outlook: </strong>A systematic literature search was performed using the PubMed database. The three discussed promising developments in pancreatic surgery are the triangle operation, a radical resection of lymphatic and nerve tissue in patients with pancreatic cancer, autologous patches for covering skeletonized arteries after resection to reduce frequent postoperative complications, and minimal invasive surgical approaches, which offer potential benefits in reduced intraoperative blood loss, shorter hospital stay and lower rate of wound infections compared to open resections. These three new operative approaches represent promising advances in a demanding surgical field. However, further studies are needed to confirm the benefits of these techniques on patient outcomes.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"10 4","pages":"197-202"},"PeriodicalIF":1.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12724681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and future developments in dental implantology - a narrative review.","authors":"Constanze Friedrich, Constantin Graw, Juliane Kröplin","doi":"10.1515/iss-2025-0020","DOIUrl":"10.1515/iss-2025-0020","url":null,"abstract":"<p><strong>Introduction: </strong>The vast majority of people are affected by tooth loss in the course of their lives. Dental implants are used to anchor prosthetic teeth and represent the gold standard for replacing missing teeth. As the preservation of chewing function and esthetics has a significant influence on the quality of life, the constant further development of techniques and materials is a central issue in oral and maxillofacial surgery. This narrative review article aims to evaluate the historical development, current status, and innovative methods of dental implants.</p><p><strong>Content: </strong>A selective literature search based on Pubmed was conducted, focusing primarily on literature from the years 2023 to 2025. Keywords used in the search were \"dental implants\" in combination with \"navigation\" and \"virtual surgical planning.\"</p><p><strong>Summary: </strong>The causes of tooth loss, the anatomical conditions of the jaw, and possible treatment approaches for oral rehabilitation are diverse and require individual consideration depending on the individual patient situation. In any case, the use of materials and geometries supporting the osseointegration of the implants, the optimal positioning of the implants in the jawbone, and surgery procedures that are as atraumatic as possible are fundamental to successful implantation. In recent years, digital and technical innovations have changed the way treatment is planned and performed. The shift toward an increasingly digital workflow has resulted in more efficient planning and improved precision in implant positioning. This is associated with improved clinical results and more satisfied patients.</p><p><strong>Outlook: </strong>In this study, the field of dental implantology is reviewed and future opportunities and challenges are identified. Despite the fact that this will result in new obstacles, dental implantation can become increasingly precise and efficient thanks to the development of digital technologies such as Augmented Reality-Assisted Navigation and autonomous dental implant robots.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"10 4","pages":"191-195"},"PeriodicalIF":1.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12724485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Student-led curriculum design and teaching by fellow students provide a feasible platform for surgical identity and a gateway to surgical careers.","authors":"Hajera Khaleqi, Kira Meißner, Abdulrahman Al-Harazi, Kim Lea Seifert, Lara Čierná, Maxim Popov, Gaby Lee, Antonia Reers, Saman Keshtkaran, Pauline Schuppert, Florian Rapp, Lucas Cröpelin, Martin Oertel, Fabian Pascal Schönewald, Jenna Sophie Schöllhorn, Atiehalsadat Nasr Esfahani, Tobias Dust, Judith Stolz, Andreas Lindner, Anas Amin Preukschas, Felix Nickel, Amila Cizmic, Melanie Le, Michael Sennert, Konrad Reinshagen, Christian Tomuschat, Hans Christian Schmidt","doi":"10.1515/iss-2025-0014","DOIUrl":"10.1515/iss-2025-0014","url":null,"abstract":"<p><strong>Objectives: </strong>Simulation-based (SBT) training is an essential component of modern surgical education as it improves both technical and non-technical skills while increasing the motivation of medical students. This study investigates the implementation of a student-led SBT based on peer teaching to overcome challenges in surgical education, maintain motivation, and facilitate access to surgical professions.</p><p><strong>Methods: </strong>From January 2024 to December 2024 a student-led voluntary course on basic laparoscopic techniques was performed, in which medical students from all semesters could participate. Satisfaction, motivation, and perceived openness for surgical professions of the participants were assessed using questionnaires and evaluated descriptively.</p><p><strong>Results: </strong>Eighty six medical students were trained in basic laparoscopic skills. The main reasons for participating were the desire for practical training (80 %), interest in laparoscopic techniques (76 %), and the pursuit of a surgical career (56 %). Overall satisfaction was high (<i>M</i>=4.88/5). After the course, participants felt better prepared for clinical internships (87 %) and said they are more likely to pursue in the surgical field (74 %).</p><p><strong>Conclusions: </strong>Peer teaching in a non-institutionalized, exam-free environment shows considerable potential for promoting surgical identity in medical students. The results underscore the importance of voluntary, creative training formats to support motivation, competence development, and identity formation in surgery.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"11 3","pages":"141-149"},"PeriodicalIF":1.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroplasty for post-traumatic carpometacarpal joint (CMC) V osteoarthritis with minced cartilage: a case report.","authors":"Vincent März, Martynas Tamulevicius, Peter Maria Vogt, Frederik Schlottmann","doi":"10.1515/iss-2025-0013","DOIUrl":"10.1515/iss-2025-0013","url":null,"abstract":"<p><strong>Objectives: </strong>Fractures and dislocations of the bases of the fourth and fifth metacarpal bones are rare, accounting for <1 % of all hand injuries. If left untreated or inadequately fixed, there is a risk of persistent pain, functional impairment, and post-traumatic osteoarthritis. While common surgical approaches such as arthrodesis or suspension arthroplasty have been described, data on alternative treatment options remain limited.</p><p><strong>Case presentation: </strong>This case report presents the first documented use of minced cartilage for treating post-traumatic CMC V osteoarthritis. A 17-year-old patient experienced persistent pain following fracture fixation with K-wires. After debriding arthrotomy, cartilage was harvested from the hamate bone, minced, and combined with platelet rich plasma before implantation. One year postoperatively, the patient showed improved joint space, complete pain relief, and restored hand function.</p><p><strong>Conclusions: </strong>Preliminary results suggest that minced cartilage may offer a promising alternative, but further studies are needed to confirm its long-term efficacy.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"11 3","pages":"183-185"},"PeriodicalIF":1.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}