Innovative Surgical Sciences最新文献

{"title":"Ovarian lesions and tumors in infants and older children.","authors":"Henning C Fiegel,&nbsp;Stefan Gfroerer,&nbsp;Till-Martin Theilen,&nbsp;Florian Friedmacher,&nbsp;Udo Rolle","doi":"10.1515/iss-2021-0006","DOIUrl":"https://doi.org/10.1515/iss-2021-0006","url":null,"abstract":"<p><strong>Objectives: </strong>Ovarian lesions are rare but frequent in children. Patients could present with abdominal pain, but ovarian lesions could also be incidentally found on ultrasound. Awareness is required in cases with acute, severe lower abdominal pain, as ovarian torsion could be the cause. Other lesions can be cysts or benign or malignant ovarian tumors. Thus, the aim of this paper is to review typical ovarian lesions according to age, imaging and laboratory findings, and surgical management.</p><p><strong>Methods: </strong>We retrospectively analysed the patient charts of 39 patients aged 10.4 ± 6.1 years (from 3 months to 18 years) with ovarian lesions treated in our institution between 01/2009 and 08/2020. All clinical and pathological findings of infants and children operated on for ovarian lesions were included.</p><p><strong>Results: </strong>Ovarian lesions in children younger than 2 years of age were typically ovarian cysts, and ovarian tumors were not observed in this age group. In older children over 10 years of age, tumors were more common - with mostly teratoma or other germ cell tumors, followed by epithelial tumors. Moreover, acute or chronic ovarian torsion was observed in all age groups. In general, ovarian tumors were much larger in size than ovarian cysts or twisted ovaries and eventually showed tumor marker expression of AFP or ß-HCG. Simple ovarian cysts or twisted ovaries were smaller in size. Surgery for all ovarian lesions should aim to preserve healthy ovarian tissue by performing partial ovariectomy.</p><p><strong>Conclusions: </strong>In adolescent girls with acute abdominal pain, immediate laparoscopy should be performed to rule out ovarian torsion. Careful imaging evaluation and the assessment of tumor markers should be performed in painless ovarian lesions to indicate an adequate surgical ovarian-sparing approach.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":" ","pages":"173-179"},"PeriodicalIF":1.3,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40593035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparing the operating room for the Covid_19 patients","authors":"Leila Ebrahimi Sheikh Shabani, Iman Masoudi Cheleh Gahi, Samaneh Dehghan Abnavi","doi":"10.1515/iss-2021-0030","DOIUrl":"https://doi.org/10.1515/iss-2021-0030","url":null,"abstract":"In December 2019, a disease called corona virus was identified in Wuhan, China, which spread rapidly around the world. The disease was first reported from seafood in Wuhan [1]. This virus belongs to the family of betacoronaviruses, which are found in abundance in nature. This Issue Creates great challenges for the prevention and treatment of Covid_19 [2]. Despite the spread of corona virus, elective surgeries have been postponed, and emergency surgeries such as trauma, complex hernias are performed with changes during surgery, including wearing personal protective clothing, and so on [3]. The indication for emergency surgery during an outbreak of coronavirus is the same as before an epidemic, but a balance between treatment time and the protection status of the treatment team against the virus is essential. However, the short time in emergency surgeries does not allow us to take PCR tests from patients before surgery, so patients should be treated like Covid_19 [4]. Necessary surgeries are defined as surgeries that cannot be delayed for more than 8 weeks because they cause disease progression and irreversible consequences. It is clear that essential and semi-essential surgeries are not always possible. Each type of surgery should be classified according to guidelines and disease status [5]. Limiting the time of cancer treatment is one of the worst cases during the Covid_19 pandemic. Also it is undeniable and has irreparable consequences. Surgery should be delayed in cancer patients with low or no advanced mass [6]. The use of a special room and a separate anesthesia machine for the patient is necessary during the pandemic. If anesthesia requires medication during induction, the hands should be disinfected first and the gloves replaced. Personnel should remove their used gloves and disinfect their hands At the end of the surgery. Minimal equipment and tools should be used in the operating room and all equipment and tools used should not be taken out of the operating room and should be disposed of in a special container. It should be taken at least 1 h betweenpatients to disinfect surfaces and equipment. The operating room should be disinfected with hydrogen peroxide. In general, there is evidence that using of PPE canminimize the risk of disease transmission and protect personnel. In conclusion, health care workers are at high risk of contracting the coronavirus. Comprehensive infection control is essential to prevent this infection.","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"32 1","pages":"87 - 88"},"PeriodicalIF":1.3,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74054564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort study of the overall survival of patients with pancreatic cancer in a hospital of specialties of Quito-Ecuador in the period 2007–2017","authors":"Andrés Moreno Roca, L. Armijos Acurio, R. Jimbo Sotomayor, Carlos Céspedes Rivadeneira, Carlos Rosero Reyes, Carlos López Ayala","doi":"10.1515/iss-2020-0030","DOIUrl":"https://doi.org/10.1515/iss-2020-0030","url":null,"abstract":"Abstract Objectives Pancreatic cancers in most patients in Ecuador are diagnosed at an advanced stage of the disease, which is associated with lower survival. To determine the characteristics and global survival of pancreatic cancer patients in a social security hospital in Ecuador between 2007 and 2017. Methods A retrospective cohort study and a survival analysis were performed using all the available data in the electronic clinical records of patients with a diagnosis of pancreatic cancer in a Hospital of Specialties of Quito-Ecuador between 2007 and 2017. The included patients were those coded according to the ICD 10 between C25.0 and C25.9. Our univariate analysis calculated frequencies, measures of central tendency and dispersion. Through the Kaplan-Meier method we estimated the median time of survival and analyzed the difference in survival time among the different categories of our included variables. These differences were shown through the log rank test. Results A total of 357 patients diagnosed with pancreatic cancer between 2007 and 2017 were included in the study. More than two-thirds (69.9%) of the patients were diagnosed in late stages of the disease. The median survival time for all patients was of 4 months (P25: 2, P75: 8). Conclusions The statistically significant difference of survival time between types of treatment is the most relevant finding in this study, when comparing to all other types of treatments.","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"21 1","pages":"75 - 79"},"PeriodicalIF":1.3,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89854247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"German oncology certification system for colorectal cancer - relative survival rates of a single certified centre vs. national and international registry data.","authors":"Maximilian Richter,&nbsp;Lena Sonnow,&nbsp;Amir Mehdizadeh-Shrifi,&nbsp;Axel Richter,&nbsp;Rainer Koch,&nbsp;Alexander Zipprich","doi":"10.1515/iss-2021-0002","DOIUrl":"https://doi.org/10.1515/iss-2021-0002","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate how the certification of specialised Oncology Centres in Germany affects the relative survival of patients with colorectal cancer (CRC) by means of national and international comparison.</p><p><strong>Methods: </strong>Between 2007 and 2013, 675 patients with colorectal cancer, treated at the Hildesheim Hospital, an academic teaching hospital of the Hannover Medical School (MHH), were included. A follow-up of the entire patient group was performed until 2014. To obtain international data, a SEER-database search was done. The relative survival of 148,957 patients was compared to our data after 12, 36 and 60 months. For national survival data, we compared our rates with 41,988 patients of the Munich Cancer Registry (MCR).</p><p><strong>Results: </strong>Relative survival at our institution tends to be higher in advanced tumour stages compared to national and international cancer registry data. Nationally we found only little variation in survival rates for low stages CRC (UICC I and II), colon, and rectal cancer. There were notable variations regarding relative survival rates for advanced CRC tumour stages (UICC IV). These variations were even more distinct for rectal cancer after 12, 36 and 60 months (Hildesheim Hospital: 89.9, 40.3, 30.1%; Munich Cancer Registry (MCR): 65.4, 28.7, 16.6%). The international comparison of CRC showed significantly higher relative survival rates for patients with advanced tumour stages after 12 months at our institution (77 vs. 54.9% for UICC IV; raw p<0.001).</p><p><strong>Conclusions: </strong>Our findings suggest that patients with advanced tumour stages of CRC and especially rectal cancer benefit most from a multidisciplinary and guidelines-oriented treatment at Certified Oncology Centres. For a better evaluation of cancer treatment and improved national and international comparison, the creation of a centralised national cancer registry is necessary.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"67-73"},"PeriodicalIF":1.3,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2021-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and scientific advances in neurosurgery.","authors":"Gabriele Schackert,&nbsp;Tareq A Juratli","doi":"10.1515/iss-2021-2037","DOIUrl":"https://doi.org/10.1515/iss-2021-2037","url":null,"abstract":"This special issue is dedicated to clinical and scientific advances in neurosurgery. It provides insights in the broad spectrum of neurosurgery, spanning topics from the peripheral neuromodulation in paretic patients, to special aspects in the management of skull base tumors as well as advances in the treatment of the degenerative spine. Finally, an outlook on experimental immunotherapeutic strategies, explaining the principles of vaccine-based immunotherapy in brain tumors, is presented. Two original articles deal with recent advances in neurosurgical techniques. The spastic drop foot, caused after stroke or during the course of multiple sclerosis (MS), limits the patients’ quality of life in a significant dimension. Martin et al. present long-term results after implantation of the ActiGait system—an implantable peroneal nerve stimulation—at 36-month follow-up. The study includes 27 stroke and six multiple sclerosis patients. Selective electrical stimulation was applied to the fascicles of the peroneal nerve through a four-channel cuff electrode proximal to the knee joint, which contracts the ankle dorsiflexor and everter muscles followed by a balanced dorsiflexion of the foot. Patients have been assessed for gait endurance, speed, risk of fall and quality of life at baseline and 36 months following implantation. Most of the patients reported remarkable improvements of their walking abilities and especially of their daily quality of life. These results highlight the long-lasting effect of the ActiGait system as an effective treatment of the spastic drop foot. Thedegenerative spine disease is awidespreaddisease with an enormous impact on the professional, the economic, and the social life. Therefore, in the second original article we focused on innovations in spine surgery. Salchow-Gille et al. undertook a study, in which they evaluated software-based pre-surgical simulation effects on device selection and device development. Based on video-fluoroscopic motion recordings and pixel-precise processing of the segmental motion patterns, a softwarebased surrogate functionalmodelwas tested. 253 randomly selected patients, requiring single-level cervical or lumbar implant, were included in the study. Based on the described software-surrogate, the authors concluded that individualized devices might decelerate degeneration of adjacent segments by influencing the intersegmental communication of the motion segments and subsequently improve patient’s outcome. Tumor surgery is one of the main domains in neurosurgery. We selected for this issue the special problems in craniopharyngioma treatment, which combines several medical disciplines e.g. endocrinology, ophthalmology, and neurosurgery. As in all brain tumor surgeries, the preservation of the neurological functions is the primary goal. The special challenge in craniopharyngioma surgery is the additional preservation of endocrine and visual functions. Fujio et al. discuss in their original article two compe","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 1","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2021-2037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor visualization and fluorescence angiography with indocyanine green (ICG) in laparoscopic and robotic hepatobiliary surgery - valuation of early adopters from Germany.","authors":"Mareike Franz,&nbsp;Jörg Arend,&nbsp;Stefanie Wolff,&nbsp;Aristotelis Perrakis,&nbsp;Mirhasan Rahimli,&nbsp;Victor-Radu Negrini,&nbsp;Jessica Stockheim,&nbsp;Eric Lorenz,&nbsp;Roland Croner","doi":"10.1515/iss-2020-0019","DOIUrl":"https://doi.org/10.1515/iss-2020-0019","url":null,"abstract":"<p><strong>Objectives: </strong>Indocyanine green (ICG) is a fluorescent dye which was initially used for liver functional assessment. Moreover, it is of value for intraoperative visualization of liver segments and bile ducts or primary and secondary liver tumors. Especially in minimally invasive liver surgery, this is essential to enhance the precision of anatomical guided surgery and oncological quality. As early adopters of ICG implementation into laparoscopic and robotic-assisted liver surgery in Germany, we summarize the current recommendations and share our experiences.</p><p><strong>Methods: </strong>Actual strategies for ICG application in minimally invasive liver surgery were evaluated and summarized during a review of the literature. Experiences in patients who underwent laparoscopic or robotic-assisted liver surgery with intraoperative ICG staining between 2018 and 2020 from the Magdeburg registry for minimally invasive liver surgery (MD-MILS) were evaluated and the data were analyzed retrospectively.</p><p><strong>Results: </strong>ICG can be used to identify anatomical liver segments by fluorescence angiography via direct or indirect tissue staining. Fluorescence cholangiography visualizes the intra- and extrahepatic bile ducts. Primary and secondary liver tumors can be identified with a sensitivity of 69-100%. For this 0.5 mg/kg body weight ICG must be applicated intravenously 2-14 days prior to surgery. Within the MD-MILS we identified 18 patients which received ICG for intraoperative tumor staining of hepatocellular carcinoma (HCC), cholangiocarcinoma, peritoneal HCC metastases, adenoma, or colorectal liver metastases. The sensitivity for tumor staining was 100%. In 27.8% additional liver tumors were identified by ICG fluorescence. In 39% a false positive signal could be detected. This occurred mainly in cirrhotic livers.</p><p><strong>Conclusions: </strong>ICG staining is a simple and useful tool to assess individual hepatic anatomy or to detect tumors during minimally invasive liver surgery. It may enhance surgical precision and improve oncological quality. False-positive detection rates of liver tumors can be reduced by respecting the tumor entity and liver functional impairments.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"59-66"},"PeriodicalIF":1.3,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2020-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of scientific publication is Open Access, but needs diversity, equability and equality!","authors":"Joachim Jähne","doi":"10.1515/iss-2021-2038","DOIUrl":"10.1515/iss-2021-2038","url":null,"abstract":"","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"49-51"},"PeriodicalIF":1.3,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective surgical solutions in degenerative spine: spinal simulation for optimal choice of implant and targeted device development.","authors":"Monique Salchow-Gille,&nbsp;Bernhard Rieger,&nbsp;Clemens Reinshagen,&nbsp;Marek Molcanyi,&nbsp;Joschka Lemke,&nbsp;Uta Brautferger,&nbsp;Kerim Hakan Sitoci-Ficici,&nbsp;Witold Polanski,&nbsp;Thomas Pinzer,&nbsp;Gabriele Schackert","doi":"10.1515/iss-2019-1002","DOIUrl":"https://doi.org/10.1515/iss-2019-1002","url":null,"abstract":"<p><strong>Objectives: </strong>The most important goal of surgical treatment for spinal degeneration, in addition to eliminating the underlying pathology, is to preserve the biomechanically relevant structures. If degeneration destroys biomechanics, the single segment must either be surgically stabilized or functionally replaced by prosthetic restoration. This study examines how software-based presurgical simulation affects device selection and device development.</p><p><strong>Methods: </strong>Based on videofluoroscopic motion recordings and pixel-precise processing of the segmental motion patterns, a software-based surrogate functional model was validated. It characterizes the individual movement of spinal segments relative to corresponding cervical or lumbar spine sections. The single segment-based motion of cervical or lumbar spine of individual patients can be simulated, if size-calibrated functional X-rays of the relevant spine section are available. The software plug-in \"biokinemetric triangle\" has been then integrated into this software to perform comparative segmental motion analyses before and after treatment in two cervical device studies: the correlation of implant-induced changes in the movement geometry and patient-related outcome was examined to investigate, whether this surrogate model could provide a guideline for implant selection and future implant development.</p><p><strong>Results: </strong>For its validation in 253 randomly selected patients requiring single-level cervical (n=122) or lumbar (n=131) implant-supported restoration, the biokinemetric triangle provided significant pattern recognition in comparable investigations (p<0.05) and the software detected device-specific changes after implant-treatment (p<0.01). Subsequently, 104 patients, who underwent cervical discectomy, showed a correlation of the neck disability index with implant-specific changes in their segmental movement geometry: the preoperative simulation supported the best choice of surgical implants, since the best outcome resulted from restricting the extent of the movement of adjacent segments influenced by the technical mechanism of the respective device (p<0.05).</p><p><strong>Conclusions: </strong>The implant restoration resulted in best outcome which modified intersegmental communication in a way that the segments adjacent to the implanted segment undergo less change in their own movement geometry. Based on our software-surrogate, individualized devices could be created that slow down further degeneration of adjacent segments by influencing the intersegmental communication of the motion segments.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 1","pages":"11-24"},"PeriodicalIF":1.3,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2019-1002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39771828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic negative pressure therapy (ENPT) of a spontaneous oesophageal rupture (Boerhaave's syndrome) with peritonitis - a new treatment option.","authors":"Gunnar Loske,&nbsp;Katrin Albers,&nbsp;Christian T Mueller","doi":"10.1515/iss-2020-0043","DOIUrl":"https://doi.org/10.1515/iss-2020-0043","url":null,"abstract":"<p><strong>Objectives: </strong>Boerhaave's syndrome is a life-threatening disease with high mortality and morbidity. Endoscopic negative pressure therapy (ENPT) can be used to treat oesophageal perforations.</p><p><strong>Case presentation: </strong>We report on a case of oesophageal rupture with peritonitis in a 35-year-old male patient. The start of treatment was 11 h after the perforation event. The treatment of the perforation defect was performed exclusively by intraluminal ENPT, the treatment of peritonitis was performed by laparotomy with abdominal lavage. For ENPT we used two different types of open-pore drains. The first treatment cycle of four days was performed with an open-pored polyurethane foam drainage (OPD), which was placed intraluminal to cover the perforation defect and to empty the stomach permanently. The second treatment cycle of nine days was performed with a thin nasogastric tube like double-lumen open-pored film drainage (OFD). For suction OPD and OFD were connected with an electronic vacuum pump (-125 mmHg). OFD enables active gastric emptying with simultaneous intestinal feeding via an integrated feeding tube. Intraluminal ENPT with a total treatment duration of 13 days was able to achieve the complete healing of the defect. Surgical treatment of the perforation defect was not necessary. The patient was discharged 20 days after initial treatment with a non-irritating abdominal wound and a closed perforation.</p><p><strong>Conclusions: </strong>In suitable cases, endoscopic negative pressure therapy is a minimally invasive, organ-preserving procedure for the treatment of spontaneous oesophageal rupture.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"81-86"},"PeriodicalIF":1.3,"publicationDate":"2021-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2020-0043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of immune checkpoint blockade and vaccine-based immunotherapy for glioblastoma","authors":"Stefanie Tietze, Susanne Michen, G. Schackert, A. Temme","doi":"10.1515/iss-2020-0034","DOIUrl":"https://doi.org/10.1515/iss-2020-0034","url":null,"abstract":"Abstract Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor endowed with a dismal prognosis. Nowadays, immunotherapy in a particular immune checkpoint blockade and therapeutic vaccines are being extensively pursued. Yet, several characteristics of GBM may impact such immunotherapeutic approaches. This includes tumor heterogeneity, the relatively low mutational load of primary GBM, insufficient delivery of antibodies to tumor parenchyma and the unique immunosuppressive microenvironment of GBM. Moreover, standard treatment of GBM, comprising temozolomide chemotherapy, radiotherapy and in most instances the application of glucocorticoids for management of brain edema, results in a further increased immunosuppression. This review will provide a brief introduction to the principles of vaccine-based immunotherapy and give an overview of the current clinical studies, which employed immune checkpoint inhibitors, oncolytic viruses-based vaccination, cell-based and peptide-based vaccines. Recent experiences as well as the latest developments are reviewed. Overcoming obstacles, which limit the induction and long-term immune response against GBM when using vaccination approaches, are necessary for the implementation of effective immunotherapy of GBM.","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"34 1","pages":"35 - 48"},"PeriodicalIF":1.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81984387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}