Clinical Medicine Insights-Reproductive Health最新文献_第5页

Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment. 补充辅酶Q10和接受IVF-ICSI治疗的妇女的卵母细胞非整倍体。

Clinical Medicine Insights-Reproductive Health Pub Date : 2014-06-08 eCollection Date: 2014-01-01 DOI: 10.4137/CMRH.S14681

Yaakov Bentov, Thomas Hannam, Andrea Jurisicova, Navid Esfandiari, Robert F Casper

{"title":"Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment.","authors":"Yaakov Bentov, Thomas Hannam, Andrea Jurisicova, Navid Esfandiari, Robert F Casper","doi":"10.4137/CMRH.S14681","DOIUrl":"https://doi.org/10.4137/CMRH.S14681","url":null,"abstract":"Background: The age-related reduction in live-birth rate is attributed to a high rate of aneuploidy and follicle depletion. We showed in an animal model that treatment with Coenzyme Q10 (CoQ10) markedly improved reproductive outcome. The aim of this study was to compare the post-meiotic oocyte aneuploidy rate in in vitro fertilization (IVF) and intra cytoplasmic sperm injection (ICSI) patients treated with CoQ10 or placebo.Methods: We conducted a double blind placebo controlled randomized trial that included IVF-ICSI patients 35-43 years of age. The patients were treated with either 600 mg of CoQ10 or an equivalent number of placebo caps. We compared the post-meiotic aneuploidy rate using polar body biopsy (PBBX) and comparative genomic hybridization (CGH). According to the power calculation, 27 patients were needed for each arm.Results: Owing to safety concerns regarding the effects of polar body biopsy on embryo quality and implantation, the study was terminated before reaching the target number of participants. A total of 39 patients were evaluated and randomized (17 CoQ10, 22 placebo), 27 were given the study medication (12 CoQ10, 15 placebo), and 24 completed an IVF-ICSI cycle including PBBX and embryo transfer (10 CoQ10, 14 placebo). Average age, base line follicle stimulating hormone (FSH), peak estradiol and progesterone serum level, as well as the total number of human menopausal gonadotropin (hMG) units-did not differ between the groups. The rate of aneuploidy was 46.5% in the CoQ10 group compared to 62.8% in the control. Clinical pregnancy rate was 33% for the CoQ10 group and 26.7% for the control group.Conclusion: No significant differences in outcome were detected between the CoQ10 and placebo groups. However, the final study was underpowered to detect a difference in the rate of aneuploidy.","PeriodicalId":44130,"journal":{"name":"Clinical Medicine Insights-Reproductive Health","volume":"8 ","pages":"31-6"},"PeriodicalIF":0.0,"publicationDate":"2014-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMRH.S14681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32474347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 89

Management of Vaginal Atrophy: Implications from the REVIVE Survey. 阴道萎缩的处理:来自REVIVE调查的启示。

Clinical Medicine Insights-Reproductive Health Pub Date : 2014-06-08 eCollection Date: 2014-01-01 DOI: 10.4137/CMRH.S14498

Susan Wysocki, Sheryl Kingsberg, Michael Krychman

引用次数: 68

Selective inhibition of steroidogenic enzymes by ketoconazole in rat ovary cells. 酮康唑对大鼠卵巢细胞甾体生成酶的选择性抑制作用。

Clinical Medicine Insights-Reproductive Health Pub Date : 2014-02-17 eCollection Date: 2014-01-01 DOI: 10.4137/CMRH.S14036

Michael Gal, Joseph Orly

{"title":"Selective inhibition of steroidogenic enzymes by ketoconazole in rat ovary cells.","authors":"Michael Gal, Joseph Orly","doi":"10.4137/CMRH.S14036","DOIUrl":"https://doi.org/10.4137/CMRH.S14036","url":null,"abstract":"Objective: Ketoconazole (KCZ) is an anti-fungal agent extensively used for clinical applications related to its inhibitory effects on adrenal and testicular steroidogenesis. Much less information is available on the effects of KCZ on synthesis of steroid hormones in the ovary. The present study aimed to characterize the in situ effects of KCZ on steroidogenic enzymes in primary rat ovary cells.Methods: Following the induction of folliculogenesis in gonadotropin treated rats, freshly prepared ovarian cells were incubated in suspension for up to four hours while radiolabeled steroid substrates were added and time dependent generation of their metabolic products was analyzed by thin layer chromatography (TLC).Results: KCZ inhibits the P450 steroidogenic enzymes in a selective and dose dependent manner, including cholesterol side-chain cleavage cytochrome P450 (CYP11A1/P450scc), the 17α-hydroxylase activity of CYP17A1/P450c17, and CYP19A1/P450arom, with IC50 values of 0.3, 1.8, and 0.3 μg/mL (0.56, 3.36, and 0.56 μM), respectively. Unaffected by KCZ, at 10 μg/mL, were the 17,20 lyase activity of CYP17A1, as well as five non-cytochrome steroidogenic enzymes including 3β-hydroxysteroid dehydrogenase-Δ(5-4) isomerase type 1 (3βHSD1), 5α-reductase, 20α-hydroxysteroid dehydrogenase (20α-HSD), 3α-hydroxysteroid dehydrogenase (3α-HSD), and 17β-hydroxysteroid dehydrogenase type 1 (17HSD1).Conclusion: These findings map the effects of KCZ on the ovarian pathways of progestin, androgen, and estrogen synthesis. Hence, the drug may have a potential use as an acute and reversible modulator of ovarian steroidogenesis in pathological circumstances.","PeriodicalId":44130,"journal":{"name":"Clinical Medicine Insights-Reproductive Health","volume":"8 ","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2014-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMRH.S14036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32327652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Educational effects of a tailored leaflet addressing drinking during pregnancy. 针对怀孕期间饮酒的量身定制传单的教育效果。

Clinical Medicine Insights-Reproductive Health Pub Date : 2014-01-13 eCollection Date: 2014-01-01 DOI: 10.4137/CMRH.S13461

Natsumi Toyama, Noriko Sudo

{"title":"Educational effects of a tailored leaflet addressing drinking during pregnancy.","authors":"Natsumi Toyama, Noriko Sudo","doi":"10.4137/CMRH.S13461","DOIUrl":"https://doi.org/10.4137/CMRH.S13461","url":null,"abstract":"Objective: To examine the educational effects of a tailored leaflet on current drinking behavior, thoughts about drinking alcohol during pregnancy, and knowledge of fetal alcohol syndrome (FAS) among pregnant women.Design: Intervention.Participants: We recruited pregnant women who were participating in maternity classes held at five municipal health centers in Saitama Prefecture and Tokyo in Japan.Methods: Questionnaires were administered before and after distribution of either a tailored or a non-tailored leaflet and again after the women delivered their babies.Results: More women read the non-tailored leaflet than the tailored one; this was because they felt they could read the non-tailored leaflet immediately. As for educational effects, the tailored leaflet was not superior to the non-tailored one in changing the women's behavior, thoughts, or knowledge.Conclusion: It is more important for health education leaflets to seem easy to read in terms of volume than to be tailored.","PeriodicalId":44130,"journal":{"name":"Clinical Medicine Insights-Reproductive Health","volume":"8 ","pages":"5-14"},"PeriodicalIF":0.0,"publicationDate":"2014-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMRH.S13461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32327651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A rare case of chronic ectopic pregnancy presenting as large hematosalpinx. 慢性异位妊娠表现为大输卵管血的罕见病例。

Clinical Medicine Insights-Reproductive Health Pub Date : 2014-01-06 eCollection Date: 2014-01-01 DOI: 10.4137/CMRH.S13110

Madhavi Nacharaju, Venkata Sujatha Vellanki, Sarath Babu Gillellamudi, Vamsi Krishna Kotha, Abhinaya Alluri

{"title":"A rare case of chronic ectopic pregnancy presenting as large hematosalpinx.","authors":"Madhavi Nacharaju, Venkata Sujatha Vellanki, Sarath Babu Gillellamudi, Vamsi Krishna Kotha, Abhinaya Alluri","doi":"10.4137/CMRH.S13110","DOIUrl":"https://doi.org/10.4137/CMRH.S13110","url":null,"abstract":"Ectopic pregnancy is defined as implantation and subsequent development of an embryo outside the uterine lining. It has wide range of presentation from acute hemoperitoneum to chronic ectopic pregnancy. This is an unusual case of chronic ectopic pregnancy with large hematosalpinx without classical symptoms. A 22-year-old South Indian woman reported to the outpatient clinic with irregular spotting for a duration of 2 months which was not associated with pain. There was no preceding amenorrhea and previous menstrual cycles were regular. Clinically, the patient was hemodynamically stable but severely anemic. The abdomen was soft on palpation, cervical movements were not tender, and human chorionic gonadotropin was absent in the urine. Ultrasound revealed a complex adnexal mass. Magnetic resonance imaging (MRI) revealed a large hematosalpinx. Laparoscopic left salpingectomy was conducted and histopathology confirmed ectopic pregnancy. Ectopic pregnancy presents diagnostic dilemmas in the absence of classical symptoms. MRI and laparoscopy are important tools in such a diagnostic dilemma. ","PeriodicalId":44130,"journal":{"name":"Clinical Medicine Insights-Reproductive Health","volume":"8 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2014-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMRH.S13110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32327650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Live birth from previously vitrified oocytes, after trophectoderm biopsy, revitrification, and transfer of a euploid blastocyst. 经滋养外胚层活检、再玻璃化和整倍体囊胚移植后，由先前玻璃化的卵母细胞活产。

Clinical Medicine Insights-Reproductive Health Pub Date : 2013-09-10 DOI: 10.4137/CMRH.S11919

Jamie A Grifo, Brooke Hodes-Wertz, Hsiao Ling Lee, Esmeralda Ampeloquio, Melicia Clarke-Williams, Alexis Adler, Santiago Munné, Alan S Berkeley

引用次数: 4

Robotics in Gynecology: Why is this Technology Worth Pursuing? 妇科机器人:为什么这项技术值得追求?

Clinical Medicine Insights-Reproductive Health Pub Date : 2013-07-24 DOI: 10.4137/CMRH.S10850

Rodrigo Ayala-Yáñez, Emilio José Olaya-Guzmán, Javier Haghenbeck-Altamirano

{"title":"Robotics in Gynecology: Why is this Technology Worth Pursuing?","authors":"Rodrigo Ayala-Yáñez, Emilio José Olaya-Guzmán, Javier Haghenbeck-Altamirano","doi":"10.4137/CMRH.S10850","DOIUrl":"https://doi.org/10.4137/CMRH.S10850","url":null,"abstract":"Robotic laparoscopy in gynecology, which started in 2005 when the Da Vinci Surgical System (Intuitive Surgical Inc) was approved by the US Food and Drug Administration for use in gynecologic procedures, represents today a modern, safe, and precise approach to pathology in this field. Since then, a great deal of experience has accumulated, and it has been shown that there is almost no gynecological surgery that cannot be approached with this technology, namely hysterectomy, myomectomy, sacrocolpopexia, and surgery for the treatment of endometriosis. Albeit no advantages have been observed over conventional laparoscopy and some open surgical procedures, robotics do seem to be advantageous in highly complicated procedures when extensive dissection and proper anatomy reestablishment is required, as in the case of oncologic surgery. There is no doubt that implementation of better logistics in finance, training, design, and application will exert a positive effect upon robotics expansion in gynecological medicine. Contrary to expectations, we estimate that a special impact is to be seen in emerging countries where novel technologies have resulted in benefits in the organization of health care systems. ","PeriodicalId":44130,"journal":{"name":"Clinical Medicine Insights-Reproductive Health","volume":"7 ","pages":"71-7"},"PeriodicalIF":0.0,"publicationDate":"2013-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMRH.S10850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32054756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Fertility preservation options after gonadotoxic chemotherapy. 促性腺毒素化疗后的生育能力保存选择。

Clinical Medicine Insights-Reproductive Health Pub Date : 2013-04-25 DOI: 10.4137/CMRH.S10848

Jordana Hadassah Hyman, Togas Tulandi

引用次数: 28

Fertility preservation in gynecological cancers. 妇科癌症患者的生育保护。

Clinical Medicine Insights-Reproductive Health Pub Date : 2013-03-21 DOI: 10.4137/CMRH.S10794

Shakuntala Chhabra, Imran Kutchi

{"title":"Fertility preservation in gynecological cancers.","authors":"Shakuntala Chhabra, Imran Kutchi","doi":"10.4137/CMRH.S10794","DOIUrl":"10.4137/CMRH.S10794","url":null,"abstract":"For cancers of reproductive system in women, fertility preservation is complex. Fertility is also affected by therapies, however prevention is possible. Radiotherapy affects gonads, uterus, and subsequent pregnancy outcomes in all ages. However, degree and damage depend on dose, irradiation field, and age at the time of exposure. Ovarian transposition is considered if ovarian involvement is unlikely. Gonadotoxic effects of chemotherapy are related to agent's type, cumulative doses, age, and ovarian reserve. Some agents are highly toxic. Rendering follicular development quiescent by suppression of gonadotropins does reduce the ovarian damage. Simple or radical trachelectomy can be used in early cervical cancer. Fertility saving surgery is possible only in early stage low grade epithelial cancers of the ovary, however, in germ cell tumors even in advanced stages it may be possible to preserve fertility. There are no standard recommendations for endometrial cancer. Embryo, oocyte, and ovarian tissue cryopreservation are possible. The human embryo is very resistant to damage. In view of these possibilities, it is advocated that attention to long term health and quality of life in gonadotoxic therapy must be incorporated into plans as early as possible. ","PeriodicalId":44130,"journal":{"name":"Clinical Medicine Insights-Reproductive Health","volume":"7 ","pages":"49-59"},"PeriodicalIF":0.0,"publicationDate":"2013-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32052742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian Stem Cells-the Pros and Cons. 卵巢干细胞的利弊。

Clinical Medicine Insights-Reproductive Health Pub Date : 2013-03-20 DOI: 10.4137/CMRH.S11086

Ayelet Evron, Zeev Blumenfeld

引用次数: 7