经滋养外胚层活检、再玻璃化和整倍体囊胚移植后，由先前玻璃化的卵母细胞活产。

Clinical Medicine Insights-Reproductive Health Pub Date : 2013-09-10 DOI:10.4137/CMRH.S11919

Jamie A Grifo, Brooke Hodes-Wertz, Hsiao Ling Lee, Esmeralda Ampeloquio, Melicia Clarke-Williams, Alexis Adler, Santiago Munné, Alan S Berkeley

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引用次数: 4

摘要

我们的目标是描述一个成功的活产卵母细胞玻璃化，随后解冻，受精，囊胚培养，滋养外胚层活检，玻璃化，随后解冻。对一例子宫因素性不孕症患者的15个成熟卵母细胞进行冷冻。13个卵母细胞在解冻后存活，5个卵母细胞接受了滋养外胚层活检并重新冷冻。获得3个整倍体胚胎。在第二个解冻周期中，将一个单一的整倍体胚胎移植到一个已知的受体中，从而产生了一个正常的男婴。本病例报告证明了植入前筛查和诊断是保留生育能力患者的一种选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Live birth from previously vitrified oocytes, after trophectoderm biopsy, revitrification, and transfer of a euploid blastocyst.

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Live birth from previously vitrified oocytes, after trophectoderm biopsy, revitrification, and transfer of a euploid blastocyst.

Our objective is to describe a successful live birth from oocyte vitrification followed by thaw, fertilization, blastocyst culture, trophectoderm biopsy, vitrification, and subsequent thaw. Fifteen mature oocytes were frozen from a patient with uterine factor infertility. Thirteen oocytes survived the thaw, and five underwent trophectoderm biopsy and were refrozen. Three euploid embryos were obtained. A single euploid embryo was transferred in the second thaw cycle to a known recipient leading to the delivery of a normal male infant. This case report is proof of the concept that preimplantation screening and diagnosis is an option for fertility preservation patients.

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来源期刊

Clinical Medicine Insights-Reproductive Health OBSTETRICS & GYNECOLOGY-

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Clinical Medicine Insights: Reproductive Health is a peer reviewed; open access journal, which covers all aspects of Reproduction: Gynecology, Obstetrics, and Infertility, spanning both male and female issues, from the physical to the psychological and the social, including: sex, contraception, pregnancy, childbirth, and related topics such as social and emotional impacts. It welcomes original research and review articles from across the health sciences. Clinical subjects include fertility and sterility, infertility and assisted reproduction, IVF, fertility preservation despite gonadotoxic chemo- and/or radiotherapy, pregnancy problems, PPD, infections and disease, surgery, diagnosis, menopause, HRT, pelvic floor problems, reproductive cancers and environmental impacts on reproduction, although this list is by no means exhaustive Subjects covered include, but are not limited to: • fertility and sterility, • infertility and ART, • ART/IVF, • fertility preservation despite gonadotoxic chemo- and/or radiotherapy, • pregnancy problems, • Postpartum depression • Infections and disease, • Gyn/Ob surgery, • diagnosis, • Contraception • Premenstrual tension • Gynecologic Oncology • reproductive cancers • environmental impacts on reproduction, • Obstetrics/Gynaecology • Women''s Health • menopause, • HRT, • pelvic floor problems, • Paediatric and adolescent gynaecology • PID