Innovative Surgical Sciences最新文献

{"title":"German oncology certification system for colorectal cancer - relative survival rates of a single certified centre vs. national and international registry data.","authors":"Maximilian Richter,&nbsp;Lena Sonnow,&nbsp;Amir Mehdizadeh-Shrifi,&nbsp;Axel Richter,&nbsp;Rainer Koch,&nbsp;Alexander Zipprich","doi":"10.1515/iss-2021-0002","DOIUrl":"https://doi.org/10.1515/iss-2021-0002","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate how the certification of specialised Oncology Centres in Germany affects the relative survival of patients with colorectal cancer (CRC) by means of national and international comparison.</p><p><strong>Methods: </strong>Between 2007 and 2013, 675 patients with colorectal cancer, treated at the Hildesheim Hospital, an academic teaching hospital of the Hannover Medical School (MHH), were included. A follow-up of the entire patient group was performed until 2014. To obtain international data, a SEER-database search was done. The relative survival of 148,957 patients was compared to our data after 12, 36 and 60 months. For national survival data, we compared our rates with 41,988 patients of the Munich Cancer Registry (MCR).</p><p><strong>Results: </strong>Relative survival at our institution tends to be higher in advanced tumour stages compared to national and international cancer registry data. Nationally we found only little variation in survival rates for low stages CRC (UICC I and II), colon, and rectal cancer. There were notable variations regarding relative survival rates for advanced CRC tumour stages (UICC IV). These variations were even more distinct for rectal cancer after 12, 36 and 60 months (Hildesheim Hospital: 89.9, 40.3, 30.1%; Munich Cancer Registry (MCR): 65.4, 28.7, 16.6%). The international comparison of CRC showed significantly higher relative survival rates for patients with advanced tumour stages after 12 months at our institution (77 vs. 54.9% for UICC IV; raw p<0.001).</p><p><strong>Conclusions: </strong>Our findings suggest that patients with advanced tumour stages of CRC and especially rectal cancer benefit most from a multidisciplinary and guidelines-oriented treatment at Certified Oncology Centres. For a better evaluation of cancer treatment and improved national and international comparison, the creation of a centralised national cancer registry is necessary.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"67-73"},"PeriodicalIF":1.3,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2021-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and scientific advances in neurosurgery.","authors":"Gabriele Schackert,&nbsp;Tareq A Juratli","doi":"10.1515/iss-2021-2037","DOIUrl":"https://doi.org/10.1515/iss-2021-2037","url":null,"abstract":"This special issue is dedicated to clinical and scientific advances in neurosurgery. It provides insights in the broad spectrum of neurosurgery, spanning topics from the peripheral neuromodulation in paretic patients, to special aspects in the management of skull base tumors as well as advances in the treatment of the degenerative spine. Finally, an outlook on experimental immunotherapeutic strategies, explaining the principles of vaccine-based immunotherapy in brain tumors, is presented. Two original articles deal with recent advances in neurosurgical techniques. The spastic drop foot, caused after stroke or during the course of multiple sclerosis (MS), limits the patients’ quality of life in a significant dimension. Martin et al. present long-term results after implantation of the ActiGait system—an implantable peroneal nerve stimulation—at 36-month follow-up. The study includes 27 stroke and six multiple sclerosis patients. Selective electrical stimulation was applied to the fascicles of the peroneal nerve through a four-channel cuff electrode proximal to the knee joint, which contracts the ankle dorsiflexor and everter muscles followed by a balanced dorsiflexion of the foot. Patients have been assessed for gait endurance, speed, risk of fall and quality of life at baseline and 36 months following implantation. Most of the patients reported remarkable improvements of their walking abilities and especially of their daily quality of life. These results highlight the long-lasting effect of the ActiGait system as an effective treatment of the spastic drop foot. Thedegenerative spine disease is awidespreaddisease with an enormous impact on the professional, the economic, and the social life. Therefore, in the second original article we focused on innovations in spine surgery. Salchow-Gille et al. undertook a study, in which they evaluated software-based pre-surgical simulation effects on device selection and device development. Based on video-fluoroscopic motion recordings and pixel-precise processing of the segmental motion patterns, a softwarebased surrogate functionalmodelwas tested. 253 randomly selected patients, requiring single-level cervical or lumbar implant, were included in the study. Based on the described software-surrogate, the authors concluded that individualized devices might decelerate degeneration of adjacent segments by influencing the intersegmental communication of the motion segments and subsequently improve patient’s outcome. Tumor surgery is one of the main domains in neurosurgery. We selected for this issue the special problems in craniopharyngioma treatment, which combines several medical disciplines e.g. endocrinology, ophthalmology, and neurosurgery. As in all brain tumor surgeries, the preservation of the neurological functions is the primary goal. The special challenge in craniopharyngioma surgery is the additional preservation of endocrine and visual functions. Fujio et al. discuss in their original article two compe","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 1","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2021-2037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor visualization and fluorescence angiography with indocyanine green (ICG) in laparoscopic and robotic hepatobiliary surgery - valuation of early adopters from Germany.","authors":"Mareike Franz,&nbsp;Jörg Arend,&nbsp;Stefanie Wolff,&nbsp;Aristotelis Perrakis,&nbsp;Mirhasan Rahimli,&nbsp;Victor-Radu Negrini,&nbsp;Jessica Stockheim,&nbsp;Eric Lorenz,&nbsp;Roland Croner","doi":"10.1515/iss-2020-0019","DOIUrl":"https://doi.org/10.1515/iss-2020-0019","url":null,"abstract":"<p><strong>Objectives: </strong>Indocyanine green (ICG) is a fluorescent dye which was initially used for liver functional assessment. Moreover, it is of value for intraoperative visualization of liver segments and bile ducts or primary and secondary liver tumors. Especially in minimally invasive liver surgery, this is essential to enhance the precision of anatomical guided surgery and oncological quality. As early adopters of ICG implementation into laparoscopic and robotic-assisted liver surgery in Germany, we summarize the current recommendations and share our experiences.</p><p><strong>Methods: </strong>Actual strategies for ICG application in minimally invasive liver surgery were evaluated and summarized during a review of the literature. Experiences in patients who underwent laparoscopic or robotic-assisted liver surgery with intraoperative ICG staining between 2018 and 2020 from the Magdeburg registry for minimally invasive liver surgery (MD-MILS) were evaluated and the data were analyzed retrospectively.</p><p><strong>Results: </strong>ICG can be used to identify anatomical liver segments by fluorescence angiography via direct or indirect tissue staining. Fluorescence cholangiography visualizes the intra- and extrahepatic bile ducts. Primary and secondary liver tumors can be identified with a sensitivity of 69-100%. For this 0.5 mg/kg body weight ICG must be applicated intravenously 2-14 days prior to surgery. Within the MD-MILS we identified 18 patients which received ICG for intraoperative tumor staining of hepatocellular carcinoma (HCC), cholangiocarcinoma, peritoneal HCC metastases, adenoma, or colorectal liver metastases. The sensitivity for tumor staining was 100%. In 27.8% additional liver tumors were identified by ICG fluorescence. In 39% a false positive signal could be detected. This occurred mainly in cirrhotic livers.</p><p><strong>Conclusions: </strong>ICG staining is a simple and useful tool to assess individual hepatic anatomy or to detect tumors during minimally invasive liver surgery. It may enhance surgical precision and improve oncological quality. False-positive detection rates of liver tumors can be reduced by respecting the tumor entity and liver functional impairments.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"59-66"},"PeriodicalIF":1.3,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2020-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of scientific publication is Open Access, but needs diversity, equability and equality!","authors":"Joachim Jähne","doi":"10.1515/iss-2021-2038","DOIUrl":"10.1515/iss-2021-2038","url":null,"abstract":"","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"49-51"},"PeriodicalIF":1.3,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective surgical solutions in degenerative spine: spinal simulation for optimal choice of implant and targeted device development.","authors":"Monique Salchow-Gille,&nbsp;Bernhard Rieger,&nbsp;Clemens Reinshagen,&nbsp;Marek Molcanyi,&nbsp;Joschka Lemke,&nbsp;Uta Brautferger,&nbsp;Kerim Hakan Sitoci-Ficici,&nbsp;Witold Polanski,&nbsp;Thomas Pinzer,&nbsp;Gabriele Schackert","doi":"10.1515/iss-2019-1002","DOIUrl":"https://doi.org/10.1515/iss-2019-1002","url":null,"abstract":"<p><strong>Objectives: </strong>The most important goal of surgical treatment for spinal degeneration, in addition to eliminating the underlying pathology, is to preserve the biomechanically relevant structures. If degeneration destroys biomechanics, the single segment must either be surgically stabilized or functionally replaced by prosthetic restoration. This study examines how software-based presurgical simulation affects device selection and device development.</p><p><strong>Methods: </strong>Based on videofluoroscopic motion recordings and pixel-precise processing of the segmental motion patterns, a software-based surrogate functional model was validated. It characterizes the individual movement of spinal segments relative to corresponding cervical or lumbar spine sections. The single segment-based motion of cervical or lumbar spine of individual patients can be simulated, if size-calibrated functional X-rays of the relevant spine section are available. The software plug-in \"biokinemetric triangle\" has been then integrated into this software to perform comparative segmental motion analyses before and after treatment in two cervical device studies: the correlation of implant-induced changes in the movement geometry and patient-related outcome was examined to investigate, whether this surrogate model could provide a guideline for implant selection and future implant development.</p><p><strong>Results: </strong>For its validation in 253 randomly selected patients requiring single-level cervical (n=122) or lumbar (n=131) implant-supported restoration, the biokinemetric triangle provided significant pattern recognition in comparable investigations (p<0.05) and the software detected device-specific changes after implant-treatment (p<0.01). Subsequently, 104 patients, who underwent cervical discectomy, showed a correlation of the neck disability index with implant-specific changes in their segmental movement geometry: the preoperative simulation supported the best choice of surgical implants, since the best outcome resulted from restricting the extent of the movement of adjacent segments influenced by the technical mechanism of the respective device (p<0.05).</p><p><strong>Conclusions: </strong>The implant restoration resulted in best outcome which modified intersegmental communication in a way that the segments adjacent to the implanted segment undergo less change in their own movement geometry. Based on our software-surrogate, individualized devices could be created that slow down further degeneration of adjacent segments by influencing the intersegmental communication of the motion segments.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 1","pages":"11-24"},"PeriodicalIF":1.3,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2019-1002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39771828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic negative pressure therapy (ENPT) of a spontaneous oesophageal rupture (Boerhaave's syndrome) with peritonitis - a new treatment option.","authors":"Gunnar Loske,&nbsp;Katrin Albers,&nbsp;Christian T Mueller","doi":"10.1515/iss-2020-0043","DOIUrl":"https://doi.org/10.1515/iss-2020-0043","url":null,"abstract":"<p><strong>Objectives: </strong>Boerhaave's syndrome is a life-threatening disease with high mortality and morbidity. Endoscopic negative pressure therapy (ENPT) can be used to treat oesophageal perforations.</p><p><strong>Case presentation: </strong>We report on a case of oesophageal rupture with peritonitis in a 35-year-old male patient. The start of treatment was 11 h after the perforation event. The treatment of the perforation defect was performed exclusively by intraluminal ENPT, the treatment of peritonitis was performed by laparotomy with abdominal lavage. For ENPT we used two different types of open-pore drains. The first treatment cycle of four days was performed with an open-pored polyurethane foam drainage (OPD), which was placed intraluminal to cover the perforation defect and to empty the stomach permanently. The second treatment cycle of nine days was performed with a thin nasogastric tube like double-lumen open-pored film drainage (OFD). For suction OPD and OFD were connected with an electronic vacuum pump (-125 mmHg). OFD enables active gastric emptying with simultaneous intestinal feeding via an integrated feeding tube. Intraluminal ENPT with a total treatment duration of 13 days was able to achieve the complete healing of the defect. Surgical treatment of the perforation defect was not necessary. The patient was discharged 20 days after initial treatment with a non-irritating abdominal wound and a closed perforation.</p><p><strong>Conclusions: </strong>In suitable cases, endoscopic negative pressure therapy is a minimally invasive, organ-preserving procedure for the treatment of spontaneous oesophageal rupture.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 2","pages":"81-86"},"PeriodicalIF":1.3,"publicationDate":"2021-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2020-0043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of immune checkpoint blockade and vaccine-based immunotherapy for glioblastoma","authors":"Stefanie Tietze, Susanne Michen, G. Schackert, A. Temme","doi":"10.1515/iss-2020-0034","DOIUrl":"https://doi.org/10.1515/iss-2020-0034","url":null,"abstract":"Abstract Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor endowed with a dismal prognosis. Nowadays, immunotherapy in a particular immune checkpoint blockade and therapeutic vaccines are being extensively pursued. Yet, several characteristics of GBM may impact such immunotherapeutic approaches. This includes tumor heterogeneity, the relatively low mutational load of primary GBM, insufficient delivery of antibodies to tumor parenchyma and the unique immunosuppressive microenvironment of GBM. Moreover, standard treatment of GBM, comprising temozolomide chemotherapy, radiotherapy and in most instances the application of glucocorticoids for management of brain edema, results in a further increased immunosuppression. This review will provide a brief introduction to the principles of vaccine-based immunotherapy and give an overview of the current clinical studies, which employed immune checkpoint inhibitors, oncolytic viruses-based vaccination, cell-based and peptide-based vaccines. Recent experiences as well as the latest developments are reviewed. Overcoming obstacles, which limit the induction and long-term immune response against GBM when using vaccination approaches, are necessary for the implementation of effective immunotherapy of GBM.","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"34 1","pages":"35 - 48"},"PeriodicalIF":1.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81984387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune response in glioma's microenvironment.","authors":"Houminji Chen,&nbsp;Ming Li,&nbsp;Yanwu Guo,&nbsp;Yongsheng Zhong,&nbsp;Zhuoyi He,&nbsp;Yuting Xu,&nbsp;Junjie Zou","doi":"10.1515/iss-2019-0001","DOIUrl":"https://doi.org/10.1515/iss-2019-0001","url":null,"abstract":"<p><strong>Objectives: </strong>Glioma is the most common tumor of the central nervous system. In this review, we outline the immunobiological factors that interact with glioma cells and tumor microenvironment (TME), providing more potential targets for clinical inhibition of glioma development and more directions for glioma treatment.</p><p><strong>Content: </strong>Recent studies have shown that glioma cells secrete a variety of immune regulatory factors and interact with immune cells such as microglial cells, peripheral macrophages, myeloid-derived suppressor cells (MDSCs), and T lymphocytes in the TME. In particular, microglia plays a key role in promoting glioma growth. Infiltrating immune cells induce local production of cytokines, chemokines and growth factors. Further leads to immune escape of malignant gliomas.</p><p><strong>Summary and outlook: </strong>The complex interaction of tumor cells with the TME has largely contributed to tumor heterogeneity and poor prognosis. We review the immunobiological factors, immune cells and current immunotherapy of gliomas, provide experimental evidence for future research and treatment of gliomas.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"5 3-4","pages":"20190001"},"PeriodicalIF":1.3,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2019-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38872723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary renal Ewing's sarcoma in an adult: an enigma.","authors":"Suvraraj Das,&nbsp;Gaurav Aggarwal,&nbsp;Sujoy Gupta,&nbsp;Divya Midha","doi":"10.1515/iss-2020-0022","DOIUrl":"https://doi.org/10.1515/iss-2020-0022","url":null,"abstract":"<p><strong>Objectives: </strong>Extraskeletal Ewing's sarcoma is a rarity, with a renal primary in an adult, being even rarer. There is no consensus on the optimal imaging modality, as well as best therapeutic option, making them an enigma for clinicians.</p><p><strong>Case presentation: </strong>We report the case of a 34-year-old lady, a known case of invasive lobular carcinoma of the left breast (ER,PR positive, Her2neu negative), having completed treatment in 2017, wherein, on an ultrasound evaluation for left flank pain, was incidentally found to have a left renal mass. A CT scan corroborated with the ultrasound, with an additional Level 1, left renal vein thrombus. She underwent an open left radical nephrectomy with renal vein thrombectomy. Histopathology of the resected tumor revealed features of Ewing's sarcoma of the kidney, confirmed by Fluorescent In Situ Hybridisation (FISH) and Immunohistochemistry (IHC).</p><p><strong>Conclusion: </strong>Primary renal Ewing's sarcoma in an adult is a rare occurrence, with no characteristic imaging features, and no universally accepted guideline based management protocols. Akin with standard Ewings sarcoma treatment strategies, a margin negative- radical nephrectomy with adjuvant chemotherapy, seems the most apt treatment strategy.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 1","pages":"20200022"},"PeriodicalIF":1.3,"publicationDate":"2021-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2020-0022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38868821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term results following electrical stimulation of the peroneal nerve using the ActiGait® system in 33 patients with central drop foot.","authors":"Daniel Martin,&nbsp;Andrei Patriciu,&nbsp;Anne-Kathrin Schulz,&nbsp;Gabriele Schackert","doi":"10.1515/iss-2019-1003","DOIUrl":"https://doi.org/10.1515/iss-2019-1003","url":null,"abstract":"<p><strong>Objective: </strong>Direct electrical stimulation of the peroneal nerve, using the implantable ActiGait® system, enables a therapy of the centrally caused drop foot, to improve the gait of the patients. In this paper, we present long-term results at 36-month follow-up post implantation.</p><p><strong>Method: </strong>A total of 33 patients, 27 stroke and six multiple sclerosis (MS) patients, suffering from spastic drop foot were implanted in our center and assessed in terms of gait endurance, speed, risk of fall, and life quality at baseline and 36 months following implantation.</p><p><strong>Results: </strong>The six min gait endurance test increased significantly from 202 ± 41 m without walking aids to 380 ± 30 m (p=0.038), while using the implant. Moreover, the time in the gait speed measured over 20 m decreased from 31.8 ± 10.2 s without to 18.5 ± 4.6 s by using the ActiGait® system (p=0.039). Similarly, gait steadiness, measured by the Timed Up and Go (TUG) test improved by 36.6%, with patients demonstrating a reduced time from 18.6 ± 5.5 to 11.2 ±  3.8 s (p=0.041) upon implant activation. Most importantly, 31 of 33 patients reported remarkable improvements of their quality of life following direct electrical nerve stimulation.</p><p><strong>Conclusion: </strong>Our findings confirm previously published efficacy data at 12 months after implantation and underline the long-lasting effect of the ActiGait® system.</p>","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":"6 1","pages":"20191003"},"PeriodicalIF":1.3,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/iss-2019-1003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38868820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}